LeishMANIAdb
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Putative GTP-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative GTP-binding protein
Gene product:
dynamin-1-like protein
Species:
Leishmania major
UniProt:
E9AE82_LEIMA
TriTrypDb:
LmjF.29.2200 , LMJLV39_290030000 , LMJSD75_290030100
Length:
696

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0005874 microtubule 6 2
GO:0016020 membrane 2 2
GO:0099080 supramolecular complex 2 2
GO:0099081 supramolecular polymer 3 2
GO:0099512 supramolecular fiber 4 2
GO:0099513 polymeric cytoskeletal fiber 5 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9AE82
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE82

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 13
GO:0003824 catalytic activity 1 13
GO:0003924 GTPase activity 7 13
GO:0005488 binding 1 13
GO:0005515 protein binding 2 2
GO:0005525 GTP binding 5 13
GO:0008017 microtubule binding 5 2
GO:0008092 cytoskeletal protein binding 3 2
GO:0015631 tubulin binding 4 2
GO:0016462 pyrophosphatase activity 5 13
GO:0016787 hydrolase activity 2 13
GO:0016817 hydrolase activity, acting on acid anhydrides 3 13
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 13
GO:0017076 purine nucleotide binding 4 13
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 13
GO:0019001 guanyl nucleotide binding 5 13
GO:0032553 ribonucleotide binding 3 13
GO:0032555 purine ribonucleotide binding 4 13
GO:0032561 guanyl ribonucleotide binding 5 13
GO:0035639 purine ribonucleoside triphosphate binding 4 13
GO:0036094 small molecule binding 2 13
GO:0043167 ion binding 2 13
GO:0043168 anion binding 3 13
GO:0097159 organic cyclic compound binding 2 13
GO:0097367 carbohydrate derivative binding 2 13
GO:1901265 nucleoside phosphate binding 3 13
GO:1901363 heterocyclic compound binding 2 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 102 104 PF00675 0.459
CLV_NRD_NRD_1 250 252 PF00675 0.487
CLV_NRD_NRD_1 658 660 PF00675 0.366
CLV_PCSK_KEX2_1 102 104 PF00082 0.454
CLV_PCSK_KEX2_1 250 252 PF00082 0.391
CLV_PCSK_KEX2_1 542 544 PF00082 0.781
CLV_PCSK_KEX2_1 549 551 PF00082 0.794
CLV_PCSK_PC1ET2_1 542 544 PF00082 0.673
CLV_PCSK_PC1ET2_1 549 551 PF00082 0.632
CLV_PCSK_SKI1_1 152 156 PF00082 0.336
CLV_PCSK_SKI1_1 160 164 PF00082 0.336
CLV_PCSK_SKI1_1 186 190 PF00082 0.385
CLV_PCSK_SKI1_1 350 354 PF00082 0.391
CLV_PCSK_SKI1_1 377 381 PF00082 0.392
CLV_PCSK_SKI1_1 422 426 PF00082 0.466
CLV_PCSK_SKI1_1 457 461 PF00082 0.333
CLV_PCSK_SKI1_1 49 53 PF00082 0.336
CLV_PCSK_SKI1_1 535 539 PF00082 0.794
CLV_PCSK_SKI1_1 578 582 PF00082 0.680
CLV_PCSK_SKI1_1 583 587 PF00082 0.667
CLV_PCSK_SKI1_1 617 621 PF00082 0.350
CLV_PCSK_SKI1_1 643 647 PF00082 0.428
CLV_PCSK_SKI1_1 660 664 PF00082 0.233
DEG_Nend_UBRbox_3 1 3 PF02207 0.571
DOC_ANK_TNKS_1 596 603 PF00023 0.336
DOC_CDC14_PxL_1 132 140 PF14671 0.350
DOC_CYCLIN_RxL_1 274 285 PF00134 0.391
DOC_CYCLIN_RxL_1 455 462 PF00134 0.397
DOC_CYCLIN_RxL_1 643 651 PF00134 0.466
DOC_MAPK_DCC_7 23 31 PF00069 0.420
DOC_MAPK_gen_1 277 284 PF00069 0.403
DOC_MAPK_gen_1 476 484 PF00069 0.359
DOC_MAPK_JIP1_4 116 122 PF00069 0.336
DOC_MAPK_MEF2A_6 165 172 PF00069 0.479
DOC_MAPK_MEF2A_6 19 26 PF00069 0.497
DOC_MAPK_MEF2A_6 61 68 PF00069 0.354
DOC_MAPK_NFAT4_5 165 173 PF00069 0.479
DOC_MAPK_NFAT4_5 19 27 PF00069 0.486
DOC_PP1_RVXF_1 275 282 PF00149 0.391
DOC_PP1_RVXF_1 420 427 PF00149 0.336
DOC_PP2B_LxvP_1 24 27 PF13499 0.436
DOC_PP2B_LxvP_1 83 86 PF13499 0.479
DOC_PP2B_PxIxI_1 26 32 PF00149 0.336
DOC_USP7_MATH_1 108 112 PF00917 0.327
DOC_USP7_MATH_1 249 253 PF00917 0.454
DOC_USP7_MATH_1 512 516 PF00917 0.783
DOC_USP7_MATH_1 518 522 PF00917 0.807
DOC_USP7_MATH_1 53 57 PF00917 0.366
DOC_USP7_MATH_1 530 534 PF00917 0.508
DOC_USP7_MATH_1 675 679 PF00917 0.409
DOC_USP7_MATH_1 688 692 PF00917 0.693
DOC_USP7_UBL2_3 19 23 PF12436 0.527
DOC_USP7_UBL2_3 307 311 PF12436 0.376
DOC_USP7_UBL2_3 531 535 PF12436 0.758
DOC_USP7_UBL2_3 538 542 PF12436 0.704
DOC_USP7_UBL2_3 549 553 PF12436 0.683
DOC_WW_Pin1_4 170 175 PF00397 0.337
DOC_WW_Pin1_4 257 262 PF00397 0.487
DOC_WW_Pin1_4 507 512 PF00397 0.763
DOC_WW_Pin1_4 562 567 PF00397 0.742
LIG_14-3-3_CanoR_1 250 257 PF00244 0.494
LIG_14-3-3_CanoR_1 464 474 PF00244 0.419
LIG_Actin_WH2_2 211 228 PF00022 0.366
LIG_APCC_ABBA_1 330 335 PF00400 0.383
LIG_CORNRBOX 283 291 PF00104 0.336
LIG_deltaCOP1_diTrp_1 76 82 PF00928 0.354
LIG_EH1_1 295 303 PF00400 0.263
LIG_FHA_1 102 108 PF00498 0.286
LIG_FHA_1 157 163 PF00498 0.336
LIG_FHA_1 165 171 PF00498 0.336
LIG_FHA_1 196 202 PF00498 0.352
LIG_FHA_1 270 276 PF00498 0.336
LIG_FHA_1 321 327 PF00498 0.514
LIG_FHA_1 347 353 PF00498 0.402
LIG_FHA_1 374 380 PF00498 0.391
LIG_FHA_2 129 135 PF00498 0.343
LIG_FHA_2 201 207 PF00498 0.336
LIG_FHA_2 502 508 PF00498 0.703
LIG_FHA_2 524 530 PF00498 0.791
LIG_FHA_2 584 590 PF00498 0.616
