Leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE75_LEIMA

TriTrypDb:

LmjF.29.2130 , LMJLV39_290029300 , LMJSD75_290029400

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 0
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

E9AE75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE75

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.605
CLV_NRD_NRD_1	391	393	PF00675	0.391
CLV_PCSK_KEX2_1	136	138	PF00082	0.530
CLV_PCSK_KEX2_1	17	19	PF00082	0.605
CLV_PCSK_KEX2_1	391	393	PF00082	0.391
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.530
CLV_PCSK_SKI1_1	100	104	PF00082	0.497
CLV_PCSK_SKI1_1	133	137	PF00082	0.481
CLV_PCSK_SKI1_1	255	259	PF00082	0.528
CLV_Separin_Metazoa	234	238	PF03568	0.525
CLV_Separin_Metazoa	385	389	PF03568	0.538
DEG_APCC_DBOX_1	285	293	PF00400	0.484
DEG_Nend_UBRbox_3	1	3	PF02207	0.604
DOC_CKS1_1	12	17	PF01111	0.592
DOC_CYCLIN_yCln2_LP_2	145	151	PF00134	0.546
DOC_MAPK_gen_1	144	151	PF00069	0.493
DOC_PP1_SILK_1	171	176	PF00149	0.396
DOC_PP2B_LxvP_1	174	177	PF13499	0.581
DOC_USP7_MATH_1	328	332	PF00917	0.439
DOC_USP7_MATH_1	55	59	PF00917	0.541
DOC_WW_Pin1_4	11	16	PF00397	0.593
DOC_WW_Pin1_4	208	213	PF00397	0.584
DOC_WW_Pin1_4	301	306	PF00397	0.619
LIG_14-3-3_CanoR_1	237	243	PF00244	0.528
LIG_14-3-3_CanoR_1	329	333	PF00244	0.477
LIG_14-3-3_CanoR_1	382	390	PF00244	0.452
LIG_Actin_WH2_2	369	384	PF00022	0.284
LIG_BRCT_BRCA1_1	434	438	PF00533	0.456
LIG_FHA_1	108	114	PF00498	0.522
LIG_FHA_1	209	215	PF00498	0.567
LIG_FHA_1	21	27	PF00498	0.624
LIG_FHA_1	289	295	PF00498	0.277
LIG_FHA_1	331	337	PF00498	0.557
LIG_FHA_1	381	387	PF00498	0.445
LIG_FHA_1	399	405	PF00498	0.386
LIG_FHA_2	162	168	PF00498	0.530
LIG_FHA_2	251	257	PF00498	0.584
LIG_FHA_2	333	339	PF00498	0.316
LIG_GBD_Chelix_1	275	283	PF00786	0.282
LIG_GBD_Chelix_1	30	38	PF00786	0.567
LIG_IRF3_LxIS_1	264	271	PF10401	0.496
LIG_IRF3_LxIS_1	390	396	PF10401	0.346
LIG_LIR_Apic_2	470	474	PF02991	0.615
LIG_LIR_Gen_1	245	254	PF02991	0.529
LIG_LIR_Gen_1	435	446	PF02991	0.365
LIG_LIR_Nem_3	125	131	PF02991	0.512
LIG_LIR_Nem_3	245	249	PF02991	0.502
LIG_LIR_Nem_3	271	275	PF02991	0.429
LIG_LIR_Nem_3	442	446	PF02991	0.411
LIG_NRBOX	278	284	PF00104	0.285
LIG_PTB_Apo_2	266	273	PF02174	0.457
LIG_SH2_CRK	246	250	PF00017	0.512
LIG_SH2_NCK_1	63	67	PF00017	0.339
LIG_SH2_SRC	415	418	PF00017	0.474
LIG_SH2_STAP1	246	250	PF00017	0.535
LIG_SH2_STAT5	246	249	PF00017	0.506
LIG_SH2_STAT5	326	329	PF00017	0.528
LIG_SH2_STAT5	415	418	PF00017	0.521
LIG_SH2_STAT5	471	474	PF00017	0.611
LIG_SH3_2	12	17	PF14604	0.592
LIG_SH3_3	182	188	PF00018	0.621
LIG_SH3_3	299	305	PF00018	0.645
LIG_SH3_3	450	456	PF00018	0.390
LIG_SH3_3	9	15	PF00018	0.621
LIG_SUMO_SIM_anti_2	365	371	PF11976	0.454
LIG_SUMO_SIM_par_1	147	153	PF11976	0.554
LIG_SUMO_SIM_par_1	218	223	PF11976	0.470
LIG_SUMO_SIM_par_1	227	234	PF11976	0.522
LIG_SUMO_SIM_par_1	290	295	PF11976	0.391
LIG_SUMO_SIM_par_1	346	351	PF11976	0.296
LIG_TRAF2_1	112	115	PF00917	0.524
