RanBD1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEC0_LEIMA

TriTrypDb:

LmjF.29.2580 , LMJLV39_290033900 , LMJSD75_290034300

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEC0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.614
CLV_C14_Caspase3-7	449	453	PF00656	0.585
CLV_C14_Caspase3-7	547	551	PF00656	0.559
CLV_NRD_NRD_1	136	138	PF00675	0.672
CLV_NRD_NRD_1	139	141	PF00675	0.643
CLV_NRD_NRD_1	246	248	PF00675	0.685
CLV_NRD_NRD_1	58	60	PF00675	0.534
CLV_PCSK_FUR_1	137	141	PF00082	0.616
CLV_PCSK_KEX2_1	136	138	PF00082	0.667
CLV_PCSK_KEX2_1	139	141	PF00082	0.642
CLV_PCSK_KEX2_1	230	232	PF00082	0.664
CLV_PCSK_KEX2_1	58	60	PF00082	0.476
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.623
CLV_PCSK_SKI1_1	251	255	PF00082	0.734
CLV_PCSK_SKI1_1	423	427	PF00082	0.575
CLV_PCSK_SKI1_1	521	525	PF00082	0.557
CLV_PCSK_SKI1_1	595	599	PF00082	0.690
DEG_SCF_FBW7_1	103	109	PF00400	0.611
DOC_CKS1_1	103	108	PF01111	0.620
DOC_MAPK_FxFP_2	650	653	PF00069	0.573
DOC_PP2B_LxvP_1	219	222	PF13499	0.616
DOC_PP2B_LxvP_1	279	282	PF13499	0.622
DOC_PP4_FxxP_1	185	188	PF00568	0.609
DOC_PP4_FxxP_1	28	31	PF00568	0.590
DOC_PP4_FxxP_1	361	364	PF00568	0.595
DOC_PP4_FxxP_1	459	462	PF00568	0.559
DOC_PP4_FxxP_1	557	560	PF00568	0.588
DOC_PP4_FxxP_1	650	653	PF00568	0.618
DOC_PP4_FxxP_1	96	99	PF00568	0.601
DOC_USP7_MATH_1	113	117	PF00917	0.656
DOC_USP7_MATH_1	121	125	PF00917	0.569
DOC_USP7_MATH_1	138	142	PF00917	0.791
DOC_USP7_MATH_1	188	192	PF00917	0.659
DOC_USP7_MATH_1	211	215	PF00917	0.774
DOC_USP7_MATH_1	23	27	PF00917	0.651
DOC_USP7_MATH_1	271	275	PF00917	0.602
DOC_USP7_MATH_1	282	286	PF00917	0.585
DOC_USP7_MATH_1	351	355	PF00917	0.788
DOC_USP7_MATH_1	39	43	PF00917	0.529
DOC_USP7_MATH_1	47	51	PF00917	0.513
DOC_USP7_MATH_1	502	506	PF00917	0.648
DOC_USP7_MATH_1	604	608	PF00917	0.499
DOC_USP7_MATH_1	658	662	PF00917	0.570
DOC_USP7_MATH_1	83	87	PF00917	0.609
DOC_USP7_UBL2_3	395	399	PF12436	0.716
DOC_USP7_UBL2_3	446	450	PF12436	0.579
DOC_USP7_UBL2_3	493	497	PF12436	0.709
DOC_USP7_UBL2_3	544	548	PF12436	0.579
DOC_USP7_UBL2_3	591	595	PF12436	0.723
DOC_WW_Pin1_4	102	107	PF00397	0.624
DOC_WW_Pin1_4	109	114	PF00397	0.691
DOC_WW_Pin1_4	233	238	PF00397	0.602
DOC_WW_Pin1_4	326	331	PF00397	0.604
DOC_WW_Pin1_4	37	42	PF00397	0.614
DOC_WW_Pin1_4	426	431	PF00397	0.571
DOC_WW_Pin1_4	524	529	PF00397	0.573
DOC_WW_Pin1_4	600	605	PF00397	0.605
DOC_WW_Pin1_4	664	669	PF00397	0.518
LIG_14-3-3_CanoR_1	137	147	PF00244	0.619
LIG_14-3-3_CanoR_1	215	219	PF00244	0.651
LIG_14-3-3_CanoR_1	412	418	PF00244	0.521
LIG_14-3-3_CanoR_1	510	516	PF00244	0.526
LIG_BIR_II_1	1	5	PF00653	0.577
LIG_BRCT_BRCA1_1	607	611	PF00533	0.615
LIG_BRCT_BRCA1_1	666	670	PF00533	0.579
LIG_EH_1	438	442	PF12763	0.582
LIG_EH_1	536	540	PF12763	0.627
LIG_EH_1	647	651	PF12763	0.592
LIG_FHA_1	103	109	PF00498	0.621
LIG_FHA_1	130	136	PF00498	0.668
LIG_FHA_1	278	284	PF00498	0.622
LIG_FHA_1	286	292	PF00498	0.541
LIG_FHA_1	427	433	PF00498	0.626
LIG_FHA_1	525	531	PF00498	0.627
LIG_FHA_2	250	256	PF00498	0.663
LIG_LIR_Apic_2	142	148	PF02991	0.565
LIG_LIR_Apic_2	25	31	PF02991	0.590
LIG_LIR_Gen_1	10	21	PF02991	0.560
LIG_LIR_Nem_3	10	16	PF02991	0.555
LIG_LIR_Nem_3	191	196	PF02991	0.768
LIG_LIR_Nem_3	416	420	PF02991	0.635
LIG_LIR_Nem_3	514	518	PF02991	0.614
LIG_LIR_Nem_3	52	57	PF02991	0.508
LIG_LYPXL_S_1	192	196	PF13949	0.621
LIG_LYPXL_SIV_4	64	72	PF13949	0.552
LIG_LYPXL_yS_3	193	196	PF13949	0.625
LIG_PCNA_PIPBox_1	178	187	PF02747	0.621
LIG_PCNA_yPIPBox_3	172	185	PF02747	0.630
LIG_PTB_Apo_2	59	66	PF02174	0.477
LIG_PTB_Phospho_1	59	65	PF10480	0.475
LIG_SH2_CRK	145	149	PF00017	0.606
LIG_SH2_CRK	65	69	PF00017	0.543
LIG_SH2_NCK_1	65	69	PF00017	0.543
LIG_SH2_STAT5	184	187	PF00017	0.612
LIG_SH2_STAT5	56	59	PF00017	0.496
LIG_SH3_1	207	213	PF00018	0.565
LIG_SH3_1	353	359	PF00018	0.649
LIG_SH3_2	210	215	PF14604	0.564
LIG_SH3_3	100	106	PF00018	0.602
LIG_SH3_3	144	150	PF00018	0.667
LIG_SH3_3	151	157	PF00018	0.727
LIG_SH3_3	207	213	PF00018	0.565
LIG_SH3_3	306	312	PF00018	0.651
LIG_SH3_3	353	359	PF00018	0.649
LIG_SH3_3	38	44	PF00018	0.614
LIG_SH3_3	434	440	PF00018	0.592
LIG_SH3_3	451	457	PF00018	0.599
LIG_SH3_3	532	538	PF00018	0.588
LIG_SH3_3	549	555	PF00018	0.510
LIG_SH3_3	650	656	PF00018	0.578
LIG_SH3_4	446	453	PF00018	0.582
LIG_SH3_4	544	551	PF00018	0.557
LIG_TRAF2_1	123	126	PF00917	0.611
LIG_TYR_ITIM	63	68	PF00017	0.534
LIG_WRC_WIRS_1	659	664	PF05994	0.500
MOD_CK1_1	109	115	PF00069	0.582
MOD_CK1_1	124	130	PF00069	0.532
MOD_CK1_1	214	220	PF00069	0.623
MOD_CK1_1	285	291	PF00069	0.710
MOD_CK1_1	37	43	PF00069	0.651
MOD_CK1_1	404	410	PF00069	0.536
MOD_CK1_1	661	667	PF00069	0.570
MOD_CK1_1	671	677	PF00069	0.538
MOD_CK2_1	167	173	PF00069	0.609
MOD_GlcNHglycan	108	111	PF01048	0.623
MOD_GlcNHglycan	117	120	PF01048	0.643
MOD_GlcNHglycan	169	172	PF01048	0.597
MOD_GlcNHglycan	25	28	PF01048	0.640
MOD_GlcNHglycan	267	270	PF01048	0.637
MOD_GlcNHglycan	345	348	PF01048	0.547
MOD_GlcNHglycan	36	39	PF01048	0.581
MOD_GlcNHglycan	406	410	PF01048	0.599
MOD_GlcNHglycan	443	446	PF01048	0.646
MOD_GlcNHglycan	49	52	PF01048	0.724
