LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania major
UniProt:
E9AE84_LEIMA
TriTrypDb:
LmjF.29.2220 , LMJLV39_290030200 * , LMJSD75_290030300 *
Length:
335

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE84
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE84

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 242 246 PF00656 0.733
CLV_NRD_NRD_1 318 320 PF00675 0.749
CLV_NRD_NRD_1 328 330 PF00675 0.622
CLV_PCSK_FUR_1 70 74 PF00082 0.592
CLV_PCSK_KEX2_1 29 31 PF00082 0.477
CLV_PCSK_KEX2_1 318 320 PF00082 0.749
CLV_PCSK_KEX2_1 72 74 PF00082 0.614
CLV_PCSK_KEX2_1 87 89 PF00082 0.441
CLV_PCSK_PC1ET2_1 29 31 PF00082 0.487
CLV_PCSK_PC1ET2_1 72 74 PF00082 0.614
CLV_PCSK_PC1ET2_1 87 89 PF00082 0.391
CLV_PCSK_SKI1_1 173 177 PF00082 0.571
CLV_PCSK_SKI1_1 284 288 PF00082 0.781
CLV_PCSK_SKI1_1 54 58 PF00082 0.468
CLV_PCSK_SKI1_1 73 77 PF00082 0.384
CLV_PCSK_SKI1_1 93 97 PF00082 0.582
DOC_CKS1_1 204 209 PF01111 0.602
DOC_CYCLIN_yClb1_LxF_4 155 161 PF00134 0.503
DOC_MAPK_gen_1 70 77 PF00069 0.594
DOC_PP1_RVXF_1 52 58 PF00149 0.394
DOC_PP1_RVXF_1 70 77 PF00149 0.538
DOC_USP7_MATH_1 189 193 PF00917 0.701
DOC_USP7_MATH_1 219 223 PF00917 0.820
DOC_USP7_MATH_1 243 247 PF00917 0.775
DOC_USP7_MATH_1 254 258 PF00917 0.600
DOC_USP7_MATH_1 271 275 PF00917 0.592
DOC_USP7_UBL2_3 326 330 PF12436 0.699
DOC_WW_Pin1_4 19 24 PF00397 0.519
DOC_WW_Pin1_4 203 208 PF00397 0.669
DOC_WW_Pin1_4 273 278 PF00397 0.751
DOC_WW_Pin1_4 287 292 PF00397 0.561
DOC_WW_Pin1_4 294 299 PF00397 0.760
DOC_WW_Pin1_4 3 8 PF00397 0.720
LIG_14-3-3_CanoR_1 210 217 PF00244 0.604
LIG_14-3-3_CanoR_1 249 256 PF00244 0.717
LIG_14-3-3_CanoR_1 264 270 PF00244 0.622
LIG_BIR_II_1 1 5 PF00653 0.699
LIG_BRCT_BRCA1_1 117 121 PF00533 0.636
LIG_BRCT_BRCA1_1 271 275 PF00533 0.738
LIG_BRCT_BRCA1_1 43 47 PF00533 0.643
LIG_Clathr_ClatBox_1 55 59 PF01394 0.596
LIG_FHA_1 107 113 PF00498 0.480
LIG_FHA_1 79 85 PF00498 0.447
LIG_FHA_2 204 210 PF00498 0.607
LIG_LIR_Gen_1 118 128 PF02991 0.517
LIG_LIR_Gen_1 129 139 PF02991 0.442
LIG_LIR_Nem_3 118 124 PF02991 0.620
LIG_LIR_Nem_3 129 134 PF02991 0.477
LIG_LIR_Nem_3 44 50 PF02991 0.633
LIG_SH2_CRK 201 205 PF00017 0.653
LIG_SH2_NCK_1 43 47 PF00017 0.643
LIG_SH2_SRC 201 204 PF00017 0.654
LIG_SH2_STAP1 151 155 PF00017 0.580
LIG_SH2_STAP1 43 47 PF00017 0.643
LIG_SH2_STAT5 49 52 PF00017 0.489
LIG_SH2_STAT5 80 83 PF00017 0.473
LIG_SH3_1 201 207 PF00018 0.677
LIG_SH3_3 183 189 PF00018 0.593
LIG_SH3_3 201 207 PF00018 0.677
LIG_SH3_3 229 235 PF00018 0.692
LIG_SH3_3 295 301 PF00018 0.799
LIG_TRFH_1 292 296 PF08558 0.698
LIG_TYR_ITIM 198 203 PF00017 0.547
LIG_UBA3_1 36 42 PF00899 0.636
LIG_WRC_WIRS_1 157 162 PF05994 0.389
MOD_CDK_SPxxK_3 19 26 PF00069 0.712
MOD_CDK_SPxxK_3 203 210 PF00069 0.561
MOD_CK1_1 2 8 PF00069 0.682
MOD_CK1_1 208 214 PF00069 0.774
MOD_CK1_1 22 28 PF00069 0.487
MOD_CK1_1 222 228 PF00069 0.629
MOD_CK1_1 248 254 PF00069 0.818
MOD_CK1_1 273 279 PF00069 0.748
MOD_CK1_1 290 296 PF00069 0.559
MOD_CK2_1 162 168 PF00069 0.485
MOD_CK2_1 203 209 PF00069 0.597
MOD_CK2_1 3 9 PF00069 0.641
MOD_Cter_Amidation 27 30 PF01082 0.516
MOD_GlcNHglycan 146 149 PF01048 0.437
MOD_GlcNHglycan 217 220 PF01048 0.752
MOD_GlcNHglycan 224 228 PF01048 0.661
MOD_GlcNHglycan 229 232 PF01048 0.708
MOD_GlcNHglycan 241 244 PF01048 0.603
MOD_GlcNHglycan 245 248 PF01048 0.688
MOD_GlcNHglycan 251 254 PF01048 0.654
MOD_GlcNHglycan 255 259 PF01048 0.593
MOD_GlcNHglycan 277 280 PF01048 0.802
MOD_GlcNHglycan 314 317 PF01048 0.736
MOD_GlcNHglycan 44 47 PF01048 0.518
MOD_GSK3_1 177 184 PF00069 0.518
MOD_GSK3_1 205 212 PF00069 0.692
MOD_GSK3_1 213 220 PF00069 0.651
MOD_GSK3_1 223 230 PF00069 0.560
MOD_GSK3_1 239 246 PF00069 0.795
MOD_GSK3_1 265 272 PF00069 0.735
MOD_GSK3_1 290 297 PF00069 0.729
MOD_NEK2_1 1 6 PF00069 0.778
MOD_NEK2_1 143 148 PF00069 0.568
MOD_NEK2_1 171 176 PF00069 0.522
MOD_NEK2_1 217 222 PF00069 0.745
MOD_NEK2_1 269 274 PF00069 0.705
MOD_PIKK_1 219 225 PF00454 0.820
MOD_PKA_2 209 215 PF00069 0.594
MOD_PKA_2 248 254 PF00069 0.694
MOD_Plk_1 126 132 PF00069 0.525
MOD_Plk_1 78 84 PF00069 0.548
MOD_Plk_4 156 162 PF00069 0.557
MOD_Plk_4 181 187 PF00069 0.584
MOD_ProDKin_1 19 25 PF00069 0.516
MOD_ProDKin_1 203 209 PF00069 0.671
MOD_ProDKin_1 273 279 PF00069 0.750
MOD_ProDKin_1 287 293 PF00069 0.563
MOD_ProDKin_1 294 300 PF00069 0.759
MOD_ProDKin_1 3 9 PF00069 0.723
MOD_SUMO_for_1 95 98 PF00179 0.567
MOD_SUMO_rev_2 11 21 PF00179 0.729
TRG_DiLeu_BaLyEn_6 320 325 PF01217 0.737
TRG_ENDOCYTIC_2 151 154 PF00928 0.479
TRG_ENDOCYTIC_2 200 203 PF00928 0.658
TRG_ER_diArg_1 114 117 PF00400 0.581
TRG_Pf-PMV_PEXEL_1 173 177 PF00026 0.530

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IFH8 Leishmania donovani 89% 98%
A4HHU4 Leishmania braziliensis 56% 72%
A4I4T1 Leishmania infantum 90% 92%
E9ALK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS