Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative

Species:

Leishmania major

UniProt:

E9AEA1_LEIMA

TriTrypDb:

LmjF.29.2390 , LMJLV39_290031900 , LMJSD75_290032200

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	6
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0099080	supramolecular complex	2	6
GO:0099081	supramolecular polymer	3	6
GO:0099512	supramolecular fiber	4	6
GO:0099513	polymeric cytoskeletal fiber	5	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AEA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEA1

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	15
GO:0007018	microtubule-based movement	3	15
GO:0009987	cellular process	1	15
GO:0006810	transport	3	1
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0046907	intracellular transport	3	1
GO:0047496	vesicle transport along microtubule	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051648	vesicle localization	3	1
GO:0051649	establishment of localization in cell	3	1
GO:0051650	establishment of vesicle localization	4	1
GO:0051656	establishment of organelle localization	3	1
GO:0072383	plus-end-directed vesicle transport along microtubule	6	1
GO:0072384	organelle transport along microtubule	4	1
GO:0072386	plus-end-directed organelle transport along microtubule	5	1
GO:0099111	microtubule-based transport	4	1
GO:0099518	vesicle cytoskeletal trafficking	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003774	cytoskeletal motor activity	1	15
GO:0003777	microtubule motor activity	2	15
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	15
GO:0005515	protein binding	2	15
GO:0005524	ATP binding	5	15
GO:0008017	microtubule binding	5	15
GO:0008092	cytoskeletal protein binding	3	15
GO:0015631	tubulin binding	4	15
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017076	purine nucleotide binding	4	15
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0030554	adenyl nucleotide binding	5	15
GO:0032553	ribonucleotide binding	3	15
GO:0032555	purine ribonucleotide binding	4	15
GO:0032559	adenyl ribonucleotide binding	5	15
GO:0035639	purine ribonucleoside triphosphate binding	4	15
GO:0036094	small molecule binding	2	15
GO:0043167	ion binding	2	15
GO:0043168	anion binding	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:0097367	carbohydrate derivative binding	2	15
GO:0140657	ATP-dependent activity	1	15
GO:1901265	nucleoside phosphate binding	3	15
GO:1901363	heterocyclic compound binding	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.379
CLV_NRD_NRD_1	193	195	PF00675	0.442
CLV_NRD_NRD_1	281	283	PF00675	0.335
CLV_NRD_NRD_1	425	427	PF00675	0.537
CLV_PCSK_FUR_1	45	49	PF00082	0.375
CLV_PCSK_KEX2_1	171	173	PF00082	0.399
CLV_PCSK_KEX2_1	424	426	PF00082	0.554
CLV_PCSK_KEX2_1	432	434	PF00082	0.569
CLV_PCSK_KEX2_1	463	465	PF00082	0.468
CLV_PCSK_KEX2_1	47	49	PF00082	0.450
CLV_PCSK_KEX2_1	559	561	PF00082	0.592
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.685
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.536
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.469
CLV_PCSK_PC1ET2_1	559	561	PF00082	0.592
CLV_PCSK_SKI1_1	115	119	PF00082	0.425
CLV_PCSK_SKI1_1	148	152	PF00082	0.346
