KLRAQ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE87_LEIMA

TriTrypDb:

LmjF.29.2250 , LMJLV39_290030600 , LMJSD75_290030800

Length:

707

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AE87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE87

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.421
CLV_C14_Caspase3-7	531	535	PF00656	0.493
CLV_NRD_NRD_1	178	180	PF00675	0.577
CLV_NRD_NRD_1	408	410	PF00675	0.633
CLV_NRD_NRD_1	67	69	PF00675	0.488
CLV_PCSK_KEX2_1	178	180	PF00082	0.661
CLV_PCSK_SKI1_1	206	210	PF00082	0.599
CLV_PCSK_SKI1_1	271	275	PF00082	0.472
CLV_PCSK_SKI1_1	533	537	PF00082	0.404
CLV_PCSK_SKI1_1	68	72	PF00082	0.558
CLV_PCSK_SKI1_1	680	684	PF00082	0.454
DEG_APCC_DBOX_1	369	377	PF00400	0.388
DEG_APCC_DBOX_1	532	540	PF00400	0.408
DEG_SPOP_SBC_1	601	605	PF00917	0.503
DOC_CKS1_1	578	583	PF01111	0.519
DOC_CYCLIN_RxL_1	268	278	PF00134	0.497
DOC_MAPK_gen_1	25	31	PF00069	0.462
DOC_MAPK_gen_1	303	310	PF00069	0.393
DOC_MAPK_gen_1	316	323	PF00069	0.396
DOC_MAPK_gen_1	507	516	PF00069	0.337
DOC_MAPK_MEF2A_6	275	284	PF00069	0.470
DOC_MAPK_MEF2A_6	303	310	PF00069	0.414
DOC_MAPK_MEF2A_6	370	377	PF00069	0.484
DOC_MAPK_MEF2A_6	619	627	PF00069	0.513
DOC_MAPK_NFAT4_5	370	378	PF00069	0.489
DOC_USP7_MATH_1	253	257	PF00917	0.572
DOC_USP7_MATH_1	262	266	PF00917	0.597
DOC_USP7_MATH_1	395	399	PF00917	0.727
DOC_USP7_MATH_1	515	519	PF00917	0.439
DOC_USP7_MATH_1	547	551	PF00917	0.592
DOC_USP7_MATH_1	601	605	PF00917	0.592
DOC_USP7_MATH_1	633	637	PF00917	0.593
DOC_USP7_MATH_1	682	686	PF00917	0.584
DOC_USP7_MATH_2	586	592	PF00917	0.523
DOC_WW_Pin1_4	121	126	PF00397	0.592
DOC_WW_Pin1_4	444	449	PF00397	0.581
DOC_WW_Pin1_4	553	558	PF00397	0.474
DOC_WW_Pin1_4	577	582	PF00397	0.692
DOC_WW_Pin1_4	702	707	PF00397	0.602
LIG_14-3-3_CanoR_1	120	124	PF00244	0.626
LIG_14-3-3_CanoR_1	130	138	PF00244	0.508
LIG_14-3-3_CanoR_1	162	170	PF00244	0.420
LIG_14-3-3_CanoR_1	178	182	PF00244	0.645
LIG_14-3-3_CanoR_1	258	262	PF00244	0.494
LIG_14-3-3_CanoR_1	275	280	PF00244	0.419
LIG_14-3-3_CanoR_1	293	297	PF00244	0.555
LIG_14-3-3_CanoR_1	305	309	PF00244	0.357
LIG_14-3-3_CanoR_1	409	419	PF00244	0.641
LIG_14-3-3_CanoR_1	41	49	PF00244	0.572
LIG_14-3-3_CanoR_1	632	638	PF00244	0.638
LIG_14-3-3_CanoR_1	68	74	PF00244	0.594
LIG_Actin_WH2_2	163	180	PF00022	0.544
LIG_APCC_ABBA_1	306	311	PF00400	0.448
LIG_APCC_ABBAyCdc20_2	305	311	PF00400	0.496
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_CtBP_PxDLS_1	486	490	PF00389	0.550
LIG_EH1_1	207	215	PF00400	0.525
LIG_EVH1_1	464	468	PF00568	0.523
LIG_FHA_1	158	164	PF00498	0.598
LIG_FHA_1	172	178	PF00498	0.604
LIG_FHA_1	226	232	PF00498	0.687
LIG_FHA_1	258	264	PF00498	0.374
LIG_FHA_1	392	398	PF00498	0.620
LIG_FHA_1	475	481	PF00498	0.766
LIG_FHA_1	51	57	PF00498	0.588
LIG_FHA_1	690	696	PF00498	0.564
LIG_FHA_2	145	151	PF00498	0.535
LIG_FHA_2	225	231	PF00498	0.692
LIG_FHA_2	293	299	PF00498	0.508
LIG_FHA_2	409	415	PF00498	0.475
LIG_FHA_2	467	473	PF00498	0.710
