SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania major

UniProt:

E9AEB6_LEIMA

TriTrypDb:

LmjF.29.2540 , LMJLV39_290033500 , LMJSD75_290033900

Length:

638

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AEB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEB6

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0032259	methylation	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.470
CLV_C14_Caspase3-7	415	419	PF00656	0.494
CLV_C14_Caspase3-7	615	619	PF00656	0.592
CLV_C14_Caspase3-7	73	77	PF00656	0.446
CLV_NRD_NRD_1	111	113	PF00675	0.566
CLV_NRD_NRD_1	243	245	PF00675	0.236
CLV_NRD_NRD_1	357	359	PF00675	0.262
CLV_NRD_NRD_1	382	384	PF00675	0.270
CLV_NRD_NRD_1	6	8	PF00675	0.569
CLV_PCSK_FUR_1	380	384	PF00082	0.249
CLV_PCSK_KEX2_1	111	113	PF00082	0.433
CLV_PCSK_KEX2_1	12	14	PF00082	0.574
CLV_PCSK_KEX2_1	357	359	PF00082	0.294
CLV_PCSK_KEX2_1	382	384	PF00082	0.227
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.396
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.571
CLV_PCSK_PC7_1	107	113	PF00082	0.420
CLV_PCSK_SKI1_1	117	121	PF00082	0.384
CLV_PCSK_SKI1_1	267	271	PF00082	0.188
CLV_PCSK_SKI1_1	335	339	PF00082	0.245
CLV_PCSK_SKI1_1	382	386	PF00082	0.260
CLV_PCSK_SKI1_1	595	599	PF00082	0.458
DEG_APCC_DBOX_1	217	225	PF00400	0.458
DEG_APCC_DBOX_1	266	274	PF00400	0.428
DEG_SPOP_SBC_1	558	562	PF00917	0.429
DOC_CYCLIN_RxL_1	434	446	PF00134	0.421
DOC_MAPK_MEF2A_6	164	173	PF00069	0.418
DOC_MAPK_MEF2A_6	595	602	PF00069	0.424
DOC_MAPK_NFAT4_5	595	603	PF00069	0.466
DOC_PP1_RVXF_1	498	504	PF00149	0.298
DOC_PP1_RVXF_1	97	104	PF00149	0.433
DOC_PP2B_LxvP_1	441	444	PF13499	0.296
DOC_PP2B_LxvP_1	598	601	PF13499	0.437
DOC_PP4_MxPP_1	140	143	PF00568	0.287
DOC_USP7_MATH_1	174	178	PF00917	0.355
DOC_USP7_MATH_1	296	300	PF00917	0.427
DOC_USP7_MATH_1	573	577	PF00917	0.430
DOC_USP7_UBL2_3	8	12	PF12436	0.617
DOC_WW_Pin1_4	312	317	PF00397	0.455
DOC_WW_Pin1_4	321	326	PF00397	0.430
DOC_WW_Pin1_4	521	526	PF00397	0.388
DOC_WW_Pin1_4	532	537	PF00397	0.412
LIG_14-3-3_CanoR_1	271	281	PF00244	0.548
LIG_14-3-3_CanoR_1	357	361	PF00244	0.473
LIG_14-3-3_CanoR_1	434	438	PF00244	0.497
LIG_14-3-3_CanoR_1	502	511	PF00244	0.295
LIG_Actin_WH2_2	228	246	PF00022	0.403
LIG_Actin_WH2_2	482	497	PF00022	0.393
LIG_BIR_II_1	1	5	PF00653	0.602
LIG_BIR_III_4	418	422	PF00653	0.482
LIG_BRCT_BRCA1_1	486	490	PF00533	0.321
LIG_BRCT_BRCA1_1	61	65	PF00533	0.335
LIG_BRCT_BRCA1_1	83	87	PF00533	0.417
LIG_Clathr_ClatBox_1	145	149	PF01394	0.402
LIG_deltaCOP1_diTrp_1	248	253	PF00928	0.403
LIG_deltaCOP1_diTrp_1	47	51	PF00928	0.329
LIG_FHA_1	163	169	PF00498	0.403
LIG_FHA_1	284	290	PF00498	0.414
LIG_FHA_1	306	312	PF00498	0.439
LIG_FHA_1	332	338	PF00498	0.380
LIG_FHA_1	368	374	PF00498	0.478
LIG_FHA_1	379	385	PF00498	0.448
LIG_FHA_1	503	509	PF00498	0.474
LIG_FHA_1	522	528	PF00498	0.366
LIG_FHA_1	544	550	PF00498	0.567
LIG_FHA_1	78	84	PF00498	0.485
LIG_FHA_2	131	137	PF00498	0.297
LIG_FHA_2	210	216	PF00498	0.403
LIG_FHA_2	30	36	PF00498	0.375
LIG_FHA_2	331	337	PF00498	0.435
LIG_Integrin_RGD_1	107	109	PF01839	0.444
LIG_LIR_Gen_1	226	236	PF02991	0.432
LIG_LIR_Gen_1	306	317	PF02991	0.543
LIG_LIR_Gen_1	446	454	PF02991	0.401
LIG_LIR_Gen_1	46	55	PF02991	0.323
LIG_LIR_Gen_1	487	496	PF02991	0.371
LIG_LIR_Nem_3	217	222	PF02991	0.418
LIG_LIR_Nem_3	226	231	PF02991	0.436
LIG_LIR_Nem_3	306	312	PF02991	0.473
LIG_LIR_Nem_3	32	37	PF02991	0.377
LIG_LIR_Nem_3	446	452	PF02991	0.407
LIG_LIR_Nem_3	46	51	PF02991	0.354
LIG_LIR_Nem_3	487	493	PF02991	0.324
LIG_MAD2	153	161	PF02301	0.414
LIG_NRBOX	168	174	PF00104	0.469
LIG_PTB_Apo_2	28	35	PF02174	0.347
LIG_SH2_CRK	449	453	PF00017	0.370
LIG_SH2_GRB2like	449	452	PF00017	0.362
LIG_SH2_GRB2like	496	499	PF00017	0.363
LIG_SH2_SRC	344	347	PF00017	0.495
LIG_SH2_STAP1	449	453	PF00017	0.468
LIG_SH2_STAT5	131	134	PF00017	0.321
LIG_SH2_STAT5	465	468	PF00017	0.354
LIG_SH2_STAT5	570	573	PF00017	0.291
LIG_SH3_3	20	26	PF00018	0.367
LIG_SH3_3	217	223	PF00018	0.403
LIG_SH3_3	422	428	PF00018	0.442
LIG_SH3_3	510	516	PF00018	0.309
LIG_SH3_3	562	568	PF00018	0.501
LIG_SH3_3	90	96	PF00018	0.377
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.416
LIG_SUMO_SIM_par_1	519	524	PF11976	0.358
LIG_TRAF2_1	133	136	PF00917	0.323
LIG_TRAF2_1	605	608	PF00917	0.674
LIG_TRAF2_1	613	616	PF00917	0.671
LIG_TRFH_1	219	223	PF08558	0.403
LIG_UBA3_1	269	277	PF00899	0.445
MOD_CK1_1	163	169	PF00069	0.433
MOD_CK1_1	275	281	PF00069	0.445
MOD_CK1_1	285	291	PF00069	0.369
MOD_CK1_1	543	549	PF00069	0.565
MOD_CK1_1	625	631	PF00069	0.601
MOD_CK2_1	130	136	PF00069	0.298
MOD_CK2_1	29	35	PF00069	0.505
MOD_CK2_1	43	49	PF00069	0.296
MOD_CK2_1	602	608	PF00069	0.600
MOD_CMANNOS	250	253	PF00535	0.203
MOD_GlcNHglycan	123	126	PF01048	0.382
MOD_GlcNHglycan	149	152	PF01048	0.274
MOD_GlcNHglycan	176	179	PF01048	0.258
MOD_GlcNHglycan	237	240	PF01048	0.215
MOD_GlcNHglycan	277	280	PF01048	0.249
MOD_GlcNHglycan	298	301	PF01048	0.249
MOD_GlcNHglycan	414	417	PF01048	0.551
MOD_GlcNHglycan	429	432	PF01048	0.375
MOD_GlcNHglycan	541	545	PF01048	0.498
MOD_GlcNHglycan	624	627	PF01048	0.484
MOD_GSK3_1	130	137	PF00069	0.360
MOD_GSK3_1	235	242	PF00069	0.403
MOD_GSK3_1	321	328	PF00069	0.435
MOD_GSK3_1	331	338	PF00069	0.402
MOD_GSK3_1	352	359	PF00069	0.458
MOD_GSK3_1	466	473	PF00069	0.427
MOD_GSK3_1	519	526	PF00069	0.433
MOD_GSK3_1	553	560	PF00069	0.424
MOD_GSK3_1	77	84	PF00069	0.366
MOD_N-GLC_1	115	120	PF02516	0.391
MOD_N-GLC_1	622	627	PF02516	0.640
MOD_NEK2_1	103	108	PF00069	0.383
MOD_NEK2_1	209	214	PF00069	0.471
MOD_NEK2_1	261	266	PF00069	0.414
MOD_NEK2_1	29	34	PF00069	0.347
MOD_NEK2_1	433	438	PF00069	0.475
MOD_NEK2_1	519	524	PF00069	0.375
MOD_NEK2_1	557	562	PF00069	0.339
MOD_NEK2_1	87	92	PF00069	0.354
MOD_NEK2_2	115	120	PF00069	0.347
MOD_NEK2_2	239	244	PF00069	0.403
MOD_NEK2_2	272	277	PF00069	0.514
MOD_PIKK_1	163	169	PF00454	0.403
MOD_PIKK_1	261	267	PF00454	0.446
MOD_PIKK_1	385	391	PF00454	0.418
MOD_PIKK_1	472	478	PF00454	0.444
MOD_PIKK_1	77	83	PF00454	0.370
MOD_PKA_2	243	249	PF00069	0.403
MOD_PKA_2	356	362	PF00069	0.464
MOD_PKA_2	433	439	PF00069	0.515
MOD_PKB_1	410	418	PF00069	0.492
MOD_Plk_1	115	121	PF00069	0.389
MOD_Plk_1	214	220	PF00069	0.427
MOD_Plk_1	622	628	PF00069	0.488
MOD_Plk_1	87	93	PF00069	0.380
MOD_Plk_4	136	142	PF00069	0.324
MOD_Plk_4	362	368	PF00069	0.442
MOD_Plk_4	489	495	PF00069	0.387
MOD_Plk_4	523	529	PF00069	0.374
MOD_Plk_4	553	559	PF00069	0.346
MOD_ProDKin_1	312	318	PF00069	0.455
MOD_ProDKin_1	321	327	PF00069	0.430
MOD_ProDKin_1	521	527	PF00069	0.384
MOD_ProDKin_1	532	538	PF00069	0.410
MOD_SUMO_rev_2	345	350	PF00179	0.509
MOD_SUMO_rev_2	414	422	PF00179	0.625
TRG_DiLeu_BaEn_2	46	52	PF01217	0.368
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.419
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.414
TRG_ENDOCYTIC_2	449	452	PF00928	0.429
TRG_ENDOCYTIC_2	539	542	PF00928	0.463
TRG_ER_diArg_1	380	383	PF00400	0.452
TRG_NLS_MonoCore_2	110	115	PF00514	0.453
TRG_NLS_MonoExtC_3	11	17	PF00514	0.604
TRG_NLS_MonoExtN_4	111	116	PF00514	0.449
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.203

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y2	Leptomonas seymouri	72%	99%
A0A0S4IKI3	Bodo saltans	52%	95%
A0A1X0P924	Trypanosomatidae	54%	93%
A0A3Q8IJ07	Leishmania donovani	95%	100%
A0A3S5IQZ3	Trypanosoma rangeli	56%	100%
A4HIZ4	Leishmania braziliensis	27%	100%
C9ZKZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	97%
D0A386	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	86%
E9AHJ5	Leishmania infantum	95%	100%
E9AIT8	Leishmania braziliensis	85%	100%
E9ALH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O13935	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	93%
P38205	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	93%
Q08J23	Homo sapiens	37%	83%
Q1HFZ0	Mus musculus	39%	84%
Q4Q6P5	Leishmania major	27%	100%
Q4V7N2	Xenopus laevis	31%	91%
Q5ZLV4	Gallus gallus	31%	80%
Q9HGQ2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	93%
Q9W4M9	Drosophila melanogaster	35%	86%
V5BSK4	Trypanosoma cruzi	53%	100%