CLV_PCSK_SKI1_1	16	20	PF00082	0.574
CLV_PCSK_SKI1_1	355	359	PF00082	0.567
CLV_PCSK_SKI1_1	389	393	PF00082	0.487
CLV_PCSK_SKI1_1	456	460	PF00082	0.563
CLV_PCSK_SKI1_1	467	471	PF00082	0.570
CLV_PCSK_SKI1_1	505	509	PF00082	0.379
CLV_PCSK_SKI1_1	540	544	PF00082	0.502
CLV_PCSK_SKI1_1	69	73	PF00082	0.352
CLV_Separin_Metazoa	191	195	PF03568	0.410
DEG_APCC_DBOX_1	559	567	PF00400	0.587
DEG_SPOP_SBC_1	477	481	PF00917	0.452
DOC_CYCLIN_RxL_1	112	120	PF00134	0.455
DOC_CYCLIN_RxL_1	344	356	PF00134	0.584
DOC_MAPK_gen_1	19	30	PF00069	0.545
DOC_MAPK_gen_1	448	455	PF00069	0.493
DOC_MAPK_gen_1	463	470	PF00069	0.431
DOC_MAPK_gen_1	505	513	PF00069	0.465
DOC_MAPK_gen_1	6	15	PF00069	0.566
DOC_MAPK_MEF2A_6	213	222	PF00069	0.361
DOC_MAPK_MEF2A_6	375	384	PF00069	0.616
DOC_MAPK_MEF2A_6	389	396	PF00069	0.439
DOC_MAPK_MEF2A_6	6	15	PF00069	0.469
DOC_MAPK_NFAT4_5	389	397	PF00069	0.605
DOC_PP1_RVXF_1	430	437	PF00149	0.451
DOC_PP1_RVXF_1	503	510	PF00149	0.481
DOC_PP2B_LxvP_1	150	153	PF13499	0.361
DOC_PP4_FxxP_1	561	564	PF00568	0.502
DOC_USP7_MATH_1	275	279	PF00917	0.336
DOC_USP7_MATH_1	359	363	PF00917	0.556
DOC_WW_Pin1_4	314	319	PF00397	0.321
DOC_WW_Pin1_4	564	569	PF00397	0.541
LIG_14-3-3_CanoR_1	176	181	PF00244	0.455
LIG_14-3-3_CanoR_1	200	207	PF00244	0.402
LIG_14-3-3_CanoR_1	274	280	PF00244	0.335
LIG_14-3-3_CanoR_1	408	414	PF00244	0.622
LIG_14-3-3_CanoR_1	433	439	PF00244	0.688
LIG_14-3-3_CanoR_1	450	456	PF00244	0.484
LIG_14-3-3_CanoR_1	525	529	PF00244	0.536
LIG_14-3-3_CanoR_1	8	14	PF00244	0.473
LIG_Actin_WH2_2	342	360	PF00022	0.615
LIG_Actin_WH2_2	377	395	PF00022	0.559
LIG_Actin_WH2_2	60	75	PF00022	0.352
LIG_APCC_ABBA_1	140	145	PF00400	0.321
LIG_APCC_ABBA_1	163	168	PF00400	0.343
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_BRCT_BRCA1_1	222	226	PF00533	0.455
LIG_BRCT_BRCA1_1	284	288	PF00533	0.418
LIG_BRCT_BRCA1_1	300	304	PF00533	0.243
LIG_BRCT_BRCA1_1	442	446	PF00533	0.628
LIG_BRCT_BRCA1_1	505	509	PF00533	0.487
LIG_BRCT_BRCA1_1	531	535	PF00533	0.548
LIG_BRCT_BRCA1_2	442	448	PF00533	0.607
LIG_Clathr_ClatBox_1	579	583	PF01394	0.536
LIG_CtBP_PxDLS_1	499	503	PF00389	0.599
LIG_FHA_1	130	136	PF00498	0.427
LIG_FHA_1	24	30	PF00498	0.634
LIG_FHA_1	295	301	PF00498	0.311
LIG_FHA_1	308	314	PF00498	0.311
LIG_FHA_1	322	328	PF00498	0.311
LIG_FHA_1	479	485	PF00498	0.468
LIG_FHA_1	574	580	PF00498	0.496
LIG_FHA_1	92	98	PF00498	0.352
LIG_FHA_2	248	254	PF00498	0.453
LIG_FHA_2	492	498	PF00498	0.578
LIG_FHA_2	544	550	PF00498	0.593
LIG_GBD_Chelix_1	360	368	PF00786	0.514
LIG_LIR_Gen_1	223	234	PF02991	0.400
LIG_LIR_Gen_1	285	296	PF02991	0.349
LIG_LIR_Gen_1	527	535	PF02991	0.508
LIG_LIR_Gen_1	581	587	PF02991	0.489
LIG_LIR_Gen_1	62	72	PF02991	0.350
LIG_LIR_Gen_1	94	101	PF02991	0.379
LIG_LIR_Nem_3	223	229	PF02991	0.361
LIG_LIR_Nem_3	285	291	PF02991	0.349
LIG_LIR_Nem_3	441	447	PF02991	0.597
LIG_LIR_Nem_3	527	531	PF02991	0.461
LIG_LIR_Nem_3	581	585	PF02991	0.480
LIG_LIR_Nem_3	62	67	PF02991	0.337
LIG_LIR_Nem_3	74	79	PF02991	0.343
LIG_LIR_Nem_3	94	98	PF02991	0.389
LIG_MAD2	512	520	PF02301	0.539
LIG_MYND_1	564	568	PF01753	0.570
LIG_NRBOX	295	301	PF00104	0.379
LIG_Pex14_2	52	56	PF04695	0.361
LIG_Rb_LxCxE_1	96	119	PF01857	0.235
