Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative

Species:

Leishmania major

UniProt:

E9AEA0_LEIMA

TriTrypDb:

LmjF.29.2380 , LMJLV39_290031800 , LMJSD75_290032200

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	4
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0099080	supramolecular complex	2	4
GO:0099081	supramolecular polymer	3	4
GO:0099512	supramolecular fiber	4	4
GO:0099513	polymeric cytoskeletal fiber	5	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AEA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEA0

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	18
GO:0007018	microtubule-based movement	3	18
GO:0009987	cellular process	1	18

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003774	cytoskeletal motor activity	1	18
GO:0003777	microtubule motor activity	2	18
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	18
GO:0005515	protein binding	2	18
GO:0005524	ATP binding	5	18
GO:0008017	microtubule binding	5	18
GO:0008092	cytoskeletal protein binding	3	18
GO:0015631	tubulin binding	4	18
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017076	purine nucleotide binding	4	18
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:0140657	ATP-dependent activity	1	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	415	419	PF00656	0.469
CLV_NRD_NRD_1	173	175	PF00675	0.393
CLV_NRD_NRD_1	195	197	PF00675	0.434
CLV_NRD_NRD_1	283	285	PF00675	0.329
CLV_NRD_NRD_1	556	558	PF00675	0.420
CLV_PCSK_FUR_1	47	51	PF00082	0.395
CLV_PCSK_KEX2_1	173	175	PF00082	0.393
CLV_PCSK_KEX2_1	49	51	PF00082	0.431
CLV_PCSK_KEX2_1	556	558	PF00082	0.420
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.441
CLV_PCSK_SKI1_1	117	121	PF00082	0.465
CLV_PCSK_SKI1_1	150	154	PF00082	0.336
CLV_PCSK_SKI1_1	396	400	PF00082	0.635
CLV_PCSK_SKI1_1	417	421	PF00082	0.588
CLV_PCSK_SKI1_1	525	529	PF00082	0.534
CLV_PCSK_SKI1_1	71	75	PF00082	0.335
CLV_Separin_Metazoa	193	197	PF03568	0.455
DEG_SCF_FBW7_1	526	532	PF00400	0.445
DOC_CKS1_1	526	531	PF01111	0.475
DOC_CYCLIN_RxL_1	114	122	PF00134	0.474
DOC_CYCLIN_RxL_1	393	400	PF00134	0.425
DOC_CYCLIN_yClb5_NLxxxL_5	477	486	PF00134	0.400
DOC_MAPK_MEF2A_6	10	17	PF00069	0.427
DOC_MAPK_MEF2A_6	215	224	PF00069	0.347
DOC_PP2B_LxvP_1	152	155	PF13499	0.360
DOC_PP2B_LxvP_1	464	467	PF13499	0.479
DOC_USP7_MATH_1	277	281	PF00917	0.345
DOC_USP7_MATH_1	419	423	PF00917	0.580
DOC_USP7_MATH_1	455	459	PF00917	0.531
DOC_USP7_MATH_1	529	533	PF00917	0.530
DOC_USP7_MATH_1	575	579	PF00917	0.544
DOC_USP7_UBL2_3	22	26	PF12436	0.204
DOC_USP7_UBL2_3	539	543	PF12436	0.572
DOC_WW_Pin1_4	316	321	PF00397	0.346
DOC_WW_Pin1_4	525	530	PF00397	0.450
LIG_14-3-3_CanoR_1	10	16	PF00244	0.466
LIG_14-3-3_CanoR_1	178	183	PF00244	0.474
LIG_14-3-3_CanoR_1	202	209	PF00244	0.445
LIG_14-3-3_CanoR_1	276	282	PF00244	0.346
LIG_14-3-3_CanoR_1	556	566	PF00244	0.522
LIG_14-3-3_CterR_2	587	590	PF00244	0.560
LIG_Actin_WH2_2	62	77	PF00022	0.335
LIG_APCC_ABBA_1	142	147	PF00400	0.335
LIG_APCC_ABBA_1	165	170	PF00400	0.351
LIG_BIR_II_1	1	5	PF00653	0.697
LIG_BRCT_BRCA1_1	224	228	PF00533	0.474
LIG_BRCT_BRCA1_1	286	290	PF00533	0.432
LIG_BRCT_BRCA1_1	302	306	PF00533	0.264
LIG_BRCT_BRCA1_1	514	518	PF00533	0.507
LIG_EH1_1	458	466	PF00400	0.533
LIG_eIF4E_1	459	465	PF01652	0.537
LIG_FHA_1	132	138	PF00498	0.474
LIG_FHA_1	297	303	PF00498	0.324
LIG_FHA_1	310	316	PF00498	0.324
LIG_FHA_1	324	330	PF00498	0.360
LIG_FHA_1	461	467	PF00498	0.413
LIG_FHA_1	507	513	PF00498	0.489
LIG_FHA_1	526	532	PF00498	0.478
LIG_FHA_1	550	556	PF00498	0.483
LIG_FHA_1	6	12	PF00498	0.526
LIG_FHA_1	94	100	PF00498	0.351
LIG_FHA_2	250	256	PF00498	0.450
LIG_FHA_2	413	419	PF00498	0.423
LIG_LIR_Gen_1	225	236	PF02991	0.439
LIG_LIR_Gen_1	287	298	PF02991	0.378
LIG_LIR_Gen_1	353	362	PF02991	0.511
LIG_LIR_Gen_1	562	571	PF02991	0.501
LIG_LIR_Gen_1	64	74	PF02991	0.338
LIG_LIR_Gen_1	96	103	PF02991	0.393
LIG_LIR_LC3C_4	463	466	PF02991	0.523
LIG_LIR_Nem_3	225	231	PF02991	0.393
LIG_LIR_Nem_3	287	293	PF02991	0.378
LIG_LIR_Nem_3	353	359	PF02991	0.542
LIG_LIR_Nem_3	562	568	PF02991	0.474
LIG_LIR_Nem_3	64	69	PF02991	0.345
LIG_LIR_Nem_3	76	81	PF02991	0.355
LIG_LIR_Nem_3	96	100	PF02991	0.351
LIG_NRBOX	297	303	PF00104	0.393
LIG_NRBOX	481	487	PF00104	0.366
LIG_Pex14_2	54	58	PF04695	0.337
LIG_PTB_Apo_2	534	541	PF02174	0.524
LIG_Rb_LxCxE_1	98	121	PF01857	0.249
LIG_Rb_pABgroove_1	114	122	PF01858	0.474
LIG_Rb_pABgroove_1	463	471	PF01858	0.450
LIG_SH2_CRK	469	473	PF00017	0.570
LIG_SH2_CRK	97	101	PF00017	0.470
LIG_SH2_NCK_1	469	473	PF00017	0.613
LIG_SH2_STAP1	334	338	PF00017	0.341
LIG_SH2_STAP1	356	360	PF00017	0.623
LIG_SH2_STAP1	380	384	PF00017	0.568
LIG_SH2_STAT3	380	383	PF00017	0.452
LIG_SH2_STAT5	176	179	PF00017	0.335
LIG_SH2_STAT5	365	368	PF00017	0.598
LIG_SH2_STAT5	546	549	PF00017	0.452
LIG_SH2_STAT5	565	568	PF00017	0.487
LIG_SH3_3	469	475	PF00018	0.491
LIG_SH3_3	523	529	PF00018	0.506
LIG_SUMO_SIM_anti_2	491	497	PF11976	0.502
LIG_SUMO_SIM_par_1	237	244	PF11976	0.393
LIG_SUMO_SIM_par_1	491	497	PF11976	0.508
LIG_TYR_ITIM	354	359	PF00017	0.562
LIG_TYR_ITIM	563	568	PF00017	0.491
LIG_UBA3_1	191	197	PF00899	0.393
LIG_WRC_WIRS_1	278	283	PF05994	0.360
MOD_CK1_1	213	219	PF00069	0.320
MOD_CK1_1	296	302	PF00069	0.335
MOD_CK1_1	328	334	PF00069	0.438
MOD_CK1_1	379	385	PF00069	0.520
MOD_CK1_1	450	456	PF00069	0.457
MOD_CK1_1	93	99	PF00069	0.360
MOD_CK2_1	137	143	PF00069	0.346
MOD_CK2_1	249	255	PF00069	0.328
MOD_CK2_1	289	295	PF00069	0.495
MOD_CK2_1	401	407	PF00069	0.554
MOD_DYRK1A_RPxSP_1	525	529	PF00069	0.441
MOD_GlcNHglycan	1	4	PF01048	0.679
MOD_GlcNHglycan	186	189	PF01048	0.474
MOD_GlcNHglycan	255	259	PF01048	0.468
MOD_GlcNHglycan	26	29	PF01048	0.425
MOD_GlcNHglycan	531	534	PF01048	0.455
MOD_GlcNHglycan	559	562	PF01048	0.631
MOD_GlcNHglycan	572	575	PF01048	0.492
MOD_GlcNHglycan	58	61	PF01048	0.430
MOD_GlcNHglycan	92	95	PF01048	0.349
MOD_GSK3_1	131	138	PF00069	0.439
MOD_GSK3_1	209	216	PF00069	0.360
MOD_GSK3_1	245	252	PF00069	0.335
MOD_GSK3_1	289	296	PF00069	0.351
MOD_GSK3_1	314	321	PF00069	0.355
MOD_GSK3_1	323	330	PF00069	0.342
MOD_GSK3_1	397	404	PF00069	0.542
MOD_GSK3_1	419	426	PF00069	0.571
MOD_GSK3_1	443	450	PF00069	0.433
MOD_GSK3_1	521	528	PF00069	0.478
MOD_N-GLC_1	209	214	PF02516	0.347
MOD_N-GLC_1	267	272	PF02516	0.335
MOD_N-GLC_1	323	328	PF02516	0.360
MOD_N-GLC_1	347	352	PF02516	0.481
MOD_N-GLC_1	401	406	PF02516	0.613
MOD_N-GLC_2	82	84	PF02516	0.330
MOD_NEK2_1	209	214	PF00069	0.344
MOD_NEK2_1	220	225	PF00069	0.327
MOD_NEK2_1	293	298	PF00069	0.340
MOD_NEK2_1	302	307	PF00069	0.326
MOD_NEK2_1	314	319	PF00069	0.335
MOD_NEK2_1	325	330	PF00069	0.336
MOD_NEK2_1	339	344	PF00069	0.471
MOD_NEK2_1	366	371	PF00069	0.426
MOD_NEK2_1	401	406	PF00069	0.517
MOD_NEK2_1	443	448	PF00069	0.474
MOD_NEK2_2	131	136	PF00069	0.474
MOD_NEK2_2	289	294	PF00069	0.335
MOD_NEK2_2	447	452	PF00069	0.576
MOD_OFUCOSY	442	447	PF10250	0.472
MOD_PIKK_1	222	228	PF00454	0.346
MOD_PIKK_1	379	385	PF00454	0.556
MOD_PIKK_1	401	407	PF00454	0.621
MOD_PIKK_1	423	429	PF00454	0.572
MOD_PK_1	178	184	PF00069	0.474
MOD_PKA_1	284	290	PF00069	0.464
MOD_PKA_2	201	207	PF00069	0.353
MOD_PKA_2	249	255	PF00069	0.346
MOD_PKA_2	293	299	PF00069	0.329
MOD_PKA_2	512	518	PF00069	0.489
MOD_Plk_1	131	137	PF00069	0.474
MOD_Plk_1	267	273	PF00069	0.335
MOD_Plk_1	401	407	PF00069	0.644
MOD_Plk_1	575	581	PF00069	0.696
MOD_Plk_2-3	161	167	PF00069	0.393
MOD_Plk_2-3	412	418	PF00069	0.470
MOD_Plk_4	137	143	PF00069	0.346
MOD_Plk_4	238	244	PF00069	0.392
MOD_Plk_4	267	273	PF00069	0.347
MOD_Plk_4	309	315	PF00069	0.346
MOD_Plk_4	36	42	PF00069	0.294
MOD_Plk_4	460	466	PF00069	0.451
MOD_Plk_4	512	518	PF00069	0.458
MOD_Plk_4	95	101	PF00069	0.335
MOD_ProDKin_1	316	322	PF00069	0.346
MOD_ProDKin_1	525	531	PF00069	0.448
MOD_SUMO_rev_2	257	267	PF00179	0.342
MOD_SUMO_rev_2	280	287	PF00179	0.477
MOD_SUMO_rev_2	292	299	PF00179	0.490
TRG_DiLeu_BaEn_1	355	360	PF01217	0.595
TRG_DiLeu_BaEn_1	416	421	PF01217	0.523
TRG_DiLeu_BaEn_1	460	465	PF01217	0.530
TRG_DiLeu_BaEn_2	553	559	PF01217	0.333
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.393
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.452
TRG_ENDOCYTIC_2	356	359	PF00928	0.539
TRG_ENDOCYTIC_2	469	472	PF00928	0.545
TRG_ENDOCYTIC_2	565	568	PF00928	0.487
TRG_ENDOCYTIC_2	78	81	PF00928	0.418
TRG_ENDOCYTIC_2	97	100	PF00928	0.393
TRG_ER_diArg_1	15	18	PF00400	0.436
TRG_ER_diArg_1	155	158	PF00400	0.346
TRG_ER_diArg_1	173	175	PF00400	0.299
TRG_ER_diArg_1	360	363	PF00400	0.575
TRG_ER_diArg_1	555	557	PF00400	0.415
TRG_NES_CRM1_1	235	249	PF08389	0.409
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P569	Leptomonas seymouri	27%	67%
A0A0N1HY56	Leptomonas seymouri	29%	86%
A0A0N1I2F8	Leptomonas seymouri	29%	70%
A0A0S4ILK1	Bodo saltans	32%	69%
A0A0S4IP49	Bodo saltans	27%	73%
A0A0S4J0Q2	Bodo saltans	34%	71%
A0A0S4JFN9	Bodo saltans	34%	69%
A0A0S4JJ54	Bodo saltans	33%	84%
A0A0S4JLW3	Bodo saltans	32%	100%
A0A0S4JXY6	Bodo saltans	31%	69%
A0A0S4KL43	Bodo saltans	29%	100%
A0A1X0NQ03	Trypanosomatidae	28%	71%
