PlsC domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase, putative

Species:

Leishmania major

UniProt:

E9AE90_LEIMA

TriTrypDb:

LmjF.29.2280 , LMJLV39_290030900 , LMJSD75_290031200

Length:

307

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 28
NetGPI	no	yes: 0, no: 28

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	23
GO:0110165	cellular anatomical entity	1	23

Expansion

Sequence features

E9AE90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE90

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	5
GO:0006644	phospholipid metabolic process	4	5
GO:0006650	glycerophospholipid metabolic process	5	5
GO:0006654	phosphatidic acid biosynthetic process	6	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0008610	lipid biosynthetic process	4	5
GO:0008654	phospholipid biosynthetic process	5	5
GO:0009058	biosynthetic process	2	5
GO:0009987	cellular process	1	5
GO:0019637	organophosphate metabolic process	3	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044249	cellular biosynthetic process	3	5
GO:0044255	cellular lipid metabolic process	3	5
GO:0045017	glycerolipid biosynthetic process	4	5
GO:0046473	phosphatidic acid metabolic process	6	5
GO:0046474	glycerophospholipid biosynthetic process	5	5
GO:0046486	glycerolipid metabolic process	4	5
GO:0071704	organic substance metabolic process	2	5
GO:0090407	organophosphate biosynthetic process	4	5
GO:1901576	organic substance biosynthetic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	29
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	7	5
GO:0008374	O-acyltransferase activity	5	5
GO:0016411	acylglycerol O-acyltransferase activity	6	5
GO:0016740	transferase activity	2	29
GO:0016746	acyltransferase activity	3	29
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	5
GO:0042171	lysophosphatidic acid acyltransferase activity	6	5
GO:0071617	lysophospholipid acyltransferase activity	5	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.321
CLV_C14_Caspase3-7	265	269	PF00656	0.284
CLV_NRD_NRD_1	22	24	PF00675	0.299
CLV_PCSK_FUR_1	291	295	PF00082	0.628
CLV_PCSK_KEX2_1	293	295	PF00082	0.573
CLV_PCSK_KEX2_1	301	303	PF00082	0.636
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.586
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.623
CLV_PCSK_SKI1_1	135	139	PF00082	0.504
CLV_PCSK_SKI1_1	218	222	PF00082	0.501
DOC_CYCLIN_RxL_1	189	199	PF00134	0.242
DOC_MAPK_DCC_7	21	30	PF00069	0.555
DOC_MAPK_gen_1	21	29	PF00069	0.516
DOC_MAPK_MEF2A_6	21	30	PF00069	0.509
DOC_MAPK_MEF2A_6	83	91	PF00069	0.317
DOC_PP1_RVXF_1	190	197	PF00149	0.338
DOC_PP2B_PxIxI_1	86	92	PF00149	0.270
DOC_PP4_FxxP_1	84	87	PF00568	0.257
DOC_USP7_UBL2_3	135	139	PF12436	0.234
DOC_USP7_UBL2_3	293	297	PF12436	0.267
DOC_WW_Pin1_4	202	207	PF00397	0.276
DOC_WW_Pin1_4	83	88	PF00397	0.250
LIG_14-3-3_CanoR_1	31	37	PF00244	0.470
LIG_BIR_II_1	1	5	PF00653	0.285
LIG_BRCT_BRCA1_1	113	117	PF00533	0.192
LIG_BRCT_BRCA1_1	192	196	PF00533	0.342
LIG_BRCT_BRCA1_1	96	100	PF00533	0.253
LIG_CORNRBOX	4	12	PF00104	0.220
LIG_CSL_BTD_1	238	241	PF09270	0.368
LIG_FHA_1	148	154	PF00498	0.295
LIG_FHA_1	203	209	PF00498	0.325
LIG_FHA_1	33	39	PF00498	0.321
LIG_GBD_Chelix_1	272	280	PF00786	0.545
LIG_LIR_Gen_1	114	125	PF02991	0.273
LIG_LIR_Gen_1	252	262	PF02991	0.355
LIG_LIR_Gen_1	35	44	PF02991	0.416
LIG_LIR_Gen_1	5	13	PF02991	0.444
LIG_LIR_Gen_1	97	105	PF02991	0.330
LIG_LIR_Nem_3	114	120	PF02991	0.294
LIG_LIR_Nem_3	216	220	PF02991	0.286
LIG_LIR_Nem_3	252	257	PF02991	0.338
LIG_LIR_Nem_3	35	39	PF02991	0.384
LIG_LIR_Nem_3	5	9	PF02991	0.461
LIG_LIR_Nem_3	97	103	PF02991	0.337
LIG_Pex14_1	124	128	PF04695	0.338
LIG_Pex14_1	299	303	PF04695	0.263
LIG_Pex14_2	158	162	PF04695	0.299
LIG_REV1ctd_RIR_1	135	143	PF16727	0.324
LIG_SH2_PTP2	254	257	PF00017	0.380
LIG_SH2_SRC	254	257	PF00017	0.331
LIG_SH2_STAP1	34	38	PF00017	0.402
LIG_SH2_STAT5	125	128	PF00017	0.305
LIG_SH2_STAT5	130	133	PF00017	0.281
LIG_SH2_STAT5	161	164	PF00017	0.263
LIG_SH2_STAT5	229	232	PF00017	0.291
LIG_SH2_STAT5	254	257	PF00017	0.305
LIG_SH2_STAT5	262	265	PF00017	0.335
LIG_SH2_STAT5	34	37	PF00017	0.368
LIG_SH3_1	244	250	PF00018	0.336
LIG_SH3_3	235	241	PF00018	0.295
LIG_SH3_3	244	250	PF00018	0.311
LIG_SH3_4	297	304	PF00018	0.279
LIG_SUMO_SIM_anti_2	150	155	PF11976	0.203
LIG_SUMO_SIM_par_1	285	292	PF11976	0.257
LIG_TYR_ITIM	126	131	PF00017	0.324
LIG_UBA3_1	287	293	PF00899	0.385
LIG_WRC_WIRS_1	134	139	PF05994	0.292
LIG_WRC_WIRS_1	214	219	PF05994	0.293
LIG_WRPW_2	296	299	PF00400	0.353
MOD_CDK_SPxxK_3	83	90	PF00069	0.299
MOD_CK1_1	2	8	PF00069	0.497
MOD_CK1_1	216	222	PF00069	0.313
MOD_CK1_1	99	105	PF00069	0.325
MOD_CK2_1	99	105	PF00069	0.377
MOD_GSK3_1	112	119	PF00069	0.281
MOD_GSK3_1	162	169	PF00069	0.264
MOD_GSK3_1	94	101	PF00069	0.356
MOD_N-GLC_1	202	207	PF02516	0.476
MOD_N-GLC_2	108	110	PF02516	0.415
MOD_NEK2_1	111	116	PF00069	0.265
MOD_NEK2_1	138	143	PF00069	0.306
MOD_NEK2_1	147	152	PF00069	0.300
MOD_NEK2_1	60	65	PF00069	0.330
MOD_NEK2_1	98	103	PF00069	0.403
MOD_NEK2_2	112	117	PF00069	0.276
MOD_PIKK_1	63	69	PF00454	0.372
MOD_Plk_4	112	118	PF00069	0.283
MOD_Plk_4	133	139	PF00069	0.251
MOD_Plk_4	147	153	PF00069	0.271
MOD_Plk_4	2	8	PF00069	0.479
MOD_Plk_4	216	222	PF00069	0.329
MOD_Plk_4	50	56	PF00069	0.375
MOD_Plk_4	65	71	PF00069	0.213
MOD_ProDKin_1	202	208	PF00069	0.276
MOD_ProDKin_1	83	89	PF00069	0.248
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.462
TRG_ENDOCYTIC_2	128	131	PF00928	0.345
TRG_ENDOCYTIC_2	13	16	PF00928	0.381
TRG_ENDOCYTIC_2	228	231	PF00928	0.281
TRG_ENDOCYTIC_2	254	257	PF00928	0.316
TRG_NES_CRM1_1	278	292	PF08389	0.350
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P455	Leptomonas seymouri	36%	90%
A0A0N1HTP4	Leptomonas seymouri	32%	100%
A0A0N1I6V1	Leptomonas seymouri	49%	100%
A0A0N1IKX5	Leptomonas seymouri	67%	100%
A0A0S4IQ05	Bodo saltans	45%	91%
A0A0S4IR22	Bodo saltans	38%	100%
A0A0S4JRB2	Bodo saltans	37%	96%
A0A1X0P9F0	Trypanosomatidae	46%	100%
A0A3R7NKA0	Trypanosoma rangeli	45%	100%
A0A3S5H5E4	Leishmania donovani	33%	71%
A0A3S5H7L8	Leishmania donovani	90%	95%
A0A3S7WNW6	Leishmania donovani	33%	86%
A4H418	Leishmania braziliensis	38%	100%
A4H419	Leishmania braziliensis	34%	91%
A4H420	Leishmania braziliensis	32%	86%
A4HHM7	Leishmania braziliensis	74%	100%
A4HSA1	Leishmania infantum	33%	100%
A4HSA2	Leishmania infantum	33%	86%
A4I4U1	Leishmania infantum	58%	95%
A4I4U2	Leishmania infantum	92%	100%
C9ZLI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AE89	Leishmania major	61%	100%
E9AK86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ALJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
Q9NF90	Leishmania major	32%	86%
Q9NF91	Leishmania major	35%	80%
V5C201	Trypanosoma cruzi	45%	100%