Putative GTP-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynamin-1-like protein

Species:

Leishmania major

UniProt:

E9AE82_LEIMA

TriTrypDb:

LmjF.29.2200 , LMJLV39_290030000 , LMJSD75_290030100

Length:

696

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005874	microtubule	6	2
GO:0016020	membrane	2	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AE82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE82

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0003924	GTPase activity	7	13
GO:0005488	binding	1	13
GO:0005515	protein binding	2	2
GO:0005525	GTP binding	5	13
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0016462	pyrophosphatase activity	5	13
GO:0016787	hydrolase activity	2	13
GO:0016817	hydrolase activity, acting on acid anhydrides	3	13
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	13
GO:0019001	guanyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032561	guanyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.459
CLV_NRD_NRD_1	250	252	PF00675	0.487
CLV_NRD_NRD_1	658	660	PF00675	0.366
CLV_PCSK_KEX2_1	102	104	PF00082	0.454
CLV_PCSK_KEX2_1	250	252	PF00082	0.391
CLV_PCSK_KEX2_1	542	544	PF00082	0.781
CLV_PCSK_KEX2_1	549	551	PF00082	0.794
CLV_PCSK_PC1ET2_1	542	544	PF00082	0.673
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.632
CLV_PCSK_SKI1_1	152	156	PF00082	0.336
CLV_PCSK_SKI1_1	160	164	PF00082	0.336
CLV_PCSK_SKI1_1	186	190	PF00082	0.385
CLV_PCSK_SKI1_1	350	354	PF00082	0.391
CLV_PCSK_SKI1_1	377	381	PF00082	0.392
CLV_PCSK_SKI1_1	422	426	PF00082	0.466
CLV_PCSK_SKI1_1	457	461	PF00082	0.333
CLV_PCSK_SKI1_1	49	53	PF00082	0.336
CLV_PCSK_SKI1_1	535	539	PF00082	0.794
CLV_PCSK_SKI1_1	578	582	PF00082	0.680
CLV_PCSK_SKI1_1	583	587	PF00082	0.667
CLV_PCSK_SKI1_1	617	621	PF00082	0.350
CLV_PCSK_SKI1_1	643	647	PF00082	0.428
CLV_PCSK_SKI1_1	660	664	PF00082	0.233
DEG_Nend_UBRbox_3	1	3	PF02207	0.571
DOC_ANK_TNKS_1	596	603	PF00023	0.336
DOC_CDC14_PxL_1	132	140	PF14671	0.350
DOC_CYCLIN_RxL_1	274	285	PF00134	0.391
DOC_CYCLIN_RxL_1	455	462	PF00134	0.397
DOC_CYCLIN_RxL_1	643	651	PF00134	0.466
DOC_MAPK_DCC_7	23	31	PF00069	0.420
DOC_MAPK_gen_1	277	284	PF00069	0.403
DOC_MAPK_gen_1	476	484	PF00069	0.359
DOC_MAPK_JIP1_4	116	122	PF00069	0.336
DOC_MAPK_MEF2A_6	165	172	PF00069	0.479
DOC_MAPK_MEF2A_6	19	26	PF00069	0.497
DOC_MAPK_MEF2A_6	61	68	PF00069	0.354
DOC_MAPK_NFAT4_5	165	173	PF00069	0.479
DOC_MAPK_NFAT4_5	19	27	PF00069	0.486
DOC_PP1_RVXF_1	275	282	PF00149	0.391
DOC_PP1_RVXF_1	420	427	PF00149	0.336
DOC_PP2B_LxvP_1	24	27	PF13499	0.436
DOC_PP2B_LxvP_1	83	86	PF13499	0.479
DOC_PP2B_PxIxI_1	26	32	PF00149	0.336
DOC_USP7_MATH_1	108	112	PF00917	0.327
DOC_USP7_MATH_1	249	253	PF00917	0.454
DOC_USP7_MATH_1	512	516	PF00917	0.783
DOC_USP7_MATH_1	518	522	PF00917	0.807
DOC_USP7_MATH_1	53	57	PF00917	0.366
DOC_USP7_MATH_1	530	534	PF00917	0.508
DOC_USP7_MATH_1	675	679	PF00917	0.409
DOC_USP7_MATH_1	688	692	PF00917	0.693
DOC_USP7_UBL2_3	19	23	PF12436	0.527
DOC_USP7_UBL2_3	307	311	PF12436	0.376
DOC_USP7_UBL2_3	531	535	PF12436	0.758
DOC_USP7_UBL2_3	538	542	PF12436	0.704
DOC_USP7_UBL2_3	549	553	PF12436	0.683
DOC_WW_Pin1_4	170	175	PF00397	0.337
DOC_WW_Pin1_4	257	262	PF00397	0.487
DOC_WW_Pin1_4	507	512	PF00397	0.763
DOC_WW_Pin1_4	562	567	PF00397	0.742
LIG_14-3-3_CanoR_1	250	257	PF00244	0.494
LIG_14-3-3_CanoR_1	464	474	PF00244	0.419
LIG_Actin_WH2_2	211	228	PF00022	0.366
LIG_APCC_ABBA_1	330	335	PF00400	0.383
LIG_CORNRBOX	283	291	PF00104	0.336
LIG_deltaCOP1_diTrp_1	76	82	PF00928	0.354
LIG_EH1_1	295	303	PF00400	0.263
LIG_FHA_1	102	108	PF00498	0.286
LIG_FHA_1	157	163	PF00498	0.336
LIG_FHA_1	165	171	PF00498	0.336
LIG_FHA_1	196	202	PF00498	0.352
LIG_FHA_1	270	276	PF00498	0.336
LIG_FHA_1	321	327	PF00498	0.514
LIG_FHA_1	347	353	PF00498	0.402
LIG_FHA_1	374	380	PF00498	0.391
LIG_FHA_2	129	135	PF00498	0.343
LIG_FHA_2	201	207	PF00498	0.336
LIG_FHA_2	502	508	PF00498	0.703
LIG_FHA_2	524	530	PF00498	0.791
LIG_FHA_2	584	590	PF00498	0.616
LIG_IRF3_LxIS_1	168	173	PF10401	0.350
LIG_LIR_Apic_2	159	164	PF02991	0.336
LIG_LIR_Apic_2	462	466	PF02991	0.351
LIG_LIR_Gen_1	212	223	PF02991	0.374
LIG_LIR_Gen_1	252	262	PF02991	0.477
LIG_LIR_Gen_1	380	391	PF02991	0.336
LIG_LIR_Gen_1	402	413	PF02991	0.336
LIG_LIR_Gen_1	425	435	PF02991	0.414
LIG_LIR_Gen_1	478	489	PF02991	0.336
LIG_LIR_Gen_1	601	612	PF02991	0.366
LIG_LIR_Gen_1	629	640	PF02991	0.350
LIG_LIR_Gen_1	81	90	PF02991	0.408
LIG_LIR_Gen_1	92	100	PF02991	0.293
LIG_LIR_Nem_3	13	18	PF02991	0.467
LIG_LIR_Nem_3	212	218	PF02991	0.374
LIG_LIR_Nem_3	252	257	PF02991	0.452
LIG_LIR_Nem_3	260	266	PF02991	0.370
LIG_LIR_Nem_3	364	369	PF02991	0.336
LIG_LIR_Nem_3	380	386	PF02991	0.336
LIG_LIR_Nem_3	402	408	PF02991	0.336
LIG_LIR_Nem_3	425	431	PF02991	0.414
LIG_LIR_Nem_3	443	448	PF02991	0.336
LIG_LIR_Nem_3	478	484	PF02991	0.336
LIG_LIR_Nem_3	601	607	PF02991	0.336
LIG_LIR_Nem_3	629	635	PF02991	0.336
LIG_LIR_Nem_3	76	82	PF02991	0.349
LIG_LIR_Nem_3	92	96	PF02991	0.348
LIG_LYPXL_yS_3	445	448	PF13949	0.440
LIG_NRBOX	278	284	PF00104	0.336
LIG_Pex14_2	362	366	PF04695	0.336
LIG_PTB_Apo_2	84	91	PF02174	0.473
LIG_SH2_CRK	263	267	PF00017	0.350
LIG_SH2_CRK	463	467	PF00017	0.366
LIG_SH2_CRK	632	636	PF00017	0.336
LIG_SH2_NCK_1	263	267	PF00017	0.336
LIG_SH2_PTP2	161	164	PF00017	0.336
LIG_SH2_PTP2	383	386	PF00017	0.336
LIG_SH2_STAP1	123	127	PF00017	0.409
LIG_SH2_STAP1	254	258	PF00017	0.401
LIG_SH2_STAP1	632	636	PF00017	0.350
LIG_SH2_STAT5	161	164	PF00017	0.336
LIG_SH2_STAT5	274	277	PF00017	0.364
LIG_SH2_STAT5	328	331	PF00017	0.391
LIG_SH2_STAT5	360	363	PF00017	0.347
LIG_SH2_STAT5	369	372	PF00017	0.367
LIG_SH2_STAT5	383	386	PF00017	0.355
LIG_SH2_STAT5	603	606	PF00017	0.353
LIG_SH3_3	130	136	PF00018	0.351
LIG_SH3_3	481	487	PF00018	0.353
LIG_SH3_3	548	554	PF00018	0.849
LIG_SH3_3	66	72	PF00018	0.350
LIG_SH3_4	553	560	PF00018	0.741
LIG_SUMO_SIM_anti_2	203	209	PF11976	0.419
LIG_SUMO_SIM_par_1	167	173	PF11976	0.336
LIG_SUMO_SIM_par_1	620	625	PF11976	0.339
LIG_TRAF2_1	74	77	PF00917	0.375
LIG_UBA3_1	283	288	PF00899	0.350
LIG_UBA3_1	326	331	PF00899	0.324
LIG_UBA3_1	665	671	PF00899	0.336
LIG_WW_3	510	514	PF00397	0.687
MOD_CDC14_SPxK_1	510	513	PF00782	0.684
MOD_CDK_SPxK_1	507	513	PF00069	0.679
MOD_CDK_SPxxK_3	562	569	PF00069	0.768
MOD_CK1_1	111	117	PF00069	0.327
MOD_CK1_1	505	511	PF00069	0.731
MOD_CK1_1	562	568	PF00069	0.645
MOD_CK1_1	641	647	PF00069	0.365
MOD_CK2_1	249	255	PF00069	0.391
MOD_CK2_1	38	44	PF00069	0.336
MOD_CK2_1	501	507	PF00069	0.582
MOD_CK2_1	583	589	PF00069	0.511
MOD_CK2_1	71	77	PF00069	0.383
MOD_GlcNHglycan	110	113	PF01048	0.327
MOD_GlcNHglycan	124	127	PF01048	0.327
MOD_GlcNHglycan	373	376	PF01048	0.400
MOD_GlcNHglycan	504	507	PF01048	0.813
MOD_GlcNHglycan	515	518	PF01048	0.784
MOD_GlcNHglycan	520	523	PF01048	0.786
MOD_GlcNHglycan	532	535	PF01048	0.778
MOD_GlcNHglycan	55	58	PF01048	0.354
MOD_GlcNHglycan	561	564	PF01048	0.650
MOD_GlcNHglycan	593	596	PF01048	0.477
MOD_GSK3_1	170	177	PF00069	0.337
MOD_GSK3_1	257	264	PF00069	0.447
MOD_GSK3_1	269	276	PF00069	0.353
MOD_GSK3_1	33	40	PF00069	0.336
MOD_GSK3_1	365	372	PF00069	0.447
MOD_GSK3_1	373	380	PF00069	0.428
MOD_GSK3_1	394	401	PF00069	0.373
MOD_GSK3_1	466	473	PF00069	0.470
MOD_GSK3_1	501	508	PF00069	0.788
MOD_GSK3_1	53	60	PF00069	0.355
MOD_GSK3_1	634	641	PF00069	0.426
MOD_N-GLC_1	128	133	PF02516	0.350
MOD_N-GLC_1	337	342	PF02516	0.362
MOD_N-GLC_1	513	518	PF02516	0.825
MOD_N-GLC_1	567	572	PF02516	0.767
MOD_N-GLC_2	241	243	PF02516	0.263
MOD_NEK2_1	128	133	PF00069	0.336
MOD_NEK2_1	179	184	PF00069	0.336
MOD_NEK2_1	302	307	PF00069	0.354
MOD_NEK2_1	394	399	PF00069	0.366
MOD_NEK2_1	581	586	PF00069	0.574
MOD_NEK2_1	591	596	PF00069	0.389
MOD_NEK2_1	622	627	PF00069	0.339
MOD_NEK2_2	675	680	PF00069	0.385
MOD_PIKK_1	179	185	PF00454	0.440
MOD_PIKK_1	233	239	PF00454	0.336
MOD_PIKK_1	31	37	PF00454	0.336
MOD_PIKK_1	523	529	PF00454	0.864
MOD_PIKK_1	654	660	PF00454	0.372
MOD_PKA_2	101	107	PF00069	0.402
MOD_PKA_2	249	255	PF00069	0.494
MOD_PKA_2	512	518	PF00069	0.690
MOD_PKA_2	53	59	PF00069	0.336
MOD_Plk_1	128	134	PF00069	0.350
MOD_Plk_1	337	343	PF00069	0.397
MOD_Plk_2-3	242	248	PF00069	0.479
MOD_Plk_4	128	134	PF00069	0.326
MOD_Plk_4	164	170	PF00069	0.351
MOD_Plk_4	365	371	PF00069	0.366
MOD_Plk_4	38	44	PF00069	0.336
MOD_Plk_4	394	400	PF00069	0.366
MOD_Plk_4	422	428	PF00069	0.479
MOD_ProDKin_1	170	176	PF00069	0.337
MOD_ProDKin_1	257	263	PF00069	0.487
MOD_ProDKin_1	507	513	PF00069	0.768
MOD_ProDKin_1	562	568	PF00069	0.740
MOD_SUMO_for_1	475	478	PF00179	0.359
MOD_SUMO_rev_2	236	246	PF00179	0.366
MOD_SUMO_rev_2	541	551	PF00179	0.805
TRG_DiLeu_BaEn_3	429	435	PF01217	0.350
TRG_DiLeu_BaEn_3	77	83	PF01217	0.366
TRG_ENDOCYTIC_2	254	257	PF00928	0.388
TRG_ENDOCYTIC_2	263	266	PF00928	0.288
TRG_ENDOCYTIC_2	383	386	PF00928	0.336
TRG_ENDOCYTIC_2	428	431	PF00928	0.366
TRG_ENDOCYTIC_2	445	448	PF00928	0.440
TRG_ENDOCYTIC_2	603	606	PF00928	0.336
TRG_ENDOCYTIC_2	632	635	PF00928	0.336
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD95	Leptomonas seymouri	81%	100%
A0A0S4IST4	Bodo saltans	54%	84%
A0A1X0P9B2	Trypanosomatidae	71%	100%
A0A3Q8IRJ0	Leishmania donovani	94%	99%
A0A422NEK1	Trypanosoma rangeli	66%	100%
A1E2I5	Macaca mulatta	33%	97%
A4HHM0	Leishmania braziliensis	84%	100%
A4I4S9	Leishmania infantum	94%	99%
A6H7I5	Bos taurus	44%	80%
C9ZLH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
C9ZLI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9ALK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O00429	Homo sapiens	37%	95%
O35303	Rattus norvegicus	36%	92%
P20592	Homo sapiens	32%	97%
P21575	Rattus norvegicus	44%	81%
P21576	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	99%
P27619	Drosophila melanogaster	44%	79%
P33238	Anas platyrhynchos	31%	97%
P39052	Rattus norvegicus	44%	80%
P39053	Mus musculus	44%	80%
P39054	Mus musculus	44%	80%
P39055	Caenorhabditis elegans	42%	84%
P42697	Arabidopsis thaliana	39%	100%
P50570	Homo sapiens	44%	80%
P54861	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	92%
Q000A9	Larimichthys crocea	31%	100%
Q05193	Homo sapiens	44%	81%
Q08877	Rattus norvegicus	43%	80%
Q08DF4	Bos taurus	44%	81%
Q09748	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	89%
Q2KIA5	Bos taurus	36%	93%
Q2KTC2	Dicentrarchus labrax	30%	100%
Q39821	Glycine max	37%	100%
Q39828	Glycine max	38%	100%
Q4ADG6	Phoca vitulina	32%	100%
Q5U752	Solea senegalensis	32%	100%
Q6DKF0	Danio rerio	32%	100%
Q7SXN5	Danio rerio	39%	100%
Q7T2P0	Ictalurus punctatus	34%	100%
Q84XF3	Arabidopsis thaliana	37%	100%
Q8BZ98	Mus musculus	43%	81%
Q8JH68	Danio rerio	33%	100%
Q8K1M6	Mus musculus	37%	94%
Q8LF21	Arabidopsis thaliana	37%	100%
Q8LFT2	Arabidopsis thaliana	35%	89%
Q8S3C9	Arabidopsis thaliana	39%	100%
Q8S944	Arabidopsis thaliana	34%	86%
Q94464	Dictyostelium discoideum	49%	82%
Q9FNX5	Arabidopsis thaliana	36%	100%
Q9LQ55	Arabidopsis thaliana	24%	76%
Q9N0Y3	Canis lupus familiaris	33%	100%
Q9SE83	Arabidopsis thaliana	24%	76%
Q9U1M9	Dictyostelium discoideum	40%	76%
Q9UQ16	Homo sapiens	43%	80%
Q9URZ5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
Q9ZP55	Arabidopsis thaliana	27%	100%
V5DTS8	Trypanosoma cruzi	68%	100%