LeishMANIAdb
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Phosphodiesterase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphodiesterase
Gene product:
3'5'-cyclic nucleotide phosphodiesterase, putative
Species:
Leishmania major
UniProt:
E9AEA6_LEIMA
TriTrypDb:
LmjF.29.2440 , LMJLV39_290032400 * , LMJSD75_290032800 *
Length:
722

Annotations

LeishMANIAdb annotations

Phosphodiesterase, with probable N-terminal lipidation signal. Not embedded in membrane, like its homologs.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0020016 ciliary pocket 2 2
GO:0110165 cellular anatomical entity 1 5
GO:0016020 membrane 2 3

Expansion

Sequence features

E9AEA6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEA6

Function

Biological processes
Term Name Level Count
GO:0007165 signal transduction 2 14
GO:0009987 cellular process 1 14
GO:0050789 regulation of biological process 2 14
GO:0050794 regulation of cellular process 3 14
GO:0065007 biological regulation 1 14
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 14
GO:0004112 cyclic-nucleotide phosphodiesterase activity 6 14
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 7 14
GO:0005488 binding 1 14
GO:0008081 phosphoric diester hydrolase activity 5 14
GO:0016787 hydrolase activity 2 14
GO:0016788 hydrolase activity, acting on ester bonds 3 14
GO:0042578 phosphoric ester hydrolase activity 4 14
GO:0043167 ion binding 2 14
GO:0043169 cation binding 3 14
GO:0046872 metal ion binding 4 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 183 187 PF00656 0.604
CLV_NRD_NRD_1 183 185 PF00675 0.594
CLV_NRD_NRD_1 303 305 PF00675 0.572
CLV_NRD_NRD_1 378 380 PF00675 0.607
CLV_NRD_NRD_1 445 447 PF00675 0.545
CLV_NRD_NRD_1 705 707 PF00675 0.625
CLV_PCSK_KEX2_1 303 305 PF00082 0.587
CLV_PCSK_KEX2_1 445 447 PF00082 0.545
CLV_PCSK_KEX2_1 705 707 PF00082 0.607
CLV_PCSK_PC7_1 299 305 PF00082 0.681
CLV_PCSK_SKI1_1 106 110 PF00082 0.599
CLV_PCSK_SKI1_1 219 223 PF00082 0.545
CLV_PCSK_SKI1_1 303 307 PF00082 0.627
CLV_PCSK_SKI1_1 355 359 PF00082 0.444
CLV_PCSK_SKI1_1 445 449 PF00082 0.433
CLV_PCSK_SKI1_1 529 533 PF00082 0.352
CLV_PCSK_SKI1_1 581 585 PF00082 0.384
CLV_PCSK_SKI1_1 604 608 PF00082 0.425
CLV_PCSK_SKI1_1 91 95 PF00082 0.564
CLV_Separin_Metazoa 542 546 PF03568 0.430
DEG_APCC_DBOX_1 444 452 PF00400 0.492
DEG_APCC_DBOX_1 518 526 PF00400 0.463
DEG_SCF_FBW7_1 13 20 PF00400 0.707
DEG_SPOP_SBC_1 75 79 PF00917 0.695
DOC_MAPK_gen_1 445 451 PF00069 0.542
DOC_MAPK_gen_1 599 607 PF00069 0.430
DOC_MAPK_MEF2A_6 599 607 PF00069 0.354
DOC_PP4_FxxP_1 116 119 PF00568 0.557
DOC_PP4_FxxP_1 203 206 PF00568 0.598
DOC_PP4_FxxP_1 505 508 PF00568 0.391