LIG_FHA_2	655	661	PF00498	0.520
LIG_GBD_Chelix_1	280	288	PF00786	0.559
LIG_LIR_Apic_2	551	557	PF02991	0.449
LIG_LIR_Gen_1	618	627	PF02991	0.618
LIG_LIR_Gen_1	636	646	PF02991	0.597
LIG_LIR_Nem_3	364	368	PF02991	0.419
LIG_LIR_Nem_3	389	393	PF02991	0.438
LIG_LIR_Nem_3	449	455	PF02991	0.569
LIG_LIR_Nem_3	618	623	PF02991	0.633
LIG_MYND_1	557	561	PF01753	0.473
LIG_NRBOX	319	325	PF00104	0.453
LIG_NRBOX	488	494	PF00104	0.555
LIG_Pex14_2	204	208	PF04695	0.459
LIG_SH2_CRK	427	431	PF00017	0.533
LIG_SH2_CRK	554	558	PF00017	0.476
LIG_SH2_SRC	643	646	PF00017	0.487
LIG_SH2_STAP1	393	397	PF00017	0.521
LIG_SH2_STAP1	427	431	PF00017	0.544
LIG_SH2_STAP1	616	620	PF00017	0.631
LIG_SH2_STAT3	637	640	PF00017	0.500
LIG_SH2_STAT5	195	198	PF00017	0.580
LIG_SH2_STAT5	322	325	PF00017	0.530
LIG_SH2_STAT5	390	393	PF00017	0.559
LIG_SH2_STAT5	538	541	PF00017	0.484
LIG_SH2_STAT5	638	641	PF00017	0.533
LIG_SH2_STAT5	643	646	PF00017	0.492
LIG_SH3_3	228	234	PF00018	0.759
LIG_SH3_3	462	468	PF00018	0.609
LIG_SH3_3	575	581	PF00018	0.655
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.366
LIG_SUMO_SIM_anti_2	378	385	PF11976	0.397
LIG_SUMO_SIM_anti_2	685	692	PF11976	0.559
LIG_SUMO_SIM_par_1	259	265	PF11976	0.448
LIG_SUMO_SIM_par_1	27	32	PF11976	0.460
LIG_SUMO_SIM_par_1	373	379	PF11976	0.448
LIG_SUMO_SIM_par_1	512	518	PF11976	0.411
LIG_SUMO_SIM_par_1	621	628	PF11976	0.602
LIG_TRAF2_1	216	219	PF00917	0.580
LIG_TRAF2_1	3	6	PF00917	0.541
LIG_TRAF2_1	337	340	PF00917	0.652
LIG_TRAF2_1	549	552	PF00917	0.574
LIG_TRAF2_1	75	78	PF00917	0.405
MOD_CDK_SPK_2	553	558	PF00069	0.468
MOD_CK1_1	222	228	PF00069	0.674
MOD_CK1_1	239	245	PF00069	0.619
MOD_CK1_1	329	335	PF00069	0.558
MOD_CK1_1	398	404	PF00069	0.768
MOD_CK1_1	50	56	PF00069	0.624
MOD_CK1_1	505	511	PF00069	0.569
MOD_CK1_1	587	593	PF00069	0.707
MOD_CK1_1	604	610	PF00069	0.585
MOD_CK1_1	636	642	PF00069	0.594
MOD_CK1_1	685	691	PF00069	0.587
MOD_CK1_1	82	88	PF00069	0.572
MOD_CK2_1	130	136	PF00069	0.475
MOD_CK2_1	144	150	PF00069	0.449
MOD_CK2_1	224	230	PF00069	0.692
MOD_CK2_1	408	414	PF00069	0.586
MOD_CK2_1	466	472	PF00069	0.745
MOD_CK2_1	475	481	PF00069	0.657
MOD_CK2_1	654	660	PF00069	0.496
MOD_GlcNHglycan	103	106	PF01048	0.664
MOD_GlcNHglycan	115	118	PF01048	0.484
MOD_GlcNHglycan	155	158	PF01048	0.599
MOD_GlcNHglycan	241	244	PF01048	0.729
MOD_GlcNHglycan	264	267	PF01048	0.505
MOD_GlcNHglycan	331	334	PF01048	0.555
MOD_GlcNHglycan	342	345	PF01048	0.647
MOD_GlcNHglycan	346	349	PF01048	0.598
MOD_GlcNHglycan	397	400	PF01048	0.678
MOD_GlcNHglycan	517	520	PF01048	0.446
MOD_GlcNHglycan	627	630	PF01048	0.558
MOD_GlcNHglycan	82	85	PF01048	0.625
MOD_GSK3_1	153	160	PF00069	0.449
MOD_GSK3_1	253	260	PF00069	0.493
MOD_GSK3_1	262	269	PF00069	0.427
MOD_GSK3_1	340	347	PF00069	0.668
MOD_GSK3_1	391	398	PF00069	0.608
MOD_GSK3_1	429	436	PF00069	0.519
MOD_GSK3_1	466	473	PF00069	0.714
MOD_GSK3_1	476	483	PF00069	0.482
MOD_GSK3_1	501	508	PF00069	0.576
MOD_GSK3_1	584	591	PF00069	0.730
MOD_GSK3_1	595	602	PF00069	0.682
MOD_GSK3_1	685	692	PF00069	0.591
MOD_N-GLC_1	474	479	PF02516	0.774
MOD_N-GLC_1	527	532	PF02516	0.514
MOD_NEK2_1	209	214	PF00069	0.607
MOD_NEK2_1	224	229	PF00069	0.661
MOD_NEK2_1	247	252	PF00069	0.712
MOD_NEK2_1	368	373	PF00069	0.501
MOD_NEK2_1	376	381	PF00069	0.491
MOD_NEK2_1	474	479	PF00069	0.694
MOD_NEK2_1	480	485	PF00069	0.619
MOD_NEK2_1	487	492	PF00069	0.413
MOD_NEK2_1	509	514	PF00069	0.517
MOD_NEK2_1	689	694	PF00069	0.592
MOD_NEK2_2	266	271	PF00069	0.535
MOD_NEK2_2	502	507	PF00069	0.489
MOD_PIKK_1	171	177	PF00454	0.626
MOD_PIKK_1	326	332	PF00454	0.526
MOD_PIKK_1	368	374	PF00454	0.531
MOD_PIKK_1	40	46	PF00454	0.591
MOD_PIKK_1	480	486	PF00454	0.666
MOD_PIKK_1	50	56	PF00454	0.608
MOD_PIKK_1	636	642	PF00454	0.476
MOD_PIKK_1	682	688	PF00454	0.461
MOD_PIKK_1	689	695	PF00454	0.460
MOD_PK_1	275	281	PF00069	0.485
MOD_PKA_1	19	25	PF00069	0.582
MOD_PKA_1	316	322	PF00069	0.479
MOD_PKA_1	409	415	PF00069	0.511
MOD_PKA_2	113	119	PF00069	0.620
MOD_PKA_2	171	177	PF00069	0.544
MOD_PKA_2	219	225	PF00069	0.671
MOD_PKA_2	257	263	PF00069	0.518
MOD_PKA_2	292	298	PF00069	0.621
MOD_PKA_2	304	310	PF00069	0.343
MOD_PKA_2	40	46	PF00069	0.575
MOD_PKA_2	408	414	PF00069	0.523
MOD_PKA_2	509	515	PF00069	0.511
MOD_PKA_2	611	617	PF00069	0.530
MOD_PKA_2	80	86	PF00069	0.616
MOD_Plk_1	487	493	PF00069	0.523
MOD_Plk_1	587	593	PF00069	0.766
MOD_Plk_2-3	292	298	PF00069	0.631
MOD_Plk_4	209	215	PF00069	0.548
MOD_Plk_4	219	225	PF00069	0.504
MOD_Plk_4	269	275	PF00069	0.393
MOD_Plk_4	304	310	PF00069	0.422
MOD_Plk_4	316	322	PF00069	0.342
MOD_Plk_4	388	394	PF00069	0.574
MOD_Plk_4	488	494	PF00069	0.565
MOD_Plk_4	509	515	PF00069	0.572
MOD_Plk_4	633	639	PF00069	0.557
MOD_Plk_4	94	100	PF00069	0.544
MOD_ProDKin_1	121	127	PF00069	0.583
MOD_ProDKin_1	444	450	PF00069	0.588
MOD_ProDKin_1	553	559	PF00069	0.474
MOD_ProDKin_1	577	583	PF00069	0.695
MOD_SUMO_for_1	163	166	PF00179	0.496
MOD_SUMO_rev_2	13	22	PF00179	0.503
MOD_SUMO_rev_2	672	679	PF00179	0.626
TRG_DiLeu_BaEn_1	364	369	PF01217	0.414
TRG_DiLeu_BaEn_1	6	11	PF01217	0.544
TRG_DiLeu_BaEn_2	218	224	PF01217	0.568
TRG_DiLeu_BaEn_2	413	419	PF01217	0.482
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.590
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.464
TRG_ENDOCYTIC_2	427	430	PF00928	0.536
TRG_ENDOCYTIC_2	620	623	PF00928	0.626
TRG_ENDOCYTIC_2	638	641	PF00928	0.389
TRG_ENDOCYTIC_2	643	646	PF00928	0.492
TRG_ER_diArg_1	177	179	PF00400	0.500
TRG_ER_diArg_1	594	597	PF00400	0.645
TRG_NES_CRM1_1	249	264	PF08389	0.380
TRG_NES_CRM1_1	298	311	PF08389	0.478
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYM6	Leptomonas seymouri	53%	95%
A0A1X0P953	Trypanosomatidae	30%	100%
A0A3R7K9I4	Trypanosoma rangeli	31%	100%
A0A3S7X2P1	Leishmania donovani	92%	100%
A4HHM5	Leishmania braziliensis	76%	100%
A4I4T4	Leishmania infantum	92%	100%
C9ZLI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ALJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BC22	Trypanosoma cruzi	32%	100%