Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE85_LEIMA

TriTrypDb:

LmjF.29.2230 , LMJLV39_290030300 , LMJSD75_290030400

Length:

540

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0009331	glycerol-3-phosphate dehydrogenase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1
GO:1990204	oxidoreductase complex	3	1

Expansion

Sequence features

E9AE85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE85

Function

Biological processes
Term	Name	Level	Count
GO:0006072	glycerol-3-phosphate metabolic process	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0019637	organophosphate metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0046168	glycerol-3-phosphate catabolic process	5	2
GO:0046434	organophosphate catabolic process	4	2
GO:0052646	alditol phosphate metabolic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901136	carbohydrate derivative catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0016491	oxidoreductase activity	2	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	2
GO:0036094	small molecule binding	2	2
GO:0047952	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	5	1
GO:0051287	NAD binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	265	269	PF00656	0.634
CLV_C14_Caspase3-7	333	337	PF00656	0.545
CLV_NRD_NRD_1	111	113	PF00675	0.415
CLV_NRD_NRD_1	2	4	PF00675	0.522
CLV_NRD_NRD_1	420	422	PF00675	0.563
CLV_NRD_NRD_1	427	429	PF00675	0.548
CLV_PCSK_KEX2_1	113	115	PF00082	0.425
CLV_PCSK_KEX2_1	2	4	PF00082	0.599
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.425
CLV_PCSK_SKI1_1	137	141	PF00082	0.523
CLV_PCSK_SKI1_1	277	281	PF00082	0.606
CLV_PCSK_SKI1_1	321	325	PF00082	0.490
CLV_PCSK_SKI1_1	530	534	PF00082	0.480
CLV_PCSK_SKI1_1	8	12	PF00082	0.442
DEG_Nend_UBRbox_1	1	4	PF02207	0.636
DEG_SCF_FBW7_1	121	127	PF00400	0.438
DEG_SCF_FBW7_1	235	242	PF00400	0.530
DEG_SCF_FBW7_1	85	92	PF00400	0.506
DOC_CKS1_1	121	126	PF01111	0.476
DOC_CKS1_1	217	222	PF01111	0.584
DOC_CKS1_1	236	241	PF01111	0.452
DOC_MAPK_gen_1	112	121	PF00069	0.393
DOC_PP1_RVXF_1	28	35	PF00149	0.319
DOC_PP1_RVXF_1	319	325	PF00149	0.445
DOC_PP1_RVXF_1	419	426	PF00149	0.611
DOC_PP2B_LxvP_1	332	335	PF13499	0.456
DOC_PP2B_LxvP_1	397	400	PF13499	0.426
DOC_USP7_MATH_1	124	128	PF00917	0.512
DOC_USP7_MATH_1	161	165	PF00917	0.658
DOC_USP7_MATH_1	239	243	PF00917	0.522
DOC_USP7_MATH_1	252	256	PF00917	0.694
DOC_USP7_MATH_1	279	283	PF00917	0.709
DOC_USP7_MATH_1	28	32	PF00917	0.516
DOC_USP7_MATH_1	325	329	PF00917	0.548
DOC_USP7_MATH_1	349	353	PF00917	0.371
