Aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Aminopeptidase

Gene product:

Aminopeptidase M1, putative

Species:

Leishmania major

UniProt:

E9AE86_LEIMA

TriTrypDb:

LmjF.29.2240 , LMJLV39_290030400 , LMJSD75_290030500

Length:

868

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AE86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE86

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006518	peptide metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043171	peptide catabolic process	4	2
GO:0043603	amide metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	2
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004177	aminopeptidase activity	5	12
GO:0005488	binding	1	12
GO:0008233	peptidase activity	3	12
GO:0008235	metalloexopeptidase activity	5	2
GO:0008237	metallopeptidase activity	4	12
GO:0008238	exopeptidase activity	4	12
GO:0008270	zinc ion binding	6	12
GO:0016787	hydrolase activity	2	12
GO:0033218	amide binding	2	2
GO:0042277	peptide binding	3	2
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0070006	metalloaminopeptidase activity	6	2
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	489	493	PF00656	0.443
CLV_NRD_NRD_1	411	413	PF00675	0.210
CLV_NRD_NRD_1	455	457	PF00675	0.417
CLV_NRD_NRD_1	527	529	PF00675	0.339
CLV_NRD_NRD_1	556	558	PF00675	0.293
CLV_NRD_NRD_1	645	647	PF00675	0.371
CLV_NRD_NRD_1	71	73	PF00675	0.422
CLV_PCSK_KEX2_1	291	293	PF00082	0.340
CLV_PCSK_KEX2_1	527	529	PF00082	0.349
CLV_PCSK_KEX2_1	556	558	PF00082	0.293
CLV_PCSK_KEX2_1	645	647	PF00082	0.371
CLV_PCSK_KEX2_1	71	73	PF00082	0.422
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.340
CLV_PCSK_SKI1_1	470	474	PF00082	0.465
CLV_PCSK_SKI1_1	5	9	PF00082	0.464
CLV_PCSK_SKI1_1	518	522	PF00082	0.412
CLV_PCSK_SKI1_1	557	561	PF00082	0.345
CLV_PCSK_SKI1_1	579	583	PF00082	0.348
CLV_PCSK_SKI1_1	65	69	PF00082	0.387
DEG_SCF_FBW7_2	625	630	PF00400	0.210
DOC_CDC14_PxL_1	571	579	PF14671	0.346
DOC_CKS1_1	624	629	PF01111	0.210
DOC_CYCLIN_yCln2_LP_2	9	15	PF00134	0.374
DOC_MAPK_DCC_7	248	256	PF00069	0.296
DOC_MAPK_gen_1	105	115	PF00069	0.422
DOC_MAPK_gen_1	223	233	PF00069	0.362
DOC_MAPK_gen_1	456	464	PF00069	0.378
DOC_MAPK_gen_1	477	486	PF00069	0.483
DOC_MAPK_gen_1	503	512	PF00069	0.540
DOC_MAPK_MEF2A_6	147	156	PF00069	0.278
DOC_MAPK_MEF2A_6	226	235	PF00069	0.210
DOC_MAPK_MEF2A_6	248	256	PF00069	0.293
DOC_MAPK_MEF2A_6	480	488	PF00069	0.469
DOC_MAPK_MEF2A_6	503	512	PF00069	0.530
DOC_MAPK_RevD_3	278	292	PF00069	0.396
DOC_PP2B_PxIxI_1	449	455	PF00149	0.357
DOC_PP2B_PxIxI_1	56	62	PF00149	0.346
DOC_PP4_FxxP_1	624	627	PF00568	0.422
DOC_USP7_MATH_1	170	174	PF00917	0.410
DOC_USP7_MATH_1	283	287	PF00917	0.349
DOC_USP7_MATH_1	439	443	PF00917	0.307
DOC_USP7_MATH_1	55	59	PF00917	0.439
DOC_USP7_MATH_1	664	668	PF00917	0.425
DOC_USP7_MATH_1	736	740	PF00917	0.434
DOC_USP7_MATH_1	806	810	PF00917	0.274
DOC_USP7_UBL2_3	116	120	PF12436	0.346
DOC_USP7_UBL2_3	615	619	PF12436	0.404
DOC_WW_Pin1_4	496	501	PF00397	0.503
DOC_WW_Pin1_4	549	554	PF00397	0.422
DOC_WW_Pin1_4	623	628	PF00397	0.479
DOC_WW_Pin1_4	633	638	PF00397	0.405
LIG_14-3-3_CanoR_1	123	132	PF00244	0.286
LIG_14-3-3_CanoR_1	470	479	PF00244	0.433
LIG_14-3-3_CanoR_1	556	560	PF00244	0.340
LIG_14-3-3_CanoR_1	702	706	PF00244	0.372
LIG_14-3-3_CanoR_1	848	853	PF00244	0.351
LIG_Actin_WH2_2	306	324	PF00022	0.278
LIG_APCC_ABBAyCdc20_2	556	562	PF00400	0.422
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_BRCT_BRCA1_1	125	129	PF00533	0.371
LIG_BRCT_BRCA1_1	741	745	PF00533	0.346
LIG_deltaCOP1_diTrp_1	317	325	PF00928	0.280
LIG_deltaCOP1_diTrp_1	781	790	PF00928	0.356
LIG_EH1_1	801	809	PF00400	0.278
LIG_FHA_1	149	155	PF00498	0.314
LIG_FHA_1	194	200	PF00498	0.395
LIG_FHA_1	2	8	PF00498	0.544
LIG_FHA_1	292	298	PF00498	0.332
LIG_FHA_1	34	40	PF00498	0.289
LIG_FHA_1	419	425	PF00498	0.278
LIG_FHA_1	435	441	PF00498	0.276
LIG_FHA_1	459	465	PF00498	0.448
LIG_FHA_1	479	485	PF00498	0.425
LIG_FHA_1	48	54	PF00498	0.265
LIG_FHA_1	497	503	PF00498	0.279
LIG_FHA_1	612	618	PF00498	0.346
LIG_FHA_1	76	82	PF00498	0.364
LIG_FHA_1	828	834	PF00498	0.371
LIG_FHA_1	85	91	PF00498	0.290
LIG_FHA_1	98	104	PF00498	0.274
LIG_FHA_2	125	131	PF00498	0.288
LIG_FHA_2	272	278	PF00498	0.410
LIG_FHA_2	30	36	PF00498	0.480
LIG_FHA_2	471	477	PF00498	0.442
LIG_FHA_2	824	830	PF00498	0.385
LIG_GBD_Chelix_1	391	399	PF00786	0.278
LIG_GBD_Chelix_1	807	815	PF00786	0.346
LIG_IBAR_NPY_1	11	13	PF08397	0.475
LIG_Integrin_RGD_1	503	505	PF01839	0.403
LIG_LIR_Apic_2	481	485	PF02991	0.317
LIG_LIR_Gen_1	160	171	PF02991	0.314
LIG_LIR_Gen_1	216	224	PF02991	0.454
LIG_LIR_Gen_1	239	249	PF02991	0.271
LIG_LIR_Gen_1	28	39	PF02991	0.301
LIG_LIR_Gen_1	377	385	PF02991	0.278
LIG_LIR_Gen_1	781	790	PF02991	0.420
LIG_LIR_Gen_1	822	832	PF02991	0.296
LIG_LIR_Gen_1	98	107	PF02991	0.301
LIG_LIR_LC3C_4	732	735	PF02991	0.256
LIG_LIR_Nem_3	126	132	PF02991	0.371
LIG_LIR_Nem_3	160	166	PF02991	0.314
LIG_LIR_Nem_3	216	221	PF02991	0.443
LIG_LIR_Nem_3	239	244	PF02991	0.271
LIG_LIR_Nem_3	268	273	PF02991	0.278
LIG_LIR_Nem_3	28	34	PF02991	0.301
LIG_LIR_Nem_3	327	331	PF02991	0.300
LIG_LIR_Nem_3	377	383	PF02991	0.314
LIG_LIR_Nem_3	630	635	PF02991	0.486
