Nucleosome assembly protein (NAP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleosome assembly protein (NAP), putative

Species:

Leishmania major

UniProt:

E9AE96_LEIMA

TriTrypDb:

LmjF.29.2340 , LMJLV39_290031500 , LMJSD75_290031800

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	2
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AE96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE96

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	10
GO:0006334	nucleosome assembly	7	10
GO:0006338	chromatin remodeling	5	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0034728	nucleosome organization	6	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0065004	protein-DNA complex assembly	6	10
GO:0071824	protein-DNA complex subunit organization	5	10
GO:0071840	cellular component organization or biogenesis	2	10

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0042393	histone binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.470
CLV_NRD_NRD_1	22	24	PF00675	0.583
CLV_NRD_NRD_1	47	49	PF00675	0.612
CLV_PCSK_KEX2_1	47	49	PF00082	0.491
CLV_PCSK_SKI1_1	102	106	PF00082	0.464
CLV_PCSK_SKI1_1	48	52	PF00082	0.560
CLV_PCSK_SKI1_1	83	87	PF00082	0.432
DEG_APCC_DBOX_1	47	55	PF00400	0.625
DEG_Nend_UBRbox_2	1	3	PF02207	0.586
DOC_CKS1_1	65	70	PF01111	0.542
DOC_PP1_RVXF_1	99	106	PF00149	0.432
DOC_USP7_UBL2_3	98	102	PF12436	0.486
DOC_WW_Pin1_4	61	66	PF00397	0.428
LIG_14-3-3_CanoR_1	142	151	PF00244	0.491
LIG_14-3-3_CanoR_1	83	91	PF00244	0.417
LIG_14-3-3_CanoR_1	93	100	PF00244	0.474
LIG_APCC_ABBAyCdc20_2	108	114	PF00400	0.415
LIG_CaM_IQ_9	85	100	PF13499	0.520
LIG_EH_1	175	179	PF12763	0.448
LIG_FHA_1	126	132	PF00498	0.467
LIG_FHA_1	13	19	PF00498	0.541
LIG_FHA_1	165	171	PF00498	0.421
LIG_FHA_1	27	33	PF00498	0.498
LIG_FHA_1	6	12	PF00498	0.531
LIG_FHA_2	122	128	PF00498	0.359
LIG_LIR_Apic_2	171	177	PF02991	0.381
LIG_LIR_Gen_1	146	156	PF02991	0.525
LIG_LIR_Gen_1	86	94	PF02991	0.493
LIG_LIR_Nem_3	145	151	PF02991	0.398
LIG_LIR_Nem_3	55	61	PF02991	0.423
LIG_LIR_Nem_3	86	91	PF02991	0.451
LIG_Pex14_2	148	152	PF04695	0.493
LIG_SH2_CRK	100	104	PF00017	0.430
LIG_SH2_CRK	174	178	PF00017	0.488
LIG_SH2_GRB2like	174	177	PF00017	0.478
LIG_SH2_SRC	174	177	PF00017	0.510
LIG_SH3_3	62	68	PF00018	0.452
LIG_WRC_WIRS_1	104	109	PF05994	0.500
MOD_CK1_1	12	18	PF00069	0.515
MOD_CK1_1	64	70	PF00069	0.529
MOD_CK2_1	121	127	PF00069	0.576
MOD_CK2_1	135	141	PF00069	0.531
MOD_CK2_1	155	161	PF00069	0.550
MOD_CK2_1	35	41	PF00069	0.449
MOD_CK2_1	60	66	PF00069	0.481
MOD_GlcNHglycan	137	140	PF01048	0.522
MOD_GlcNHglycan	58	61	PF01048	0.420
MOD_GSK3_1	1	8	PF00069	0.538
MOD_GSK3_1	121	128	PF00069	0.491
MOD_GSK3_1	150	157	PF00069	0.542
MOD_GSK3_1	52	59	PF00069	0.520
MOD_GSK3_1	60	67	PF00069	0.494
MOD_N-GLC_1	154	159	PF02516	0.453
MOD_N-GLC_1	73	78	PF02516	0.406
MOD_NEK2_1	1	6	PF00069	0.563
MOD_NEK2_1	126	131	PF00069	0.478
MOD_NEK2_2	169	174	PF00069	0.485
MOD_PIKK_1	1	7	PF00454	0.528
MOD_PKA_2	92	98	PF00069	0.558
MOD_PKB_1	142	150	PF00069	0.495
MOD_Plk_1	126	132	PF00069	0.432
MOD_Plk_1	27	33	PF00069	0.553
MOD_Plk_2-3	121	127	PF00069	0.353
MOD_Plk_2-3	17	23	PF00069	0.465
MOD_Plk_4	144	150	PF00069	0.409
MOD_Plk_4	169	175	PF00069	0.489
MOD_ProDKin_1	61	67	PF00069	0.424
MOD_SUMO_rev_2	95	99	PF00179	0.530
TRG_DiLeu_BaEn_1	46	51	PF01217	0.500
TRG_DiLeu_BaEn_4	27	33	PF01217	0.579
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.542
TRG_ENDOCYTIC_2	100	103	PF00928	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I131	Leptomonas seymouri	75%	100%
A0A0S4JW42	Bodo saltans	35%	92%
A0A1X0P944	Trypanosomatidae	44%	99%
A0A3S7X2Q8	Leishmania donovani	95%	100%
A0A422MX53	Trypanosoma rangeli	46%	99%
A4HHN3	Leishmania braziliensis	82%	100%
A4I4U8	Leishmania infantum	95%	100%
C9ZLJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ALJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q8LC68	Arabidopsis thaliana	26%	72%