PlsC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase, putative

Species:

Leishmania major

UniProt:

E9AEA3_LEIMA

TriTrypDb:

LmjF.29.2410 , LMJLV39_290032100 , LMJSD75_290032500

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 7
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AEA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEA3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008374	O-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0005488	binding	1	2
GO:0005509	calcium ion binding	5	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	238	240	PF00675	0.485
CLV_NRD_NRD_1	277	279	PF00675	0.522
CLV_NRD_NRD_1	406	408	PF00675	0.606
CLV_PCSK_KEX2_1	277	279	PF00082	0.515
CLV_PCSK_KEX2_1	371	373	PF00082	0.590
CLV_PCSK_KEX2_1	406	408	PF00082	0.569
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.479
CLV_PCSK_SKI1_1	146	150	PF00082	0.382
CLV_PCSK_SKI1_1	306	310	PF00082	0.468
CLV_PCSK_SKI1_1	402	406	PF00082	0.617
CLV_PCSK_SKI1_1	5	9	PF00082	0.437
DEG_APCC_KENBOX_2	239	243	PF00400	0.334
DOC_CKS1_1	12	17	PF01111	0.659
DOC_CKS1_1	122	127	PF01111	0.499
DOC_MAPK_gen_1	239	245	PF00069	0.306
DOC_PP1_RVXF_1	62	69	PF00149	0.370
DOC_PP2B_LxvP_1	26	29	PF13499	0.575
DOC_PP2B_LxvP_1	92	95	PF13499	0.619
DOC_USP7_MATH_1	150	154	PF00917	0.335
DOC_USP7_MATH_1	206	210	PF00917	0.534
DOC_USP7_MATH_1	216	220	PF00917	0.372
DOC_USP7_MATH_1	264	268	PF00917	0.247
DOC_USP7_MATH_1	54	58	PF00917	0.453
DOC_USP7_MATH_1	6	10	PF00917	0.629
DOC_USP7_UBL2_3	371	375	PF12436	0.413
DOC_WW_Pin1_4	11	16	PF00397	0.669
DOC_WW_Pin1_4	121	126	PF00397	0.514
LIG_14-3-3_CanoR_1	146	155	PF00244	0.413
LIG_14-3-3_CanoR_1	169	173	PF00244	0.372
LIG_14-3-3_CanoR_1	181	189	PF00244	0.450
LIG_14-3-3_CanoR_1	253	260	PF00244	0.326
LIG_14-3-3_CanoR_1	347	355	PF00244	0.274
LIG_14-3-3_CanoR_1	383	389	PF00244	0.368
LIG_14-3-3_CanoR_1	98	103	PF00244	0.583
LIG_APCC_ABBA_1	287	292	PF00400	0.254
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_BRCT_BRCA1_1	243	247	PF00533	0.357
LIG_BRCT_BRCA1_1	348	352	PF00533	0.323
LIG_BRCT_BRCA1_1	56	60	PF00533	0.420
LIG_CaM_NSCaTE_8	35	42	PF13499	0.452
LIG_deltaCOP1_diTrp_1	223	233	PF00928	0.452
LIG_eIF4E_1	355	361	PF01652	0.378
LIG_FHA_1	12	18	PF00498	0.671
LIG_FHA_1	149	155	PF00498	0.363
LIG_FHA_1	158	164	PF00498	0.338
LIG_FHA_1	181	187	PF00498	0.425
LIG_FHA_1	80	86	PF00498	0.381
LIG_FHA_2	122	128	PF00498	0.546
LIG_FHA_2	205	211	PF00498	0.551
LIG_FHA_2	365	371	PF00498	0.333
LIG_FHA_2	47	53	PF00498	0.422
LIG_LIR_Apic_2	121	125	PF02991	0.544
LIG_LIR_Apic_2	168	173	PF02991	0.386
LIG_LIR_Gen_1	127	137	PF02991	0.509
LIG_LIR_Gen_1	183	193	PF02991	0.392
LIG_LIR_Gen_1	223	234	PF02991	0.389
LIG_LIR_Gen_1	23	33	PF02991	0.506
LIG_LIR_Nem_3	127	132	PF02991	0.512
LIG_LIR_Nem_3	152	158	PF02991	0.366
LIG_LIR_Nem_3	183	188	PF02991	0.355
LIG_LIR_Nem_3	223	229	PF02991	0.370
LIG_LIR_Nem_3	23	28	PF02991	0.582
LIG_LIR_Nem_3	244	248	PF02991	0.360
LIG_LIR_Nem_3	349	355	PF02991	0.313
LIG_LIR_Nem_3	397	401	PF02991	0.307
LIG_LIR_Nem_3	403	408	PF02991	0.340
LIG_MLH1_MIPbox_1	243	247	PF16413	0.329
LIG_NRP_CendR_1	412	415	PF00754	0.633
LIG_PCNA_yPIPBox_3	375	389	PF02747	0.319
LIG_Pex14_1	174	178	PF04695	0.348
LIG_Pex14_1	68	72	PF04695	0.294
LIG_Pex14_2	144	148	PF04695	0.345