LIG_LIR_Nem_3	781	786	PF02991	0.418
LIG_LIR_Nem_3	822	827	PF02991	0.296
LIG_LIR_Nem_3	98	102	PF02991	0.410
LIG_LYPXL_yS_3	449	452	PF13949	0.346
LIG_PALB2_WD40_1	302	310	PF16756	0.278
LIG_PCNA_PIPBox_1	104	113	PF02747	0.301
LIG_PCNA_PIPBox_1	598	607	PF02747	0.278
LIG_PCNA_yPIPBox_3	104	116	PF02747	0.440
LIG_PCNA_yPIPBox_3	615	625	PF02747	0.331
LIG_Pex14_1	544	548	PF04695	0.422
LIG_Pex14_2	236	240	PF04695	0.297
LIG_Pex14_2	241	245	PF04695	0.262
LIG_Pex14_2	604	608	PF04695	0.422
LIG_Pex14_2	786	790	PF04695	0.293
LIG_Pex14_2	824	828	PF04695	0.278
LIG_PTB_Apo_2	535	542	PF02174	0.422
LIG_Rb_LxCxE_1	268	289	PF01857	0.293
LIG_REV1ctd_RIR_1	238	247	PF16727	0.308
LIG_SH2_CRK	218	222	PF00017	0.331
LIG_SH2_CRK	548	552	PF00017	0.287
LIG_SH2_CRK	717	721	PF00017	0.322
LIG_SH2_GRB2like	536	539	PF00017	0.422
LIG_SH2_NCK_1	31	35	PF00017	0.301
LIG_SH2_NCK_1	571	575	PF00017	0.371
LIG_SH2_PTP2	163	166	PF00017	0.346
LIG_SH2_SRC	13	16	PF00017	0.474
LIG_SH2_SRC	360	363	PF00017	0.275
LIG_SH2_SRC	536	539	PF00017	0.422
LIG_SH2_SRC	571	574	PF00017	0.371
LIG_SH2_SRC	649	652	PF00017	0.337
LIG_SH2_STAP1	536	540	PF00017	0.276
LIG_SH2_STAT3	337	340	PF00017	0.301
LIG_SH2_STAT3	763	766	PF00017	0.392
LIG_SH2_STAT5	13	16	PF00017	0.425
LIG_SH2_STAT5	138	141	PF00017	0.312
LIG_SH2_STAT5	163	166	PF00017	0.312
LIG_SH2_STAT5	194	197	PF00017	0.294
LIG_SH2_STAT5	31	34	PF00017	0.394
LIG_SH2_STAT5	410	413	PF00017	0.278
LIG_SH2_STAT5	592	595	PF00017	0.430
LIG_SH2_STAT5	649	652	PF00017	0.337
LIG_SH3_3	151	157	PF00018	0.287
LIG_SH3_3	186	192	PF00018	0.293
LIG_SH3_3	254	260	PF00018	0.278
LIG_SH3_3	363	369	PF00018	0.257
LIG_SH3_3	40	46	PF00018	0.301
LIG_SH3_3	507	513	PF00018	0.370
LIG_SH3_3	9	15	PF00018	0.374
LIG_SUMO_SIM_par_1	149	155	PF11976	0.346
LIG_SUMO_SIM_par_1	255	261	PF11976	0.278
LIG_SUMO_SIM_par_1	458	465	PF11976	0.366
LIG_SUMO_SIM_par_1	484	489	PF11976	0.366
LIG_TRAF2_1	427	430	PF00917	0.323
LIG_TRAF2_1	843	846	PF00917	0.301
LIG_TRAF2_2	144	149	PF00917	0.422
LIG_TYR_ITIM	569	574	PF00017	0.210
LIG_UBA3_1	379	387	PF00899	0.293
LIG_WRC_WIRS_1	440	445	PF05994	0.337
LIG_WRC_WIRS_1	601	606	PF05994	0.337
LIG_WRC_WIRS_1	807	812	PF05994	0.417
LIG_WRC_WIRS_1	824	829	PF05994	0.176
MOD_CDK_SPxxK_3	496	503	PF00069	0.501
MOD_CDK_SPxxK_3	549	556	PF00069	0.422
MOD_CK1_1	27	33	PF00069	0.422
MOD_CK1_1	442	448	PF00069	0.333
MOD_CK1_1	475	481	PF00069	0.526
MOD_CK1_1	549	555	PF00069	0.315
MOD_CK1_1	558	564	PF00069	0.354
MOD_CK1_1	653	659	PF00069	0.336
MOD_CK1_1	739	745	PF00069	0.450
MOD_CK1_1	770	776	PF00069	0.356
MOD_CK2_1	124	130	PF00069	0.278
MOD_CK2_1	271	277	PF00069	0.399
MOD_CK2_1	283	289	PF00069	0.324
MOD_CK2_1	29	35	PF00069	0.355
MOD_CK2_1	470	476	PF00069	0.416
MOD_CK2_1	582	588	PF00069	0.300
MOD_CK2_1	775	781	PF00069	0.346
MOD_CK2_1	823	829	PF00069	0.385
MOD_GlcNHglycan	132	135	PF01048	0.333
MOD_GlcNHglycan	15	18	PF01048	0.508
MOD_GlcNHglycan	352	355	PF01048	0.271
MOD_GlcNHglycan	404	407	PF01048	0.301
MOD_GlcNHglycan	584	587	PF01048	0.301
MOD_GlcNHglycan	665	669	PF01048	0.374
MOD_GlcNHglycan	683	686	PF01048	0.360
MOD_GlcNHglycan	738	741	PF01048	0.428
MOD_GlcNHglycan	777	780	PF01048	0.454
MOD_GlcNHglycan	815	818	PF01048	0.368
MOD_GSK3_1	148	155	PF00069	0.312
MOD_GSK3_1	213	220	PF00069	0.389
MOD_GSK3_1	25	32	PF00069	0.333
MOD_GSK3_1	434	441	PF00069	0.378
MOD_GSK3_1	458	465	PF00069	0.530
MOD_GSK3_1	55	62	PF00069	0.360
MOD_GSK3_1	600	607	PF00069	0.480
MOD_GSK3_1	609	616	PF00069	0.420
MOD_GSK3_1	653	660	PF00069	0.440
MOD_GSK3_1	735	742	PF00069	0.486
MOD_GSK3_1	823	830	PF00069	0.289
MOD_N-GLC_1	546	551	PF02516	0.303
MOD_N-GLC_1	640	645	PF02516	0.210
MOD_NEK2_1	1	6	PF00069	0.591
MOD_NEK2_1	124	129	PF00069	0.278
MOD_NEK2_1	150	155	PF00069	0.300
MOD_NEK2_1	229	234	PF00069	0.344
MOD_NEK2_1	416	421	PF00069	0.436
MOD_NEK2_1	428	433	PF00069	0.272
MOD_NEK2_1	508	513	PF00069	0.488
MOD_NEK2_1	560	565	PF00069	0.450
MOD_NEK2_1	608	613	PF00069	0.390
MOD_NEK2_1	650	655	PF00069	0.355
MOD_NEK2_1	729	734	PF00069	0.410
MOD_NEK2_1	827	832	PF00069	0.371
MOD_NEK2_1	97	102	PF00069	0.412
MOD_NEK2_2	33	38	PF00069	0.479
MOD_PIKK_1	374	380	PF00454	0.278
MOD_PIKK_1	429	435	PF00454	0.303
MOD_PIKK_1	442	448	PF00454	0.317
MOD_PIKK_1	462	468	PF00454	0.476
MOD_PIKK_1	546	552	PF00454	0.278
MOD_PIKK_1	758	764	PF00454	0.312
MOD_PKA_1	291	297	PF00069	0.354
MOD_PKA_2	291	297	PF00069	0.396
MOD_PKA_2	526	532	PF00069	0.404
MOD_PKA_2	555	561	PF00069	0.422
MOD_PKA_2	701	707	PF00069	0.210
MOD_Plk_1	148	154	PF00069	0.287
MOD_Plk_1	24	30	PF00069	0.399
MOD_Plk_1	374	380	PF00069	0.293
MOD_Plk_1	429	435	PF00069	0.355
MOD_Plk_1	458	464	PF00069	0.542
MOD_Plk_1	475	481	PF00069	0.371
MOD_Plk_1	508	514	PF00069	0.571
MOD_Plk_1	546	552	PF00069	0.441
MOD_Plk_1	59	65	PF00069	0.380
MOD_Plk_1	608	614	PF00069	0.318
MOD_Plk_1	640	646	PF00069	0.256
MOD_Plk_1	650	656	PF00069	0.272
MOD_Plk_1	97	103	PF00069	0.385
MOD_Plk_2-3	823	829	PF00069	0.210
MOD_Plk_4	177	183	PF00069	0.466
MOD_Plk_4	205	211	PF00069	0.475
MOD_Plk_4	213	219	PF00069	0.449
MOD_Plk_4	458	464	PF00069	0.479
MOD_Plk_4	600	606	PF00069	0.301
MOD_Plk_4	628	634	PF00069	0.422
MOD_Plk_4	653	659	PF00069	0.443