MOD_GlcNHglycan	504	508	PF01048	0.615
MOD_GlcNHglycan	541	544	PF01048	0.660
MOD_GlcNHglycan	600	603	PF01048	0.653
MOD_GlcNHglycan	607	610	PF01048	0.564
MOD_GlcNHglycan	625	628	PF01048	0.620
MOD_GlcNHglycan	642	645	PF01048	0.496
MOD_GlcNHglycan	68	71	PF01048	0.395
MOD_GlcNHglycan	91	94	PF01048	0.637
MOD_GSK3_1	102	109	PF00069	0.618
MOD_GSK3_1	217	224	PF00069	0.603
MOD_GSK3_1	261	268	PF00069	0.731
MOD_GSK3_1	271	278	PF00069	0.587
MOD_GSK3_1	324	331	PF00069	0.600
MOD_GSK3_1	401	408	PF00069	0.637
MOD_GSK3_1	426	433	PF00069	0.671
MOD_GSK3_1	524	531	PF00069	0.695
MOD_GSK3_1	596	603	PF00069	0.620
MOD_GSK3_1	605	612	PF00069	0.684
MOD_GSK3_1	632	639	PF00069	0.597
MOD_GSK3_1	658	665	PF00069	0.541
MOD_GSK3_1	666	673	PF00069	0.492
MOD_N-GLC_1	47	52	PF02516	0.605
MOD_N-GLC_1	83	88	PF02516	0.622
MOD_N-GLC_1	89	94	PF02516	0.648
MOD_NEK2_1	324	329	PF00069	0.637
MOD_NEK2_1	441	446	PF00069	0.637
MOD_NEK2_1	539	544	PF00069	0.602
MOD_NEK2_1	630	635	PF00069	0.590
MOD_NEK2_1	636	641	PF00069	0.593
MOD_NEK2_1	662	667	PF00069	0.621
MOD_NEK2_1	670	675	PF00069	0.528
MOD_NEK2_2	188	193	PF00069	0.563
MOD_PIKK_1	271	277	PF00454	0.630
MOD_PKA_1	139	145	PF00069	0.620
MOD_PKA_2	121	127	PF00069	0.705
MOD_PKA_2	138	144	PF00069	0.587
MOD_PKA_2	214	220	PF00069	0.592
MOD_PKB_1	137	145	PF00069	0.669
MOD_Plk_1	124	130	PF00069	0.802
MOD_Plk_1	188	194	PF00069	0.639
MOD_Plk_1	259	265	PF00069	0.650
MOD_Plk_1	275	281	PF00069	0.485
MOD_Plk_1	301	307	PF00069	0.598
MOD_Plk_4	214	220	PF00069	0.586
MOD_Plk_4	365	371	PF00069	0.719
MOD_Plk_4	463	469	PF00069	0.629
MOD_Plk_4	561	567	PF00069	0.636
MOD_ProDKin_1	102	108	PF00069	0.626
MOD_ProDKin_1	109	115	PF00069	0.692
MOD_ProDKin_1	233	239	PF00069	0.604
MOD_ProDKin_1	326	332	PF00069	0.601
MOD_ProDKin_1	37	43	PF00069	0.614
MOD_ProDKin_1	426	432	PF00069	0.572
MOD_ProDKin_1	524	530	PF00069	0.572
MOD_ProDKin_1	600	606	PF00069	0.603
MOD_ProDKin_1	664	670	PF00069	0.519
MOD_SUMO_for_1	597	600	PF00179	0.646
MOD_SUMO_rev_2	588	597	PF00179	0.604
TRG_ENDOCYTIC_2	193	196	PF00928	0.775
TRG_ENDOCYTIC_2	65	68	PF00928	0.543
TRG_ER_diArg_1	135	137	PF00400	0.665
TRG_ER_diArg_1	138	140	PF00400	0.637
TRG_ER_diArg_1	231	234	PF00400	0.682
TRG_ER_diArg_1	57	59	PF00400	0.539
TRG_NLS_MonoCore_2	229	234	PF00514	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEM6	Leishmania donovani	92%	100%
A4HHQ6	Leishmania braziliensis	66%	100%
A4I4X1	Leishmania infantum	84%	100%
E9ALG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BSK6	Trypanosoma cruzi	28%	100%