LeishMANIAdb
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5-demethoxyubiquinone hydroxylase, mitochondrial

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
5-demethoxyubiquinone hydroxylase, mitochondrial
Gene product:
Ubiquinone biosynthesis protein COQ7, putative
Species:
Leishmania major
UniProt:
E9AE97_LEIMA
TriTrypDb:
LmjF.29.2350 * , LMJLV39_290031600 , LMJSD75_290031900
Length:
280

Annotations

LeishMANIAdb annotations

Very conserved, homologous to animal COQ7 proteins. Probably perimembrane protein.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005743 mitochondrial inner membrane 5 2
GO:0016020 membrane 2 2
GO:0019866 organelle inner membrane 4 2
GO:0019898 extrinsic component of membrane 2 10
GO:0031090 organelle membrane 3 2
GO:0031312 extrinsic component of organelle membrane 3 10
GO:0031314 extrinsic component of mitochondrial inner membrane 4 10
GO:0031966 mitochondrial membrane 4 2
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

E9AE97
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE97

Function

Biological processes
Term Name Level Count
GO:0006743 ubiquinone metabolic process 5 10
GO:0006744 ubiquinone biosynthetic process 6 10
GO:0008152 metabolic process 1 10
GO:0009058 biosynthetic process 2 10
GO:0009987 cellular process 1 10
GO:0042180 cellular ketone metabolic process 3 10
GO:0042181 ketone biosynthetic process 4 10
GO:0044237 cellular metabolic process 2 10
GO:0044249 cellular biosynthetic process 3 10
GO:0044281 small molecule metabolic process 2 10
GO:0044283 small molecule biosynthetic process 3 10
GO:0071704 organic substance metabolic process 2 10
GO:1901576 organic substance biosynthetic process 3 10
GO:1901661 quinone metabolic process 4 10
GO:1901663 quinone biosynthetic process 5 10
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0004497 monooxygenase activity 3 10
GO:0005488 binding 1 10
GO:0008682 3-demethoxyubiquinol 3-hydroxylase activity 4 10
GO:0016491 oxidoreductase activity 2 10
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3 10
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4 10
GO:0043167 ion binding 2 10
GO:0043169 cation binding 3 10
GO:0046872 metal ion binding 4 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 278 280 PF00082 0.352
CLV_PCSK_PC1ET2_1 278 280 PF00082 0.352
CLV_PCSK_SKI1_1 14 18 PF00082 0.461
CLV_PCSK_SKI1_1 76 80 PF00082 0.599
CLV_Separin_Metazoa 101 105 PF03568 0.285
DEG_APCC_DBOX_1 117 125 PF00400 0.365
DEG_Nend_UBRbox_1 1 4 PF02207 0.407
DEG_SPOP_SBC_1 157 161 PF00917 0.325
DEG_SPOP_SBC_1 70 74 PF00917 0.396
DOC_MAPK_gen_1 95 105 PF00069 0.309
DOC_MAPK_MEF2A_6 76 85 PF00069 0.555
DOC_PP4_FxxP_1 90 93 PF00568 0.436
DOC_USP7_MATH_1 70 74 PF00917 0.396
DOC_WW_Pin1_4 122 127 PF00397 0.283
DOC_WW_Pin1_4 16 21 PF00397 0.443
LIG_14-3-3_CanoR_1 158 163 PF00244 0.294
LIG_14-3-3_CanoR_1 22 28 PF00244 0.479
LIG_14-3-3_CanoR_1 35 40 PF00244 0.356
LIG_14-3-3_CanoR_1 50 55 PF00244 0.431
LIG_BIR_III_2 129 133 PF00653 0.365
LIG_BRCT_BRCA1_1 39 43 PF00533 0.366
LIG_BRCT_BRCA1_1 60 64 PF00533 0.376
LIG_FHA_1 132 138 PF00498 0.412
LIG_FHA_1 157 163 PF00498 0.345
LIG_FHA_1 175 181 PF00498 0.144
LIG_FHA_1 22 28 PF00498 0.400
LIG_FHA_1 4 10 PF00498 0.467
LIG_FHA_2 158 164 PF00498 0.264
LIG_FHA_2 193 199 PF00498 0.367
LIG_FHA_2 26 32 PF00498 0.495
LIG_LIR_Apic_2 122 126 PF02991 0.383
LIG_LIR_Gen_1 225 235 PF02991 0.348
LIG_LIR_Nem_3 195 200 PF02991 0.360
LIG_LIR_Nem_3 225 230 PF02991 0.290
LIG_LIR_Nem_3 42 47 PF02991 0.420
LIG_LRP6_Inhibitor_1 261 267 PF00058 0.249
LIG_LYPXL_S_1 258 262 PF13949 0.180
LIG_LYPXL_yS_3 259 262 PF13949 0.249
LIG_PCNA_yPIPBox_3 95 103 PF02747 0.311
LIG_Pex14_2 44 48 PF04695 0.354
LIG_Rb_LxCxE_1 24 42 PF01857 0.388
LIG_SH2_CRK 263 267 PF00017 0.249
LIG_SH2_STAP1 23 27 PF00017 0.401
LIG_SH2_STAT3 200 203 PF00017 0.249
LIG_SH2_STAT5 23 26 PF00017 0.437
LIG_SH2_STAT5 233 236 PF00017 0.295
LIG_SH3_3 254 260 PF00018 0.289
LIG_SH3_3 82 88 PF00018 0.419
LIG_SUMO_SIM_anti_2 82 87 PF11976 0.377
LIG_SUMO_SIM_par_1 23 28 PF11976 0.509
LIG_TYR_ITIM 261 266 PF00017 0.249
MOD_CDC14_SPxK_1 19 22 PF00782 0.386
MOD_CDK_SPxK_1 16 22 PF00069 0.443
MOD_CK1_1 21 27 PF00069 0.410
MOD_CK1_1 62 68 PF00069 0.391
MOD_CK1_1 74 80 PF00069 0.450
MOD_CK2_1 192 198 PF00069 0.391
MOD_CK2_1 217 223 PF00069 0.413
MOD_CK2_1 25 31 PF00069 0.496
MOD_GlcNHglycan 56 59 PF01048 0.429
MOD_GSK3_1 21 28 PF00069 0.406
MOD_GSK3_1 31 38 PF00069 0.370
MOD_GSK3_1 50 57 PF00069 0.346
MOD_GSK3_1 58 65 PF00069 0.355
MOD_GSK3_1 70 77 PF00069 0.433
MOD_LATS_1 144 150 PF00433 0.344
MOD_NEK2_1 1 6 PF00069 0.437
MOD_NEK2_1 25 30 PF00069 0.455
MOD_NEK2_1 54 59 PF00069 0.354
MOD_NEK2_1 60 65 PF00069 0.516
MOD_PIKK_1 131 137 PF00454 0.459
MOD_PK_1 35 41 PF00069 0.379
MOD_PKA_2 1 7 PF00069 0.415
MOD_PKA_2 157 163 PF00069 0.249
MOD_PKA_2 21 27 PF00069 0.477
MOD_PKA_2 31 37 PF00069 0.386
MOD_Plk_1 192 198 PF00069 0.249
MOD_Plk_1 222 228 PF00069 0.180
MOD_Plk_4 192 198 PF00069 0.277
MOD_Plk_4 39 45 PF00069 0.362
MOD_Plk_4 50 56 PF00069 0.321
MOD_Plk_4 74 80 PF00069 0.577
MOD_ProDKin_1 122 128 PF00069 0.283
MOD_ProDKin_1 16 22 PF00069 0.443
MOD_SUMO_rev_2 206 215 PF00179 0.421
TRG_DiLeu_BaLyEn_6 257 262 PF01217 0.273
TRG_ENDOCYTIC_2 259 262 PF00928 0.249
TRG_ENDOCYTIC_2 263 266 PF00928 0.249
TRG_NES_CRM1_1 122 136 PF08389 0.356

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PB42 Leptomonas seymouri 80% 100%
A0A1X0P9Z6 Trypanosomatidae 64% 100%
A0A3R7LIB4 Trypanosoma rangeli 65% 100%
A0A3S7X2Q6 Leishmania donovani 93% 100%
A4HHN4 Leishmania braziliensis 87% 100%
A4I4U9 Leishmania infantum 93% 100%
C9ZLJ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 100%
E9ALI9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q2TBW2 Bos taurus 37% 100%
Q54VB3 Dictyostelium discoideum 35% 100%
Q99807 Homo sapiens 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS