Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AEA5_LEIMA

TriTrypDb:

LmjF.29.2430 , LMJLV39_290032300 , LMJSD75_290032700

Length:

761

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.743
CLV_C14_Caspase3-7	263	267	PF00656	0.603
CLV_C14_Caspase3-7	477	481	PF00656	0.608
CLV_NRD_NRD_1	113	115	PF00675	0.692
CLV_NRD_NRD_1	128	130	PF00675	0.543
CLV_NRD_NRD_1	186	188	PF00675	0.639
CLV_NRD_NRD_1	282	284	PF00675	0.704
CLV_NRD_NRD_1	312	314	PF00675	0.691
CLV_NRD_NRD_1	394	396	PF00675	0.702
CLV_NRD_NRD_1	413	415	PF00675	0.683
CLV_NRD_NRD_1	504	506	PF00675	0.655
CLV_NRD_NRD_1	544	546	PF00675	0.654
CLV_NRD_NRD_1	706	708	PF00675	0.728
CLV_NRD_NRD_1	711	713	PF00675	0.643
CLV_NRD_NRD_1	86	88	PF00675	0.574
CLV_PCSK_FUR_1	502	506	PF00082	0.598
CLV_PCSK_KEX2_1	113	115	PF00082	0.692
CLV_PCSK_KEX2_1	128	130	PF00082	0.543
CLV_PCSK_KEX2_1	141	143	PF00082	0.555
CLV_PCSK_KEX2_1	282	284	PF00082	0.652
CLV_PCSK_KEX2_1	312	314	PF00082	0.686
CLV_PCSK_KEX2_1	363	365	PF00082	0.596
CLV_PCSK_KEX2_1	394	396	PF00082	0.702
CLV_PCSK_KEX2_1	413	415	PF00082	0.683
CLV_PCSK_KEX2_1	504	506	PF00082	0.655
CLV_PCSK_KEX2_1	543	545	PF00082	0.656
CLV_PCSK_KEX2_1	591	593	PF00082	0.804
CLV_PCSK_KEX2_1	616	618	PF00082	0.730
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.597
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.596
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.712
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.730
CLV_PCSK_SKI1_1	322	326	PF00082	0.601
CLV_PCSK_SKI1_1	524	528	PF00082	0.726
CLV_PCSK_SKI1_1	707	711	PF00082	0.711
CLV_PCSK_SKI1_1	79	83	PF00082	0.618
CLV_Separin_Metazoa	720	724	PF03568	0.596
DEG_SCF_FBW7_1	376	382	PF00400	0.642
DEG_SCF_FBW7_1	695	701	PF00400	0.666
DEG_SCF_FBW7_2	196	202	PF00400	0.657
DEG_SCF_TRCP1_1	57	62	PF00400	0.555
DOC_CKS1_1	196	201	PF01111	0.642
DOC_CKS1_1	323	328	PF01111	0.585
DOC_CKS1_1	376	381	PF01111	0.639
DOC_CKS1_1	667	672	PF01111	0.569
DOC_CKS1_1	695	700	PF01111	0.665
DOC_CYCLIN_RxL_1	164	175	PF00134	0.617
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	574	580	PF00134	0.599
DOC_MAPK_DCC_7	579	587	PF00069	0.682
DOC_MAPK_gen_1	712	719	PF00069	0.525
DOC_MAPK_HePTP_8	709	721	PF00069	0.530
DOC_MAPK_MEF2A_6	712	721	PF00069	0.524
DOC_PP1_RVXF_1	165	172	PF00149	0.620
DOC_PP2B_LxvP_1	190	193	PF13499	0.570
DOC_PP2B_LxvP_1	240	243	PF13499	0.538
DOC_PP2B_LxvP_1	292	295	PF13499	0.682
DOC_PP2B_LxvP_1	324	327	PF13499	0.581
DOC_PP2B_LxvP_1	358	361	PF13499	0.619
DOC_PP2B_LxvP_1	384	387	PF13499	0.681
DOC_PP2B_LxvP_1	46	49	PF13499	0.690
DOC_PP2B_LxvP_1	574	577	PF13499	0.596
DOC_USP7_MATH_1	15	19	PF00917	0.661
DOC_USP7_MATH_1	153	157	PF00917	0.700
DOC_USP7_MATH_1	300	304	PF00917	0.579
DOC_USP7_MATH_1	353	357	PF00917	0.554
DOC_USP7_MATH_1	400	404	PF00917	0.605
