ALIX_LYPXL_bnd domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE95_LEIMA

TriTrypDb:

LmjF.29.2330 , LMJLV39_290031400 , LMJSD75_290031700

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE95

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	390	396	PF00089	0.522
CLV_NRD_NRD_1	112	114	PF00675	0.402
CLV_NRD_NRD_1	133	135	PF00675	0.368
CLV_NRD_NRD_1	17	19	PF00675	0.434
CLV_NRD_NRD_1	230	232	PF00675	0.417
CLV_NRD_NRD_1	272	274	PF00675	0.528
CLV_NRD_NRD_1	344	346	PF00675	0.498
CLV_PCSK_FUR_1	227	231	PF00082	0.509
CLV_PCSK_KEX2_1	103	105	PF00082	0.450
CLV_PCSK_KEX2_1	112	114	PF00082	0.368
CLV_PCSK_KEX2_1	229	231	PF00082	0.431
CLV_PCSK_KEX2_1	343	345	PF00082	0.521
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.525
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.549
CLV_PCSK_SKI1_1	113	117	PF00082	0.433
CLV_PCSK_SKI1_1	183	187	PF00082	0.373
CLV_PCSK_SKI1_1	344	348	PF00082	0.546
DEG_APCC_DBOX_1	112	120	PF00400	0.419
DEG_APCC_KENBOX_2	14	18	PF00400	0.422
DEG_APCC_KENBOX_2	234	238	PF00400	0.541
DEG_Nend_Nbox_1	1	3	PF02207	0.561
DOC_CKS1_1	382	387	PF01111	0.489
DOC_CYCLIN_RxL_1	110	120	PF00134	0.406
DOC_MAPK_gen_1	112	118	PF00069	0.480
DOC_MAPK_gen_1	15	23	PF00069	0.444
DOC_PP2B_LxvP_1	38	41	PF13499	0.418
DOC_USP7_MATH_1	212	216	PF00917	0.362
DOC_USP7_MATH_1	267	271	PF00917	0.548
DOC_USP7_MATH_1	29	33	PF00917	0.410
DOC_USP7_MATH_1	376	380	PF00917	0.636
DOC_USP7_MATH_1	392	396	PF00917	0.699
DOC_USP7_UBL2_3	15	19	PF12436	0.433
DOC_USP7_UBL2_3	330	334	PF12436	0.508
DOC_WW_Pin1_4	372	377	PF00397	0.619
DOC_WW_Pin1_4	381	386	PF00397	0.553
DOC_WW_Pin1_4	393	398	PF00397	0.579
LIG_14-3-3_CanoR_1	245	252	PF00244	0.531
LIG_14-3-3_CanoR_1	393	397	PF00244	0.735
LIG_AP2alpha_1	118	122	PF02296	0.269
LIG_AP2alpha_1	185	189	PF02296	0.343
LIG_BIR_III_2	164	168	PF00653	0.389
LIG_BRCT_BRCA1_1	300	304	PF00533	0.387
LIG_FHA_1	127	133	PF00498	0.445
LIG_FHA_1	2	8	PF00498	0.418
LIG_FHA_1	359	365	PF00498	0.513
LIG_FHA_1	43	49	PF00498	0.611
LIG_FHA_1	50	56	PF00498	0.555
LIG_FHA_1	79	85	PF00498	0.574
LIG_FHA_2	193	199	PF00498	0.479
LIG_FHA_2	221	227	PF00498	0.390
LIG_FHA_2	245	251	PF00498	0.513
LIG_FHA_2	62	68	PF00498	0.612
LIG_FHA_2	94	100	PF00498	0.578
LIG_FXI_DFP_1	222	226	PF00024	0.504
LIG_GBD_Chelix_1	132	140	PF00786	0.364
LIG_LIR_Gen_1	32	43	PF02991	0.421
LIG_LIR_Nem_3	120	125	PF02991	0.394
LIG_LIR_Nem_3	32	38	PF02991	0.419
LIG_LIR_Nem_3	88	93	PF02991	0.525
LIG_NRBOX	74	80	PF00104	0.380
LIG_Pex14_2	118	122	PF04695	0.269
LIG_Pex14_2	185	189	PF04695	0.365
LIG_SH2_PTP2	35	38	PF00017	0.422
LIG_SH2_SRC	275	278	PF00017	0.489
LIG_SH2_STAT3	171	174	PF00017	0.405
LIG_SH2_STAT5	171	174	PF00017	0.405
LIG_SH2_STAT5	261	264	PF00017	0.481
LIG_SH2_STAT5	275	278	PF00017	0.531
LIG_SH2_STAT5	35	38	PF00017	0.702
LIG_SH2_STAT5	366	369	PF00017	0.461
LIG_SH2_STAT5	6	9	PF00017	0.398
LIG_SH2_STAT5	60	63	PF00017	0.540
LIG_SH3_3	391	397	PF00018	0.700
LIG_TYR_ITIM	254	259	PF00017	0.414
LIG_UBA3_1	311	320	PF00899	0.533
LIG_UBA3_1	326	334	PF00899	0.427
LIG_WRC_WIRS_1	2	7	PF05994	0.409
LIG_WRC_WIRS_1	30	35	PF05994	0.621
MOD_CK1_1	192	198	PF00069	0.477
MOD_CK1_1	244	250	PF00069	0.505
MOD_CK1_1	293	299	PF00069	0.377
MOD_CK1_1	313	319	PF00069	0.218
MOD_CK1_1	362	368	PF00069	0.537
MOD_CK1_1	395	401	PF00069	0.730
MOD_CK1_1	85	91	PF00069	0.452
MOD_CK2_1	22	28	PF00069	0.448
MOD_CK2_1	244	250	PF00069	0.640
MOD_CK2_1	393	399	PF00069	0.685
MOD_CK2_1	61	67	PF00069	0.578
MOD_CK2_1	93	99	PF00069	0.509
MOD_Cter_Amidation	271	274	PF01082	0.511
MOD_DYRK1A_RPxSP_1	393	397	PF00069	0.541
MOD_GlcNHglycan	104	107	PF01048	0.478
MOD_GlcNHglycan	187	192	PF01048	0.527
MOD_GlcNHglycan	24	27	PF01048	0.449
MOD_GlcNHglycan	247	250	PF01048	0.457
MOD_GlcNHglycan	314	318	PF01048	0.461
MOD_GlcNHglycan	390	393	PF01048	0.792
MOD_GSK3_1	241	248	PF00069	0.478
MOD_GSK3_1	293	300	PF00069	0.407
MOD_GSK3_1	325	332	PF00069	0.460
MOD_GSK3_1	333	340	PF00069	0.525
MOD_GSK3_1	358	365	PF00069	0.578
MOD_GSK3_1	372	379	PF00069	0.565
MOD_GSK3_1	388	395	PF00069	0.668
MOD_GSK3_1	58	65	PF00069	0.513
MOD_GSK3_1	78	85	PF00069	0.314
MOD_N-GLC_1	108	113	PF02516	0.461
MOD_N-GLC_1	362	367	PF02516	0.428
MOD_NEK2_1	1	6	PF00069	0.517
MOD_NEK2_1	189	194	PF00069	0.473
MOD_NEK2_1	283	288	PF00069	0.454
MOD_NEK2_1	290	295	PF00069	0.432
MOD_NEK2_1	48	53	PF00069	0.614
MOD_NEK2_1	58	63	PF00069	0.523
MOD_NEK2_1	78	83	PF00069	0.393
MOD_PIKK_1	329	335	PF00454	0.570
MOD_PKA_1	102	108	PF00069	0.358
MOD_PKA_2	244	250	PF00069	0.511
MOD_PKA_2	392	398	PF00069	0.722
MOD_PKA_2	402	408	PF00069	0.430
MOD_Plk_1	290	296	PF00069	0.425
MOD_Plk_1	313	319	PF00069	0.448
MOD_Plk_1	362	368	PF00069	0.434
MOD_Plk_4	1	7	PF00069	0.410
MOD_Plk_4	362	368	PF00069	0.507
MOD_Plk_4	82	88	PF00069	0.457
MOD_ProDKin_1	372	378	PF00069	0.622
MOD_ProDKin_1	381	387	PF00069	0.551
MOD_ProDKin_1	393	399	PF00069	0.577
TRG_DiLeu_BaEn_3	341	347	PF01217	0.507
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.368
TRG_ENDOCYTIC_2	256	259	PF00928	0.447
TRG_ENDOCYTIC_2	35	38	PF00928	0.422
TRG_ER_diArg_1	227	230	PF00400	0.472
TRG_ER_diArg_1	344	346	PF00400	0.478
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAR2	Leptomonas seymouri	54%	100%
A0A0S4K0W0	Bodo saltans	25%	88%
A0A1X0P9E6	Trypanosomatidae	30%	100%
A0A3R7JW64	Trypanosoma rangeli	31%	100%
A0A3S7X2T0	Leishmania donovani	90%	100%
A4HHN2	Leishmania braziliensis	71%	100%
A4I4U7	Leishmania infantum	90%	100%
E9ALJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BSJ0	Trypanosoma cruzi	30%	100%