A0A1X0NWZ8	Trypanosomatidae	31%	79%
A0A1X0P0C2	Trypanosomatidae	32%	72%
A0A1X0P9E3	Trypanosomatidae	60%	99%
A0A1X0PAG9	Trypanosomatidae	50%	99%
A0A3Q8IBS7	Leishmania donovani	30%	97%
A0A3Q8IEL2	Leishmania donovani	70%	100%
A0A3Q8IHG6	Leishmania donovani	97%	100%
A0A3R7MDH9	Trypanosoma rangeli	28%	83%
A0A3R7R330	Trypanosoma rangeli	62%	100%
A0A3R7RD86	Trypanosoma rangeli	34%	74%
A0A3S7WPL3	Leishmania donovani	30%	66%
A0A3S7WU64	Leishmania donovani	32%	68%
A0A3S7X2P9	Leishmania donovani	95%	100%
A0A422MZ05	Trypanosoma rangeli	28%	87%
A0A422NE49	Trypanosoma rangeli	32%	66%
A0A422NEQ8	Trypanosoma rangeli	31%	78%
A4H4R6	Leishmania braziliensis	30%	67%
A4HAQ7	Leishmania braziliensis	27%	100%
A4HCT2	Leishmania braziliensis	31%	82%
A4HHN7	Leishmania braziliensis	87%	100%
A4HSA6	Leishmania infantum	34%	100%
A4HSZ5	Leishmania infantum	29%	66%
A4HX45	Leishmania infantum	32%	74%
A4I4V2	Leishmania infantum	97%	100%
A4I4V3	Leishmania infantum	85%	100%
A4I562	Leishmania infantum	30%	97%
B9G2X9	Oryza sativa subsp. japonica	34%	98%
C9ZI82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	67%
C9ZL08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZL09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
C9ZTV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	66%
C9ZU98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	73%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	79%
E9AKY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	66%
E9ALI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	97%
O14782	Homo sapiens	33%	74%
O35066	Mus musculus	32%	74%
O55165	Rattus norvegicus	33%	74%
P46870	Chlamydomonas reinhardtii	30%	76%
P53086	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	73%
Q10E64	Oryza sativa subsp. japonica	34%	80%
Q14807	Homo sapiens	30%	89%
Q1MTQ1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	94%
Q1MTQ7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	93%
Q29DY1	Drosophila pseudoobscura pseudoobscura	34%	74%
Q2R2P7	Oryza sativa subsp. japonica	34%	92%
Q3V300	Mus musculus	30%	89%
Q4Q7S4	Leishmania major	30%	97%
Q4QEL8	Leishmania major	32%	73%
Q4QIX3	Leishmania major	29%	67%
Q4R918	Macaca fascicularis	28%	100%
Q5I0E8	Rattus norvegicus	30%	90%
Q5R706	Pongo abelii	33%	74%
Q5REP4	Pongo abelii	30%	89%
Q651Z7	Oryza sativa subsp. japonica	30%	68%
Q6H638	Oryza sativa subsp. japonica	31%	67%
Q7ZYL5	Xenopus laevis	29%	91%
Q8VWI7	Arabidopsis thaliana	27%	68%
Q8W5R6	Arabidopsis thaliana	30%	66%
Q9I869	Xenopus laevis	29%	91%
Q9S7P3	Arabidopsis thaliana	34%	72%
Q9SCJ4	Arabidopsis thaliana	33%	73%
Q9V877	Drosophila melanogaster	29%	94%
Q9WV04	Mus musculus	30%	75%
V5B325	Trypanosoma cruzi	28%	71%
V5B8M1	Trypanosoma cruzi	37%	96%
V5B8X9	Trypanosoma cruzi	28%	84%
V5BAA8	Trypanosoma cruzi	32%	72%
V5BCN9	Trypanosoma cruzi	27%	83%
V5BIC1	Trypanosoma cruzi	32%	93%
V5BK25	Trypanosoma cruzi	29%	82%
V5D733	Trypanosoma cruzi	32%	79%
V5DFA7	Trypanosoma cruzi	32%	100%
V5DTU1	Trypanosoma cruzi	62%	100%