DOC_USP7_MATH_1	406	410	PF00917	0.605
DOC_USP7_MATH_1	489	493	PF00917	0.772
DOC_USP7_MATH_1	55	59	PF00917	0.626
DOC_USP7_MATH_1	612	616	PF00917	0.558
DOC_USP7_MATH_1	629	633	PF00917	0.608
DOC_USP7_MATH_1	650	654	PF00917	0.642
DOC_USP7_MATH_1	684	688	PF00917	0.718
DOC_USP7_MATH_1	96	100	PF00917	0.680
DOC_USP7_UBL2_3	563	567	PF12436	0.678
DOC_USP7_UBL2_3	704	708	PF12436	0.671
DOC_USP7_UBL2_3	752	756	PF12436	0.612
DOC_WW_Pin1_4	121	126	PF00397	0.800
DOC_WW_Pin1_4	127	132	PF00397	0.724
DOC_WW_Pin1_4	192	197	PF00397	0.647
DOC_WW_Pin1_4	266	271	PF00397	0.709
DOC_WW_Pin1_4	322	327	PF00397	0.687
DOC_WW_Pin1_4	372	377	PF00397	0.696
DOC_WW_Pin1_4	527	532	PF00397	0.674
DOC_WW_Pin1_4	555	560	PF00397	0.787
DOC_WW_Pin1_4	569	574	PF00397	0.716
DOC_WW_Pin1_4	59	64	PF00397	0.605
DOC_WW_Pin1_4	591	596	PF00397	0.628
DOC_WW_Pin1_4	600	605	PF00397	0.661
DOC_WW_Pin1_4	616	621	PF00397	0.637
DOC_WW_Pin1_4	648	653	PF00397	0.628
DOC_WW_Pin1_4	657	662	PF00397	0.694
DOC_WW_Pin1_4	666	671	PF00397	0.655
DOC_WW_Pin1_4	694	699	PF00397	0.777
DOC_WW_Pin1_4	756	761	PF00397	0.633
LIG_14-3-3_CanoR_1	113	119	PF00244	0.690
LIG_14-3-3_CanoR_1	129	139	PF00244	0.657
LIG_14-3-3_CanoR_1	187	191	PF00244	0.610
LIG_14-3-3_CanoR_1	282	292	PF00244	0.567
LIG_14-3-3_CanoR_1	312	320	PF00244	0.657
LIG_14-3-3_CanoR_1	342	350	PF00244	0.691
LIG_14-3-3_CanoR_1	413	423	PF00244	0.585
LIG_14-3-3_CanoR_1	543	552	PF00244	0.644
LIG_14-3-3_CanoR_1	707	714	PF00244	0.649
LIG_14-3-3_CanoR_1	87	92	PF00244	0.650
LIG_BIR_II_1	1	5	PF00653	0.531
LIG_BRCT_BRCA1_1	1	5	PF00533	0.516
LIG_BRCT_BRCA1_1	285	289	PF00533	0.587
LIG_BRCT_BRCA1_1	315	319	PF00533	0.551
LIG_FHA_1	134	140	PF00498	0.703
LIG_FHA_1	196	202	PF00498	0.634
LIG_FHA_1	367	373	PF00498	0.628
LIG_FHA_1	438	444	PF00498	0.571
LIG_FHA_1	569	575	PF00498	0.675
LIG_FHA_1	678	684	PF00498	0.540
LIG_FHA_2	135	141	PF00498	0.548
LIG_FHA_2	170	176	PF00498	0.584
LIG_FHA_2	475	481	PF00498	0.569
LIG_FHA_2	570	576	PF00498	0.736
LIG_FHA_2	80	86	PF00498	0.606
LIG_Integrin_isoDGR_2	396	398	PF01839	0.585
LIG_LIR_Apic_2	503	509	PF02991	0.695
LIG_LIR_Gen_1	286	295	PF02991	0.583
LIG_LIR_Gen_1	318	327	PF02991	0.635
LIG_LIR_Gen_1	401	411	PF02991	0.601
LIG_LIR_Gen_1	82	91	PF02991	0.587
LIG_LIR_Nem_3	162	168	PF02991	0.613
LIG_LIR_Nem_3	286	292	PF02991	0.588
LIG_LIR_Nem_3	318	323	PF02991	0.654
LIG_LIR_Nem_3	401	407	PF02991	0.606
LIG_LIR_Nem_3	82	86	PF02991	0.608
LIG_PAM2_1	414	426	PF00658	0.518
LIG_PTAP_UEV_1	471	476	PF05743	0.559
LIG_PTAP_UEV_1	548	553	PF05743	0.568
LIG_SH2_CRK	165	169	PF00017	0.583
LIG_SH2_CRK	320	324	PF00017	0.652
LIG_SH2_PTP2	506	509	PF00017	0.688
LIG_SH2_SRC	506	509	PF00017	0.688
LIG_SH2_STAP1	237	241	PF00017	0.556
LIG_SH2_STAP1	320	324	PF00017	0.652
LIG_SH2_STAT3	91	94	PF00017	0.559
LIG_SH2_STAT5	332	335	PF00017	0.614
LIG_SH2_STAT5	506	509	PF00017	0.602
LIG_SH2_STAT5	748	751	PF00017	0.591
LIG_SH3_3	157	163	PF00018	0.637
LIG_SH3_3	190	196	PF00018	0.739
LIG_SH3_3	210	216	PF00018	0.686
LIG_SH3_3	292	298	PF00018	0.714
LIG_SH3_3	320	326	PF00018	0.611
LIG_SH3_3	347	353	PF00018	0.691
LIG_SH3_3	373	379	PF00018	0.694
LIG_SH3_3	464	470	PF00018	0.737
LIG_SH3_3	528	534	PF00018	0.649
LIG_SH3_3	546	552	PF00018	0.821
LIG_SH3_3	606	612	PF00018	0.615
LIG_SH3_3	623	629	PF00018	0.716
LIG_SH3_3	631	637	PF00018	0.619
LIG_SH3_3	693	699	PF00018	0.630
LIG_SH3_4	752	759	PF00018	0.592
LIG_SUMO_SIM_par_1	497	503	PF11976	0.611
LIG_SUMO_SIM_par_1	664	669	PF11976	0.532
LIG_SUMO_SIM_par_1	679	685	PF11976	0.546
LIG_TRAF2_1	172	175	PF00917	0.578
LIG_TRAF2_1	509	512	PF00917	0.599
LIG_TRAF2_1	526	529	PF00917	0.666
LIG_TRAF2_1	69	72	PF00917	0.648
LIG_UBA3_1	288	297	PF00899	0.558
MOD_CDK_SPK_2	659	664	PF00069	0.534
MOD_CDK_SPK_2	756	761	PF00069	0.633
MOD_CDK_SPxxK_3	121	128	PF00069	0.578
MOD_CDK_SPxxK_3	657	664	PF00069	0.541
MOD_CK1_1	115	121	PF00069	0.725
MOD_CK1_1	195	201	PF00069	0.569
MOD_CK1_1	206	212	PF00069	0.575
MOD_CK1_1	259	265	PF00069	0.643
MOD_CK1_1	272	278	PF00069	0.594
MOD_CK1_1	343	349	PF00069	0.675
MOD_CK1_1	375	381	PF00069	0.706
MOD_CK1_1	445	451	PF00069	0.624
MOD_CK1_1	492	498	PF00069	0.594
MOD_CK1_1	651	657	PF00069	0.700
MOD_CK1_1	90	96	PF00069	0.566
MOD_CK2_1	169	175	PF00069	0.593
MOD_CK2_1	211	217	PF00069	0.669
MOD_CK2_1	406	412	PF00069	0.713
MOD_CK2_1	558	564	PF00069	0.580
MOD_CK2_1	569	575	PF00069	0.734
MOD_CK2_1	629	635	PF00069	0.674
MOD_CK2_1	79	85	PF00069	0.583
MOD_Cter_Amidation	392	395	PF01082	0.653
MOD_DYRK1A_RPxSP_1	322	326	PF00069	0.601
MOD_GlcNHglycan	115	118	PF01048	0.614
MOD_GlcNHglycan	342	345	PF01048	0.640
MOD_GlcNHglycan	400	403	PF01048	0.660
MOD_GlcNHglycan	425	428	PF01048	0.642
MOD_GlcNHglycan	449	452	PF01048	0.597
MOD_GlcNHglycan	486	489	PF01048	0.642
MOD_GlcNHglycan	57	60	PF01048	0.599
MOD_GlcNHglycan	623	626	PF01048	0.693
MOD_GlcNHglycan	684	687	PF01048	0.704
MOD_GlcNHglycan	98	101	PF01048	0.777
MOD_GSK3_1	105	112	PF00069	0.816
MOD_GSK3_1	113	120	PF00069	0.686
MOD_GSK3_1	130	137	PF00069	0.602
MOD_GSK3_1	191	198	PF00069	0.644
MOD_GSK3_1	211	218	PF00069	0.751
MOD_GSK3_1	256	263	PF00069	0.648
MOD_GSK3_1	268	275	PF00069	0.580
MOD_GSK3_1	366	373	PF00069	0.624
MOD_GSK3_1	375	382	PF00069	0.638
MOD_GSK3_1	414	421	PF00069	0.693
MOD_GSK3_1	437	444	PF00069	0.632
MOD_GSK3_1	470	477	PF00069	0.590
MOD_GSK3_1	5	12	PF00069	0.555
MOD_GSK3_1	53	60	PF00069	0.654
MOD_GSK3_1	543	550	PF00069	0.695
MOD_GSK3_1	554	561	PF00069	0.533
MOD_GSK3_1	612	619	PF00069	0.807
MOD_GSK3_1	638	645	PF00069	0.652
MOD_GSK3_1	651	658	PF00069	0.615
MOD_GSK3_1	694	701	PF00069	0.728
MOD_GSK3_1	96	103	PF00069	0.685
MOD_LATS_1	705	711	PF00433	0.610
MOD_N-GLC_1	169	174	PF02516	0.675
MOD_N-GLC_1	340	345	PF02516	0.633
MOD_N-GLC_1	677	682	PF02516	0.636
MOD_N-GLC_1	79	84	PF02516	0.746
MOD_N-GLC_1	96	101	PF02516	0.625
MOD_NEK2_1	201	206	PF00069	0.665
MOD_NEK2_1	229	234	PF00069	0.534
MOD_NEK2_1	273	278	PF00069	0.819
MOD_NEK2_1	5	10	PF00069	0.605
MOD_NEK2_1	568	573	PF00069	0.654
MOD_NEK2_2	186	191	PF00069	0.607
MOD_NEK2_2	284	289	PF00069	0.566
MOD_PIKK_1	101	107	PF00454	0.627
MOD_PIKK_1	201	207	PF00454	0.687
MOD_PIKK_1	229	235	PF00454	0.525
MOD_PIKK_1	256	262	PF00454	0.594
MOD_PIKK_1	442	448	PF00454	0.701
MOD_PIKK_1	603	609	PF00454	0.590
MOD_PIKK_1	638	644	PF00454	0.572
MOD_PIKK_1	9	15	PF00454	0.545
MOD_PIKK_1	90	96	PF00454	0.728
MOD_PK_1	713	719	PF00069	0.553
MOD_PKA_1	113	119	PF00069	0.692
MOD_PKA_1	282	288	PF00069	0.692
MOD_PKA_1	543	549	PF00069	0.646
MOD_PKA_1	707	713	PF00069	0.706
MOD_PKA_1	87	93	PF00069	0.625
MOD_PKA_2	112	118	PF00069	0.699
MOD_PKA_2	186	192	PF00069	0.557
MOD_PKA_2	282	288	PF00069	0.632
MOD_PKA_2	543	549	PF00069	0.646
MOD_PKB_1	313	321	PF00069	0.654
MOD_Plk_1	677	683	PF00069	0.562
MOD_Plk_1	79	85	PF00069	0.576
MOD_Plk_2-3	677	683	PF00069	0.615
MOD_Plk_4	15	21	PF00069	0.657
MOD_Plk_4	153	159	PF00069	0.684
MOD_Plk_4	284	290	PF00069	0.565
MOD_Plk_4	315	321	PF00069	0.657
MOD_Plk_4	79	85	PF00069	0.617
MOD_ProDKin_1	121	127	PF00069	0.799
MOD_ProDKin_1	192	198	PF00069	0.636
MOD_ProDKin_1	266	272	PF00069	0.707
MOD_ProDKin_1	322	328	PF00069	0.684
MOD_ProDKin_1	372	378	PF00069	0.699
MOD_ProDKin_1	527	533	PF00069	0.674
MOD_ProDKin_1	555	561	PF00069	0.787
MOD_ProDKin_1	569	575	PF00069	0.719
MOD_ProDKin_1	59	65	PF00069	0.606
MOD_ProDKin_1	591	597	PF00069	0.629
MOD_ProDKin_1	600	606	PF00069	0.661
MOD_ProDKin_1	616	622	PF00069	0.635
MOD_ProDKin_1	648	654	PF00069	0.628
MOD_ProDKin_1	657	663	PF00069	0.690
MOD_ProDKin_1	666	672	PF00069	0.655
MOD_ProDKin_1	694	700	PF00069	0.777
MOD_SUMO_for_1	526	529	PF00179	0.732
MOD_SUMO_for_1	717	720	PF00179	0.592
MOD_SUMO_rev_2	700	706	PF00179	0.661
TRG_DiLeu_BaEn_4	304	310	PF01217	0.632
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.667
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.560
TRG_ENDOCYTIC_2	165	168	PF00928	0.618
TRG_ENDOCYTIC_2	237	240	PF00928	0.605
TRG_ENDOCYTIC_2	320	323	PF00928	0.656
TRG_ER_diArg_1	281	283	PF00400	0.643
TRG_ER_diArg_1	312	315	PF00400	0.691
TRG_ER_diArg_1	413	415	PF00400	0.631
TRG_ER_diArg_1	501	504	PF00400	0.612
TRG_ER_diArg_1	542	545	PF00400	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0L3	Leptomonas seymouri	36%	88%
A0A3S7X2R9	Leishmania donovani	85%	100%
A4HHP2	Leishmania braziliensis	50%	99%
A4I4V7	Leishmania infantum	82%	97%
E9ALI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	96%