LIG_Rb_pABgroove_1	112	120	PF01858	0.469
LIG_Rb_pABgroove_1	529	537	PF01858	0.573
LIG_RPA_C_Fungi	421	433	PF08784	0.650
LIG_SH2_CRK	95	99	PF00017	0.455
LIG_SH2_STAP1	332	336	PF00017	0.325
LIG_SH2_STAT5	174	177	PF00017	0.361
LIG_SH2_STAT5	541	544	PF00017	0.500
LIG_SUMO_SIM_anti_2	381	388	PF11976	0.573
LIG_SUMO_SIM_par_1	235	242	PF11976	0.361
LIG_UBA3_1	189	195	PF00899	0.361
LIG_WRC_WIRS_1	276	281	PF05994	0.346
LIG_WRC_WIRS_1	579	584	PF05994	0.503
MOD_CK1_1	211	217	PF00069	0.299
MOD_CK1_1	294	300	PF00069	0.320
MOD_CK1_1	326	332	PF00069	0.433
MOD_CK1_1	401	407	PF00069	0.608
MOD_CK1_1	91	97	PF00069	0.333
MOD_CK2_1	135	141	PF00069	0.333
MOD_CK2_1	247	253	PF00069	0.334
MOD_CK2_1	287	293	PF00069	0.471
MOD_CK2_1	359	365	PF00069	0.568
MOD_CK2_1	491	497	PF00069	0.599
MOD_CK2_1	542	548	PF00069	0.549
MOD_GlcNHglycan	184	187	PF01048	0.486
MOD_GlcNHglycan	253	257	PF01048	0.422
MOD_GlcNHglycan	56	59	PF01048	0.427
MOD_GlcNHglycan	90	93	PF01048	0.333
MOD_GSK3_1	129	136	PF00069	0.425
MOD_GSK3_1	207	214	PF00069	0.340
MOD_GSK3_1	243	250	PF00069	0.333
MOD_GSK3_1	287	294	PF00069	0.360
MOD_GSK3_1	312	319	PF00069	0.330
MOD_GSK3_1	321	328	PF00069	0.315
MOD_GSK3_1	344	351	PF00069	0.502
MOD_GSK3_1	487	494	PF00069	0.630
MOD_GSK3_1	543	550	PF00069	0.471
MOD_N-GLC_1	207	212	PF02516	0.347
MOD_N-GLC_1	265	270	PF02516	0.311
MOD_N-GLC_1	321	326	PF02516	0.361
MOD_N-GLC_2	80	82	PF02516	0.333
MOD_NEK2_1	207	212	PF00069	0.343
MOD_NEK2_1	218	223	PF00069	0.290
MOD_NEK2_1	291	296	PF00069	0.343
MOD_NEK2_1	300	305	PF00069	0.299
MOD_NEK2_1	312	317	PF00069	0.298
MOD_NEK2_1	323	328	PF00069	0.312
MOD_NEK2_1	337	342	PF00069	0.415
MOD_NEK2_1	409	414	PF00069	0.595
MOD_NEK2_1	542	547	PF00069	0.542
MOD_NEK2_2	129	134	PF00069	0.455
MOD_NEK2_2	287	292	PF00069	0.333
MOD_NEK2_2	451	456	PF00069	0.563
MOD_PIKK_1	220	226	PF00454	0.333
MOD_PIKK_1	398	404	PF00454	0.594
MOD_PK_1	176	182	PF00069	0.455
MOD_PK_1	344	350	PF00069	0.494
MOD_PKA_1	282	288	PF00069	0.449
MOD_PKA_2	199	205	PF00069	0.321
MOD_PKA_2	247	253	PF00069	0.333
MOD_PKA_2	291	297	PF00069	0.311
MOD_PKA_2	524	530	PF00069	0.526
MOD_Plk_1	129	135	PF00069	0.433
MOD_Plk_1	265	271	PF00069	0.311
MOD_Plk_1	380	386	PF00069	0.368
MOD_Plk_1	440	446	PF00069	0.613
MOD_Plk_1	491	497	PF00069	0.631
MOD_Plk_2-3	159	165	PF00069	0.379
MOD_Plk_4	135	141	PF00069	0.333
MOD_Plk_4	236	242	PF00069	0.364
MOD_Plk_4	265	271	PF00069	0.322
MOD_Plk_4	307	313	PF00069	0.334
MOD_Plk_4	34	40	PF00069	0.410
MOD_Plk_4	344	350	PF00069	0.602
MOD_Plk_4	380	386	PF00069	0.368
MOD_Plk_4	440	446	PF00069	0.622
MOD_Plk_4	529	535	PF00069	0.502
MOD_Plk_4	93	99	PF00069	0.321
MOD_ProDKin_1	314	320	PF00069	0.321
MOD_ProDKin_1	564	570	PF00069	0.536
MOD_SUMO_rev_2	2	7	PF00179	0.643
MOD_SUMO_rev_2	255	265	PF00179	0.337
MOD_SUMO_rev_2	278	285	PF00179	0.455
MOD_SUMO_rev_2	290	297	PF00179	0.323
MOD_SUMO_rev_2	347	357	PF00179	0.503
TRG_DiLeu_BaEn_4	387	393	PF01217	0.545
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.379
TRG_ENDOCYTIC_2	76	79	PF00928	0.405
TRG_ENDOCYTIC_2	95	98	PF00928	0.175
TRG_ER_diArg_1	13	16	PF00400	0.467
TRG_ER_diArg_1	153	156	PF00400	0.354
TRG_ER_diArg_1	171	173	PF00400	0.258
TRG_ER_diArg_1	22	25	PF00400	0.632
