Aspartyl putative aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aspartyl aminopeptidase, putative

Species:

Leishmania major

UniProt:

E9AE98_LEIMA

TriTrypDb:

LmjF.29.2360 , LMJLV39_290031700 , LMJSD75_290032000

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

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Expansion

Sequence features

E9AE98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE98

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004177	aminopeptidase activity	5	11
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	11
GO:0008237	metallopeptidase activity	4	11
GO:0008238	exopeptidase activity	4	11
GO:0008270	zinc ion binding	6	11
GO:0016787	hydrolase activity	2	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.582
CLV_PCSK_SKI1_1	11	15	PF00082	0.433
CLV_PCSK_SKI1_1	128	132	PF00082	0.293
CLV_PCSK_SKI1_1	146	150	PF00082	0.293
CLV_PCSK_SKI1_1	347	351	PF00082	0.317
CLV_PCSK_SKI1_1	35	39	PF00082	0.306
CLV_PCSK_SKI1_1	363	367	PF00082	0.236
DOC_CDC14_PxL_1	154	162	PF14671	0.493
DOC_CYCLIN_yClb5_NLxxxL_5	155	164	PF00134	0.568
DOC_MAPK_DCC_7	152	162	PF00069	0.493

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTZ6	Leptomonas seymouri	80%	100%
A0A1X0P949	Trypanosomatidae	65%	100%
A0A3Q8IEG8	Leishmania donovani	95%	100%
A0A3R7K726	Trypanosoma rangeli	62%	100%
A0PYH7	Clostridium novyi (strain NT)	38%	100%
A1KGT3	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	35%	100%
A4HHN5	Leishmania braziliensis	88%	100%
A4I4V0	Leishmania infantum	95%	100%
A4VJG1	Pseudomonas stutzeri (strain A1501)	39%	100%
A4XRN0	Pseudomonas mendocina (strain ymp)	41%	100%

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