LRRcap domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat-containing protein

Species:

Leishmania major

UniProt:

E9AE83_LEIMA

TriTrypDb:

LmjF.29.2210 , LMJLV39_290030100 , LMJSD75_290030200

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005815	microtubule organizing center	2	2
GO:0005929	cilium	4	11
GO:0036064	ciliary basal body	3	2
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

E9AE83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE83

Function

Biological processes
Term	Name	Level	Count
GO:0000281	mitotic cytokinesis	4	2
GO:0000910	cytokinesis	3	2
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	2
GO:0030030	cell projection organization	4	2
GO:0044782	cilium organization	5	2
GO:0061640	cytoskeleton-dependent cytokinesis	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120036	plasma membrane bounded cell projection organization	5	2
GO:1903047	mitotic cell cycle process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.533
CLV_NRD_NRD_1	11	13	PF00675	0.249
CLV_NRD_NRD_1	224	226	PF00675	0.475
CLV_NRD_NRD_1	358	360	PF00675	0.529
CLV_PCSK_FUR_1	225	229	PF00082	0.584
CLV_PCSK_KEX2_1	10	12	PF00082	0.249
CLV_PCSK_KEX2_1	227	229	PF00082	0.514
CLV_PCSK_KEX2_1	247	249	PF00082	0.605
CLV_PCSK_KEX2_1	358	360	PF00082	0.511
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.545
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.605
CLV_PCSK_SKI1_1	267	271	PF00082	0.468
CLV_PCSK_SKI1_1	370	374	PF00082	0.641
CLV_PCSK_SKI1_1	449	453	PF00082	0.700
CLV_PCSK_SKI1_1	63	67	PF00082	0.267
CLV_Separin_Metazoa	7	11	PF03568	0.501
DEG_APCC_DBOX_1	362	370	PF00400	0.617
DEG_APCC_DBOX_1	403	411	PF00400	0.725
DEG_SPOP_SBC_1	384	388	PF00917	0.701
DOC_CDC14_PxL_1	136	144	PF14671	0.501
DOC_CKS1_1	231	236	PF01111	0.673
DOC_CKS1_1	478	483	PF01111	0.639
DOC_CYCLIN_RxL_1	262	273	PF00134	0.497
DOC_MAPK_gen_1	262	270	PF00069	0.597
DOC_MAPK_gen_1	317	325	PF00069	0.382
DOC_MAPK_gen_1	63	73	PF00069	0.470
DOC_MAPK_HePTP_8	156	168	PF00069	0.605
DOC_MAPK_MEF2A_6	159	168	PF00069	0.581
DOC_MAPK_MEF2A_6	271	278	PF00069	0.481
DOC_MAPK_MEF2A_6	317	325	PF00069	0.390
DOC_MAPK_MEF2A_6	415	424	PF00069	0.541
DOC_MAPK_MEF2A_6	66	75	PF00069	0.449
DOC_MAPK_MEF2A_6	92	99	PF00069	0.449
DOC_MAPK_NFAT4_5	92	100	PF00069	0.449
DOC_MAPK_RevD_3	345	359	PF00069	0.519
DOC_PP1_RVXF_1	61	68	PF00149	0.528
DOC_PP2B_LxvP_1	321	324	PF13499	0.449
DOC_USP7_MATH_1	402	406	PF00917	0.708
DOC_USP7_MATH_1	456	460	PF00917	0.737
DOC_USP7_MATH_1	471	475	PF00917	0.590
DOC_USP7_MATH_1	484	488	PF00917	0.643
DOC_USP7_UBL2_3	197	201	PF12436	0.594
DOC_WW_Pin1_4	206	211	PF00397	0.455
DOC_WW_Pin1_4	230	235	PF00397	0.667
DOC_WW_Pin1_4	385	390	PF00397	0.776
DOC_WW_Pin1_4	391	396	PF00397	0.555
DOC_WW_Pin1_4	416	421	PF00397	0.758
DOC_WW_Pin1_4	452	457	PF00397	0.706
DOC_WW_Pin1_4	477	482	PF00397	0.640
LIG_14-3-3_CanoR_1	3	7	PF00244	0.449
LIG_14-3-3_CanoR_1	338	347	PF00244	0.515
LIG_14-3-3_CanoR_1	404	408	PF00244	0.755
LIG_14-3-3_CanoR_1	415	420	PF00244	0.580
LIG_AP2alpha_2	192	194	PF02296	0.510
LIG_BIR_II_1	1	5	PF00653	0.448
LIG_Clathr_ClatBox_1	407	411	PF01394	0.728
LIG_EH_1	111	115	PF12763	0.528
LIG_FHA_1	298	304	PF00498	0.446
LIG_FHA_1	3	9	PF00498	0.449
LIG_FHA_1	340	346	PF00498	0.458
LIG_FHA_1	428	434	PF00498	0.767
LIG_FHA_1	458	464	PF00498	0.713
LIG_FHA_1	474	480	PF00498	0.476
LIG_FHA_2	124	130	PF00498	0.501
LIG_FHA_2	207	213	PF00498	0.440
LIG_FHA_2	255	261	PF00498	0.528
LIG_FHA_2	404	410	PF00498	0.757
LIG_FHA_2	77	83	PF00498	0.451
LIG_LIR_Nem_3	128	134	PF02991	0.463
LIG_LIR_Nem_3	263	268	PF02991	0.586
LIG_RPA_C_Fungi	354	366	PF08784	0.605
LIG_SH2_GRB2like	70	73	PF00017	0.302
LIG_SH2_SRC	134	137	PF00017	0.374
LIG_SH2_STAT5	134	137	PF00017	0.321
LIG_SH2_STAT5	50	53	PF00017	0.289
LIG_SH2_STAT5	55	58	PF00017	0.281
LIG_SH2_STAT5	70	73	PF00017	0.116
LIG_SH3_1	271	277	PF00018	0.483
LIG_SH3_3	190	196	PF00018	0.474
LIG_SH3_3	271	277	PF00018	0.483
LIG_SH3_3	344	350	PF00018	0.411
LIG_SH3_3	395	401	PF00018	0.554
LIG_SH3_3	475	481	PF00018	0.673
LIG_SUMO_SIM_anti_2	308	313	PF11976	0.525
LIG_SUMO_SIM_anti_2	34	41	PF11976	0.302
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.321
LIG_SUMO_SIM_par_1	162	172	PF11976	0.519
LIG_SUMO_SIM_par_1	287	293	PF11976	0.478
LIG_SUMO_SIM_par_1	405	411	PF11976	0.724
LIG_TRAF2_1	169	172	PF00917	0.524
LIG_TRAF2_1	209	212	PF00917	0.442
LIG_TRAF2_1	257	260	PF00917	0.517
LIG_TYR_ITIM	68	73	PF00017	0.302
LIG_WW_1	195	198	PF00397	0.522
MOD_CDC14_SPxK_1	394	397	PF00782	0.559
MOD_CDK_SPxK_1	391	397	PF00069	0.557
MOD_CDK_SPxxK_3	206	213	PF00069	0.444
MOD_CK1_1	105	111	PF00069	0.383
MOD_CK1_1	339	345	PF00069	0.481
MOD_CK1_1	377	383	PF00069	0.748
MOD_CK1_1	418	424	PF00069	0.767
MOD_CK2_1	123	129	PF00069	0.363
MOD_CK2_1	206	212	PF00069	0.467
MOD_CK2_1	254	260	PF00069	0.531
MOD_CK2_1	403	409	PF00069	0.753
MOD_CK2_1	54	60	PF00069	0.317
MOD_GlcNHglycan	377	380	PF01048	0.736
MOD_GlcNHglycan	382	385	PF01048	0.799
MOD_GlcNHglycan	435	438	PF01048	0.771
MOD_GlcNHglycan	444	447	PF01048	0.757
MOD_GlcNHglycan	463	466	PF01048	0.659
MOD_GSK3_1	101	108	PF00069	0.390
MOD_GSK3_1	114	121	PF00069	0.337
MOD_GSK3_1	250	257	PF00069	0.668
MOD_GSK3_1	297	304	PF00069	0.533
MOD_GSK3_1	370	377	PF00069	0.656
MOD_GSK3_1	379	386	PF00069	0.695
MOD_GSK3_1	414	421	PF00069	0.759
MOD_GSK3_1	427	434	PF00069	0.518
MOD_GSK3_1	437	444	PF00069	0.660
MOD_GSK3_1	452	459	PF00069	0.726
MOD_GSK3_1	469	476	PF00069	0.540
MOD_GSK3_1	479	486	PF00069	0.689
MOD_N-GLC_1	438	443	PF02516	0.617
MOD_N-GLC_1	76	81	PF02516	0.321
MOD_NEK2_1	114	119	PF00069	0.313
MOD_NEK2_1	297	302	PF00069	0.457
MOD_NEK2_1	414	419	PF00069	0.760
MOD_NEK2_1	433	438	PF00069	0.778
MOD_NEK2_1	93	98	PF00069	0.302
MOD_PIKK_1	250	256	PF00454	0.628
MOD_PIKK_1	469	475	PF00454	0.692
MOD_PKA_2	154	160	PF00069	0.257
MOD_PKA_2	2	8	PF00069	0.321
MOD_PKA_2	254	260	PF00069	0.575
MOD_PKA_2	337	343	PF00069	0.569
MOD_PKA_2	403	409	PF00069	0.756
MOD_PKA_2	414	420	PF00069	0.580
MOD_PKB_1	413	421	PF00069	0.537
MOD_Plk_1	76	82	PF00069	0.313
MOD_Plk_1	93	99	PF00069	0.293
MOD_Plk_4	105	111	PF00069	0.383
MOD_Plk_4	298	304	PF00069	0.433
MOD_Plk_4	403	409	PF00069	0.762
MOD_ProDKin_1	206	212	PF00069	0.448
MOD_ProDKin_1	230	236	PF00069	0.673
MOD_ProDKin_1	385	391	PF00069	0.773
MOD_ProDKin_1	416	422	PF00069	0.761
MOD_ProDKin_1	452	458	PF00069	0.703
MOD_ProDKin_1	477	483	PF00069	0.640
MOD_SUMO_for_1	182	185	PF00179	0.434
TRG_DiLeu_BaEn_1	34	39	PF01217	0.374
TRG_DiLeu_BaEn_3	211	217	PF01217	0.429
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.482
TRG_ENDOCYTIC_2	70	73	PF00928	0.283
TRG_ER_diArg_1	174	177	PF00400	0.445
TRG_ER_diArg_1	363	366	PF00400	0.564
TRG_ER_diArg_1	9	12	PF00400	0.302
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R7	Leptomonas seymouri	75%	100%
A0A0S4IYI1	Bodo saltans	61%	100%
A0A1L8G016	Xenopus laevis	37%	100%
A0A1X0P946	Trypanosomatidae	65%	100%
A0A3Q8IBL9	Leishmania donovani	95%	100%
A0A3R7LV56	Trypanosoma rangeli	64%	100%
A4HHM1	Leishmania braziliensis	84%	100%
A4I4T0	Leishmania infantum	94%	100%
B3DH20	Danio rerio	37%	100%
C9ZLH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9ALK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O88978	Mus musculus	35%	100%
Q1RMR5	Bos taurus	36%	100%
Q28FY0	Xenopus tropicalis	38%	100%
Q4R3F0	Macaca fascicularis	35%	100%
Q86X45	Homo sapiens	33%	100%
Q9NJE9	Trypanosoma brucei brucei	61%	100%
Q9VR52	Drosophila melanogaster	36%	100%