MOD_Plk_4	75	81	PF00069	0.399
MOD_Plk_4	806	812	PF00069	0.300
MOD_Plk_4	823	829	PF00069	0.181
MOD_ProDKin_1	496	502	PF00069	0.497
MOD_ProDKin_1	549	555	PF00069	0.422
MOD_ProDKin_1	623	629	PF00069	0.479
MOD_ProDKin_1	633	639	PF00069	0.405
MOD_SUMO_for_1	157	160	PF00179	0.422
MOD_SUMO_for_1	7	10	PF00179	0.454
TRG_DiLeu_BaEn_2	466	472	PF01217	0.358
TRG_DiLeu_BaEn_2	619	625	PF01217	0.422
TRG_DiLeu_BaEn_4	429	435	PF01217	0.371
TRG_ENDOCYTIC_2	163	166	PF00928	0.312
TRG_ENDOCYTIC_2	218	221	PF00928	0.336
TRG_ENDOCYTIC_2	31	34	PF00928	0.490
TRG_ENDOCYTIC_2	449	452	PF00928	0.346
TRG_ENDOCYTIC_2	548	551	PF00928	0.293
TRG_ENDOCYTIC_2	571	574	PF00928	0.371
TRG_ENDOCYTIC_2	717	720	PF00928	0.322
TRG_ER_diArg_1	526	528	PF00400	0.304
TRG_ER_diArg_1	532	535	PF00400	0.282
TRG_ER_diArg_1	644	646	PF00400	0.368
TRG_ER_diArg_1	847	850	PF00400	0.317
TRG_Pf-PMV_PEXEL_1	557	562	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R5	Leptomonas seymouri	71%	100%
A0A0S4IPD6	Bodo saltans	40%	97%
A0A0S4JBK9	Bodo saltans	31%	100%
A0A1X0P9F6	Trypanosomatidae	52%	100%
A0A3R7K1R9	Trypanosoma rangeli	31%	100%
A0A3S7X2P7	Leishmania donovani	95%	100%
A0A422NEK9	Trypanosoma rangeli	52%	100%
A4HHM4	Leishmania braziliensis	82%	100%
A4I4T3	Leishmania infantum	96%	100%
A5HUI5	Gloydius brevicaudus	30%	91%
A6QPT7	Bos taurus	25%	91%
C9ZLI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D3UW23	Bitis rhinoceros	30%	91%
E9AIS1	Leishmania braziliensis	28%	99%
E9ALJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O57579	Gallus gallus	27%	89%
O93655	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	30%	100%
P15541	Oryctolagus cuniculus	26%	90%
P15684	Rattus norvegicus	25%	90%
P16406	Mus musculus	31%	92%
P40462	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	92%
P55786	Homo sapiens	28%	94%
P97629	Rattus norvegicus	30%	85%
Q0J2B5	Oryza sativa subsp. japonica	30%	99%
Q0J5V5	Oryza sativa subsp. japonica	31%	99%
Q10737	Haemonchus contortus	29%	89%
Q11000	Heliothis virescens	26%	86%
Q11001	Manduca sexta	25%	88%
Q11011	Mus musculus	28%	94%
Q4TT88	Caenorhabditis elegans	29%	92%
Q59KZ1	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	94%
Q5RFP3	Pongo abelii	24%	90%
Q6K4E7	Oryza sativa subsp. japonica	35%	99%
Q6P179	Homo sapiens	25%	90%
Q6Z6L4	Oryza sativa subsp. japonica	29%	99%
Q8C129	Mus musculus	30%	85%
Q8VZH2	Arabidopsis thaliana	29%	99%
Q9JJ22	Rattus norvegicus	29%	93%
Q9NZ08	Homo sapiens	25%	92%
Q9USX1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	98%
V5BSI2	Trypanosoma cruzi	52%	100%
V5D7P4	Trypanosoma cruzi	30%	100%