DOC_SPAK_OSR1_1 223 227 PF12202 0.531
DOC_SPAK_OSR1_1 446 450 PF12202 0.545
DOC_USP7_MATH_1 15 19 PF00917 0.746
DOC_USP7_MATH_1 285 289 PF00917 0.628
DOC_USP7_MATH_1 450 454 PF00917 0.517
DOC_USP7_MATH_2 346 352 PF00917 0.567
DOC_USP7_UBL2_3 631 635 PF12436 0.493
DOC_USP7_UBL2_3 85 89 PF12436 0.617
DOC_WW_Pin1_4 11 16 PF00397 0.765
DOC_WW_Pin1_4 212 217 PF00397 0.620
DOC_WW_Pin1_4 333 338 PF00397 0.738
DOC_WW_Pin1_4 358 363 PF00397 0.564
DOC_WW_Pin1_4 649 654 PF00397 0.352
DOC_WW_Pin1_4 65 70 PF00397 0.755
LIG_14-3-3_CanoR_1 139 146 PF00244 0.503
LIG_14-3-3_CanoR_1 589 596 PF00244 0.436
LIG_14-3-3_CanoR_1 604 610 PF00244 0.335
LIG_APCC_ABBA_1 113 118 PF00400 0.560
LIG_APCC_ABBA_1 651 656 PF00400 0.391
LIG_BRCT_BRCA1_1 633 637 PF00533 0.391
LIG_CSL_BTD_1 334 337 PF09270 0.742
LIG_CtBP_PxDLS_1 206 210 PF00389 0.611
LIG_eIF4E_1 422 428 PF01652 0.426
LIG_FHA_1 110 116 PF00498 0.482
LIG_FHA_1 131 137 PF00498 0.584
LIG_FHA_1 166 172 PF00498 0.527
LIG_FHA_1 228 234 PF00498 0.579
LIG_FHA_1 265 271 PF00498 0.659
LIG_FHA_1 30 36 PF00498 0.768
LIG_FHA_1 406 412 PF00498 0.498
LIG_FHA_1 421 427 PF00498 0.398
LIG_FHA_1 538 544 PF00498 0.484
LIG_FHA_1 689 695 PF00498 0.509
LIG_FHA_1 69 75 PF00498 0.781
LIG_FHA_1 8 14 PF00498 0.771
LIG_FHA_2 140 146 PF00498 0.500
LIG_FHA_2 176 182 PF00498 0.591
LIG_FHA_2 552 558 PF00498 0.413
LIG_FHA_2 564 570 PF00498 0.320
LIG_IBAR_NPY_1 458 460 PF08397 0.436
LIG_Integrin_isoDGR_2 217 219 PF01839 0.430
LIG_IRF3_LxIS_1 647 652 PF10401 0.457
LIG_LIR_Apic_2 200 206 PF02991 0.611
LIG_LIR_Apic_2 504 508 PF02991 0.352
LIG_LIR_Gen_1 186 197 PF02991 0.553
LIG_LIR_Gen_1 393 401 PF02991 0.445
LIG_LIR_Gen_1 405 414 PF02991 0.382
LIG_LIR_Gen_1 423 433 PF02991 0.375
LIG_LIR_Gen_1 540 549 PF02991 0.412
LIG_LIR_Nem_3 158 162 PF02991 0.443
LIG_LIR_Nem_3 186 192 PF02991 0.531
LIG_LIR_Nem_3 198 204 PF02991 0.572
LIG_LIR_Nem_3 220 225 PF02991 0.564
LIG_LIR_Nem_3 393 398 PF02991 0.424
LIG_LIR_Nem_3 405 409 PF02991 0.424
LIG_LIR_Nem_3 423 428 PF02991 0.397
LIG_LIR_Nem_3 491 497 PF02991 0.454
LIG_LIR_Nem_3 540 544 PF02991 0.432
LIG_LIR_Nem_3 670 674 PF02991 0.354
LIG_LIR_Nem_3 95 99 PF02991 0.621
LIG_LYPXL_yS_3 201 204 PF13949 0.536
LIG_Pex14_1 159 163 PF04695 0.426
LIG_PTB_Apo_2 543 550 PF02174 0.429
LIG_PTB_Apo_2 697 704 PF02174 0.568
LIG_PTB_Phospho_1 543 549 PF10480 0.454
LIG_PTB_Phospho_1 697 703 PF10480 0.568
LIG_Rb_pABgroove_1 316 324 PF01858 0.691
LIG_REV1ctd_RIR_1 160 168 PF16727 0.438
LIG_SH2_CRK 406 410 PF00017 0.458
LIG_SH2_CRK 96 100 PF00017 0.610
LIG_SH2_GRB2like 436 439 PF00017 0.531
LIG_SH2_GRB2like 460 463 PF00017 0.363
LIG_SH2_NCK_1 235 239 PF00017 0.628
LIG_SH2_NCK_1 406 410 PF00017 0.458
LIG_SH2_SRC 322 325 PF00017 0.651
