DNA replication complex GINS protein SLD5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication complex GINS protein SLD5, putative

Species:

Leishmania major

UniProt:

E9AE88_LEIMA

TriTrypDb:

LmjF.29.2260 , LMJLV39_290030700 , LMJSD75_290030900

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000811	GINS complex	4	2
GO:0031261	DNA replication preinitiation complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0032993	protein-DNA complex	2	2
GO:0140513	nuclear protein-containing complex	2	2
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AE88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE88

Function

Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	2
GO:0000725	recombinational repair	6	2
GO:0000727	double-strand break repair via break-induced replication	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	12
GO:0006261	DNA-templated DNA replication	6	12
GO:0006281	DNA repair	5	2
GO:0006302	double-strand break repair	6	2
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.360
CLV_PCSK_KEX2_1	123	125	PF00082	0.530
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.483
CLV_PCSK_SKI1_1	129	133	PF00082	0.587
CLV_PCSK_SKI1_1	225	229	PF00082	0.435
CLV_Separin_Metazoa	153	157	PF03568	0.305
DEG_APCC_DBOX_1	155	163	PF00400	0.315
DEG_Nend_Nbox_1	1	3	PF02207	0.540
DOC_CKS1_1	301	306	PF01111	0.521
DOC_MAPK_MEF2A_6	135	144	PF00069	0.415
DOC_PP1_RVXF_1	144	150	PF00149	0.418
DOC_PP4_FxxP_1	301	304	PF00568	0.424
DOC_USP7_MATH_1	127	131	PF00917	0.548
DOC_USP7_MATH_1	176	180	PF00917	0.601
DOC_USP7_MATH_1	194	198	PF00917	0.638
DOC_USP7_MATH_1	251	255	PF00917	0.517
DOC_USP7_MATH_1	40	44	PF00917	0.659
DOC_USP7_MATH_1	58	62	PF00917	0.517
DOC_WW_Pin1_4	300	305	PF00397	0.521
DOC_WW_Pin1_4	87	92	PF00397	0.479
LIG_14-3-3_CanoR_1	212	218	PF00244	0.385
LIG_14-3-3_CanoR_1	225	235	PF00244	0.525
LIG_Actin_WH2_2	144	162	PF00022	0.340
LIG_BRCT_BRCA1_1	45	49	PF00533	0.664
LIG_FHA_1	46	52	PF00498	0.661
LIG_FHA_2	82	88	PF00498	0.369
LIG_LIR_Apic_2	299	304	PF02991	0.424
LIG_LIR_Gen_1	10	19	PF02991	0.568
LIG_LIR_Gen_1	303	313	PF02991	0.510
LIG_LIR_Nem_3	10	16	PF02991	0.624
LIG_LIR_Nem_3	168	174	PF02991	0.446
LIG_LIR_Nem_3	303	308	PF02991	0.485
LIG_NRBOX	150	156	PF00104	0.323
LIG_PCNA_yPIPBox_3	110	119	PF02747	0.499
LIG_SH2_GRB2like	305	308	PF00017	0.510
LIG_SH2_STAP1	13	17	PF00017	0.570
LIG_SH2_STAT5	248	251	PF00017	0.498
LIG_SH2_STAT5	270	273	PF00017	0.424
LIG_SH2_STAT5	311	314	PF00017	0.453
LIG_SH3_3	130	136	PF00018	0.447
LIG_SH3_3	20	26	PF00018	0.592
LIG_SH3_3	204	210	PF00018	0.509
LIG_SH3_3	247	253	PF00018	0.345
LIG_SH3_3	52	58	PF00018	0.712
LIG_SUMO_SIM_anti_2	257	264	PF11976	0.452
LIG_TYR_ITIM	11	16	PF00017	0.467
LIG_TYR_ITIM	169	174	PF00017	0.450
LIG_WRPW_2	308	311	PF00400	0.435
MOD_CK1_1	196	202	PF00069	0.664
MOD_CK1_1	28	34	PF00069	0.706
MOD_CK1_1	43	49	PF00069	0.689
MOD_CK2_1	213	219	PF00069	0.353
MOD_CK2_1	251	257	PF00069	0.534
MOD_CK2_1	81	87	PF00069	0.361
MOD_GlcNHglycan	183	186	PF01048	0.575
MOD_GlcNHglycan	196	199	PF01048	0.677
MOD_GlcNHglycan	228	231	PF01048	0.453
MOD_GlcNHglycan	236	239	PF01048	0.360
MOD_GlcNHglycan	313	316	PF01048	0.316
MOD_GlcNHglycan	36	39	PF01048	0.648
MOD_GlcNHglycan	42	45	PF01048	0.635
MOD_GlcNHglycan	60	63	PF01048	0.523
MOD_GlcNHglycan	70	73	PF01048	0.409
MOD_GSK3_1	177	184	PF00069	0.587
MOD_GSK3_1	189	196	PF00069	0.652
MOD_GSK3_1	234	241	PF00069	0.488
MOD_GSK3_1	34	41	PF00069	0.644
MOD_GSK3_1	66	73	PF00069	0.477
MOD_GSK3_1	96	103	PF00069	0.495
MOD_N-GLC_1	213	218	PF02516	0.494
MOD_N-GLC_1	7	12	PF02516	0.636
MOD_NEK2_1	165	170	PF00069	0.337
MOD_NEK2_1	226	231	PF00069	0.459
MOD_NEK2_1	234	239	PF00069	0.363
MOD_PIKK_1	108	114	PF00454	0.497
MOD_PIKK_1	25	31	PF00454	0.691
MOD_PIKK_1	66	72	PF00454	0.593
MOD_PKA_2	134	140	PF00069	0.416
MOD_Plk_1	213	219	PF00069	0.407
MOD_Plk_1	7	13	PF00069	0.543
MOD_Plk_4	100	106	PF00069	0.430
MOD_Plk_4	12	18	PF00069	0.637
MOD_Plk_4	165	171	PF00069	0.368
MOD_ProDKin_1	300	306	PF00069	0.521
MOD_ProDKin_1	87	93	PF00069	0.476
TRG_DiLeu_BaEn_1	12	17	PF01217	0.635
TRG_ENDOCYTIC_2	13	16	PF00928	0.633
TRG_ENDOCYTIC_2	171	174	PF00928	0.458
TRG_ENDOCYTIC_2	305	308	PF00928	0.424
TRG_ER_diArg_1	155	158	PF00400	0.322
TRG_NES_CRM1_1	266	278	PF08389	0.473
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I580	Leptomonas seymouri	63%	100%
A0A0S4IV76	Bodo saltans	39%	100%
A0A1X0PA08	Trypanosomatidae	40%	100%
A0A3R7MDL7	Trypanosoma rangeli	42%	100%
A0A3S7X2T6	Leishmania donovani	97%	100%
A4HHM6	Leishmania braziliensis	81%	100%
A4I4U0	Leishmania infantum	96%	100%
C9ZLI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ALJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q6CKF3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	30%	100%
V5DTT2	Trypanosoma cruzi	47%	100%