LIG_IRF3_LxIS_1 168 173 PF10401 0.350
LIG_LIR_Apic_2 159 164 PF02991 0.336
LIG_LIR_Apic_2 462 466 PF02991 0.351
LIG_LIR_Gen_1 212 223 PF02991 0.374
LIG_LIR_Gen_1 252 262 PF02991 0.477
LIG_LIR_Gen_1 380 391 PF02991 0.336
LIG_LIR_Gen_1 402 413 PF02991 0.336
LIG_LIR_Gen_1 425 435 PF02991 0.414
LIG_LIR_Gen_1 478 489 PF02991 0.336
LIG_LIR_Gen_1 601 612 PF02991 0.366
LIG_LIR_Gen_1 629 640 PF02991 0.350
LIG_LIR_Gen_1 81 90 PF02991 0.408
LIG_LIR_Gen_1 92 100 PF02991 0.293
LIG_LIR_Nem_3 13 18 PF02991 0.467
LIG_LIR_Nem_3 212 218 PF02991 0.374
LIG_LIR_Nem_3 252 257 PF02991 0.452
LIG_LIR_Nem_3 260 266 PF02991 0.370
LIG_LIR_Nem_3 364 369 PF02991 0.336
LIG_LIR_Nem_3 380 386 PF02991 0.336
LIG_LIR_Nem_3 402 408 PF02991 0.336
LIG_LIR_Nem_3 425 431 PF02991 0.414
LIG_LIR_Nem_3 443 448 PF02991 0.336
LIG_LIR_Nem_3 478 484 PF02991 0.336
LIG_LIR_Nem_3 601 607 PF02991 0.336
LIG_LIR_Nem_3 629 635 PF02991 0.336
LIG_LIR_Nem_3 76 82 PF02991 0.349
LIG_LIR_Nem_3 92 96 PF02991 0.348
LIG_LYPXL_yS_3 445 448 PF13949 0.440
LIG_NRBOX 278 284 PF00104 0.336
LIG_Pex14_2 362 366 PF04695 0.336
LIG_PTB_Apo_2 84 91 PF02174 0.473
LIG_SH2_CRK 263 267 PF00017 0.350
LIG_SH2_CRK 463 467 PF00017 0.366
LIG_SH2_CRK 632 636 PF00017 0.336
LIG_SH2_NCK_1 263 267 PF00017 0.336
LIG_SH2_PTP2 161 164 PF00017 0.336
LIG_SH2_PTP2 383 386 PF00017 0.336
LIG_SH2_STAP1 123 127 PF00017 0.409
LIG_SH2_STAP1 254 258 PF00017 0.401
LIG_SH2_STAP1 632 636 PF00017 0.350
LIG_SH2_STAT5 161 164 PF00017 0.336
LIG_SH2_STAT5 274 277 PF00017 0.364
LIG_SH2_STAT5 328 331 PF00017 0.391
LIG_SH2_STAT5 360 363 PF00017 0.347
LIG_SH2_STAT5 369 372 PF00017 0.367
LIG_SH2_STAT5 383 386 PF00017 0.355
LIG_SH2_STAT5 603 606 PF00017 0.353
LIG_SH3_3 130 136 PF00018 0.351
LIG_SH3_3 481 487 PF00018 0.353
LIG_SH3_3 548 554 PF00018 0.849
LIG_SH3_3 66 72 PF00018 0.350
LIG_SH3_4 553 560 PF00018 0.741
LIG_SUMO_SIM_anti_2 203 209 PF11976 0.419
LIG_SUMO_SIM_par_1 167 173 PF11976 0.336
LIG_SUMO_SIM_par_1 620 625 PF11976 0.339
LIG_TRAF2_1 74 77 PF00917 0.375
LIG_UBA3_1 283 288 PF00899 0.350
LIG_UBA3_1 326 331 PF00899 0.324
LIG_UBA3_1 665 671 PF00899 0.336
LIG_WW_3 510 514 PF00397 0.687
MOD_CDC14_SPxK_1 510 513 PF00782 0.684
MOD_CDK_SPxK_1 507 513 PF00069 0.679
MOD_CDK_SPxxK_3 562 569 PF00069 0.768
MOD_CK1_1 111 117 PF00069 0.327
MOD_CK1_1 505 511 PF00069 0.731
MOD_CK1_1 562 568 PF00069 0.645
MOD_CK1_1 641 647 PF00069 0.365
