Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AE91_LEIMA

TriTrypDb:

LmjF.29.2290 , LMJLV39_290031000 , LMJSD75_290031300

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.800
CLV_NRD_NRD_1	8	10	PF00675	0.667
CLV_PCSK_KEX2_1	8	10	PF00082	0.667
CLV_PCSK_SKI1_1	186	190	PF00082	0.825
CLV_PCSK_SKI1_1	8	12	PF00082	0.702
DEG_APCC_DBOX_1	183	191	PF00400	0.820
DEG_Nend_Nbox_1	1	3	PF02207	0.749
DEG_SCF_FBW7_1	55	62	PF00400	0.831
DEG_SPOP_SBC_1	223	227	PF00917	0.627
DEG_SPOP_SBC_1	344	348	PF00917	0.713
DOC_CKS1_1	145	150	PF01111	0.800
DOC_CKS1_1	46	51	PF01111	0.805
DOC_CKS1_1	92	97	PF01111	0.622
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.654
DOC_CYCLIN_yCln2_LP_2	230	236	PF00134	0.833
DOC_PP2B_LxvP_1	399	402	PF13499	0.657
DOC_PP2B_LxvP_1	47	50	PF13499	0.737
DOC_PP4_FxxP_1	11	14	PF00568	0.702
DOC_PP4_FxxP_1	142	145	PF00568	0.794
DOC_PP4_FxxP_1	376	379	PF00568	0.667
DOC_PP4_MxPP_1	108	111	PF00568	0.746
DOC_USP7_MATH_1	100	104	PF00917	0.825
DOC_USP7_MATH_1	122	126	PF00917	0.686
DOC_USP7_MATH_1	14	18	PF00917	0.757
DOC_USP7_MATH_1	195	199	PF00917	0.697
DOC_USP7_MATH_1	214	218	PF00917	0.839
DOC_USP7_MATH_1	24	28	PF00917	0.731
DOC_USP7_MATH_1	300	304	PF00917	0.744
DOC_USP7_MATH_1	325	329	PF00917	0.769
DOC_USP7_MATH_1	381	385	PF00917	0.668
DOC_USP7_MATH_1	50	54	PF00917	0.710
DOC_USP7_MATH_1	59	63	PF00917	0.733
DOC_WW_Pin1_4	127	132	PF00397	0.804
DOC_WW_Pin1_4	144	149	PF00397	0.784
DOC_WW_Pin1_4	164	169	PF00397	0.487
DOC_WW_Pin1_4	177	182	PF00397	0.585
DOC_WW_Pin1_4	229	234	PF00397	0.807
DOC_WW_Pin1_4	235	240	PF00397	0.733
DOC_WW_Pin1_4	255	260	PF00397	0.446
DOC_WW_Pin1_4	292	297	PF00397	0.773
DOC_WW_Pin1_4	311	316	PF00397	0.626
DOC_WW_Pin1_4	336	341	PF00397	0.756
DOC_WW_Pin1_4	345	350	PF00397	0.766
DOC_WW_Pin1_4	359	364	PF00397	0.627
DOC_WW_Pin1_4	45	50	PF00397	0.805
DOC_WW_Pin1_4	55	60	PF00397	0.633
DOC_WW_Pin1_4	91	96	PF00397	0.764
LIG_14-3-3_CanoR_1	123	132	PF00244	0.702
LIG_14-3-3_CanoR_1	134	140	PF00244	0.598
LIG_14-3-3_CanoR_1	274	279	PF00244	0.692
LIG_14-3-3_CanoR_1	374	379	PF00244	0.742
LIG_BRCT_BRCA1_1	168	172	PF00533	0.818
LIG_BRCT_BRCA1_1	19	23	PF00533	0.780
LIG_BRCT_BRCA1_1	246	250	PF00533	0.759
LIG_CSL_BTD_1	279	282	PF09270	0.728
LIG_EH_1	199	203	PF12763	0.530
LIG_FHA_1	225	231	PF00498	0.831
LIG_FHA_1	302	308	PF00498	0.746
LIG_IBAR_NPY_1	3	5	PF08397	0.736
LIG_LIR_Gen_1	247	254	PF02991	0.760
LIG_LIR_Gen_1	271	279	PF02991	0.649
LIG_LIR_Nem_3	130	135	PF02991	0.829
LIG_LIR_Nem_3	247	253	PF02991	0.798
LIG_LIR_Nem_3	271	275	PF02991	0.698
LIG_PTB_Apo_2	197	204	PF02174	0.529
LIG_PTB_Phospho_1	197	203	PF10480	0.527
LIG_SH2_NCK_1	25	29	PF00017	0.671
LIG_SH2_SRC	119	122	PF00017	0.805
LIG_SH2_STAT3	203	206	PF00017	0.810
LIG_SH2_STAT3	51	54	PF00017	0.703
LIG_SH2_STAT5	252	255	PF00017	0.697
LIG_SH2_STAT5	46	49	PF00017	0.698
LIG_SH3_1	46	52	PF00018	0.765
LIG_SH3_2	4	9	PF14604	0.699
LIG_SH3_3	1	7	PF00018	0.695
LIG_SH3_3	107	113	PF00018	0.736
LIG_SH3_3	142	148	PF00018	0.746
LIG_SH3_3	165	171	PF00018	0.750
LIG_SH3_3	198	204	PF00018	0.716
LIG_SH3_3	264	270	PF00018	0.767
LIG_SH3_3	276	282	PF00018	0.742
LIG_SH3_3	32	38	PF00018	0.772
LIG_SH3_3	385	391	PF00018	0.680
LIG_SH3_3	46	52	PF00018	0.705
LIG_SUMO_SIM_anti_2	101	106	PF11976	0.822
LIG_UBA3_1	73	80	PF00899	0.553
MOD_CDC14_SPxK_1	348	351	PF00782	0.774
MOD_CDK_SPxK_1	345	351	PF00069	0.773
MOD_CDK_SPxxK_3	127	134	PF00069	0.713
MOD_CDK_SPxxK_3	177	184	PF00069	0.769
MOD_CK1_1	115	121	PF00069	0.722
MOD_CK1_1	125	131	PF00069	0.751
MOD_CK1_1	17	23	PF00069	0.716
MOD_CK1_1	217	223	PF00069	0.837
MOD_CK1_1	225	231	PF00069	0.700
MOD_CK1_1	238	244	PF00069	0.607
MOD_CK1_1	268	274	PF00069	0.773
MOD_CK1_1	290	296	PF00069	0.752
MOD_CK1_1	311	317	PF00069	0.781
MOD_CK1_1	53	59	PF00069	0.768
MOD_CK2_1	374	380	PF00069	0.740
MOD_CK2_1	61	67	PF00069	0.805
MOD_GlcNHglycan	17	20	PF01048	0.680
MOD_GlcNHglycan	175	178	PF01048	0.726
MOD_GlcNHglycan	190	193	PF01048	0.740
MOD_GlcNHglycan	216	219	PF01048	0.848
MOD_GlcNHglycan	244	247	PF01048	0.705
MOD_GlcNHglycan	255	258	PF01048	0.614
MOD_GlcNHglycan	26	29	PF01048	0.759
MOD_GlcNHglycan	290	293	PF01048	0.843
MOD_GlcNHglycan	30	33	PF01048	0.721
MOD_GlcNHglycan	322	325	PF01048	0.760
MOD_GlcNHglycan	376	379	PF01048	0.734
MOD_GlcNHglycan	59	62	PF01048	0.786
MOD_GlcNHglycan	77	80	PF01048	0.788
MOD_GSK3_1	123	130	PF00069	0.703
MOD_GSK3_1	140	147	PF00069	0.758
MOD_GSK3_1	15	22	PF00069	0.705
MOD_GSK3_1	166	173	PF00069	0.816
MOD_GSK3_1	225	232	PF00069	0.831
MOD_GSK3_1	234	241	PF00069	0.683
MOD_GSK3_1	24	31	PF00069	0.706
MOD_GSK3_1	288	295	PF00069	0.785
MOD_GSK3_1	332	339	PF00069	0.804
MOD_GSK3_1	53	60	PF00069	0.740
MOD_GSK3_1	80	87	PF00069	0.813
MOD_GSK3_1	94	101	PF00069	0.595
MOD_N-GLC_1	115	120	PF02516	0.819
MOD_N-GLC_1	374	379	PF02516	0.742
MOD_NEK2_1	124	129	PF00069	0.802
MOD_NEK2_1	149	154	PF00069	0.768
MOD_NEK2_1	172	177	PF00069	0.646
MOD_NEK2_1	188	193	PF00069	0.603
MOD_NEK2_1	263	268	PF00069	0.741
MOD_NEK2_1	288	293	PF00069	0.825
MOD_NEK2_1	320	325	PF00069	0.799
MOD_NEK2_1	68	73	PF00069	0.812
MOD_PIKK_1	135	141	PF00454	0.746
MOD_PIKK_1	149	155	PF00454	0.698
MOD_PIKK_1	166	172	PF00454	0.717
MOD_PIKK_1	225	231	PF00454	0.831
MOD_PIKK_1	238	244	PF00454	0.607
MOD_PIKK_1	265	271	PF00454	0.703
MOD_PIKK_1	274	280	PF00454	0.743
MOD_PIKK_1	313	319	PF00454	0.802
MOD_PIKK_1	325	331	PF00454	0.763
MOD_PIKK_1	50	56	PF00454	0.702
MOD_PIKK_1	68	74	PF00454	0.813
MOD_PKA_2	122	128	PF00069	0.761
MOD_PKA_2	300	306	PF00069	0.787
MOD_Plk_1	115	121	PF00069	0.817
MOD_Plk_1	301	307	PF00069	0.723
MOD_Plk_4	100	106	PF00069	0.789
MOD_Plk_4	268	274	PF00069	0.737
MOD_Plk_4	332	338	PF00069	0.776
MOD_ProDKin_1	127	133	PF00069	0.806
MOD_ProDKin_1	144	150	PF00069	0.784
MOD_ProDKin_1	164	170	PF00069	0.486
MOD_ProDKin_1	177	183	PF00069	0.582
MOD_ProDKin_1	229	235	PF00069	0.806
MOD_ProDKin_1	255	261	PF00069	0.773
MOD_ProDKin_1	292	298	PF00069	0.775
MOD_ProDKin_1	311	317	PF00069	0.625
MOD_ProDKin_1	336	342	PF00069	0.755
MOD_ProDKin_1	345	351	PF00069	0.769
MOD_ProDKin_1	359	365	PF00069	0.626
MOD_ProDKin_1	45	51	PF00069	0.806
MOD_ProDKin_1	55	61	PF00069	0.633
MOD_ProDKin_1	91	97	PF00069	0.760
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.777
TRG_ER_diArg_1	184	187	PF00400	0.824
TRG_ER_diArg_1	7	9	PF00400	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C9	Leptomonas seymouri	33%	98%
A0A3S7X2N6	Leishmania donovani	95%	100%
A4HHM8	Leishmania braziliensis	81%	100%
A4I4U3	Leishmania infantum	96%	100%
E9ALJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%