Putative GTP-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynamin-1-like protein

Species:

Leishmania major

UniProt:

E9AE82_LEIMA

TriTrypDb:

LmjF.29.2200 , LMJLV39_290030000 , LMJSD75_290030100

Length:

696

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005874	microtubule	6	2
GO:0016020	membrane	2	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

E9AE82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE82

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0003924	GTPase activity	7	13
GO:0005488	binding	1	13
GO:0005515	protein binding	2	2
GO:0005525	GTP binding	5	13
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0016462	pyrophosphatase activity	5	13

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.459
CLV_NRD_NRD_1	250	252	PF00675	0.487
CLV_NRD_NRD_1	658	660	PF00675	0.366
CLV_PCSK_KEX2_1	102	104	PF00082	0.454
CLV_PCSK_KEX2_1	250	252	PF00082	0.391
CLV_PCSK_KEX2_1	542	544	PF00082	0.781
CLV_PCSK_KEX2_1	549	551	PF00082	0.794
CLV_PCSK_PC1ET2_1	542	544	PF00082	0.673
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.632
CLV_PCSK_SKI1_1	152	156	PF00082	0.336

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD95	Leptomonas seymouri	81%	100%
A0A0S4IST4	Bodo saltans	54%	84%
A0A1X0P9B2	Trypanosomatidae	71%	100%
A0A3Q8IRJ0	Leishmania donovani	94%	99%
A0A422NEK1	Trypanosoma rangeli	66%	100%
A1E2I5	Macaca mulatta	33%	97%
A4HHM0	Leishmania braziliensis	84%	100%
A4I4S9	Leishmania infantum	94%	99%
A6H7I5	Bos taurus	44%	80%
C9ZLH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%

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