LIG_Pex14_2	155	159	PF04695	0.350
LIG_Pex14_2	327	331	PF04695	0.269
LIG_PTAP_UEV_1	281	286	PF05743	0.329
LIG_SH2_CRK	122	126	PF00017	0.550
LIG_SH2_CRK	36	40	PF00017	0.335
LIG_SH2_NCK_1	122	126	PF00017	0.601
LIG_SH2_SRC	106	109	PF00017	0.589
LIG_SH2_SRC	355	358	PF00017	0.354
LIG_SH2_STAT3	197	200	PF00017	0.416
LIG_SH2_STAT5	16	19	PF00017	0.646
LIG_SH2_STAT5	166	169	PF00017	0.375
LIG_SH2_STAT5	170	173	PF00017	0.354
LIG_SH2_STAT5	228	231	PF00017	0.452
LIG_SH2_STAT5	25	28	PF00017	0.541
LIG_SH2_STAT5	72	75	PF00017	0.339
LIG_SH3_3	279	285	PF00018	0.265
LIG_SH3_3	360	366	PF00018	0.301
LIG_SH3_3	9	15	PF00018	0.656
LIG_TRAF2_1	366	369	PF00917	0.358
LIG_TYR_ITIM	34	39	PF00017	0.374
LIG_TYR_ITIM	353	358	PF00017	0.354
LIG_WRC_WIRS_1	233	238	PF05994	0.254
MOD_CK1_1	180	186	PF00069	0.309
MOD_CK1_1	235	241	PF00069	0.286
MOD_CK1_1	394	400	PF00069	0.300
MOD_CK2_1	204	210	PF00069	0.563
MOD_CK2_1	235	241	PF00069	0.254
MOD_CK2_1	364	370	PF00069	0.328
MOD_CK2_1	46	52	PF00069	0.439
MOD_GlcNHglycan	39	42	PF01048	0.459
MOD_GSK3_1	121	128	PF00069	0.571
MOD_GSK3_1	146	153	PF00069	0.384
MOD_GSK3_1	180	187	PF00069	0.356
MOD_GSK3_1	7	14	PF00069	0.692
MOD_N-GLC_1	216	221	PF02516	0.326
MOD_N-GLC_1	241	246	PF02516	0.534
MOD_N-GLC_1	391	396	PF02516	0.525
MOD_NEK2_1	137	142	PF00069	0.311
MOD_NEK2_1	148	153	PF00069	0.317
MOD_NEK2_1	159	164	PF00069	0.312
MOD_NEK2_1	346	351	PF00069	0.327
MOD_NEK2_1	376	381	PF00069	0.371
MOD_NEK2_1	384	389	PF00069	0.306
MOD_NEK2_1	7	12	PF00069	0.642
MOD_NEK2_1	79	84	PF00069	0.326
MOD_NEK2_2	150	155	PF00069	0.396
MOD_NEK2_2	54	59	PF00069	0.444
MOD_PKA_2	168	174	PF00069	0.405
MOD_PKA_2	180	186	PF00069	0.326
MOD_PKA_2	252	258	PF00069	0.326
MOD_PKA_2	346	352	PF00069	0.326
MOD_Plk_1	216	222	PF00069	0.326
MOD_Plk_1	241	247	PF00069	0.334
MOD_Plk_4	150	156	PF00069	0.305
MOD_Plk_4	232	238	PF00069	0.254
MOD_Plk_4	241	247	PF00069	0.254
MOD_Plk_4	254	260	PF00069	0.324
MOD_Plk_4	271	277	PF00069	0.357
MOD_Plk_4	384	390	PF00069	0.319
MOD_Plk_4	7	13	PF00069	0.684
MOD_Plk_4	79	85	PF00069	0.362
MOD_ProDKin_1	11	17	PF00069	0.665
MOD_ProDKin_1	121	127	PF00069	0.514
MOD_SUMO_rev_2	209	214	PF00179	0.471
MOD_SUMO_rev_2	368	376	PF00179	0.412
MOD_SUMO_rev_2	394	404	PF00179	0.386
TRG_DiLeu_BaEn_1	210	215	PF01217	0.468
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.352
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.270
TRG_ENDOCYTIC_2	129	132	PF00928	0.499
TRG_ENDOCYTIC_2	202	205	PF00928	0.561
TRG_ENDOCYTIC_2	25	28	PF00928	0.570
TRG_ENDOCYTIC_2	324	327	PF00928	0.300
TRG_ENDOCYTIC_2	355	358	PF00928	0.354
TRG_ENDOCYTIC_2	36	39	PF00928	0.369
TRG_ENDOCYTIC_2	4	7	PF00928	0.716
TRG_ER_diArg_1	276	278	PF00400	0.355
TRG_ER_diArg_1	405	407	PF00400	0.406
TRG_ER_diLys_1	412	415	PF00400	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C8	Leptomonas seymouri	61%	99%
A0A0S4IPK1	Bodo saltans	45%	86%
A0A1X0P927	Trypanosomatidae	47%	88%
A0A3R7NZP9	Trypanosoma rangeli	52%	91%
A0A3S7X2X4	Leishmania donovani	94%	100%
A4HHP0	Leishmania braziliensis	83%	100%
A4I4V5	Leishmania infantum	94%	100%
C9ZL05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	89%
E9ALI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q643R3	Homo sapiens	34%	79%
Q8S8S2	Arabidopsis thaliana	28%	77%