TRG_ER_diArg_1	423	426	PF00400	0.531
TRG_NES_CRM1_1	233	247	PF08389	0.400
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P569	Leptomonas seymouri	27%	67%
A0A0N1HY56	Leptomonas seymouri	29%	86%
A0A0N1I0Y5	Leptomonas seymouri	30%	96%
A0A0N1PDD6	Leptomonas seymouri	30%	77%
A0A0S4IKE6	Bodo saltans	51%	100%
A0A0S4IP49	Bodo saltans	26%	73%
A0A0S4J0Q2	Bodo saltans	33%	71%
A0A0S4JEF6	Bodo saltans	29%	88%
A0A0S4JJ54	Bodo saltans	30%	84%
A0A0S4JXY6	Bodo saltans	30%	68%
A0A0S4KL43	Bodo saltans	29%	100%
A0A1X0NJN6	Trypanosomatidae	29%	100%
A0A1X0NNQ8	Trypanosomatidae	24%	92%
A0A1X0NP27	Trypanosomatidae	40%	80%
A0A1X0NQ03	Trypanosomatidae	27%	71%
A0A1X0NWZ8	Trypanosomatidae	31%	79%
A0A1X0P0C2	Trypanosomatidae	32%	72%
A0A1X0P2B6	Trypanosomatidae	31%	96%
A0A1X0P9E3	Trypanosomatidae	56%	99%
A0A1X0P9H3	Trypanosomatidae	32%	68%
A0A1X0P9T0	Trypanosomatidae	32%	100%
A0A1X0PAG9	Trypanosomatidae	59%	99%
A0A3Q8IEL2	Leishmania donovani	95%	100%
A0A3R7MDH9	Trypanosoma rangeli	28%	83%
A0A3S7WPL3	Leishmania donovani	30%	66%
A0A3S7WS99	Leishmania donovani	30%	81%
A0A422MZ05	Trypanosoma rangeli	28%	87%
A0A422N3U0	Trypanosoma rangeli	27%	78%
A0A422NE49	Trypanosoma rangeli	31%	66%
A0A422NEQ8	Trypanosoma rangeli	31%	78%
A0A422NXU3	Trypanosoma rangeli	59%	100%
A4H4I4	Leishmania braziliensis	28%	89%
A4H4R6	Leishmania braziliensis	30%	67%
A4HAQ7	Leishmania braziliensis	27%	100%
A4HCT2	Leishmania braziliensis	31%	82%
A4HHN8	Leishmania braziliensis	87%	100%
A4HHY2	Leishmania braziliensis	29%	97%
A4HSA6	Leishmania infantum	34%	100%
A4HSZ5	Leishmania infantum	29%	66%
A4HVE9	Leishmania infantum	30%	81%
A4I4V3	Leishmania infantum	95%	100%
C9ZK93	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	79%
C9ZL08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
C9ZQI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	94%
C9ZTV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	66%
C9ZU98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	73%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	79%
E9AKY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	66%
E9ALI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AW71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	90%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	97%
F4I1T9	Arabidopsis thaliana	31%	69%
Q10E64	Oryza sativa subsp. japonica	33%	80%
Q1MTQ1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	94%
Q4QIX3	Leishmania major	29%	66%
Q5VQ09	Oryza sativa subsp. japonica	32%	66%
Q651Z7	Oryza sativa subsp. japonica	31%	68%
Q6H638	Oryza sativa subsp. japonica	32%	67%
Q8GW44	Arabidopsis thaliana	34%	100%
Q96FN5	Homo sapiens	32%	91%
Q9HAQ2	Homo sapiens	31%	75%
Q9NF78	Leishmania major	30%	100%
Q9SCJ4	Arabidopsis thaliana	32%	72%
Q9UTL2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q9V877	Drosophila melanogaster	29%	94%
Q9WV04	Mus musculus	30%	75%
V5B8M1	Trypanosoma cruzi	34%	96%
V5B8X9	Trypanosoma cruzi	28%	84%
V5BAR9	Trypanosoma cruzi	33%	92%
V5BHY4	Trypanosoma cruzi	31%	79%
V5BIC1	Trypanosoma cruzi	32%	92%
V5BK25	Trypanosoma cruzi	29%	82%
V5DFA7	Trypanosoma cruzi	32%	100%
V5DMS2	Trypanosoma cruzi	36%	100%
V5DTU1	Trypanosoma cruzi	62%	100%