UPF0573 protein C2orf70 homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4586), putative

Species:

Leishmania major

UniProt:

E9AEB8_LEIMA

TriTrypDb:

LmjF.29.2560 , LMJLV39_290033700 , LMJSD75_290034100

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	17
GO:0005815	microtubule organizing center	2	17
GO:0110165	cellular anatomical entity	1	17
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AEB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.550
CLV_NRD_NRD_1	12	14	PF00675	0.417
CLV_NRD_NRD_1	270	272	PF00675	0.345
CLV_NRD_NRD_1	321	323	PF00675	0.249
CLV_NRD_NRD_1	373	375	PF00675	0.283
CLV_NRD_NRD_1	410	412	PF00675	0.472
CLV_PCSK_FUR_1	268	272	PF00082	0.274
CLV_PCSK_KEX2_1	134	136	PF00082	0.219
CLV_PCSK_KEX2_1	215	217	PF00082	0.256
CLV_PCSK_KEX2_1	270	272	PF00082	0.285
CLV_PCSK_KEX2_1	321	323	PF00082	0.276
CLV_PCSK_KEX2_1	325	327	PF00082	0.272
CLV_PCSK_KEX2_1	389	391	PF00082	0.323
CLV_PCSK_KEX2_1	410	412	PF00082	0.497
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.219
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.265
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.276
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.272
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.380
CLV_PCSK_SKI1_1	114	118	PF00082	0.273
CLV_PCSK_SKI1_1	134	138	PF00082	0.162
CLV_PCSK_SKI1_1	322	326	PF00082	0.325
CLV_PCSK_SKI1_1	370	374	PF00082	0.277
DOC_CYCLIN_yCln2_LP_2	282	288	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	53	59	PF00134	0.418
DOC_MAPK_DCC_7	27	36	PF00069	0.426
DOC_MAPK_gen_1	13	19	PF00069	0.416
DOC_MAPK_MEF2A_6	27	36	PF00069	0.484
DOC_PP2B_LxvP_1	21	24	PF13499	0.404
DOC_PP2B_LxvP_1	282	285	PF13499	0.501
DOC_PP2B_LxvP_1	34	37	PF13499	0.415
DOC_PP4_FxxP_1	286	289	PF00568	0.458
DOC_PP4_FxxP_1	83	86	PF00568	0.465
DOC_USP7_MATH_1	106	110	PF00917	0.606
DOC_USP7_MATH_1	181	185	PF00917	0.490
DOC_USP7_MATH_1	289	293	PF00917	0.450
DOC_USP7_MATH_1	314	318	PF00917	0.450
DOC_USP7_MATH_1	344	348	PF00917	0.430
DOC_USP7_UBL2_3	210	214	PF12436	0.441
DOC_USP7_UBL2_3	215	219	PF12436	0.433
DOC_USP7_UBL2_3	321	325	PF12436	0.435
DOC_USP7_UBL2_3	375	379	PF12436	0.472
DOC_USP7_UBL2_3	72	76	PF12436	0.411
DOC_WW_Pin1_4	52	57	PF00397	0.410
LIG_14-3-3_CanoR_1	135	140	PF00244	0.419
LIG_14-3-3_CanoR_1	395	400	PF00244	0.505
LIG_14-3-3_CanoR_1	8	16	PF00244	0.422
LIG_APCC_ABBA_1	359	364	PF00400	0.450
LIG_BIR_III_2	105	109	PF00653	0.577
LIG_BRCT_BRCA1_1	54	58	PF00533	0.406
LIG_deltaCOP1_diTrp_1	392	399	PF00928	0.514
LIG_EH_1	353	357	PF12763	0.450
LIG_eIF4E_1	241	247	PF01652	0.529
LIG_EVH1_1	29	33	PF00568	0.425
LIG_FHA_1	400	406	PF00498	0.499
LIG_LIR_Apic_2	240	244	PF02991	0.434
LIG_LIR_Gen_1	133	140	PF02991	0.427
LIG_LIR_Gen_1	42	53	PF02991	0.475
LIG_LIR_Nem_3	133	139	PF02991	0.427
LIG_LIR_Nem_3	174	180	PF02991	0.537
LIG_LIR_Nem_3	189	194	PF02991	0.514
LIG_LIR_Nem_3	240	246	PF02991	0.459
LIG_LIR_Nem_3	26	32	PF02991	0.542
LIG_LIR_Nem_3	305	311	PF02991	0.532
LIG_LIR_Nem_3	42	48	PF02991	0.420
LIG_LIR_Nem_3	77	82	PF02991	0.449
LIG_LYPXL_yS_3	243	246	PF13949	0.517
LIG_MYND_3	62	66	PF01753	0.414
LIG_NRBOX	16	22	PF00104	0.413
LIG_Pex14_1	257	261	PF04695	0.517
LIG_Pex14_2	132	136	PF04695	0.491
LIG_Pex14_2	356	360	PF04695	0.429
LIG_PTB_Apo_2	193	200	PF02174	0.474
LIG_PTB_Apo_2	247	254	PF02174	0.437
LIG_PTB_Phospho_1	193	199	PF10480	0.517
LIG_PTB_Phospho_1	247	253	PF10480	0.437
LIG_SH2_CRK	241	245	PF00017	0.449
LIG_SH2_CRK	79	83	PF00017	0.459
LIG_SH2_NCK_1	261	265	PF00017	0.439
LIG_SH2_NCK_1	311	315	PF00017	0.494
LIG_SH2_PTP2	45	48	PF00017	0.416
LIG_SH2_SRC	152	155	PF00017	0.520
LIG_SH2_STAT5	111	114	PF00017	0.432
LIG_SH2_STAT5	131	134	PF00017	0.362
LIG_SH2_STAT5	16	19	PF00017	0.498
LIG_SH2_STAT5	295	298	PF00017	0.479
LIG_SH2_STAT5	45	48	PF00017	0.416
LIG_SH2_STAT5	88	91	PF00017	0.532
LIG_SH3_1	27	33	PF00018	0.431
LIG_SH3_3	25	31	PF00018	0.434
LIG_SH3_3	390	396	PF00018	0.456
LIG_SH3_3	57	63	PF00018	0.424
LIG_TRAF2_1	220	223	PF00917	0.439
LIG_TRAF2_2	124	129	PF00917	0.450
LIG_WW_2	30	33	PF00397	0.440
MOD_CK1_1	249	255	PF00069	0.435
MOD_CK1_1	403	409	PF00069	0.532
MOD_CK2_1	168	174	PF00069	0.542
MOD_CK2_1	176	182	PF00069	0.521
MOD_CK2_1	314	320	PF00069	0.597
MOD_GlcNHglycan	304	307	PF01048	0.258
MOD_GlcNHglycan	316	319	PF01048	0.237
MOD_GlcNHglycan	342	345	PF01048	0.246
MOD_GlcNHglycan	346	349	PF01048	0.222
MOD_GSK3_1	135	142	PF00069	0.450
MOD_GSK3_1	152	159	PF00069	0.375
MOD_GSK3_1	182	189	PF00069	0.494
MOD_GSK3_1	340	347	PF00069	0.456
MOD_GSK3_1	395	402	PF00069	0.445
MOD_GSK3_1	48	55	PF00069	0.419
MOD_N-GLC_1	114	119	PF02516	0.317
MOD_N-GLC_1	344	349	PF02516	0.317
MOD_NEK2_1	175	180	PF00069	0.563
MOD_NEK2_1	246	251	PF00069	0.534
MOD_NEK2_1	340	345	PF00069	0.428
MOD_NEK2_1	399	404	PF00069	0.540
MOD_NEK2_1	48	53	PF00069	0.590
MOD_NEK2_1	64	69	PF00069	0.616
MOD_PIKK_1	363	369	PF00454	0.560
MOD_PKA_1	237	243	PF00069	0.445
MOD_PKA_2	7	13	PF00069	0.429
MOD_Plk_1	114	120	PF00069	0.517
MOD_Plk_1	74	80	PF00069	0.286
MOD_Plk_4	186	192	PF00069	0.540
MOD_Plk_4	291	297	PF00069	0.580
MOD_Plk_4	330	336	PF00069	0.505
MOD_Plk_4	400	406	PF00069	0.459
MOD_Plk_4	74	80	PF00069	0.284
MOD_ProDKin_1	52	58	PF00069	0.418
MOD_SUMO_for_1	220	223	PF00179	0.441
MOD_SUMO_for_1	324	327	PF00179	0.450
MOD_SUMO_rev_2	204	211	PF00179	0.501
MOD_SUMO_rev_2	90	98	PF00179	0.431
MOD_SUMO_rev_2	99	106	PF00179	0.446
TRG_DiLeu_BaEn_4	223	229	PF01217	0.450
TRG_ENDOCYTIC_2	16	19	PF00928	0.412
TRG_ENDOCYTIC_2	191	194	PF00928	0.521
TRG_ENDOCYTIC_2	199	202	PF00928	0.480
TRG_ENDOCYTIC_2	243	246	PF00928	0.511
TRG_ENDOCYTIC_2	45	48	PF00928	0.416
TRG_ENDOCYTIC_2	79	82	PF00928	0.475
TRG_ER_diArg_1	268	271	PF00400	0.430
TRG_ER_diArg_1	409	411	PF00400	0.467
TRG_NLS_MonoCore_2	211	216	PF00514	0.455
TRG_NLS_MonoExtC_3	211	216	PF00514	0.409
TRG_NLS_MonoExtC_3	321	326	PF00514	0.442
TRG_NLS_MonoExtN_4	210	217	PF00514	0.439
TRG_NLS_MonoExtN_4	321	326	PF00514	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6K0	Leptomonas seymouri	67%	100%
A0A0S4IPI4	Bodo saltans	38%	100%
A0A1X0P929	Trypanosomatidae	50%	100%
A0A3Q8IGT8	Leishmania donovani	29%	100%
A0A3R7NAQ1	Trypanosoma rangeli	47%	100%
A0A3S7X2W5	Leishmania donovani	96%	100%
A4HGN9	Leishmania braziliensis	31%	100%
A4HHQ4	Leishmania braziliensis	82%	100%
A4I3R2	Leishmania infantum	31%	100%
A4I4W9	Leishmania infantum	89%	100%
C9ZKZ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ALG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	97%
E9B005	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q4Q880	Leishmania major	30%	100%
V5DTV3	Trypanosoma cruzi	49%	100%