Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania major

UniProt:

E9AEB1_LEIMA

TriTrypDb:

LmjF.29.2490 , LMJLV39_290033000 , LMJSD75_290033400

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEB1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	16
GO:0006793	phosphorus metabolic process	3	16
GO:0006796	phosphate-containing compound metabolic process	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0016310	phosphorylation	5	16
GO:0019538	protein metabolic process	3	16
GO:0036211	protein modification process	4	16
GO:0043170	macromolecule metabolic process	3	16
GO:0043412	macromolecule modification	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	16
GO:0004672	protein kinase activity	3	16
GO:0004674	protein serine/threonine kinase activity	4	6
GO:0005488	binding	1	16
GO:0005524	ATP binding	5	16
GO:0016301	kinase activity	4	16
GO:0016740	transferase activity	2	16
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	16
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	16
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0140096	catalytic activity, acting on a protein	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.567
CLV_NRD_NRD_1	165	167	PF00675	0.427
CLV_NRD_NRD_1	260	262	PF00675	0.311
CLV_NRD_NRD_1	329	331	PF00675	0.341
CLV_NRD_NRD_1	402	404	PF00675	0.234
CLV_NRD_NRD_1	43	45	PF00675	0.494
CLV_NRD_NRD_1	66	68	PF00675	0.322
CLV_PCSK_FUR_1	64	68	PF00082	0.310
CLV_PCSK_KEX2_1	121	123	PF00082	0.728
CLV_PCSK_KEX2_1	328	330	PF00082	0.342
CLV_PCSK_KEX2_1	394	396	PF00082	0.299
CLV_PCSK_KEX2_1	402	404	PF00082	0.221
CLV_PCSK_KEX2_1	66	68	PF00082	0.492
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.390
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.232
CLV_PCSK_SKI1_1	166	170	PF00082	0.519
CLV_PCSK_SKI1_1	262	266	PF00082	0.383
CLV_PCSK_SKI1_1	293	297	PF00082	0.300
DEG_Nend_UBRbox_1	1	4	PF02207	0.376
DOC_CYCLIN_RxL_1	161	172	PF00134	0.512
DOC_MAPK_gen_1	259	269	PF00069	0.388
DOC_MAPK_gen_1	293	303	PF00069	0.322
DOC_MAPK_gen_1	44	51	PF00069	0.327
DOC_MAPK_MEF2A_6	236	245	PF00069	0.264
DOC_MAPK_MEF2A_6	268	276	PF00069	0.247
DOC_MAPK_MEF2A_6	44	51	PF00069	0.361
DOC_PP2B_LxvP_1	132	135	PF13499	0.613
DOC_PP2B_LxvP_1	143	146	PF13499	0.486
DOC_USP7_MATH_1	135	139	PF00917	0.655
DOC_WW_Pin1_4	138	143	PF00397	0.616
DOC_WW_Pin1_4	330	335	PF00397	0.278
DOC_WW_Pin1_4	386	391	PF00397	0.341
DOC_WW_Pin1_4	51	56	PF00397	0.466
LIG_14-3-3_CanoR_1	2	6	PF00244	0.616
LIG_14-3-3_CanoR_1	261	269	PF00244	0.375
LIG_14-3-3_CanoR_1	406	416	PF00244	0.312
LIG_14-3-3_CanoR_1	428	433	PF00244	0.304
LIG_14-3-3_CanoR_1	66	72	PF00244	0.532
LIG_APCC_ABBAyCdc20_2	196	202	PF00400	0.411
LIG_BRCT_BRCA1_1	409	413	PF00533	0.339
LIG_Clathr_ClatBox_1	311	315	PF01394	0.245
LIG_FHA_1	317	323	PF00498	0.314
LIG_FHA_2	204	210	PF00498	0.378
LIG_FHA_2	348	354	PF00498	0.321
LIG_FHA_2	364	370	PF00498	0.256
LIG_FHA_2	406	412	PF00498	0.404
LIG_FHA_2	52	58	PF00498	0.548
LIG_FHA_2	92	98	PF00498	0.356
LIG_FXI_DFP_1	367	371	PF00024	0.390
LIG_GBD_Chelix_1	272	280	PF00786	0.305
LIG_LIR_Apic_2	335	341	PF02991	0.268
LIG_LIR_Gen_1	410	421	PF02991	0.339
LIG_LIR_Gen_1	6	15	PF02991	0.428
LIG_LIR_Gen_1	75	85	PF02991	0.360
LIG_LIR_Nem_3	163	168	PF02991	0.391
LIG_LIR_Nem_3	369	373	PF02991	0.237
LIG_LIR_Nem_3	410	416	PF02991	0.362
LIG_LIR_Nem_3	6	11	PF02991	0.430
LIG_LIR_Nem_3	70	74	PF02991	0.418
LIG_SH2_CRK	165	169	PF00017	0.420
LIG_SH2_SRC	229	232	PF00017	0.306
LIG_SH2_STAP1	336	340	PF00017	0.354
LIG_SH2_STAP1	409	413	PF00017	0.260
LIG_SH2_STAT3	282	285	PF00017	0.163
LIG_SH2_STAT5	229	232	PF00017	0.261
LIG_SH2_STAT5	282	285	PF00017	0.255
LIG_SH2_STAT5	407	410	PF00017	0.455
LIG_SH3_3	142	148	PF00018	0.696
LIG_SH3_3	240	246	PF00018	0.313
LIG_SH3_3	365	371	PF00018	0.339
LIG_SH3_3	419	425	PF00018	0.400
LIG_SUMO_SIM_anti_2	191	197	PF11976	0.390
LIG_SUMO_SIM_anti_2	298	304	PF11976	0.260
LIG_SUMO_SIM_anti_2	306	313	PF11976	0.260
LIG_SUMO_SIM_par_1	191	197	PF11976	0.390
LIG_TYR_ITIM	227	232	PF00017	0.243
LIG_TYR_ITIM	69	74	PF00017	0.359
LIG_WW_1	55	58	PF00397	0.370
MOD_CK1_1	138	144	PF00069	0.579
MOD_CK1_1	3	9	PF00069	0.458
MOD_CK1_1	386	392	PF00069	0.313
MOD_CK1_1	92	98	PF00069	0.469
MOD_CK2_1	203	209	PF00069	0.410
MOD_CK2_1	405	411	PF00069	0.383
MOD_CK2_1	91	97	PF00069	0.454
MOD_GlcNHglycan	138	141	PF01048	0.591
MOD_GlcNHglycan	376	379	PF01048	0.350
MOD_GlcNHglycan	383	386	PF01048	0.349
MOD_GlcNHglycan	91	94	PF01048	0.516
MOD_GSK3_1	316	323	PF00069	0.286
MOD_GSK3_1	343	350	PF00069	0.277
MOD_GSK3_1	85	92	PF00069	0.404
MOD_N-GLC_1	200	205	PF02516	0.390
MOD_N-GLC_1	320	325	PF02516	0.163
MOD_N-GLC_2	23	25	PF02516	0.348
MOD_NEK2_1	1	6	PF00069	0.559
MOD_NEK2_1	101	106	PF00069	0.528
MOD_NEK2_1	136	141	PF00069	0.597
MOD_NEK2_1	230	235	PF00069	0.352
MOD_NEK2_1	316	321	PF00069	0.163
MOD_NEK2_1	343	348	PF00069	0.276
MOD_NEK2_1	381	386	PF00069	0.343
MOD_PIKK_1	109	115	PF00454	0.597
MOD_PIKK_1	34	40	PF00454	0.455
MOD_PK_1	268	274	PF00069	0.260
MOD_PKA_2	1	7	PF00069	0.507
MOD_PKA_2	405	411	PF00069	0.236
MOD_PKA_2	427	433	PF00069	0.278
MOD_Plk_1	203	209	PF00069	0.354
MOD_Plk_1	230	236	PF00069	0.460
MOD_Plk_4	268	274	PF00069	0.248
MOD_Plk_4	322	328	PF00069	0.345
MOD_ProDKin_1	138	144	PF00069	0.616
MOD_ProDKin_1	330	336	PF00069	0.278
MOD_ProDKin_1	386	392	PF00069	0.341
MOD_ProDKin_1	51	57	PF00069	0.477
MOD_SUMO_for_1	295	298	PF00179	0.306
MOD_SUMO_rev_2	249	256	PF00179	0.369
MOD_SUMO_rev_2	344	352	PF00179	0.341
TRG_DiLeu_BaEn_1	298	303	PF01217	0.284
TRG_DiLeu_BaEn_1	306	311	PF01217	0.233
TRG_DiLeu_BaEn_1	412	417	PF01217	0.310
TRG_ENDOCYTIC_2	165	168	PF00928	0.395
TRG_ENDOCYTIC_2	229	232	PF00928	0.260
TRG_ENDOCYTIC_2	71	74	PF00928	0.438
TRG_ENDOCYTIC_2	8	11	PF00928	0.417
TRG_ER_diArg_1	120	122	PF00400	0.726
TRG_ER_diArg_1	401	403	PF00400	0.247
TRG_ER_diArg_1	64	67	PF00400	0.306
TRG_NES_CRM1_1	412	424	PF08389	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT76	Leptomonas seymouri	73%	100%
A0A0N1PCH4	Leptomonas seymouri	25%	100%
A0A0N1PE38	Leptomonas seymouri	32%	67%
A0A0S4IXR9	Bodo saltans	27%	97%
A0A0S4JWD5	Bodo saltans	28%	100%
A0A0S4JZV2	Bodo saltans	25%	100%
A0A1X0P1A2	Trypanosomatidae	24%	98%
A0A1X0P9C1	Trypanosomatidae	28%	100%
A0A1X0PA19	Trypanosomatidae	46%	91%
A0A3Q8IDY1	Leishmania donovani	97%	100%
A0A3R7K1T4	Trypanosoma rangeli	46%	89%
A0A3R7NGF4	Trypanosoma rangeli	28%	80%
A0A3S5H4Z4	Leishmania donovani	28%	85%
A0A3S7X2W9	Leishmania donovani	25%	100%
A0A3S7X7D5	Leishmania donovani	29%	100%
A0A422P2B2	Trypanosoma rangeli	27%	98%
A0A422P3P9	Trypanosoma rangeli	27%	91%
A4HHP8	Leishmania braziliensis	82%	100%
A4HHS9	Leishmania braziliensis	25%	100%
A4HRM6	Leishmania infantum	28%	85%
A4I4W3	Leishmania infantum	97%	100%
A4I4Y0	Leishmania infantum	25%	100%
A4I9H1	Leishmania infantum	29%	100%
C9ZKZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	96%
C9ZW20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	78%
C9ZX15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	90%
E9AED4	Leishmania major	24%	100%
E9AJJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	84%
E9AKG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ALF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ALH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B4G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
O04086	Arabidopsis thaliana	26%	72%
O35831	Rattus norvegicus	26%	86%
Q15131	Homo sapiens	26%	100%
Q2TBL8	Bos taurus	26%	100%
Q2V419	Arabidopsis thaliana	26%	100%
Q3UMM4	Mus musculus	27%	100%
Q52WX2	Homo sapiens	28%	100%
Q6GPL3	Xenopus laevis	25%	100%
Q8K0D0	Mus musculus	26%	86%
Q8LF80	Arabidopsis thaliana	26%	100%
Q8QZX0	Mus musculus	28%	100%
Q924X7	Mus musculus	26%	92%
Q9NI63	Drosophila melanogaster	26%	85%
Q9SII6	Arabidopsis thaliana	26%	100%
Q9STF0	Arabidopsis thaliana	29%	100%
Q9U2Q9	Caenorhabditis elegans	26%	100%
Q9VT57	Drosophila melanogaster	26%	99%
Q9Z335	Rattus norvegicus	28%	100%
V5BJT8	Trypanosoma cruzi	31%	100%
V5BPJ0	Trypanosoma cruzi	26%	91%
V5BSK0	Trypanosoma cruzi	49%	91%
V5CI11	Trypanosoma cruzi	27%	94%