SP-RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MIZ/SP-RING zinc finger, putative

Species:

Leishmania major

UniProt:

E9AEB4_LEIMA

TriTrypDb:

LmjF.29.2520 , LMJLV39_290033300 , LMJSD75_290033700

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEB4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.466
CLV_C14_Caspase3-7	325	329	PF00656	0.543
CLV_NRD_NRD_1	183	185	PF00675	0.418
CLV_NRD_NRD_1	20	22	PF00675	0.491
CLV_NRD_NRD_1	354	356	PF00675	0.631
CLV_NRD_NRD_1	390	392	PF00675	0.638
CLV_NRD_NRD_1	95	97	PF00675	0.348
CLV_PCSK_FUR_1	183	187	PF00082	0.447
CLV_PCSK_FUR_1	352	356	PF00082	0.544
CLV_PCSK_KEX2_1	183	185	PF00082	0.418
CLV_PCSK_KEX2_1	20	22	PF00082	0.523
CLV_PCSK_KEX2_1	354	356	PF00082	0.589
CLV_PCSK_KEX2_1	389	391	PF00082	0.553
CLV_PCSK_KEX2_1	95	97	PF00082	0.365
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.449
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.579
CLV_PCSK_SKI1_1	315	319	PF00082	0.390
DEG_SPOP_SBC_1	154	158	PF00917	0.496
DEG_SPOP_SBC_1	320	324	PF00917	0.507
DOC_CKS1_1	137	142	PF01111	0.501
DOC_CKS1_1	216	221	PF01111	0.505
DOC_CKS1_1	237	242	PF01111	0.496
DOC_CKS1_1	371	376	PF01111	0.675
DOC_CYCLIN_yCln2_LP_2	216	222	PF00134	0.502
DOC_MAPK_gen_1	255	264	PF00069	0.402
DOC_MAPK_gen_1	388	394	PF00069	0.586
DOC_MAPK_HePTP_8	290	302	PF00069	0.388
DOC_MAPK_MEF2A_6	255	264	PF00069	0.432
DOC_MAPK_MEF2A_6	293	302	PF00069	0.380
DOC_PP4_FxxP_1	137	140	PF00568	0.504
DOC_USP7_MATH_1	289	293	PF00917	0.472
DOC_USP7_MATH_1	309	313	PF00917	0.271
DOC_USP7_MATH_1	319	323	PF00917	0.481
DOC_USP7_MATH_1	359	363	PF00917	0.782
DOC_USP7_MATH_1	372	376	PF00917	0.622
DOC_USP7_MATH_1	380	384	PF00917	0.681
DOC_USP7_MATH_1	78	82	PF00917	0.502
DOC_WW_Pin1_4	136	141	PF00397	0.440
DOC_WW_Pin1_4	215	220	PF00397	0.498
DOC_WW_Pin1_4	236	241	PF00397	0.509
DOC_WW_Pin1_4	370	375	PF00397	0.709
LIG_14-3-3_CanoR_1	102	108	PF00244	0.515
LIG_14-3-3_CanoR_1	20	28	PF00244	0.487
LIG_14-3-3_CanoR_1	277	283	PF00244	0.530
LIG_14-3-3_CanoR_1	354	364	PF00244	0.729
LIG_14-3-3_CanoR_1	40	46	PF00244	0.404
LIG_AP2alpha_2	221	223	PF02296	0.495
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_BIR_III_2	328	332	PF00653	0.498
LIG_Clathr_ClatBox_1	264	268	PF01394	0.377
LIG_FHA_1	118	124	PF00498	0.534
LIG_FHA_1	129	135	PF00498	0.497
LIG_FHA_1	137	143	PF00498	0.499
LIG_FHA_1	150	156	PF00498	0.610
LIG_FHA_1	157	163	PF00498	0.333
LIG_FHA_1	204	210	PF00498	0.522
LIG_FHA_1	23	29	PF00498	0.547
LIG_FHA_1	233	239	PF00498	0.627
LIG_FHA_1	279	285	PF00498	0.523
LIG_FHA_1	292	298	PF00498	0.466
LIG_FHA_1	302	308	PF00498	0.348
LIG_FHA_1	316	322	PF00498	0.409
LIG_FHA_1	345	351	PF00498	0.592
LIG_FHA_1	40	46	PF00498	0.403
LIG_FHA_2	104	110	PF00498	0.647
LIG_FHA_2	148	154	PF00498	0.478
LIG_FHA_2	216	222	PF00498	0.551
LIG_FHA_2	225	231	PF00498	0.674
LIG_LIR_Gen_1	104	113	PF02991	0.610
LIG_LIR_Gen_1	278	287	PF02991	0.513
LIG_LIR_Gen_1	62	72	PF02991	0.598
LIG_LIR_Nem_3	104	110	PF02991	0.593
LIG_LIR_Nem_3	278	282	PF02991	0.588
LIG_LIR_Nem_3	62	68	PF02991	0.619
LIG_NRBOX	190	196	PF00104	0.547
LIG_SH2_CRK	13	17	PF00017	0.411
LIG_SH2_NCK_1	107	111	PF00017	0.614
LIG_SH2_NCK_1	313	317	PF00017	0.499
LIG_SH2_SRC	107	110	PF00017	0.635
LIG_SH2_STAP1	313	317	PF00017	0.499
LIG_SH2_STAT3	126	129	PF00017	0.419
LIG_SH2_STAT3	190	193	PF00017	0.506
LIG_SH2_STAT5	105	108	PF00017	0.657
LIG_SH2_STAT5	161	164	PF00017	0.359
LIG_SH2_STAT5	190	193	PF00017	0.525
LIG_SH2_STAT5	65	68	PF00017	0.662
LIG_SH3_2	371	376	PF14604	0.724
LIG_SH3_3	216	222	PF00018	0.576
LIG_SH3_3	234	240	PF00018	0.544
LIG_SH3_3	281	287	PF00018	0.504
LIG_SH3_3	368	374	PF00018	0.764
LIG_SUMO_SIM_anti_2	347	352	PF11976	0.448
LIG_SUMO_SIM_par_1	208	215	PF11976	0.473
LIG_TRAF2_1	358	361	PF00917	0.599
LIG_WRC_WIRS_1	267	272	PF05994	0.384
MOD_CDK_SPxK_1	236	242	PF00069	0.505
MOD_CDK_SPxK_1	370	376	PF00069	0.718
MOD_CK1_1	156	162	PF00069	0.603
MOD_CK1_1	228	234	PF00069	0.626
MOD_CK1_1	278	284	PF00069	0.587
MOD_CK1_1	322	328	PF00069	0.665
MOD_CK1_1	70	76	PF00069	0.522
MOD_CK2_1	208	214	PF00069	0.438
MOD_CK2_1	224	230	PF00069	0.660
MOD_CK2_1	355	361	PF00069	0.758
MOD_Cter_Amidation	352	355	PF01082	0.536
MOD_GlcNHglycan	1	4	PF01048	0.617
MOD_GlcNHglycan	123	126	PF01048	0.556
MOD_GlcNHglycan	357	360	PF01048	0.657
MOD_GlcNHglycan	361	364	PF01048	0.706
MOD_GlcNHglycan	72	75	PF01048	0.539
MOD_GSK3_1	117	124	PF00069	0.612
MOD_GSK3_1	149	156	PF00069	0.588
MOD_GSK3_1	208	215	PF00069	0.470
MOD_GSK3_1	224	231	PF00069	0.602
MOD_GSK3_1	232	239	PF00069	0.533
MOD_GSK3_1	271	278	PF00069	0.516
MOD_GSK3_1	315	322	PF00069	0.521
MOD_GSK3_1	340	347	PF00069	0.582
MOD_GSK3_1	355	362	PF00069	0.631
MOD_GSK3_1	380	387	PF00069	0.700
MOD_GSK3_1	66	73	PF00069	0.441
MOD_N-GLC_1	212	217	PF02516	0.481
MOD_NEK2_1	101	106	PF00069	0.469
MOD_NEK2_1	155	160	PF00069	0.659
MOD_NEK2_1	212	217	PF00069	0.523
MOD_NEK2_1	38	43	PF00069	0.464
MOD_NEK2_1	66	71	PF00069	0.476
MOD_NEK2_2	117	122	PF00069	0.621
MOD_NEK2_2	291	296	PF00069	0.501
MOD_PIKK_1	203	209	PF00454	0.488
MOD_PIKK_1	243	249	PF00454	0.508
MOD_PIKK_1	271	277	PF00454	0.399
MOD_PIKK_1	78	84	PF00454	0.505
MOD_PKA_2	101	107	PF00069	0.591
MOD_PKA_2	22	28	PF00069	0.485
MOD_PKA_2	39	45	PF00069	0.476
MOD_Plk_1	212	218	PF00069	0.498
MOD_Plk_1	228	234	PF00069	0.631
MOD_Plk_1	359	365	PF00069	0.619
MOD_Plk_4	156	162	PF00069	0.521
MOD_Plk_4	245	251	PF00069	0.433
MOD_Plk_4	266	272	PF00069	0.355
MOD_Plk_4	84	90	PF00069	0.346
MOD_ProDKin_1	136	142	PF00069	0.434
MOD_ProDKin_1	215	221	PF00069	0.499
MOD_ProDKin_1	236	242	PF00069	0.505
MOD_ProDKin_1	370	376	PF00069	0.713
TRG_ENDOCYTIC_2	107	110	PF00928	0.603
TRG_ENDOCYTIC_2	13	16	PF00928	0.425
TRG_ENDOCYTIC_2	65	68	PF00928	0.617
TRG_ER_diArg_1	183	186	PF00400	0.405
TRG_ER_diArg_1	19	21	PF00400	0.523
TRG_ER_diArg_1	351	354	PF00400	0.506
TRG_ER_diArg_1	390	392	PF00400	0.640
TRG_ER_diArg_1	95	97	PF00400	0.365
TRG_NLS_MonoCore_2	387	392	PF00514	0.648
TRG_NLS_MonoExtC_3	387	393	PF00514	0.642
TRG_NLS_MonoExtN_4	183	188	PF00514	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I530	Leptomonas seymouri	56%	99%
A0A1X0P9D0	Trypanosomatidae	25%	100%
A0A3R7LU18	Trypanosoma rangeli	27%	100%
A0A3S7X2U8	Leishmania donovani	92%	100%
A4HHQ1	Leishmania braziliensis	79%	99%
A4I4W6	Leishmania infantum	93%	100%
C9ZKZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ALH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5C220	Trypanosoma cruzi	27%	100%