Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEA4_LEIMA

TriTrypDb:

LmjF.29.2420 , LMJLV39_290032200 , LMJSD75_290032600

Length:

644

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.529
CLV_C14_Caspase3-7	372	376	PF00656	0.569
CLV_C14_Caspase3-7	465	469	PF00656	0.482
CLV_C14_Caspase3-7	9	13	PF00656	0.612
CLV_NRD_NRD_1	164	166	PF00675	0.511
CLV_NRD_NRD_1	223	225	PF00675	0.501
CLV_NRD_NRD_1	247	249	PF00675	0.642
CLV_NRD_NRD_1	253	255	PF00675	0.647
CLV_NRD_NRD_1	433	435	PF00675	0.446
CLV_NRD_NRD_1	441	443	PF00675	0.472
CLV_NRD_NRD_1	484	486	PF00675	0.510
CLV_NRD_NRD_1	590	592	PF00675	0.646
CLV_NRD_NRD_1	608	610	PF00675	0.590
CLV_NRD_NRD_1	91	93	PF00675	0.617
CLV_PCSK_FUR_1	162	166	PF00082	0.582
CLV_PCSK_FUR_1	251	255	PF00082	0.488
CLV_PCSK_KEX2_1	164	166	PF00082	0.467
CLV_PCSK_KEX2_1	222	224	PF00082	0.462
CLV_PCSK_KEX2_1	247	249	PF00082	0.568
CLV_PCSK_KEX2_1	253	255	PF00082	0.573
CLV_PCSK_KEX2_1	432	434	PF00082	0.448
CLV_PCSK_KEX2_1	484	486	PF00082	0.538
CLV_PCSK_KEX2_1	608	610	PF00082	0.666
CLV_PCSK_KEX2_1	91	93	PF00082	0.647
CLV_PCSK_SKI1_1	111	115	PF00082	0.572
CLV_PCSK_SKI1_1	193	197	PF00082	0.633
CLV_PCSK_SKI1_1	313	317	PF00082	0.675
DEG_APCC_DBOX_1	203	211	PF00400	0.491
DEG_COP1_1	182	190	PF00400	0.567
DEG_COP1_1	205	215	PF00400	0.475
DEG_SCF_FBW7_1	408	415	PF00400	0.774
DEG_SPOP_SBC_1	412	416	PF00917	0.646
DEG_SPOP_SBC_1	461	465	PF00917	0.579
DEG_SPOP_SBC_1	527	531	PF00917	0.623
DOC_CKS1_1	290	295	PF01111	0.578
DOC_CKS1_1	396	401	PF01111	0.612
DOC_CYCLIN_yCln2_LP_2	290	296	PF00134	0.540
DOC_MAPK_gen_1	116	123	PF00069	0.465
DOC_PP1_RVXF_1	274	281	PF00149	0.532
DOC_PP2B_LxvP_1	584	587	PF13499	0.516
DOC_USP7_MATH_1	328	332	PF00917	0.696
DOC_USP7_MATH_1	360	364	PF00917	0.599
DOC_USP7_MATH_1	381	385	PF00917	0.698
DOC_USP7_MATH_1	386	390	PF00917	0.688
DOC_USP7_MATH_1	418	422	PF00917	0.590
DOC_USP7_MATH_1	46	50	PF00917	0.574
DOC_USP7_MATH_1	461	465	PF00917	0.685
DOC_USP7_MATH_1	469	473	PF00917	0.695
DOC_USP7_MATH_1	483	487	PF00917	0.530
DOC_USP7_MATH_1	526	530	PF00917	0.644
DOC_USP7_UBL2_3	148	152	PF12436	0.607
DOC_WW_Pin1_4	289	294	PF00397	0.472
DOC_WW_Pin1_4	377	382	PF00397	0.669
DOC_WW_Pin1_4	38	43	PF00397	0.770
DOC_WW_Pin1_4	395	400	PF00397	0.590
DOC_WW_Pin1_4	408	413	PF00397	0.633
DOC_WW_Pin1_4	528	533	PF00397	0.635
DOC_WW_Pin1_4	540	545	PF00397	0.507
LIG_14-3-3_CanoR_1	323	328	PF00244	0.636
LIG_14-3-3_CanoR_1	34	42	PF00244	0.599
LIG_14-3-3_CanoR_1	570	576	PF00244	0.600
LIG_14-3-3_CanoR_1	599	604	PF00244	0.687
LIG_14-3-3_CanoR_1	608	613	PF00244	0.741
LIG_BIR_III_4	375	379	PF00653	0.607
LIG_BRCT_BRCA1_1	317	321	PF00533	0.516
LIG_deltaCOP1_diTrp_1	277	287	PF00928	0.571
LIG_DLG_GKlike_1	599	606	PF00625	0.483
LIG_DLG_GKlike_1	608	616	PF00625	0.460
LIG_FHA_1	140	146	PF00498	0.395
LIG_FHA_1	310	316	PF00498	0.742
LIG_FHA_1	461	467	PF00498	0.462
LIG_FHA_1	51	57	PF00498	0.629
LIG_FHA_1	581	587	PF00498	0.660
LIG_FHA_2	28	34	PF00498	0.724
LIG_FHA_2	348	354	PF00498	0.574
LIG_FHA_2	620	626	PF00498	0.676
LIG_LIR_Apic_2	149	154	PF02991	0.705
LIG_LIR_Apic_2	366	370	PF02991	0.598
LIG_LIR_Nem_3	277	283	PF02991	0.431
LIG_LIR_Nem_3	534	538	PF02991	0.677
LIG_LIR_Nem_3	602	606	PF02991	0.476
LIG_SH2_PTP2	367	370	PF00017	0.653
LIG_SH2_SRC	367	370	PF00017	0.669
LIG_SH2_STAP1	267	271	PF00017	0.520
LIG_SH2_STAP1	57	61	PF00017	0.523
LIG_SH2_STAT5	367	370	PF00017	0.669
LIG_SH2_STAT5	550	553	PF00017	0.484
LIG_SH3_3	129	135	PF00018	0.534
LIG_SH3_3	207	213	PF00018	0.431
LIG_SH3_3	280	286	PF00018	0.545
LIG_SH3_3	294	300	PF00018	0.555
LIG_SH3_3	583	589	PF00018	0.560
LIG_SH3_3	615	621	PF00018	0.661
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.536
LIG_TRAF2_1	622	625	PF00917	0.557
LIG_TRAF2_1	634	637	PF00917	0.540
LIG_WRC_WIRS_1	600	605	PF05994	0.499
MOD_CDC14_SPxK_1	41	44	PF00782	0.614
MOD_CDK_SPxK_1	38	44	PF00069	0.763
MOD_CK1_1	322	328	PF00069	0.732
MOD_CK1_1	35	41	PF00069	0.658
MOD_CK1_1	363	369	PF00069	0.628
MOD_CK1_1	377	383	PF00069	0.619
MOD_CK1_1	413	419	PF00069	0.504
MOD_CK1_1	531	537	PF00069	0.681
MOD_CK1_1	582	588	PF00069	0.647
MOD_CK2_1	173	179	PF00069	0.519
MOD_CK2_1	18	24	PF00069	0.705
MOD_CK2_1	27	33	PF00069	0.667
MOD_CK2_1	347	353	PF00069	0.495
MOD_CK2_1	619	625	PF00069	0.639
MOD_CK2_1	631	637	PF00069	0.655
MOD_Cter_Amidation	606	609	PF01082	0.624
MOD_GlcNHglycan	175	178	PF01048	0.572
MOD_GlcNHglycan	193	196	PF01048	0.567
MOD_GlcNHglycan	27	30	PF01048	0.736
MOD_GlcNHglycan	325	328	PF01048	0.759
MOD_GlcNHglycan	339	342	PF01048	0.552
MOD_GlcNHglycan	358	361	PF01048	0.463
MOD_GlcNHglycan	375	379	PF01048	0.555
MOD_GlcNHglycan	399	402	PF01048	0.678
MOD_GlcNHglycan	415	418	PF01048	0.484
MOD_GlcNHglycan	471	474	PF01048	0.683
MOD_GlcNHglycan	479	482	PF01048	0.560
MOD_GlcNHglycan	485	488	PF01048	0.489
MOD_GlcNHglycan	633	636	PF01048	0.670
MOD_GlcNHglycan	639	642	PF01048	0.634
MOD_GlcNHglycan	88	91	PF01048	0.732
MOD_GSK3_1	23	30	PF00069	0.640
MOD_GSK3_1	305	312	PF00069	0.719
MOD_GSK3_1	315	322	PF00069	0.672
MOD_GSK3_1	32	39	PF00069	0.627
MOD_GSK3_1	328	335	PF00069	0.584
MOD_GSK3_1	356	363	PF00069	0.587
MOD_GSK3_1	377	384	PF00069	0.599
MOD_GSK3_1	406	413	PF00069	0.635
MOD_GSK3_1	419	426	PF00069	0.445
MOD_GSK3_1	46	53	PF00069	0.703
MOD_GSK3_1	522	529	PF00069	0.578
MOD_GSK3_1	608	615	PF00069	0.705
MOD_NEK2_1	172	177	PF00069	0.437
MOD_NEK2_1	315	320	PF00069	0.636
MOD_NEK2_1	36	41	PF00069	0.784
MOD_NEK2_1	533	538	PF00069	0.712
MOD_NEK2_1	612	617	PF00069	0.702
MOD_NEK2_2	47	52	PF00069	0.487
MOD_PIKK_1	36	42	PF00454	0.524
MOD_PIKK_1	386	392	PF00454	0.703
MOD_PIKK_1	6	12	PF00454	0.612
MOD_PIKK_1	620	626	PF00454	0.748
MOD_PK_1	254	260	PF00069	0.485
MOD_PKA_1	608	614	PF00069	0.510
MOD_PKA_2	322	328	PF00069	0.659
MOD_PKA_2	356	362	PF00069	0.592
MOD_PKA_2	483	489	PF00069	0.591
MOD_PKA_2	569	575	PF00069	0.554
MOD_PKA_2	607	613	PF00069	0.669
MOD_PKB_1	23	31	PF00069	0.594
MOD_Plk_1	32	38	PF00069	0.677
MOD_Plk_1	451	457	PF00069	0.525
MOD_Plk_1	511	517	PF00069	0.538
MOD_Plk_2-3	369	375	PF00069	0.598
MOD_Plk_4	363	369	PF00069	0.670
MOD_Plk_4	419	425	PF00069	0.646
MOD_Plk_4	533	539	PF00069	0.560
MOD_Plk_4	608	614	PF00069	0.686
MOD_ProDKin_1	289	295	PF00069	0.468
MOD_ProDKin_1	377	383	PF00069	0.642
MOD_ProDKin_1	38	44	PF00069	0.771
MOD_ProDKin_1	395	401	PF00069	0.588
MOD_ProDKin_1	408	414	PF00069	0.629
MOD_ProDKin_1	528	534	PF00069	0.634
MOD_ProDKin_1	540	546	PF00069	0.500
MOD_SUMO_rev_2	110	118	PF00179	0.592
MOD_SUMO_rev_2	141	149	PF00179	0.605
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.473
TRG_ENDOCYTIC_2	57	60	PF00928	0.561
TRG_ER_diArg_1	161	164	PF00400	0.520
TRG_ER_diArg_1	222	224	PF00400	0.512
TRG_ER_diArg_1	251	254	PF00400	0.534
TRG_ER_diArg_1	432	434	PF00400	0.509
TRG_ER_diArg_1	560	563	PF00400	0.508
TRG_ER_diArg_1	91	93	PF00400	0.650
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	272	277	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y8	Leptomonas seymouri	58%	95%
A0A0S4IQ31	Bodo saltans	31%	98%
A0A0S4JIT3	Bodo saltans	27%	100%
A0A0S4JQK5	Bodo saltans	27%	100%
A0A1X0P950	Trypanosomatidae	33%	94%
A0A3Q8IRK3	Leishmania donovani	86%	94%
A0A3R7MS13	Trypanosoma rangeli	34%	97%
A4HHP1	Leishmania braziliensis	71%	92%
A4I4V6	Leishmania infantum	86%	76%
E9ALI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%
V5BC37	Trypanosoma cruzi	33%	97%