DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379), putative

Species:

Leishmania major

UniProt:

E9AE80_LEIMA

TriTrypDb:

LmjF.29.2180 , LMJLV39_290029800 , LMJSD75_290029900

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.768
CLV_C14_Caspase3-7	127	131	PF00656	0.727
CLV_C14_Caspase3-7	178	182	PF00656	0.824
CLV_C14_Caspase3-7	187	191	PF00656	0.508
CLV_C14_Caspase3-7	206	210	PF00656	0.749
CLV_NRD_NRD_1	115	117	PF00675	0.699
CLV_NRD_NRD_1	196	198	PF00675	0.781
CLV_NRD_NRD_1	200	202	PF00675	0.625
CLV_NRD_NRD_1	33	35	PF00675	0.825
CLV_NRD_NRD_1	444	446	PF00675	0.503
CLV_NRD_NRD_1	447	449	PF00675	0.473
CLV_NRD_NRD_1	99	101	PF00675	0.728
CLV_PCSK_FUR_1	197	201	PF00082	0.814
CLV_PCSK_FUR_1	442	446	PF00082	0.430
CLV_PCSK_KEX2_1	101	103	PF00082	0.678
CLV_PCSK_KEX2_1	115	117	PF00082	0.699
CLV_PCSK_KEX2_1	196	198	PF00082	0.775
CLV_PCSK_KEX2_1	199	201	PF00082	0.640
CLV_PCSK_KEX2_1	33	35	PF00082	0.825
CLV_PCSK_KEX2_1	444	446	PF00082	0.445
CLV_PCSK_KEX2_1	447	449	PF00082	0.426
CLV_PCSK_KEX2_1	86	88	PF00082	0.782
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.576
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.730
CLV_PCSK_PC7_1	111	117	PF00082	0.736
CLV_PCSK_PC7_1	196	202	PF00082	0.698
CLV_PCSK_SKI1_1	11	15	PF00082	0.622
CLV_PCSK_SKI1_1	201	205	PF00082	0.688
CLV_PCSK_SKI1_1	283	287	PF00082	0.424
CLV_PCSK_SKI1_1	298	302	PF00082	0.339
CLV_PCSK_SKI1_1	457	461	PF00082	0.714
DEG_APCC_DBOX_1	319	327	PF00400	0.411
DEG_APCC_DBOX_1	446	454	PF00400	0.436
DOC_CYCLIN_RxL_1	241	252	PF00134	0.634
DOC_MAPK_gen_1	318	326	PF00069	0.424
DOC_MAPK_JIP1_4	320	326	PF00069	0.411
DOC_PP1_RVXF_1	418	424	PF00149	0.411
DOC_PP4_FxxP_1	140	143	PF00568	0.817
DOC_PP4_FxxP_1	335	338	PF00568	0.411
DOC_USP7_MATH_1	224	228	PF00917	0.721
DOC_USP7_MATH_1	27	31	PF00917	0.755
DOC_USP7_MATH_1	342	346	PF00917	0.358
DOC_USP7_MATH_1	390	394	PF00917	0.490
DOC_USP7_MATH_1	77	81	PF00917	0.842
DOC_USP7_MATH_1	94	98	PF00917	0.540
DOC_WW_Pin1_4	410	415	PF00397	0.513
DOC_WW_Pin1_4	92	97	PF00397	0.719
LIG_14-3-3_CanoR_1	100	106	PF00244	0.684
LIG_14-3-3_CanoR_1	312	317	PF00244	0.532
LIG_14-3-3_CanoR_1	381	388	PF00244	0.581
LIG_14-3-3_CanoR_1	445	451	PF00244	0.471
LIG_Actin_WH2_2	47	63	PF00022	0.583
LIG_BIR_III_4	216	220	PF00653	0.594
LIG_BRCT_BRCA1_1	136	140	PF00533	0.836
LIG_BRCT_BRCA1_1	292	296	PF00533	0.513
LIG_BRCT_BRCA1_1	62	66	PF00533	0.686
LIG_deltaCOP1_diTrp_1	288	296	PF00928	0.436
LIG_EH_1	332	336	PF12763	0.411
LIG_FHA_1	127	133	PF00498	0.700
LIG_FHA_1	218	224	PF00498	0.606
LIG_FHA_1	232	238	PF00498	0.593
LIG_FHA_1	311	317	PF00498	0.642
LIG_FHA_1	458	464	PF00498	0.732
LIG_FHA_2	14	20	PF00498	0.706
LIG_FHA_2	150	156	PF00498	0.763
LIG_FHA_2	176	182	PF00498	0.741
LIG_LIR_Apic_2	137	143	PF02991	0.823
LIG_LIR_Apic_2	348	354	PF02991	0.411
LIG_LIR_Nem_3	398	402	PF02991	0.372
LIG_MYND_1	334	338	PF01753	0.411
LIG_REV1ctd_RIR_1	64	73	PF16727	0.652
LIG_SH2_NCK_1	257	261	PF00017	0.411
LIG_SH2_STAP1	360	364	PF00017	0.411
LIG_SH2_STAT5	245	248	PF00017	0.513
LIG_SH3_3	369	375	PF00018	0.389
LIG_TRAF2_1	152	155	PF00917	0.839
LIG_TRAF2_1	389	392	PF00917	0.692
LIG_TRAF2_1	72	75	PF00917	0.761
MOD_CK1_1	345	351	PF00069	0.406
MOD_CK1_1	446	452	PF00069	0.438
MOD_CK1_1	46	52	PF00069	0.762
MOD_CK2_1	13	19	PF00069	0.705
MOD_CK2_1	149	155	PF00069	0.741
MOD_CK2_1	181	187	PF00069	0.777
MOD_CK2_1	219	225	PF00069	0.762
MOD_CK2_1	69	75	PF00069	0.731
MOD_Cter_Amidation	84	87	PF01082	0.763
MOD_GlcNHglycan	112	115	PF01048	0.714
MOD_GlcNHglycan	166	169	PF01048	0.733
MOD_GlcNHglycan	171	174	PF01048	0.699
MOD_GlcNHglycan	275	278	PF01048	0.411
MOD_GlcNHglycan	292	295	PF01048	0.411
MOD_GlcNHglycan	383	386	PF01048	0.606
MOD_GlcNHglycan	45	48	PF01048	0.776
MOD_GlcNHglycan	96	99	PF01048	0.752
MOD_GSK3_1	134	141	PF00069	0.833
MOD_GSK3_1	169	176	PF00069	0.796
MOD_GSK3_1	215	222	PF00069	0.735
MOD_GSK3_1	306	313	PF00069	0.444
MOD_GSK3_1	410	417	PF00069	0.443
MOD_GSK3_1	45	52	PF00069	0.744
MOD_GSK3_1	7	14	PF00069	0.602
MOD_LATS_1	455	461	PF00433	0.708
MOD_N-GLC_1	310	315	PF02516	0.662
MOD_N-GLC_2	303	305	PF02516	0.375
MOD_NEK2_1	110	115	PF00069	0.605
MOD_NEK2_1	203	208	PF00069	0.692
MOD_NEK2_1	273	278	PF00069	0.513
MOD_NEK2_1	379	384	PF00069	0.579
MOD_NEK2_1	60	65	PF00069	0.753
MOD_PIKK_1	181	187	PF00454	0.826
MOD_PIKK_1	379	385	PF00454	0.685
MOD_PIKK_1	70	76	PF00454	0.782
MOD_PKA_1	101	107	PF00069	0.724
MOD_PKA_2	101	107	PF00069	0.679
MOD_PKA_2	110	116	PF00069	0.813
MOD_PKA_2	164	170	PF00069	0.739
MOD_PKA_2	173	179	PF00069	0.737
MOD_PKA_2	311	317	PF00069	0.540
MOD_PKA_2	356	362	PF00069	0.453
MOD_PKA_2	443	449	PF00069	0.419
MOD_PKA_2	68	74	PF00069	0.736
MOD_PKA_2	7	13	PF00069	0.698
MOD_Plk_1	390	396	PF00069	0.671
MOD_Plk_1	432	438	PF00069	0.411
MOD_Plk_2-3	142	148	PF00069	0.802
MOD_Plk_4	345	351	PF00069	0.411
MOD_Plk_4	390	396	PF00069	0.574
MOD_ProDKin_1	410	416	PF00069	0.513
MOD_ProDKin_1	92	98	PF00069	0.717
MOD_SUMO_for_1	336	339	PF00179	0.402
MOD_SUMO_rev_2	19	28	PF00179	0.706
MOD_SUMO_rev_2	339	348	PF00179	0.395
MOD_SUMO_rev_2	410	419	PF00179	0.389
TRG_DiLeu_BaEn_4	391	397	PF01217	0.668
TRG_ENDOCYTIC_2	245	248	PF00928	0.610
TRG_ER_diArg_1	115	117	PF00400	0.699
TRG_ER_diArg_1	196	199	PF00400	0.774
TRG_ER_diArg_1	33	35	PF00400	0.591
TRG_ER_diArg_1	443	445	PF00400	0.506
TRG_NLS_Bipartite_1	86	104	PF00514	0.801

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKX8	Leptomonas seymouri	52%	98%
A0A3Q8IEK2	Leishmania donovani	89%	100%
A4HHL8	Leishmania braziliensis	73%	95%
A4I4S7	Leishmania infantum	89%	100%
E9ALK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%