MOD_CK2_1 249 255 PF00069 0.391
MOD_CK2_1 38 44 PF00069 0.336
MOD_CK2_1 501 507 PF00069 0.582
MOD_CK2_1 583 589 PF00069 0.511
MOD_CK2_1 71 77 PF00069 0.383
MOD_GlcNHglycan 110 113 PF01048 0.327
MOD_GlcNHglycan 124 127 PF01048 0.327
MOD_GlcNHglycan 373 376 PF01048 0.400
MOD_GlcNHglycan 504 507 PF01048 0.813
MOD_GlcNHglycan 515 518 PF01048 0.784
MOD_GlcNHglycan 520 523 PF01048 0.786
MOD_GlcNHglycan 532 535 PF01048 0.778
MOD_GlcNHglycan 55 58 PF01048 0.354
MOD_GlcNHglycan 561 564 PF01048 0.650
MOD_GlcNHglycan 593 596 PF01048 0.477
MOD_GSK3_1 170 177 PF00069 0.337
MOD_GSK3_1 257 264 PF00069 0.447
MOD_GSK3_1 269 276 PF00069 0.353
MOD_GSK3_1 33 40 PF00069 0.336
MOD_GSK3_1 365 372 PF00069 0.447
MOD_GSK3_1 373 380 PF00069 0.428
MOD_GSK3_1 394 401 PF00069 0.373
MOD_GSK3_1 466 473 PF00069 0.470
MOD_GSK3_1 501 508 PF00069 0.788
MOD_GSK3_1 53 60 PF00069 0.355
MOD_GSK3_1 634 641 PF00069 0.426
MOD_N-GLC_1 128 133 PF02516 0.350
MOD_N-GLC_1 337 342 PF02516 0.362
MOD_N-GLC_1 513 518 PF02516 0.825
MOD_N-GLC_1 567 572 PF02516 0.767
MOD_N-GLC_2 241 243 PF02516 0.263
MOD_NEK2_1 128 133 PF00069 0.336
MOD_NEK2_1 179 184 PF00069 0.336
MOD_NEK2_1 302 307 PF00069 0.354
MOD_NEK2_1 394 399 PF00069 0.366
MOD_NEK2_1 581 586 PF00069 0.574
MOD_NEK2_1 591 596 PF00069 0.389
MOD_NEK2_1 622 627 PF00069 0.339
MOD_NEK2_2 675 680 PF00069 0.385
MOD_PIKK_1 179 185 PF00454 0.440
MOD_PIKK_1 233 239 PF00454 0.336
MOD_PIKK_1 31 37 PF00454 0.336
MOD_PIKK_1 523 529 PF00454 0.864
MOD_PIKK_1 654 660 PF00454 0.372
MOD_PKA_2 101 107 PF00069 0.402
MOD_PKA_2 249 255 PF00069 0.494
MOD_PKA_2 512 518 PF00069 0.690
MOD_PKA_2 53 59 PF00069 0.336
MOD_Plk_1 128 134 PF00069 0.350
MOD_Plk_1 337 343 PF00069 0.397
MOD_Plk_2-3 242 248 PF00069 0.479
MOD_Plk_4 128 134 PF00069 0.326
MOD_Plk_4 164 170 PF00069 0.351
MOD_Plk_4 365 371 PF00069 0.366
MOD_Plk_4 38 44 PF00069 0.336
MOD_Plk_4 394 400 PF00069 0.366
MOD_Plk_4 422 428 PF00069 0.479
MOD_ProDKin_1 170 176 PF00069 0.337
MOD_ProDKin_1 257 263 PF00069 0.487
MOD_ProDKin_1 507 513 PF00069 0.768
MOD_ProDKin_1 562 568 PF00069 0.740
MOD_SUMO_for_1 475 478 PF00179 0.359
MOD_SUMO_rev_2 236 246 PF00179 0.366
MOD_SUMO_rev_2 541 551 PF00179 0.805
TRG_DiLeu_BaEn_3 429 435 PF01217 0.350
TRG_DiLeu_BaEn_3 77 83 PF01217 0.366
TRG_ENDOCYTIC_2 254 257 PF00928 0.388
TRG_ENDOCYTIC_2 263 266 PF00928 0.288
TRG_ENDOCYTIC_2 383 386 PF00928 0.336
TRG_ENDOCYTIC_2 428 431 PF00928 0.366
TRG_ENDOCYTIC_2 445 448 PF00928 0.440
TRG_ENDOCYTIC_2 603 606 PF00928 0.336
TRG_ENDOCYTIC_2 632 635 PF00928 0.336
TRG_Pf-PMV_PEXEL_1 152 156 PF00026 0.385

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD95 Leptomonas seymouri 81% 100%
A0A0S4IST4 Bodo saltans 54% 84%
A0A1X0P9B2 Trypanosomatidae 71% 100%
A0A3Q8IRJ0 Leishmania donovani 94% 99%
A0A422NEK1 Trypanosoma rangeli 66% 100%
A1E2I5 Macaca mulatta 33% 97%
A4HHM0 Leishmania braziliensis 84% 100%
A4I4S9 Leishmania infantum 94% 99%
A6H7I5 Bos taurus 44% 80%
C9ZLH7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
C9ZLI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
E9ALK3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
O00429 Homo sapiens 37% 95%
O35303 Rattus norvegicus 36% 92%
P20592 Homo sapiens 32% 97%
P21575 Rattus norvegicus 44% 81%
P21576 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 99%
P27619 Drosophila melanogaster 44% 79%
P33238 Anas platyrhynchos 31% 97%
P39052 Rattus norvegicus 44% 80%
P39053 Mus musculus 44% 80%
P39054 Mus musculus 44% 80%
P39055 Caenorhabditis elegans 42% 84%
P42697 Arabidopsis thaliana 39% 100%
P50570 Homo sapiens 44% 80%
P54861 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 37% 92%
Q000A9 Larimichthys crocea 31% 100%
Q05193 Homo sapiens 44% 81%
Q08877 Rattus norvegicus 43% 80%
Q08DF4 Bos taurus 44% 81%
Q09748 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 35% 89%
Q2KIA5 Bos taurus 36% 93%
Q2KTC2 Dicentrarchus labrax 30% 100%
Q39821 Glycine max 37% 100%
Q39828 Glycine max 38% 100%
Q4ADG6 Phoca vitulina 32% 100%
Q5U752 Solea senegalensis 32% 100%
Q6DKF0 Danio rerio 32% 100%
Q7SXN5 Danio rerio 39% 100%
Q7T2P0 Ictalurus punctatus 34% 100%
Q84XF3 Arabidopsis thaliana 37% 100%
Q8BZ98 Mus musculus 43% 81%
Q8JH68 Danio rerio 33% 100%
Q8K1M6 Mus musculus 37% 94%
Q8LF21 Arabidopsis thaliana 37% 100%
Q8LFT2 Arabidopsis thaliana 35% 89%
Q8S3C9 Arabidopsis thaliana 39% 100%
Q8S944 Arabidopsis thaliana 34% 86%
Q94464 Dictyostelium discoideum 49% 82%
Q9FNX5 Arabidopsis thaliana 36% 100%
Q9LQ55 Arabidopsis thaliana 24% 76%
Q9N0Y3 Canis lupus familiaris 33% 100%
Q9SE83 Arabidopsis thaliana 24% 76%
Q9U1M9 Dictyostelium discoideum 40% 76%
Q9UQ16 Homo sapiens 43% 80%
Q9URZ5 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 38% 100%
Q9ZP55 Arabidopsis thaliana 27% 100%
V5DTS8 Trypanosoma cruzi 68% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS