Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEB0_LEIMA

TriTrypDb:

LmjF.29.2480 , LMJLV39_290032900 , LMJSD75_290033300

Length:

844

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEB0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.643
CLV_C14_Caspase3-7	203	207	PF00656	0.544
CLV_C14_Caspase3-7	223	227	PF00656	0.601
CLV_C14_Caspase3-7	444	448	PF00656	0.570
CLV_C14_Caspase3-7	559	563	PF00656	0.489
CLV_C14_Caspase3-7	585	589	PF00656	0.526
CLV_MEL_PAP_1	830	836	PF00089	0.540
CLV_NRD_NRD_1	182	184	PF00675	0.484
CLV_NRD_NRD_1	196	198	PF00675	0.543
CLV_NRD_NRD_1	365	367	PF00675	0.618
CLV_NRD_NRD_1	503	505	PF00675	0.660
CLV_NRD_NRD_1	549	551	PF00675	0.477
CLV_NRD_NRD_1	560	562	PF00675	0.407
CLV_NRD_NRD_1	628	630	PF00675	0.720
CLV_NRD_NRD_1	638	640	PF00675	0.636
CLV_NRD_NRD_1	703	705	PF00675	0.766
CLV_NRD_NRD_1	714	716	PF00675	0.504
CLV_NRD_NRD_1	725	727	PF00675	0.541
CLV_NRD_NRD_1	755	757	PF00675	0.485
CLV_NRD_NRD_1	832	834	PF00675	0.651
CLV_PCSK_FUR_1	363	367	PF00082	0.623
CLV_PCSK_FUR_1	558	562	PF00082	0.490
CLV_PCSK_FUR_1	626	630	PF00082	0.706
CLV_PCSK_FUR_1	753	757	PF00082	0.536
CLV_PCSK_KEX2_1	181	183	PF00082	0.533
CLV_PCSK_KEX2_1	196	198	PF00082	0.490
CLV_PCSK_KEX2_1	356	358	PF00082	0.629
CLV_PCSK_KEX2_1	363	365	PF00082	0.586
CLV_PCSK_KEX2_1	433	435	PF00082	0.578
CLV_PCSK_KEX2_1	502	504	PF00082	0.661
CLV_PCSK_KEX2_1	526	528	PF00082	0.611
CLV_PCSK_KEX2_1	548	550	PF00082	0.478
CLV_PCSK_KEX2_1	560	562	PF00082	0.399
CLV_PCSK_KEX2_1	628	630	PF00082	0.738
CLV_PCSK_KEX2_1	638	640	PF00082	0.618
CLV_PCSK_KEX2_1	702	704	PF00082	0.765
CLV_PCSK_KEX2_1	714	716	PF00082	0.494
CLV_PCSK_KEX2_1	725	727	PF00082	0.490
CLV_PCSK_KEX2_1	755	757	PF00082	0.485
CLV_PCSK_KEX2_1	832	834	PF00082	0.651
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.533
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.490
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.629
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.608
CLV_PCSK_PC1ET2_1	526	528	PF00082	0.611
CLV_PCSK_PC7_1	556	562	PF00082	0.484
CLV_PCSK_SKI1_1	347	351	PF00082	0.648
CLV_PCSK_SKI1_1	353	357	PF00082	0.626
CLV_PCSK_SKI1_1	402	406	PF00082	0.609
CLV_PCSK_SKI1_1	549	553	PF00082	0.478
CLV_PCSK_SKI1_1	571	575	PF00082	0.539
CLV_PCSK_SKI1_1	715	719	PF00082	0.719
DEG_APCC_DBOX_1	548	556	PF00400	0.476
DEG_COP1_1	311	321	PF00400	0.573
DEG_Nend_UBRbox_3	1	3	PF02207	0.590
DEG_SPOP_SBC_1	674	678	PF00917	0.604
DOC_ANK_TNKS_1	701	708	PF00023	0.525
DOC_CYCLIN_RxL_1	547	554	PF00134	0.479
DOC_MAPK_gen_1	526	536	PF00069	0.549
DOC_MAPK_gen_1	548	555	PF00069	0.479
DOC_MAPK_MEF2A_6	548	555	PF00069	0.479
DOC_PP1_RVXF_1	569	576	PF00149	0.538
DOC_PP2B_LxvP_1	245	248	PF13499	0.651
DOC_PP2B_LxvP_1	316	319	PF13499	0.617
DOC_PP2B_LxvP_1	410	413	PF13499	0.542
DOC_PP2B_LxvP_1	542	545	PF13499	0.460
DOC_PP4_FxxP_1	617	620	PF00568	0.578
DOC_USP7_MATH_1	120	124	PF00917	0.608
DOC_USP7_MATH_1	142	146	PF00917	0.629
DOC_USP7_MATH_1	149	153	PF00917	0.625
DOC_USP7_MATH_1	212	216	PF00917	0.601
DOC_USP7_MATH_1	22	26	PF00917	0.651
DOC_USP7_MATH_1	256	260	PF00917	0.627
DOC_USP7_MATH_1	297	301	PF00917	0.684
DOC_USP7_MATH_1	31	35	PF00917	0.638
DOC_USP7_MATH_1	317	321	PF00917	0.616
DOC_USP7_MATH_1	339	343	PF00917	0.631
DOC_USP7_MATH_1	370	374	PF00917	0.590
DOC_USP7_MATH_1	379	383	PF00917	0.577
DOC_USP7_MATH_1	404	408	PF00917	0.618
DOC_USP7_MATH_1	417	421	PF00917	0.555
DOC_USP7_MATH_1	423	427	PF00917	0.508
DOC_USP7_MATH_1	475	479	PF00917	0.624
DOC_USP7_MATH_1	485	489	PF00917	0.581
DOC_USP7_MATH_1	495	499	PF00917	0.521
DOC_USP7_MATH_1	506	510	PF00917	0.578
DOC_USP7_MATH_1	657	661	PF00917	0.516
DOC_USP7_MATH_1	674	678	PF00917	0.527
DOC_USP7_MATH_1	713	717	PF00917	0.568
DOC_USP7_MATH_1	736	740	PF00917	0.631
DOC_USP7_MATH_1	824	828	PF00917	0.639
DOC_USP7_UBL2_3	347	351	PF12436	0.652
DOC_USP7_UBL2_3	526	530	PF12436	0.592
DOC_WW_Pin1_4	224	229	PF00397	0.644
DOC_WW_Pin1_4	252	257	PF00397	0.636
DOC_WW_Pin1_4	433	438	PF00397	0.572
DOC_WW_Pin1_4	445	450	PF00397	0.577
DOC_WW_Pin1_4	587	592	PF00397	0.631
DOC_WW_Pin1_4	597	602	PF00397	0.560
DOC_WW_Pin1_4	610	615	PF00397	0.526
DOC_WW_Pin1_4	618	623	PF00397	0.561
DOC_WW_Pin1_4	628	633	PF00397	0.492
DOC_WW_Pin1_4	675	680	PF00397	0.750
DOC_WW_Pin1_4	708	713	PF00397	0.598
DOC_WW_Pin1_4	724	729	PF00397	0.495
DOC_WW_Pin1_4	732	737	PF00397	0.590
DOC_WW_Pin1_4	780	785	PF00397	0.588
DOC_WW_Pin1_4	93	98	PF00397	0.618
LIG_14-3-3_CanoR_1	197	204	PF00244	0.583
LIG_14-3-3_CanoR_1	23	27	PF00244	0.534
LIG_14-3-3_CanoR_1	3	9	PF00244	0.606
LIG_14-3-3_CanoR_1	394	403	PF00244	0.664
LIG_14-3-3_CanoR_1	54	61	PF00244	0.579
LIG_14-3-3_CanoR_1	675	679	PF00244	0.606
LIG_14-3-3_CanoR_1	714	718	PF00244	0.616
LIG_14-3-3_CanoR_1	726	732	PF00244	0.524
LIG_14-3-3_CanoR_1	755	762	PF00244	0.610
LIG_14-3-3_CanoR_1	809	818	PF00244	0.614
LIG_14-3-3_CanoR_1	821	830	PF00244	0.552
LIG_14-3-3_CanoR_1	832	841	PF00244	0.575
LIG_APCC_ABBA_1	154	159	PF00400	0.621
LIG_BIR_III_2	588	592	PF00653	0.597
LIG_BIR_III_2	709	713	PF00653	0.574
LIG_BRCT_BRCA1_1	604	608	PF00533	0.597
LIG_deltaCOP1_diTrp_1	569	575	PF00928	0.532
LIG_eIF4E_1	547	553	PF01652	0.479
LIG_FHA_1	217	223	PF00498	0.562
LIG_FHA_1	313	319	PF00498	0.624
LIG_FHA_1	530	536	PF00498	0.594
LIG_FHA_1	694	700	PF00498	0.614
LIG_FHA_1	795	801	PF00498	0.617
LIG_FHA_2	14	20	PF00498	0.564
LIG_FHA_2	201	207	PF00498	0.565
LIG_FHA_2	442	448	PF00498	0.573
LIG_FHA_2	54	60	PF00498	0.579
LIG_FHA_2	838	844	PF00498	0.575
LIG_FHA_2	93	99	PF00498	0.611
LIG_GSK3_LRP6_1	93	98	PF00069	0.615
LIG_IBAR_NPY_1	581	583	PF08397	0.535
LIG_Integrin_RGD_1	792	794	PF01839	0.603
LIG_LIR_Apic_2	615	620	PF02991	0.582
LIG_LIR_Gen_1	716	724	PF02991	0.595
LIG_LIR_Nem_3	569	573	PF02991	0.523
LIG_LIR_Nem_3	716	721	PF02991	0.590
LIG_Pex14_2	608	612	PF04695	0.525
LIG_REV1ctd_RIR_1	175	186	PF16727	0.464
LIG_SH2_NCK_1	119	123	PF00017	0.544
LIG_SH2_SRC	108	111	PF00017	0.533
LIG_SH2_STAP1	463	467	PF00017	0.572
LIG_SH2_STAP1	469	473	PF00017	0.556
LIG_SH2_STAT5	700	703	PF00017	0.589
LIG_SH3_1	638	644	PF00018	0.608
LIG_SH3_1	742	748	PF00018	0.531
LIG_SH3_3	158	164	PF00018	0.628
LIG_SH3_3	329	335	PF00018	0.638
LIG_SH3_3	440	446	PF00018	0.622
LIG_SH3_3	638	644	PF00018	0.653
LIG_SH3_3	645	651	PF00018	0.633
LIG_SH3_3	676	682	PF00018	0.589
LIG_SH3_3	684	690	PF00018	0.542
LIG_SH3_3	742	748	PF00018	0.711
LIG_SH3_3	759	765	PF00018	0.533
LIG_SH3_3	82	88	PF00018	0.558
LIG_SH3_3	91	97	PF00018	0.642
LIG_SH3_4	347	354	PF00018	0.666
LIG_SUMO_SIM_par_1	217	223	PF11976	0.557
LIG_TRAF2_1	16	19	PF00917	0.601
LIG_TRAF2_1	215	218	PF00917	0.623
LIG_TRAF2_1	271	274	PF00917	0.637
LIG_TRAF2_1	840	843	PF00917	0.586
LIG_UBA3_1	191	198	PF00899	0.540
LIG_WW_3	711	715	PF00397	0.587
MOD_CDC14_SPxK_1	731	734	PF00782	0.651
MOD_CDC14_SPxK_1	735	738	PF00782	0.636
MOD_CDK_SPK_2	252	257	PF00069	0.578
MOD_CDK_SPK_2	628	633	PF00069	0.589
MOD_CDK_SPxK_1	708	714	PF00069	0.596
MOD_CDK_SPxK_1	728	734	PF00069	0.652
MOD_CDK_SPxxK_3	708	715	PF00069	0.626
MOD_CK1_1	111	117	PF00069	0.557
MOD_CK1_1	145	151	PF00069	0.661
MOD_CK1_1	25	31	PF00069	0.595
MOD_CK1_1	260	266	PF00069	0.649
MOD_CK1_1	311	317	PF00069	0.610
MOD_CK1_1	35	41	PF00069	0.614
MOD_CK1_1	373	379	PF00069	0.629
MOD_CK1_1	386	392	PF00069	0.593
MOD_CK1_1	395	401	PF00069	0.587
MOD_CK1_1	426	432	PF00069	0.626
MOD_CK1_1	436	442	PF00069	0.574
MOD_CK1_1	45	51	PF00069	0.585
MOD_CK1_1	471	477	PF00069	0.619
MOD_CK1_1	488	494	PF00069	0.535
MOD_CK1_1	510	516	PF00069	0.636
MOD_CK1_1	522	528	PF00069	0.582
MOD_CK1_1	600	606	PF00069	0.632
MOD_CK1_1	615	621	PF00069	0.505
MOD_CK1_1	693	699	PF00069	0.462
MOD_CK1_1	727	733	PF00069	0.650
MOD_CK1_1	774	780	PF00069	0.499
MOD_CK1_1	810	816	PF00069	0.642
MOD_CK2_1	13	19	PF00069	0.596
MOD_CK2_1	212	218	PF00069	0.605
MOD_CK2_1	268	274	PF00069	0.607
MOD_CK2_1	284	290	PF00069	0.543
MOD_CK2_1	386	392	PF00069	0.638
MOD_CK2_1	53	59	PF00069	0.557
MOD_CK2_1	813	819	PF00069	0.576
MOD_CK2_1	837	843	PF00069	0.582
MOD_DYRK1A_RPxSP_1	597	601	PF00069	0.629
MOD_DYRK1A_RPxSP_1	675	679	PF00069	0.589
MOD_GlcNHglycan	103	107	PF01048	0.615
MOD_GlcNHglycan	120	123	PF01048	0.630
MOD_GlcNHglycan	147	150	PF01048	0.573
MOD_GlcNHglycan	170	173	PF01048	0.579
MOD_GlcNHglycan	200	203	PF01048	0.564
MOD_GlcNHglycan	210	213	PF01048	0.629
MOD_GlcNHglycan	214	217	PF01048	0.608
MOD_GlcNHglycan	290	294	PF01048	0.654
MOD_GlcNHglycan	298	302	PF01048	0.637
MOD_GlcNHglycan	341	344	PF01048	0.666
MOD_GlcNHglycan	37	40	PF01048	0.648
MOD_GlcNHglycan	372	375	PF01048	0.632
MOD_GlcNHglycan	394	397	PF01048	0.580
MOD_GlcNHglycan	410	413	PF01048	0.526
MOD_GlcNHglycan	420	423	PF01048	0.539
MOD_GlcNHglycan	425	428	PF01048	0.520
MOD_GlcNHglycan	453	456	PF01048	0.642
MOD_GlcNHglycan	459	462	PF01048	0.565
MOD_GlcNHglycan	473	476	PF01048	0.481
MOD_GlcNHglycan	490	493	PF01048	0.536
MOD_GlcNHglycan	504	507	PF01048	0.587
MOD_GlcNHglycan	509	512	PF01048	0.548
MOD_GlcNHglycan	516	519	PF01048	0.564
MOD_GlcNHglycan	522	525	PF01048	0.525
MOD_GlcNHglycan	614	617	PF01048	0.590
MOD_GlcNHglycan	738	741	PF01048	0.694
MOD_GlcNHglycan	757	760	PF01048	0.566
MOD_GlcNHglycan	826	829	PF01048	0.543
MOD_GSK3_1	108	115	PF00069	0.615
MOD_GSK3_1	145	152	PF00069	0.618
MOD_GSK3_1	200	207	PF00069	0.588
MOD_GSK3_1	208	215	PF00069	0.614
MOD_GSK3_1	234	241	PF00069	0.629
MOD_GSK3_1	252	259	PF00069	0.556
MOD_GSK3_1	280	287	PF00069	0.642
MOD_GSK3_1	308	315	PF00069	0.632
MOD_GSK3_1	31	38	PF00069	0.668
MOD_GSK3_1	379	386	PF00069	0.657
MOD_GSK3_1	404	411	PF00069	0.621
MOD_GSK3_1	418	425	PF00069	0.552
MOD_GSK3_1	441	448	PF00069	0.607
MOD_GSK3_1	449	456	PF00069	0.588
MOD_GSK3_1	457	464	PF00069	0.523
MOD_GSK3_1	467	474	PF00069	0.505
MOD_GSK3_1	475	482	PF00069	0.527
MOD_GSK3_1	484	491	PF00069	0.556
MOD_GSK3_1	502	509	PF00069	0.615
MOD_GSK3_1	510	517	PF00069	0.592
MOD_GSK3_1	525	532	PF00069	0.547
MOD_GSK3_1	587	594	PF00069	0.597
MOD_GSK3_1	724	731	PF00069	0.665
MOD_GSK3_1	732	739	PF00069	0.684
MOD_GSK3_1	799	806	PF00069	0.641
MOD_GSK3_1	807	814	PF00069	0.599
MOD_GSK3_1	820	827	PF00069	0.538
MOD_GSK3_1	9	16	PF00069	0.585
MOD_N-GLC_1	45	50	PF02516	0.621
MOD_N-GLC_1	780	785	PF02516	0.611
MOD_N-GLC_2	584	586	PF02516	0.579
MOD_NEK2_1	102	107	PF00069	0.615
MOD_NEK2_1	112	117	PF00069	0.531
MOD_NEK2_1	284	289	PF00069	0.618
MOD_NEK2_1	479	484	PF00069	0.587
MOD_NEK2_1	602	607	PF00069	0.601
MOD_NEK2_1	634	639	PF00069	0.579
MOD_NEK2_1	834	839	PF00069	0.599
MOD_NEK2_2	142	147	PF00069	0.611
MOD_NEK2_2	713	718	PF00069	0.569
MOD_PIKK_1	129	135	PF00454	0.634
MOD_PIKK_1	163	169	PF00454	0.586
MOD_PIKK_1	22	28	PF00454	0.571
MOD_PIKK_1	258	264	PF00454	0.555
MOD_PIKK_1	61	67	PF00454	0.636
MOD_PIKK_1	832	838	PF00454	0.636
MOD_PK_1	190	196	PF00069	0.542
MOD_PK_1	530	536	PF00069	0.577
MOD_PKA_1	168	174	PF00069	0.596
MOD_PKA_1	197	203	PF00069	0.570
MOD_PKA_1	364	370	PF00069	0.623
MOD_PKA_1	502	508	PF00069	0.627
MOD_PKA_1	755	761	PF00069	0.487
MOD_PKA_1	832	838	PF00069	0.639
MOD_PKA_2	198	204	PF00069	0.547
MOD_PKA_2	2	8	PF00069	0.604
MOD_PKA_2	22	28	PF00069	0.528
MOD_PKA_2	234	240	PF00069	0.622
MOD_PKA_2	364	370	PF00069	0.623
MOD_PKA_2	502	508	PF00069	0.660
MOD_PKA_2	53	59	PF00069	0.574
MOD_PKA_2	674	680	PF00069	0.606
MOD_PKA_2	713	719	PF00069	0.536
MOD_PKA_2	755	761	PF00069	0.487
MOD_PKA_2	771	777	PF00069	0.558
MOD_PKA_2	808	814	PF00069	0.617
MOD_PKA_2	820	826	PF00069	0.549
MOD_PKA_2	832	838	PF00069	0.571
MOD_PKB_1	286	294	PF00069	0.638
MOD_PKB_1	753	761	PF00069	0.538
MOD_Plk_1	216	222	PF00069	0.601
MOD_Plk_1	280	286	PF00069	0.639
MOD_Plk_1	311	317	PF00069	0.604
MOD_Plk_1	45	51	PF00069	0.607
MOD_Plk_1	571	577	PF00069	0.549
MOD_Plk_1	75	81	PF00069	0.648
MOD_Plk_1	807	813	PF00069	0.567
MOD_Plk_1	814	820	PF00069	0.540
MOD_Plk_2-3	218	224	PF00069	0.605
MOD_Plk_4	108	114	PF00069	0.600
MOD_Plk_4	317	323	PF00069	0.558
MOD_Plk_4	530	536	PF00069	0.594
MOD_Plk_4	657	663	PF00069	0.470
MOD_ProDKin_1	224	230	PF00069	0.648
MOD_ProDKin_1	252	258	PF00069	0.636
MOD_ProDKin_1	433	439	PF00069	0.572
MOD_ProDKin_1	445	451	PF00069	0.578
MOD_ProDKin_1	587	593	PF00069	0.633
MOD_ProDKin_1	597	603	PF00069	0.560
MOD_ProDKin_1	610	616	PF00069	0.526
MOD_ProDKin_1	618	624	PF00069	0.562
MOD_ProDKin_1	628	634	PF00069	0.492
MOD_ProDKin_1	675	681	PF00069	0.751
MOD_ProDKin_1	708	714	PF00069	0.596
MOD_ProDKin_1	724	730	PF00069	0.499
MOD_ProDKin_1	732	738	PF00069	0.592
MOD_ProDKin_1	780	786	PF00069	0.589
MOD_ProDKin_1	93	99	PF00069	0.614
TRG_DiLeu_BaLyEn_6	630	635	PF01217	0.764
TRG_DiLeu_BaLyEn_6	781	786	PF01217	0.525
TRG_ER_diArg_1	362	365	PF00400	0.622
TRG_ER_diArg_1	501	504	PF00400	0.651
TRG_ER_diArg_1	547	550	PF00400	0.480
TRG_ER_diArg_1	555	558	PF00400	0.421
TRG_ER_diArg_1	625	628	PF00400	0.721
TRG_ER_diArg_1	702	704	PF00400	0.645
TRG_ER_diArg_1	713	715	PF00400	0.513
TRG_ER_diArg_1	724	726	PF00400	0.518
TRG_ER_diArg_1	753	756	PF00400	0.488
TRG_ER_diArg_1	832	834	PF00400	0.617
TRG_NLS_Bipartite_1	168	185	PF00514	0.579
TRG_NLS_MonoCore_2	180	185	PF00514	0.489
TRG_NLS_MonoCore_2	195	200	PF00514	0.540
TRG_NLS_MonoExtN_4	196	201	PF00514	0.578
TRG_NLS_MonoExtN_4	353	360	PF00514	0.627
TRG_Pf-PMV_PEXEL_1	550	554	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7L9	Leishmania donovani	88%	100%
A4HHP7	Leishmania braziliensis	50%	87%
A4I4W2	Leishmania infantum	88%	100%
E9ALH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%