FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania major

UniProt:

E9AEA2_LEIMA

TriTrypDb:

LmjF.29.2400 , LMJLV39_290032000 , LMJSD75_290032400

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AEA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEA2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004721	phosphoprotein phosphatase activity	3	4
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0016791	phosphatase activity	5	5
GO:0042578	phosphoric ester hydrolase activity	4	5
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.603
CLV_NRD_NRD_1	188	190	PF00675	0.311
CLV_PCSK_KEX2_1	12	14	PF00082	0.614
CLV_PCSK_KEX2_1	188	190	PF00082	0.315
CLV_PCSK_KEX2_1	202	204	PF00082	0.434
CLV_PCSK_KEX2_1	66	68	PF00082	0.192
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.689
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.452
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.192
CLV_PCSK_SKI1_1	137	141	PF00082	0.331
CLV_PCSK_SKI1_1	174	178	PF00082	0.165
CLV_PCSK_SKI1_1	188	192	PF00082	0.447
CLV_PCSK_SKI1_1	75	79	PF00082	0.372
DOC_CYCLIN_RxL_1	171	181	PF00134	0.165
DOC_CYCLIN_yCln2_LP_2	24	30	PF00134	0.623
DOC_CYCLIN_yCln2_LP_2	34	37	PF00134	0.475
DOC_MAPK_gen_1	202	211	PF00069	0.505
DOC_MAPK_gen_1	66	73	PF00069	0.326
DOC_MAPK_gen_1	75	85	PF00069	0.283
DOC_MAPK_MEF2A_6	213	221	PF00069	0.419
DOC_MAPK_MEF2A_6	45	52	PF00069	0.264
DOC_PP2B_LxvP_1	24	27	PF13499	0.560
DOC_PP2B_LxvP_1	34	37	PF13499	0.395
DOC_PP4_FxxP_1	161	164	PF00568	0.192
DOC_PP4_FxxP_1	190	193	PF00568	0.341
DOC_USP7_MATH_1	152	156	PF00917	0.376
DOC_WW_Pin1_4	141	146	PF00397	0.311
DOC_WW_Pin1_4	189	194	PF00397	0.504
DOC_WW_Pin1_4	220	225	PF00397	0.412
DOC_WW_Pin1_4	5	10	PF00397	0.542
LIG_14-3-3_CanoR_1	188	193	PF00244	0.493
LIG_FHA_1	117	123	PF00498	0.341
LIG_FHA_1	142	148	PF00498	0.310
LIG_FHA_1	173	179	PF00498	0.192
LIG_FHA_1	19	25	PF00498	0.587
LIG_FHA_1	27	33	PF00498	0.502
LIG_GBD_Chelix_1	48	56	PF00786	0.318
LIG_LIR_Apic_2	159	164	PF02991	0.191
LIG_LIR_Apic_2	63	68	PF02991	0.192
LIG_LIR_Gen_1	181	190	PF02991	0.215
LIG_LIR_Gen_1	215	224	PF02991	0.249
LIG_LIR_Nem_3	181	186	PF02991	0.347
LIG_LIR_Nem_3	215	219	PF02991	0.254
LIG_LIR_Nem_3	22	28	PF02991	0.445
LIG_MAD2	137	145	PF02301	0.332
LIG_PDZ_Class_1	220	225	PF00595	0.260
LIG_Pex14_2	183	187	PF04695	0.192
LIG_SH2_CRK	65	69	PF00017	0.327
LIG_SH2_PTP2	25	28	PF00017	0.347
LIG_SH2_STAP1	93	97	PF00017	0.319
LIG_SH2_STAT3	169	172	PF00017	0.192
LIG_SH2_STAT5	109	112	PF00017	0.325
LIG_SH2_STAT5	25	28	PF00017	0.572
LIG_SH3_3	160	166	PF00018	0.426
LIG_SH3_3	218	224	PF00018	0.297
LIG_SH3_3	34	40	PF00018	0.464
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.302
LIG_SUMO_SIM_anti_2	175	181	PF11976	0.356
LIG_SUMO_SIM_anti_2	31	36	PF11976	0.445
LIG_SUMO_SIM_par_1	136	142	PF11976	0.325
LIG_SUMO_SIM_par_1	175	181	PF11976	0.165
LIG_SUMO_SIM_par_1	45	51	PF11976	0.304
LIG_SxIP_EBH_1	28	39	PF03271	0.313
LIG_TYR_ITIM	23	28	PF00017	0.352
LIG_UBA3_1	73	80	PF00899	0.355
LIG_WW_3	36	40	PF00397	0.282
MOD_CDK_SPK_2	5	10	PF00069	0.422
MOD_CDK_SPxxK_3	5	12	PF00069	0.422
MOD_GlcNHglycan	5	8	PF01048	0.587
MOD_GSK3_1	198	205	PF00069	0.462
MOD_GSK3_1	26	33	PF00069	0.603
MOD_GSK3_1	52	59	PF00069	0.262
MOD_NEK2_1	28	33	PF00069	0.529
MOD_NEK2_1	52	57	PF00069	0.311
MOD_NEK2_1	73	78	PF00069	0.297
MOD_PK_1	13	19	PF00069	0.677
MOD_PKA_1	188	194	PF00069	0.242
MOD_PKA_1	202	208	PF00069	0.227
MOD_PKA_2	188	194	PF00069	0.418
MOD_PKA_2	202	208	PF00069	0.344
MOD_Plk_1	172	178	PF00069	0.312
MOD_Plk_1	52	58	PF00069	0.299
MOD_Plk_1	60	66	PF00069	0.293
MOD_Plk_4	143	149	PF00069	0.400
MOD_Plk_4	152	158	PF00069	0.396
MOD_Plk_4	172	178	PF00069	0.339
MOD_Plk_4	19	25	PF00069	0.504
MOD_Plk_4	30	36	PF00069	0.425
MOD_Plk_4	52	58	PF00069	0.289
MOD_Plk_4	60	66	PF00069	0.286
MOD_ProDKin_1	141	147	PF00069	0.311
MOD_ProDKin_1	189	195	PF00069	0.498
MOD_ProDKin_1	5	11	PF00069	0.542
TRG_DiLeu_BaEn_1	173	178	PF01217	0.165
TRG_DiLeu_BaEn_2	211	217	PF01217	0.241
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.418
TRG_ENDOCYTIC_2	25	28	PF00928	0.470
TRG_ER_diArg_1	187	189	PF00400	0.299
TRG_Pf-PMV_PEXEL_1	137	142	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Z9	Leptomonas seymouri	37%	77%
A0A0N1HTD7	Leptomonas seymouri	28%	78%
A0A0N1IKD3	Leptomonas seymouri	36%	92%
A0A0S4IJH3	Bodo saltans	28%	78%
A0A0S4JCX0	Bodo saltans	30%	69%
A0A1X0NJT2	Trypanosomatidae	39%	84%
A0A3Q8IHT4	Leishmania donovani	28%	78%
A0A3R7NSE5	Trypanosoma rangeli	40%	84%
A0A3S7WZH2	Leishmania donovani	27%	78%
A0A3S7X8P8	Leishmania donovani	39%	94%
A0A422N4T2	Trypanosoma rangeli	31%	66%
A0A422NVW2	Trypanosoma rangeli	38%	88%
A4HEM1	Leishmania braziliensis	28%	78%
A4HFZ5	Leishmania braziliensis	28%	78%
A4HHN9	Leishmania braziliensis	84%	91%
A4HQK0	Leishmania braziliensis	37%	77%
A4I1V3	Leishmania infantum	27%	78%
A4I314	Leishmania infantum	28%	78%
A4IAS0	Leishmania infantum	39%	94%
E9ACT5	Leishmania major	28%	78%
E9AEJ6	Leishmania major	38%	94%
E9ALI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	75%
E9AXZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	78%
E9AZC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	78%
E9B5Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	94%
O14595	Homo sapiens	29%	83%
O15194	Homo sapiens	30%	82%
P58466	Mus musculus	30%	86%
Q09695	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	69%
Q4Q077	Leishmania major	42%	77%
Q4Q9H6	Leishmania major	27%	78%
Q8BX07	Mus musculus	30%	83%
Q9PTJ6	Gallus gallus	30%	82%
V5BHN4	Trypanosoma cruzi	38%	88%
V5BSW0	Trypanosoma cruzi	38%	83%