DOC_USP7_MATH_1	400	404	PF00917	0.408
DOC_USP7_MATH_1	68	72	PF00917	0.731
DOC_USP7_MATH_1	73	77	PF00917	0.695
DOC_USP7_MATH_1	80	84	PF00917	0.595
DOC_USP7_MATH_1	89	93	PF00917	0.540
DOC_WW_Pin1_4	120	125	PF00397	0.424
DOC_WW_Pin1_4	216	221	PF00397	0.589
DOC_WW_Pin1_4	235	240	PF00397	0.481
DOC_WW_Pin1_4	248	253	PF00397	0.671
DOC_WW_Pin1_4	300	305	PF00397	0.468
DOC_WW_Pin1_4	392	397	PF00397	0.407
DOC_WW_Pin1_4	460	465	PF00397	0.393
DOC_WW_Pin1_4	75	80	PF00397	0.687
DOC_WW_Pin1_4	85	90	PF00397	0.593
LIG_14-3-3_CanoR_1	154	159	PF00244	0.508
LIG_14-3-3_CanoR_1	523	531	PF00244	0.461
LIG_14-3-3_CanoR_1	8	13	PF00244	0.372
LIG_BRCT_BRCA1_1	30	34	PF00533	0.340
LIG_BRCT_BRCA1_1	413	417	PF00533	0.434
LIG_CtBP_PxDLS_1	4	8	PF00389	0.458
LIG_deltaCOP1_diTrp_1	133	140	PF00928	0.487
LIG_FHA_1	146	152	PF00498	0.431
LIG_FHA_1	217	223	PF00498	0.448
LIG_FHA_1	301	307	PF00498	0.432
LIG_FHA_1	379	385	PF00498	0.332
LIG_FHA_1	408	414	PF00498	0.488
LIG_FHA_1	49	55	PF00498	0.616
LIG_FHA_1	7	13	PF00498	0.523
LIG_FHA_2	263	269	PF00498	0.517
LIG_FHA_2	331	337	PF00498	0.532
LIG_FHA_2	495	501	PF00498	0.571
LIG_FHA_2	508	514	PF00498	0.569
LIG_LIR_Gen_1	31	42	PF02991	0.331
LIG_LIR_Gen_1	463	473	PF02991	0.380
LIG_LIR_Nem_3	31	37	PF02991	0.303
LIG_LIR_Nem_3	463	469	PF02991	0.362
LIG_LIR_Nem_3	489	494	PF02991	0.616
LIG_LIR_Nem_3	88	93	PF02991	0.573
LIG_PDZ_Class_1	535	540	PF00595	0.581
LIG_Pex14_2	175	179	PF04695	0.409
LIG_SH2_SRC	128	131	PF00017	0.378
LIG_SH2_STAP1	373	377	PF00017	0.467
LIG_SH2_STAP1	466	470	PF00017	0.344
LIG_SH2_STAT5	128	131	PF00017	0.499
LIG_SH2_STAT5	331	334	PF00017	0.469
LIG_SH2_STAT5	362	365	PF00017	0.627
LIG_SH2_STAT5	426	429	PF00017	0.632
LIG_SH3_3	251	257	PF00018	0.691
LIG_SH3_3	458	464	PF00018	0.497
LIG_SH3_3	76	82	PF00018	0.666
LIG_SUMO_SIM_anti_2	33	39	PF11976	0.545
LIG_SUMO_SIM_par_1	218	225	PF11976	0.470
LIG_SxIP_EBH_1	246	256	PF03271	0.679
LIG_TRAF2_2	190	195	PF00917	0.378
LIG_WRC_WIRS_1	350	355	PF05994	0.478
MOD_CK1_1	164	170	PF00069	0.684
MOD_CK1_1	234	240	PF00069	0.611
MOD_CK1_1	243	249	PF00069	0.652
MOD_CK1_1	259	265	PF00069	0.759
MOD_CK1_1	360	366	PF00069	0.510
MOD_CK1_1	56	62	PF00069	0.721
MOD_CK1_1	83	89	PF00069	0.552
MOD_CK2_1	210	216	PF00069	0.625
MOD_CK2_1	281	287	PF00069	0.554
MOD_CK2_1	494	500	PF00069	0.556
MOD_CK2_1	515	521	PF00069	0.524
MOD_CK2_1	63	69	PF00069	0.594
MOD_Cter_Amidation	419	422	PF01082	0.589
MOD_GlcNHglycan	107	110	PF01048	0.659
MOD_GlcNHglycan	156	159	PF01048	0.476
MOD_GlcNHglycan	207	210	PF01048	0.666
MOD_GlcNHglycan	224	227	PF01048	0.348
MOD_GlcNHglycan	242	245	PF01048	0.528
MOD_GlcNHglycan	258	261	PF01048	0.678
MOD_GlcNHglycan	281	284	PF01048	0.662
MOD_GlcNHglycan	292	295	PF01048	0.393
MOD_GlcNHglycan	458	461	PF01048	0.431
MOD_GlcNHglycan	500	504	PF01048	0.641
MOD_GlcNHglycan	517	520	PF01048	0.440
MOD_GlcNHglycan	58	61	PF01048	0.707
MOD_GlcNHglycan	65	68	PF01048	0.755
MOD_GlcNHglycan	71	74	PF01048	0.604
MOD_GSK3_1	120	127	PF00069	0.489
MOD_GSK3_1	150	157	PF00069	0.502
MOD_GSK3_1	212	219	PF00069	0.542
MOD_GSK3_1	231	238	PF00069	0.478
MOD_GSK3_1	239	246	PF00069	0.598
MOD_GSK3_1	248	255	PF00069	0.533
MOD_GSK3_1	269	276	PF00069	0.721
MOD_GSK3_1	298	305	PF00069	0.411
MOD_GSK3_1	356	363	PF00069	0.430
MOD_GSK3_1	407	414	PF00069	0.403
MOD_GSK3_1	456	463	PF00069	0.421
MOD_GSK3_1	69	76	PF00069	0.771
MOD_GSK3_1	81	88	PF00069	0.610
MOD_N-GLC_1	28	33	PF02516	0.469
MOD_N-GLC_1	63	68	PF02516	0.554
MOD_N-GLC_2	345	347	PF02516	0.333
MOD_NEK2_1	222	227	PF00069	0.554
MOD_NEK2_1	240	245	PF00069	0.505
MOD_NEK2_1	357	362	PF00069	0.513
MOD_NEK2_1	456	461	PF00069	0.427
MOD_NEK2_1	469	474	PF00069	0.373
MOD_NEK2_1	535	540	PF00069	0.552
MOD_PKA_2	325	331	PF00069	0.424
MOD_PKA_2	477	483	PF00069	0.506
MOD_PKA_2	494	500	PF00069	0.402
MOD_PKA_2	522	528	PF00069	0.615
MOD_Plk_1	231	237	PF00069	0.446
MOD_Plk_1	28	34	PF00069	0.567
MOD_Plk_4	124	130	PF00069	0.470
MOD_Plk_4	327	333	PF00069	0.410
MOD_Plk_4	33	39	PF00069	0.455
MOD_Plk_4	357	363	PF00069	0.548
MOD_Plk_4	401	407	PF00069	0.425
MOD_Plk_4	472	478	PF00069	0.428
MOD_Plk_4	53	59	PF00069	0.638
MOD_Plk_4	8	14	PF00069	0.492
MOD_Plk_4	89	95	PF00069	0.466
MOD_ProDKin_1	120	126	PF00069	0.424
MOD_ProDKin_1	216	222	PF00069	0.579
MOD_ProDKin_1	235	241	PF00069	0.490
MOD_ProDKin_1	248	254	PF00069	0.671
MOD_ProDKin_1	300	306	PF00069	0.468
MOD_ProDKin_1	392	398	PF00069	0.401
MOD_ProDKin_1	460	466	PF00069	0.385
MOD_ProDKin_1	75	81	PF00069	0.685
MOD_ProDKin_1	85	91	PF00069	0.578
MOD_SUMO_rev_2	92	102	PF00179	0.483
TRG_DiLeu_BaEn_1	218	223	PF01217	0.433
TRG_DiLeu_BaEn_1	501	506	PF01217	0.523
TRG_ENDOCYTIC_2	466	469	PF00928	0.349
TRG_ENDOCYTIC_2	473	476	PF00928	0.392
TRG_ER_diArg_1	1	3	PF00400	0.685

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P658	Leptomonas seymouri	54%	100%
A0A0S4ITH1	Bodo saltans	24%	100%
A0A3Q8IFB4	Leishmania donovani	93%	100%
A0A422NEK6	Trypanosoma rangeli	33%	100%
A4HHM3	Leishmania braziliensis	79%	100%
A4I4T2	Leishmania infantum	93%	93%
C9ZLH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ALK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%