LIG_SH2_STAP1 137 141 PF00017 0.521
LIG_SH2_STAP1 422 426 PF00017 0.365
LIG_SH2_STAP1 626 630 PF00017 0.430
LIG_SH2_STAT3 674 677 PF00017 0.454
LIG_SH2_STAT5 141 144 PF00017 0.648
LIG_SH2_STAT5 269 272 PF00017 0.663
LIG_SH2_STAT5 422 425 PF00017 0.413
LIG_SH2_STAT5 436 439 PF00017 0.460
LIG_SH2_STAT5 475 478 PF00017 0.353
LIG_SH2_STAT5 521 524 PF00017 0.363
LIG_SH2_STAT5 638 641 PF00017 0.437
LIG_SH2_STAT5 674 677 PF00017 0.352
LIG_SH2_STAT5 92 95 PF00017 0.500
LIG_SH3_3 222 228 PF00018 0.600
LIG_SH3_3 356 362 PF00018 0.469
LIG_SH3_3 54 60 PF00018 0.796
LIG_SH3_3 63 69 PF00018 0.749
LIG_SUMO_SIM_par_1 31 38 PF11976 0.594
LIG_SUMO_SIM_par_1 447 453 PF11976 0.531
LIG_TRAF2_1 142 145 PF00917 0.626
LIG_TRAF2_1 307 310 PF00917 0.608
LIG_TRAF2_1 341 344 PF00917 0.622
LIG_TRAF2_1 489 492 PF00917 0.409
LIG_TRAF2_1 716 719 PF00917 0.499
LIG_TRFH_1 358 362 PF08558 0.472
LIG_TYR_ITIM 434 439 PF00017 0.513
LIG_TYR_ITSM 421 428 PF00017 0.429
LIG_WRC_WIRS_1 349 354 PF05994 0.465
LIG_WRC_WIRS_1 689 694 PF05994 0.424
MOD_CDK_SPxxK_3 212 219 PF00069 0.587
MOD_CDK_SPxxK_3 358 365 PF00069 0.568
MOD_CK1_1 132 138 PF00069 0.574
MOD_CK1_1 165 171 PF00069 0.427
MOD_CK1_1 173 179 PF00069 0.470
MOD_CK1_1 211 217 PF00069 0.573
MOD_CK1_1 239 245 PF00069 0.639
MOD_CK1_1 3 9 PF00069 0.731
MOD_CK1_1 367 373 PF00069 0.562
MOD_CK1_1 591 597 PF00069 0.469
MOD_CK1_1 68 74 PF00069 0.769
MOD_CK2_1 139 145 PF00069 0.508
MOD_CK2_1 16 22 PF00069 0.834
MOD_CK2_1 240 246 PF00069 0.709
MOD_CK2_1 486 492 PF00069 0.396
MOD_CK2_1 527 533 PF00069 0.352
MOD_CK2_1 563 569 PF00069 0.382
MOD_CK2_1 595 601 PF00069 0.417
MOD_CK2_1 713 719 PF00069 0.679
MOD_GlcNHglycan 2 5 PF01048 0.768
MOD_GlcNHglycan 238 241 PF01048 0.632
MOD_GlcNHglycan 282 286 PF01048 0.672
MOD_GlcNHglycan 368 372 PF01048 0.517
MOD_GlcNHglycan 37 40 PF01048 0.692
MOD_GlcNHglycan 452 455 PF01048 0.487
MOD_GlcNHglycan 683 686 PF01048 0.467
MOD_GlcNHglycan 79 82 PF01048 0.741
MOD_GSK3_1 11 18 PF00069 0.760
MOD_GSK3_1 176 183 PF00069 0.534
MOD_GSK3_1 187 194 PF00069 0.450
MOD_GSK3_1 208 215 PF00069 0.625
MOD_GSK3_1 236 243 PF00069 0.630
MOD_GSK3_1 260 267 PF00069 0.633
MOD_GSK3_1 281 288 PF00069 0.611
MOD_GSK3_1 3 10 PF00069 0.785
MOD_GSK3_1 326 333 PF00069 0.732
MOD_GSK3_1 591 598 PF00069 0.411
MOD_GSK3_1 70 77 PF00069 0.722
MOD_N-GLC_1 187 192 PF02516 0.527
MOD_N-GLC_1 631 636 PF02516 0.425
MOD_N-GLC_1 647 652 PF02516 0.352
MOD_N-GLC_1 75 80 PF02516 0.824
MOD_N-GLC_2 695 697 PF02516 0.554
MOD_NEK2_1 109 114 PF00069 0.563
MOD_NEK2_1 162 167 PF00069 0.414
MOD_NEK2_1 330 335 PF00069 0.705
MOD_NEK2_1 420 425 PF00069 0.358
MOD_NEK2_1 439 444 PF00069 0.392
MOD_NEK2_1 605 610 PF00069 0.353
MOD_NEK2_1 647 652 PF00069 0.430
MOD_NEK2_1 70 75 PF00069 0.662
MOD_NEK2_1 99 104 PF00069 0.516
MOD_NEK2_2 187 192 PF00069 0.606
MOD_NEK2_2 240 245 PF00069 0.551
MOD_NEK2_2 254 259 PF00069 0.593
MOD_NEK2_2 521 526 PF00069 0.352
MOD_NMyristoyl 1 7 PF02799 0.693
MOD_PIKK_1 195 201 PF00454 0.535
MOD_PIKK_1 467 473 PF00454 0.409
MOD_PIKK_1 68 74 PF00454 0.817
MOD_PKA_1 705 711 PF00069 0.613
MOD_PKA_2 236 242 PF00069 0.549
MOD_PKA_2 486 492 PF00069 0.366
MOD_PKA_2 563 569 PF00069 0.366
MOD_PKA_2 588 594 PF00069 0.454
MOD_PKA_2 705 711 PF00069 0.605
MOD_Plk_1 121 127 PF00069 0.500
MOD_Plk_1 187 193 PF00069 0.478
MOD_Plk_1 254 260 PF00069 0.611
MOD_Plk_1 281 287 PF00069 0.602
MOD_Plk_1 439 445 PF00069 0.346
MOD_Plk_1 467 473 PF00069 0.363
MOD_Plk_1 527 533 PF00069 0.355
MOD_Plk_1 647 653 PF00069 0.454
MOD_Plk_2-3 297 303 PF00069 0.626
MOD_Plk_2-3 713 719 PF00069 0.485
MOD_Plk_4 109 115 PF00069 0.520
MOD_Plk_4 121 127 PF00069 0.460
MOD_Plk_4 132 138 PF00069 0.387
MOD_Plk_4 330 336 PF00069 0.714
MOD_Plk_4 421 427 PF00069 0.364
MOD_Plk_4 439 445 PF00069 0.398
MOD_Plk_4 521 527 PF00069 0.352
MOD_Plk_4 563 569 PF00069 0.363
MOD_Plk_4 667 673 PF00069 0.405
MOD_Plk_4 70 76 PF00069 0.588
MOD_ProDKin_1 11 17 PF00069 0.759
MOD_ProDKin_1 212 218 PF00069 0.622
MOD_ProDKin_1 333 339 PF00069 0.735
MOD_ProDKin_1 358 364 PF00069 0.564
MOD_ProDKin_1 649 655 PF00069 0.352
MOD_ProDKin_1 65 71 PF00069 0.759
MOD_SUMO_rev_2 642 647 PF00179 0.484
TRG_DiLeu_BaEn_1 558 563 PF01217 0.502
TRG_DiLeu_BaEn_2 219 225 PF01217 0.506
TRG_DiLeu_BaLyEn_6 557 562 PF01217 0.463
TRG_ENDOCYTIC_2 201 204 PF00928 0.566
TRG_ENDOCYTIC_2 406 409 PF00928 0.403
TRG_ENDOCYTIC_2 425 428 PF00928 0.355
TRG_ENDOCYTIC_2 436 439 PF00928 0.398
TRG_ENDOCYTIC_2 474 477 PF00928 0.363
TRG_ENDOCYTIC_2 549 552 PF00928 0.368
TRG_ENDOCYTIC_2 96 99 PF00928 0.612
TRG_ER_diArg_1 303 305 PF00400 0.606
TRG_ER_diArg_1 444 446 PF00400 0.542
TRG_ER_diArg_1 704 706 PF00400 0.605
TRG_Pf-PMV_PEXEL_1 278 282 PF00026 0.602
TRG_Pf-PMV_PEXEL_1 529 533 PF00026 0.363
TRG_Pf-PMV_PEXEL_1 560 565 PF00026 0.486

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1Y4 Leptomonas seymouri 71% 100%
A0A0S4IPG9 Bodo saltans 45% 97%
A0A0S4IRJ2 Bodo saltans 46% 100%
A0A1X0P701 Trypanosomatidae 31% 100%
A0A1X0P936 Trypanosomatidae 54% 100%
A0A3R7KV25 Trypanosoma rangeli 55% 100%
A0A3S7X2R6 Leishmania donovani 94% 100%
A4HHP3 Leishmania braziliensis 81% 98%
A4I4V8 Leishmania infantum 94% 100%
C9ZL03 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
E9ALI0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
V5DTU5 Trypanosoma cruzi 53% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS