Putative heat shock protein 20

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein 20, putative

Species:

Leishmania major

UniProt:

E9AEA7_LEIMA

TriTrypDb:

LmjF.29.2450 , LMJLV39_290032500 , LMJSD75_290032900

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AEA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.306
CLV_NRD_NRD_1	88	90	PF00675	0.276
CLV_PCSK_KEX2_1	7	9	PF00082	0.540
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.540
CLV_PCSK_SKI1_1	31	35	PF00082	0.509
CLV_PCSK_SKI1_1	90	94	PF00082	0.287
DEG_Nend_Nbox_1	1	3	PF02207	0.558
DOC_MAPK_DCC_7	43	52	PF00069	0.442
DOC_MAPK_FxFP_2	23	26	PF00069	0.455
DOC_MAPK_gen_1	69	75	PF00069	0.393
DOC_MAPK_MEF2A_6	43	52	PF00069	0.442
DOC_PP2B_LxvP_1	136	139	PF13499	0.181
DOC_PP4_FxxP_1	114	117	PF00568	0.408
DOC_PP4_FxxP_1	23	26	PF00568	0.455
DOC_USP7_MATH_1	148	152	PF00917	0.389
DOC_USP7_MATH_1	39	43	PF00917	0.423
DOC_USP7_UBL2_3	90	94	PF12436	0.345
LIG_14-3-3_CanoR_1	74	83	PF00244	0.393
LIG_APCC_ABBA_1	73	78	PF00400	0.393
LIG_BRCT_BRCA1_1	34	38	PF00533	0.616
LIG_CSL_BTD_1	1	4	PF09270	0.594
LIG_FHA_2	116	122	PF00498	0.331
LIG_LIR_Apic_2	111	117	PF02991	0.393
LIG_LIR_Gen_1	56	66	PF02991	0.397
LIG_LIR_Nem_3	15	21	PF02991	0.573
LIG_LIR_Nem_3	56	62	PF02991	0.268
LIG_MLH1_MIPbox_1	34	38	PF16413	0.600
LIG_Pex14_2	110	114	PF04695	0.393
LIG_Pex14_2	19	23	PF04695	0.547
LIG_REV1ctd_RIR_1	35	45	PF16727	0.556
LIG_SH2_PTP2	59	62	PF00017	0.181
LIG_SH2_STAT5	59	62	PF00017	0.393
LIG_SH2_STAT5	76	79	PF00017	0.331
LIG_UBA3_1	82	90	PF00899	0.331
LIG_WRC_WIRS_1	34	39	PF05994	0.565
MOD_CK1_1	119	125	PF00069	0.292
MOD_CK1_1	14	20	PF00069	0.390
MOD_CK1_1	146	152	PF00069	0.361
MOD_CK1_1	42	48	PF00069	0.423
MOD_GlcNHglycan	145	148	PF01048	0.327
MOD_GlcNHglycan	85	88	PF01048	0.311
MOD_GSK3_1	115	122	PF00069	0.341
MOD_GSK3_1	146	153	PF00069	0.451
MOD_GSK3_1	33	40	PF00069	0.551
MOD_GSK3_1	7	14	PF00069	0.622
MOD_GSK3_1	74	81	PF00069	0.415
MOD_N-GLC_1	134	139	PF02516	0.399
MOD_NEK2_1	134	139	PF00069	0.291
MOD_NEK2_1	141	146	PF00069	0.350
MOD_NEK2_1	33	38	PF00069	0.545
MOD_PKA_1	7	13	PF00069	0.528
MOD_PKA_2	141	147	PF00069	0.430
MOD_PKA_2	42	48	PF00069	0.388
MOD_PKA_2	7	13	PF00069	0.528
MOD_Plk_1	134	140	PF00069	0.376
MOD_Plk_1	14	20	PF00069	0.390
MOD_Plk_1	77	83	PF00069	0.360
MOD_Plk_4	14	20	PF00069	0.659
MOD_Plk_4	33	39	PF00069	0.509
MOD_Plk_4	42	48	PF00069	0.403
MOD_Plk_4	7	13	PF00069	0.528
MOD_Plk_4	78	84	PF00069	0.406
MOD_SUMO_for_1	68	71	PF00179	0.256
TRG_DiLeu_BaEn_1	97	102	PF01217	0.331
TRG_ENDOCYTIC_2	59	62	PF00928	0.251

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHY2	Leptomonas seymouri	59%	100%
A0A0S4ITJ1	Bodo saltans	40%	100%
A0A1X0P9Y3	Trypanosomatidae	39%	100%
A0A3Q8IBN6	Leishmania donovani	92%	100%
A0A3R7N2L9	Trypanosoma rangeli	42%	100%
A4HHP4	Leishmania braziliensis	81%	100%
A4I4V9	Leishmania infantum	92%	100%
C9ZL02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ALH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O14368	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
O30851	Streptococcus thermophilus	32%	100%
O82011	Solanum peruvianum	30%	100%
O82013	Solanum peruvianum	27%	100%
P02519	Glycine max	30%	100%
P04793	Glycine max	33%	100%
P04794	Glycine max	32%	100%
P04795	Glycine max	32%	100%
P05478	Glycine max	31%	96%
P15992	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	72%
P19037	Arabidopsis thaliana	29%	96%
P19243	Pisum sativum	34%	98%
P19244	Pisum sativum	31%	79%
P27880	Medicago sativa	33%	98%
P29830	Arabidopsis thaliana	27%	100%
P30236	Glycine max	31%	81%
P46516	Helianthus annuus	26%	97%
Q01545	Ipomoea nil	29%	93%
Q03928	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	37%	100%
Q06823	Stigmatella aurantiaca (strain DW4/3-1)	31%	92%
Q38806	Arabidopsis thaliana	31%	79%
Q4UJB1	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	30%	95%
Q4UKR8	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	29%	100%
Q53M11	Oryza sativa subsp. japonica	29%	75%
Q7XUW5	Oryza sativa subsp. japonica	31%	72%
Q943Q3	Oryza sativa subsp. japonica	27%	100%
Q9ZW31	Arabidopsis thaliana	34%	100%
V5BXI2	Trypanosoma cruzi	43%	100%