Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania major

UniProt:

E9AE92_LEIMA

TriTrypDb:

LmjF.29.2300 , LMJLV39_290031100 , LMJSD75_290031400

Length:

748

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AE92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE92

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0016579	protein deubiquitination	6	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0070646	protein modification by small protein removal	5	12
GO:0070647	protein modification by small protein conjugation or removal	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004843	cysteine-type deubiquitinase activity	5	12
GO:0005488	binding	1	12
GO:0008233	peptidase activity	3	12
GO:0008234	cysteine-type peptidase activity	4	12
GO:0008270	zinc ion binding	6	12
GO:0016787	hydrolase activity	2	12
GO:0019783	ubiquitin-like protein peptidase activity	4	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0101005	deubiquitinase activity	5	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.679
CLV_NRD_NRD_1	542	544	PF00675	0.322
CLV_NRD_NRD_1	745	747	PF00675	0.399
CLV_PCSK_KEX2_1	542	544	PF00082	0.322
CLV_PCSK_SKI1_1	266	270	PF00082	0.442
CLV_PCSK_SKI1_1	329	333	PF00082	0.302
CLV_PCSK_SKI1_1	381	385	PF00082	0.296
CLV_PCSK_SKI1_1	626	630	PF00082	0.295
CLV_PCSK_SKI1_1	719	723	PF00082	0.308
DOC_CDC14_PxL_1	115	123	PF14671	0.500
DOC_CDC14_PxL_1	653	661	PF14671	0.273
DOC_CKS1_1	19	24	PF01111	0.401
DOC_CYCLIN_RxL_1	713	726	PF00134	0.315
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	466	472	PF00134	0.277
DOC_MAPK_gen_1	38	48	PF00069	0.345
DOC_MAPK_gen_1	554	562	PF00069	0.281
DOC_MAPK_MEF2A_6	41	50	PF00069	0.345
DOC_MAPK_MEF2A_6	464	472	PF00069	0.377
DOC_PP1_RVXF_1	717	724	PF00149	0.308
DOC_PP2B_LxvP_1	466	469	PF13499	0.277
DOC_PP4_FxxP_1	644	647	PF00568	0.368
DOC_USP7_MATH_1	137	141	PF00917	0.601
DOC_USP7_MATH_1	290	294	PF00917	0.506
DOC_USP7_MATH_1	333	337	PF00917	0.386
DOC_USP7_MATH_1	476	480	PF00917	0.319
DOC_USP7_MATH_1	482	486	PF00917	0.450
DOC_USP7_MATH_1	494	498	PF00917	0.201
DOC_USP7_MATH_1	584	588	PF00917	0.397
DOC_USP7_MATH_1	611	615	PF00917	0.489
DOC_USP7_UBL2_3	265	269	PF12436	0.468
DOC_USP7_UBL2_3	79	83	PF12436	0.564
DOC_WW_Pin1_4	162	167	PF00397	0.384
DOC_WW_Pin1_4	18	23	PF00397	0.514
DOC_WW_Pin1_4	334	339	PF00397	0.433
DOC_WW_Pin1_4	504	509	PF00397	0.401
DOC_WW_Pin1_4	586	591	PF00397	0.280
LIG_14-3-3_CanoR_1	455	461	PF00244	0.345
LIG_14-3-3_CanoR_1	493	499	PF00244	0.282
LIG_14-3-3_CanoR_1	529	534	PF00244	0.334
LIG_14-3-3_CanoR_1	542	546	PF00244	0.419
LIG_APCC_ABBA_1	65	70	PF00400	0.207
LIG_APCC_ABBAyCdc20_2	719	725	PF00400	0.308
LIG_BRCT_BRCA1_1	278	282	PF00533	0.481
LIG_BRCT_BRCA1_1	363	367	PF00533	0.289
LIG_BRCT_BRCA1_1	739	743	PF00533	0.298
LIG_Clathr_ClatBox_1	157	161	PF01394	0.380
LIG_FHA_1	353	359	PF00498	0.342
LIG_FHA_1	373	379	PF00498	0.375
LIG_FHA_1	691	697	PF00498	0.393
LIG_FHA_1	83	89	PF00498	0.635
LIG_FHA_2	171	177	PF00498	0.528
LIG_FHA_2	268	274	PF00498	0.444
LIG_FHA_2	301	307	PF00498	0.295
LIG_FHA_2	542	548	PF00498	0.393
LIG_LIR_Apic_2	641	647	PF02991	0.368
LIG_LIR_Gen_1	283	292	PF02991	0.417
LIG_LIR_Gen_1	44	51	PF02991	0.368
LIG_LIR_Gen_1	557	566	PF02991	0.308
LIG_LIR_Gen_1	717	728	PF02991	0.320
LIG_LIR_Nem_3	124	129	PF02991	0.363
LIG_LIR_Nem_3	235	239	PF02991	0.484
LIG_LIR_Nem_3	283	287	PF02991	0.388
LIG_LIR_Nem_3	404	408	PF02991	0.274
LIG_LIR_Nem_3	521	527	PF02991	0.342
LIG_LIR_Nem_3	532	536	PF02991	0.220
LIG_LIR_Nem_3	557	562	PF02991	0.308
LIG_LIR_Nem_3	717	723	PF02991	0.320
LIG_LIR_Nem_3	90	96	PF02991	0.693
LIG_MLH1_MIPbox_1	739	743	PF16413	0.321
LIG_NRBOX	405	411	PF00104	0.368
LIG_Pex14_2	327	331	PF04695	0.274
LIG_PTB_Apo_2	307	314	PF02174	0.274
LIG_PTB_Apo_2	730	737	PF02174	0.368
LIG_PTB_Phospho_1	307	313	PF10480	0.274
LIG_REV1ctd_RIR_1	741	748	PF16727	0.482
LIG_SH2_CRK	126	130	PF00017	0.382
LIG_SH2_CRK	627	631	PF00017	0.333
LIG_SH2_CRK	74	78	PF00017	0.419
LIG_SH2_PTP2	559	562	PF00017	0.419
LIG_SH2_SRC	276	279	PF00017	0.525
LIG_SH2_SRC	559	562	PF00017	0.419
LIG_SH2_STAP1	102	106	PF00017	0.328
LIG_SH2_STAP1	278	282	PF00017	0.481
LIG_SH2_STAP1	690	694	PF00017	0.339
LIG_SH2_STAT3	278	281	PF00017	0.473
LIG_SH2_STAT3	387	390	PF00017	0.295
LIG_SH2_STAT3	742	745	PF00017	0.455
LIG_SH2_STAT5	237	240	PF00017	0.439
LIG_SH2_STAT5	313	316	PF00017	0.393
LIG_SH2_STAT5	35	38	PF00017	0.275
LIG_SH2_STAT5	405	408	PF00017	0.291
LIG_SH2_STAT5	458	461	PF00017	0.308
LIG_SH2_STAT5	47	50	PF00017	0.274
LIG_SH2_STAT5	525	528	PF00017	0.349
LIG_SH2_STAT5	540	543	PF00017	0.374
LIG_SH2_STAT5	545	548	PF00017	0.384
LIG_SH2_STAT5	559	562	PF00017	0.372
LIG_SH2_STAT5	642	645	PF00017	0.289
LIG_SH2_STAT5	708	711	PF00017	0.274
LIG_SH2_STAT5	74	77	PF00017	0.357
LIG_SH2_STAT5	742	745	PF00017	0.310
LIG_SH2_STAT5	93	96	PF00017	0.689
LIG_SH3_3	149	155	PF00018	0.445
LIG_SH3_3	166	172	PF00018	0.470
LIG_SH3_3	468	474	PF00018	0.293
LIG_SH3_3	557	563	PF00018	0.308
LIG_SH3_3	578	584	PF00018	0.289
LIG_SH3_3	674	680	PF00018	0.379
LIG_SH3_3	93	99	PF00018	0.569
LIG_SUMO_SIM_anti_2	608	614	PF11976	0.368
LIG_SUMO_SIM_par_1	611	617	PF11976	0.419
LIG_TRAF2_1	603	606	PF00917	0.419
LIG_TRAF2_2	603	608	PF00917	0.339
LIG_TYR_ITIM	91	96	PF00017	0.678
MOD_CDC14_SPxK_1	589	592	PF00782	0.229
MOD_CDK_SPxK_1	586	592	PF00069	0.351
MOD_CK1_1	421	427	PF00069	0.405
MOD_CK1_1	586	592	PF00069	0.365
MOD_CK1_1	614	620	PF00069	0.446
MOD_CK1_1	702	708	PF00069	0.289
MOD_CK1_1	737	743	PF00069	0.365
MOD_CK2_1	267	273	PF00069	0.447
MOD_CK2_1	300	306	PF00069	0.295
MOD_CK2_1	482	488	PF00069	0.297
MOD_CK2_1	506	512	PF00069	0.335
MOD_GlcNHglycan	126	129	PF01048	0.490
MOD_GlcNHglycan	139	142	PF01048	0.431
MOD_GlcNHglycan	16	19	PF01048	0.459
MOD_GlcNHglycan	363	366	PF01048	0.276
MOD_GlcNHglycan	421	424	PF01048	0.417
MOD_GlcNHglycan	425	428	PF01048	0.421
MOD_GlcNHglycan	436	439	PF01048	0.439
MOD_GlcNHglycan	478	481	PF01048	0.294
MOD_GlcNHglycan	508	511	PF01048	0.307
MOD_GlcNHglycan	520	523	PF01048	0.248
MOD_GlcNHglycan	701	704	PF01048	0.307
MOD_GSK3_1	14	21	PF00069	0.542
MOD_GSK3_1	260	267	PF00069	0.429
MOD_GSK3_1	290	297	PF00069	0.584
MOD_GSK3_1	361	368	PF00069	0.316
MOD_GSK3_1	418	425	PF00069	0.407
MOD_GSK3_1	525	532	PF00069	0.327
MOD_GSK3_1	546	553	PF00069	0.441
MOD_GSK3_1	668	675	PF00069	0.386
MOD_GSK3_1	686	693	PF00069	0.216
MOD_LATS_1	416	422	PF00433	0.207
MOD_N-GLC_1	419	424	PF02516	0.334
MOD_N-GLC_1	672	677	PF02516	0.375
MOD_N-GLC_2	310	312	PF02516	0.274
MOD_NEK2_1	191	196	PF00069	0.445
MOD_NEK2_1	327	332	PF00069	0.454
MOD_NEK2_1	419	424	PF00069	0.303
MOD_NEK2_1	448	453	PF00069	0.489
MOD_NEK2_1	489	494	PF00069	0.442
MOD_NEK2_1	546	551	PF00069	0.450
MOD_NEK2_1	629	634	PF00069	0.275
MOD_NEK2_1	699	704	PF00069	0.333
MOD_NEK2_1	73	78	PF00069	0.469
MOD_NEK2_2	24	29	PF00069	0.409
MOD_NEK2_2	36	41	PF00069	0.288
MOD_OFUCOSY	33	40	PF10250	0.289
MOD_PIKK_1	277	283	PF00454	0.436
MOD_PIKK_1	3	9	PF00454	0.459
MOD_PIKK_1	728	734	PF00454	0.419
MOD_PKA_2	456	462	PF00069	0.328
MOD_PKA_2	494	500	PF00069	0.333
MOD_PKA_2	541	547	PF00069	0.419
MOD_PKA_2	571	577	PF00069	0.347
MOD_Plk_1	672	678	PF00069	0.240
MOD_Plk_1	690	696	PF00069	0.270
MOD_Plk_2-3	176	182	PF00069	0.512
MOD_Plk_4	290	296	PF00069	0.377
MOD_Plk_4	313	319	PF00069	0.289
MOD_Plk_4	611	617	PF00069	0.339
MOD_Plk_4	737	743	PF00069	0.333
MOD_ProDKin_1	162	168	PF00069	0.396
MOD_ProDKin_1	18	24	PF00069	0.419
MOD_ProDKin_1	334	340	PF00069	0.433
MOD_ProDKin_1	504	510	PF00069	0.401
MOD_ProDKin_1	586	592	PF00069	0.280
MOD_SUMO_rev_2	651	656	PF00179	0.339
MOD_SUMO_rev_2	84	91	PF00179	0.620
TRG_ENDOCYTIC_2	126	129	PF00928	0.348
TRG_ENDOCYTIC_2	47	50	PF00928	0.419
TRG_ENDOCYTIC_2	524	527	PF00928	0.481
TRG_ENDOCYTIC_2	545	548	PF00928	0.419
TRG_ENDOCYTIC_2	559	562	PF00928	0.419
TRG_ENDOCYTIC_2	627	630	PF00928	0.308
TRG_ENDOCYTIC_2	74	77	PF00928	0.308
TRG_ENDOCYTIC_2	93	96	PF00928	0.689
TRG_ER_diArg_1	455	458	PF00400	0.443
TRG_ER_diArg_1	541	543	PF00400	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2C0	Leptomonas seymouri	73%	100%
A0A0S4IPD1	Bodo saltans	46%	100%
A0A1X0PA40	Trypanosomatidae	55%	100%
A0A3Q8IDW9	Leishmania donovani	95%	100%
A0A422NEJ9	Trypanosoma rangeli	55%	100%
A4HHM9	Leishmania braziliensis	83%	100%
A4I4U4	Leishmania infantum	95%	100%
C9ZLJ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E1BMF7	Bos taurus	30%	87%
E1BY77	Gallus gallus	30%	87%
E9ALJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
F1QFS9	Danio rerio	30%	87%
F6V6I0	Xenopus tropicalis	29%	88%
P38237	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	96%
P45974	Homo sapiens	32%	87%
P54201	Dictyostelium discoideum	28%	89%
P56399	Mus musculus	32%	87%
Q11119	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	97%
Q5BKP2	Mus musculus	29%	87%
Q5R407	Pongo abelii	32%	87%
Q8L6Y1	Arabidopsis thaliana	30%	94%
Q92995	Homo sapiens	30%	87%
V5BC27	Trypanosoma cruzi	55%	100%