LeishMANIAdb
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Membrane-associated protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-associated protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AE81_LEIMA
TriTrypDb:
LmjF.29.2190 , LMJLV39_290029900 , LMJSD75_290030000 *
Length:
1436

Annotations

LeishMANIAdb annotations

A family of single-pass TM proteins carrying a variable number of extracellular domains.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 10, no: 0
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
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Expansion

Sequence features

E9AE81
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 1244 1248 PF00656 0.394
CLV_C14_Caspase3-7 149 153 PF00656 0.387
CLV_C14_Caspase3-7 50 54 PF00656 0.318
CLV_C14_Caspase3-7 962 966 PF00656 0.392
CLV_NRD_NRD_1 1329 1331 PF00675 0.632
CLV_NRD_NRD_1 709 711 PF00675 0.636
CLV_NRD_NRD_1 722 724 PF00675 0.560
CLV_PCSK_KEX2_1 1130 1132 PF00082 0.528
CLV_PCSK_KEX2_1 1329 1331 PF00082 0.632
CLV_PCSK_KEX2_1 1354 1356 PF00082 0.678
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IKH7 Leptomonas seymouri 62% 84%
A0A0S4IKD5 Bodo saltans 38% 97%
A0A1X0P0Q5 Trypanosomatidae 45% 100%
A0A3S7X2S5 Leishmania donovani 90% 100%
A0A422NEL0 Trypanosoma rangeli 46% 100%
A4HHL9 Leishmania braziliensis 69% 100%
A4I4S8 Leishmania infantum 90% 100%
E9ALK4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
V5BGK1 Trypanosoma cruzi 43% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS