Doublecortin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEC1_LEIMA

TriTrypDb:

LmjF.29.2590 , LMJLV39_290034000 , LMJSD75_290034400

Length:

695

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEC1

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	6
GO:0009987	cellular process	1	6
GO:0035556	intracellular signal transduction	3	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0065007	biological regulation	1	6

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	332	336	PF00656	0.599
CLV_C14_Caspase3-7	343	347	PF00656	0.722
CLV_C14_Caspase3-7	372	376	PF00656	0.637
CLV_C14_Caspase3-7	414	418	PF00656	0.656
CLV_C14_Caspase3-7	659	663	PF00656	0.562
CLV_MEL_PAP_1	68	74	PF00089	0.488
CLV_NRD_NRD_1	195	197	PF00675	0.766
CLV_NRD_NRD_1	263	265	PF00675	0.724
CLV_NRD_NRD_1	339	341	PF00675	0.698
CLV_NRD_NRD_1	411	413	PF00675	0.768
CLV_NRD_NRD_1	459	461	PF00675	0.548
CLV_NRD_NRD_1	567	569	PF00675	0.778
CLV_NRD_NRD_1	6	8	PF00675	0.644
CLV_PCSK_KEX2_1	195	197	PF00082	0.766
CLV_PCSK_KEX2_1	227	229	PF00082	0.790
CLV_PCSK_KEX2_1	339	341	PF00082	0.698
CLV_PCSK_KEX2_1	410	412	PF00082	0.770
CLV_PCSK_KEX2_1	584	586	PF00082	0.750
CLV_PCSK_KEX2_1	6	8	PF00082	0.644
CLV_PCSK_KEX2_1	641	643	PF00082	0.375
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.790
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.750
CLV_PCSK_PC1ET2_1	641	643	PF00082	0.375
CLV_PCSK_PC7_1	191	197	PF00082	0.668
CLV_PCSK_SKI1_1	107	111	PF00082	0.594
CLV_PCSK_SKI1_1	128	132	PF00082	0.529
CLV_PCSK_SKI1_1	161	165	PF00082	0.701
CLV_PCSK_SKI1_1	170	174	PF00082	0.591
CLV_PCSK_SKI1_1	389	393	PF00082	0.622
CLV_PCSK_SKI1_1	473	477	PF00082	0.551
CLV_PCSK_SKI1_1	613	617	PF00082	0.557
CLV_PCSK_SKI1_1	658	662	PF00082	0.528
CLV_Separin_Metazoa	281	285	PF03568	0.689
CLV_Separin_Metazoa	438	442	PF03568	0.576
DEG_ODPH_VHL_1	586	599	PF01847	0.597
DEG_SCF_FBW7_1	353	360	PF00400	0.752
DEG_SPOP_SBC_1	548	552	PF00917	0.760
DEG_SPOP_SBC_1	553	557	PF00917	0.695
DEG_SPOP_SBC_1	558	562	PF00917	0.637
DOC_CKS1_1	391	396	PF01111	0.611
DOC_CYCLIN_yCln2_LP_2	172	175	PF00134	0.665
DOC_CYCLIN_yCln2_LP_2	311	317	PF00134	0.673
DOC_CYCLIN_yCln2_LP_2	436	442	PF00134	0.572
DOC_MAPK_gen_1	638	647	PF00069	0.573
DOC_MAPK_HePTP_8	635	647	PF00069	0.570
DOC_MAPK_MEF2A_6	115	122	PF00069	0.526
DOC_MAPK_MEF2A_6	288	295	PF00069	0.680
DOC_MAPK_MEF2A_6	638	647	PF00069	0.573
DOC_PP1_RVXF_1	126	132	PF00149	0.510
DOC_PP1_RVXF_1	420	426	PF00149	0.557
DOC_PP1_RVXF_1	458	465	PF00149	0.541
DOC_PP1_RVXF_1	631	638	PF00149	0.572
DOC_PP2B_LxvP_1	172	175	PF13499	0.724
DOC_PP2B_LxvP_1	190	193	PF13499	0.570
DOC_PP4_FxxP_1	209	212	PF00568	0.729
DOC_PP4_FxxP_1	240	243	PF00568	0.837
DOC_PP4_FxxP_1	391	394	PF00568	0.545
DOC_PP4_FxxP_1	674	677	PF00568	0.564
DOC_SPAK_OSR1_1	673	677	PF12202	0.569
DOC_USP7_MATH_1	146	150	PF00917	0.753
DOC_USP7_MATH_1	234	238	PF00917	0.763
DOC_USP7_MATH_1	246	250	PF00917	0.698
DOC_USP7_MATH_1	344	348	PF00917	0.828
DOC_USP7_MATH_1	355	359	PF00917	0.649
DOC_USP7_MATH_1	373	377	PF00917	0.509
DOC_USP7_MATH_1	416	420	PF00917	0.666
DOC_USP7_MATH_1	517	521	PF00917	0.658
DOC_USP7_MATH_1	538	542	PF00917	0.765
DOC_USP7_MATH_1	547	551	PF00917	0.730
DOC_USP7_MATH_1	558	562	PF00917	0.559
DOC_USP7_MATH_1	564	568	PF00917	0.551
DOC_USP7_MATH_1	574	578	PF00917	0.626
DOC_USP7_MATH_1	580	584	PF00917	0.708
DOC_USP7_MATH_1	70	74	PF00917	0.491
DOC_WW_Pin1_4	175	180	PF00397	0.630
DOC_WW_Pin1_4	229	234	PF00397	0.737
DOC_WW_Pin1_4	287	292	PF00397	0.742
DOC_WW_Pin1_4	324	329	PF00397	0.747
DOC_WW_Pin1_4	353	358	PF00397	0.741
DOC_WW_Pin1_4	390	395	PF00397	0.737
DOC_WW_Pin1_4	527	532	PF00397	0.694
DOC_WW_Pin1_4	533	538	PF00397	0.635
DOC_WW_Pin1_4	559	564	PF00397	0.717
DOC_WW_Pin1_4	586	591	PF00397	0.676
LIG_14-3-3_CanoR_1	107	113	PF00244	0.611
LIG_14-3-3_CanoR_1	151	159	PF00244	0.754
LIG_14-3-3_CanoR_1	161	167	PF00244	0.721
LIG_14-3-3_CanoR_1	235	241	PF00244	0.746
LIG_14-3-3_CanoR_1	441	445	PF00244	0.548
LIG_14-3-3_CanoR_1	468	475	PF00244	0.553
LIG_14-3-3_CanoR_1	493	502	PF00244	0.467
LIG_14-3-3_CanoR_1	58	62	PF00244	0.533
LIG_14-3-3_CanoR_1	613	618	PF00244	0.562
LIG_14-3-3_CanoR_1	642	646	PF00244	0.361
LIG_14-3-3_CanoR_1	71	75	PF00244	0.351
LIG_BIR_II_1	1	5	PF00653	0.680
LIG_BIR_III_4	648	652	PF00653	0.548
LIG_BRCT_BRCA1_1	236	240	PF00533	0.696
LIG_BRCT_BRCA1_1	643	647	PF00533	0.471
LIG_FHA_1	158	164	PF00498	0.789
LIG_FHA_1	266	272	PF00498	0.697
LIG_FHA_1	299	305	PF00498	0.679
LIG_FHA_1	457	463	PF00498	0.538
LIG_FHA_1	577	583	PF00498	0.695
LIG_FHA_1	612	618	PF00498	0.564
LIG_FHA_1	630	636	PF00498	0.314
LIG_FHA_1	650	656	PF00498	0.288
LIG_FHA_2	215	221	PF00498	0.763
LIG_FHA_2	341	347	PF00498	0.728
LIG_FHA_2	370	376	PF00498	0.636
LIG_IRF3_LxIS_1	436	443	PF10401	0.540
LIG_LIR_Apic_2	237	243	PF02991	0.771
LIG_LIR_Apic_2	513	519	PF02991	0.474
LIG_LIR_Apic_2	672	677	PF02991	0.571
LIG_LIR_Gen_1	449	458	PF02991	0.529
LIG_LIR_Gen_1	508	519	PF02991	0.569
LIG_LIR_Nem_3	449	455	PF02991	0.534
LIG_LIR_Nem_3	508	514	PF02991	0.563
LIG_LIR_Nem_3	609	615	PF02991	0.589
LIG_LIR_Nem_3	620	624	PF02991	0.427
LIG_MYND_1	351	355	PF01753	0.754
LIG_NRBOX	656	662	PF00104	0.567
LIG_NRP_CendR_1	693	695	PF00754	0.459
LIG_PCNA_yPIPBox_3	95	109	PF02747	0.487
LIG_PTAP_UEV_1	196	201	PF05743	0.664
LIG_PTB_Apo_2	601	608	PF02174	0.546
LIG_PTB_Phospho_1	601	607	PF10480	0.539
LIG_Rb_pABgroove_1	641	649	PF01858	0.544
LIG_SH2_CRK	516	520	PF00017	0.521
LIG_SH2_CRK	612	616	PF00017	0.566
LIG_SH2_CRK	621	625	PF00017	0.451
LIG_SH2_GRB2like	602	605	PF00017	0.542
LIG_SH2_NCK_1	516	520	PF00017	0.521
LIG_SH2_SRC	602	605	PF00017	0.542
LIG_SH2_STAP1	607	611	PF00017	0.594
LIG_SH2_STAT5	400	403	PF00017	0.575
LIG_SH2_STAT5	88	91	PF00017	0.558
LIG_SH2_STAT5	98	101	PF00017	0.461
LIG_SH3_1	280	286	PF00018	0.693
LIG_SH3_2	283	288	PF14604	0.702
LIG_SH3_2	563	568	PF14604	0.703
LIG_SH3_3	168	174	PF00018	0.775
LIG_SH3_3	194	200	PF00018	0.712
LIG_SH3_3	208	214	PF00018	0.553
LIG_SH3_3	240	246	PF00018	0.780
LIG_SH3_3	280	286	PF00018	0.738
LIG_SH3_3	539	545	PF00018	0.598
LIG_SH3_3	560	566	PF00018	0.769
LIG_SUMO_SIM_par_1	300	305	PF11976	0.585
LIG_SUMO_SIM_par_1	652	659	PF11976	0.560
LIG_TRAF2_1	217	220	PF00917	0.678
LIG_ULM_U2AF65_1	460	465	PF00076	0.555
LIG_WRC_WIRS_1	109	114	PF05994	0.604
LIG_WW_3	281	285	PF00397	0.689
MOD_CDC14_SPxK_1	565	568	PF00782	0.672
MOD_CDK_SPxK_1	229	235	PF00069	0.678
MOD_CDK_SPxK_1	562	568	PF00069	0.672
MOD_CDK_SPxxK_3	395	402	PF00069	0.561
MOD_CDK_SPxxK_3	527	534	PF00069	0.698
MOD_CDK_SPxxK_3	562	569	PF00069	0.718
MOD_CK1_1	138	144	PF00069	0.660
MOD_CK1_1	165	171	PF00069	0.759
MOD_CK1_1	198	204	PF00069	0.571
MOD_CK1_1	327	333	PF00069	0.707
MOD_CK1_1	342	348	PF00069	0.627
MOD_CK1_1	525	531	PF00069	0.632
MOD_CK1_1	552	558	PF00069	0.720
MOD_CK1_1	559	565	PF00069	0.675
MOD_CK1_1	589	595	PF00069	0.625
MOD_CK2_1	214	220	PF00069	0.753
MOD_CK2_1	342	348	PF00069	0.603
MOD_CK2_1	36	42	PF00069	0.585
MOD_CK2_1	647	653	PF00069	0.546
MOD_Cter_Amidation	639	642	PF01082	0.599
MOD_GlcNHglycan	148	151	PF01048	0.723
MOD_GlcNHglycan	167	170	PF01048	0.503
MOD_GlcNHglycan	197	200	PF01048	0.765
MOD_GlcNHglycan	201	204	PF01048	0.724
MOD_GlcNHglycan	37	41	PF01048	0.553
MOD_GlcNHglycan	375	378	PF01048	0.691
MOD_GlcNHglycan	413	416	PF01048	0.737
MOD_GlcNHglycan	417	421	PF01048	0.637
MOD_GlcNHglycan	483	486	PF01048	0.619
MOD_GlcNHglycan	551	554	PF01048	0.725
MOD_GlcNHglycan	648	652	PF01048	0.548
MOD_GlcNHglycan	668	671	PF01048	0.301
MOD_GSK3_1	141	148	PF00069	0.587
MOD_GSK3_1	150	157	PF00069	0.576
MOD_GSK3_1	195	202	PF00069	0.826
MOD_GSK3_1	294	301	PF00069	0.752
MOD_GSK3_1	338	345	PF00069	0.821
MOD_GSK3_1	353	360	PF00069	0.597
MOD_GSK3_1	369	376	PF00069	0.517
MOD_GSK3_1	390	397	PF00069	0.601
MOD_GSK3_1	406	413	PF00069	0.649
MOD_GSK3_1	469	476	PF00069	0.571
MOD_GSK3_1	506	513	PF00069	0.453
MOD_GSK3_1	548	555	PF00069	0.742
MOD_GSK3_1	558	565	PF00069	0.693
MOD_GSK3_1	574	581	PF00069	0.596
MOD_GSK3_1	613	620	PF00069	0.508
MOD_N-GLC_1	394	399	PF02516	0.582
MOD_N-GLC_1	434	439	PF02516	0.522
MOD_NEK2_1	329	334	PF00069	0.690
MOD_NEK2_1	440	445	PF00069	0.552
MOD_NEK2_1	469	474	PF00069	0.578
MOD_NEK2_1	494	499	PF00069	0.524
MOD_NEK2_1	647	652	PF00069	0.544
MOD_NEK2_2	70	75	PF00069	0.487
MOD_PIKK_1	135	141	PF00454	0.546
MOD_PIKK_1	246	252	PF00454	0.720
MOD_PKA_1	195	201	PF00069	0.761
MOD_PKA_1	265	271	PF00069	0.702
MOD_PKA_1	339	345	PF00069	0.698
MOD_PKA_1	410	416	PF00069	0.746
MOD_PKA_1	641	647	PF00069	0.487
MOD_PKA_2	150	156	PF00069	0.738
MOD_PKA_2	17	23	PF00069	0.552
MOD_PKA_2	195	201	PF00069	0.761
MOD_PKA_2	234	240	PF00069	0.667
MOD_PKA_2	338	344	PF00069	0.693
MOD_PKA_2	410	416	PF00069	0.749
MOD_PKA_2	440	446	PF00069	0.558
MOD_PKA_2	467	473	PF00069	0.575
MOD_PKA_2	517	523	PF00069	0.702
MOD_PKA_2	525	531	PF00069	0.677
MOD_PKA_2	57	63	PF00069	0.540
MOD_PKA_2	617	623	PF00069	0.516
MOD_PKA_2	641	647	PF00069	0.359
MOD_PKA_2	70	76	PF00069	0.359
MOD_Plk_1	403	409	PF00069	0.726
MOD_Plk_1	41	47	PF00069	0.574
MOD_Plk_1	64	70	PF00069	0.560
MOD_Plk_4	307	313	PF00069	0.712
MOD_Plk_4	447	453	PF00069	0.554
MOD_Plk_4	626	632	PF00069	0.544
MOD_Plk_4	641	647	PF00069	0.348
MOD_ProDKin_1	175	181	PF00069	0.633
MOD_ProDKin_1	229	235	PF00069	0.741
MOD_ProDKin_1	287	293	PF00069	0.743
MOD_ProDKin_1	324	330	PF00069	0.750
MOD_ProDKin_1	353	359	PF00069	0.743
MOD_ProDKin_1	390	396	PF00069	0.738
MOD_ProDKin_1	527	533	PF00069	0.698
MOD_ProDKin_1	559	565	PF00069	0.716
MOD_ProDKin_1	586	592	PF00069	0.675
MOD_SUMO_for_1	278	281	PF00179	0.726
MOD_SUMO_rev_2	477	485	PF00179	0.614
MOD_SUMO_rev_2	634	643	PF00179	0.551
TRG_ENDOCYTIC_2	612	615	PF00928	0.568
TRG_ENDOCYTIC_2	621	624	PF00928	0.448
TRG_ER_diArg_1	195	197	PF00400	0.766
TRG_ER_diArg_1	338	340	PF00400	0.688
TRG_ER_diArg_1	410	412	PF00400	0.710
TRG_NLS_MonoExtC_3	459	465	PF00514	0.548
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.627
TRG_Pf-PMV_PEXEL_1	460	465	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	658	662	PF00026	0.528
TRG_PTS2	1	14	PF00400	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IRL3	Leishmania donovani	91%	100%
A4HHQ7	Leishmania braziliensis	68%	99%
A4I4T5	Leishmania infantum	91%	100%
E9ALG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%