LIG_TYR_ITIM	244	249	PF00017	0.494
LIG_TYR_ITIM	413	418	PF00017	0.531
MOD_CDK_SPxK_1	11	17	PF00069	0.593
MOD_CDK_SPxxK_3	11	18	PF00069	0.591
MOD_CK1_1	20	26	PF00069	0.624
MOD_CK1_1	304	310	PF00069	0.472
MOD_CK1_1	313	319	PF00069	0.456
MOD_CK2_1	161	167	PF00069	0.519
MOD_CK2_1	250	256	PF00069	0.598
MOD_CK2_1	292	298	PF00069	0.492
MOD_CK2_1	318	324	PF00069	0.462
MOD_CK2_1	40	46	PF00069	0.603
MOD_GlcNHglycan	100	103	PF01048	0.589
MOD_GlcNHglycan	178	181	PF01048	0.627
MOD_GlcNHglycan	19	22	PF01048	0.495
MOD_GlcNHglycan	222	225	PF01048	0.455
MOD_GlcNHglycan	23	26	PF01048	0.609
MOD_GlcNHglycan	283	286	PF01048	0.474
MOD_GlcNHglycan	293	297	PF01048	0.373
MOD_GlcNHglycan	306	309	PF01048	0.428
MOD_GlcNHglycan	317	320	PF01048	0.402
MOD_GlcNHglycan	405	409	PF01048	0.439
MOD_GlcNHglycan	41	45	PF01048	0.489
MOD_GlcNHglycan	423	426	PF01048	0.415
MOD_GlcNHglycan	57	60	PF01048	0.585
MOD_GlcNHglycan	86	89	PF01048	0.615
MOD_GSK3_1	17	24	PF00069	0.600
MOD_GSK3_1	238	245	PF00069	0.490
MOD_GSK3_1	288	295	PF00069	0.408
MOD_GSK3_1	297	304	PF00069	0.540
MOD_GSK3_1	306	313	PF00069	0.385
MOD_GSK3_1	328	335	PF00069	0.528
MOD_N-GLC_1	268	273	PF02516	0.458
MOD_N-GLC_1	340	345	PF02516	0.459
MOD_N-GLC_1	427	432	PF02516	0.450
MOD_NEK2_1	149	154	PF00069	0.479
MOD_NEK2_1	161	166	PF00069	0.416
MOD_NEK2_1	220	225	PF00069	0.404
MOD_NEK2_1	242	247	PF00069	0.516
MOD_NEK2_1	249	254	PF00069	0.615
MOD_NEK2_1	268	273	PF00069	0.249
MOD_NEK2_1	281	286	PF00069	0.486
MOD_NEK2_1	292	297	PF00069	0.456
MOD_NEK2_1	306	311	PF00069	0.487
MOD_NEK2_1	332	337	PF00069	0.395
MOD_NEK2_1	89	94	PF00069	0.584
MOD_NEK2_1	98	103	PF00069	0.339
MOD_NEK2_2	250	255	PF00069	0.556
MOD_PIKK_1	244	250	PF00454	0.511
MOD_PIKK_1	306	312	PF00454	0.545
MOD_PIKK_1	358	364	PF00454	0.268
MOD_PIKK_1	427	433	PF00454	0.470
MOD_PK_1	62	68	PF00069	0.574
MOD_PKA_1	17	23	PF00069	0.593
MOD_PKA_2	107	113	PF00069	0.529
MOD_PKA_2	17	23	PF00069	0.626
MOD_PKA_2	328	334	PF00069	0.473
MOD_PKA_2	381	387	PF00069	0.520
MOD_Plk_1	268	274	PF00069	0.457
MOD_Plk_1	40	46	PF00069	0.588
MOD_Plk_1	404	410	PF00069	0.471
MOD_Plk_1	427	433	PF00069	0.457
MOD_Plk_4	169	175	PF00069	0.600
MOD_Plk_4	263	269	PF00069	0.482
MOD_ProDKin_1	11	17	PF00069	0.593
MOD_ProDKin_1	208	214	PF00069	0.575
MOD_ProDKin_1	301	307	PF00069	0.607
MOD_SUMO_for_1	203	206	PF00179	0.591
TRG_DiLeu_BaEn_1	365	370	PF01217	0.469
TRG_DiLeu_BaEn_2	433	439	PF01217	0.452
TRG_ENDOCYTIC_2	246	249	PF00928	0.506
TRG_ENDOCYTIC_2	415	418	PF00928	0.481
TRG_ENDOCYTIC_2	443	446	PF00928	0.421
TRG_ENDOCYTIC_2	63	66	PF00928	0.542
TRG_ER_diArg_1	137	140	PF00400	0.522
TRG_ER_diArg_1	17	19	PF00400	0.601
TRG_ER_diArg_1	390	392	PF00400	0.390
TRG_NES_CRM1_1	234	248	PF08389	0.510
TRG_NES_CRM1_1	385	397	PF08389	0.527
TRG_NES_CRM1_1	431	445	PF08389	0.454
TRG_NLS_MonoExtN_4	133	140	PF00514	0.520
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P012	Trypanosomatidae	29%	100%
A0A3R7KGL7	Trypanosoma rangeli	31%	100%
A0A3S5H7L7	Leishmania donovani	92%	100%
A4HHL3	Leishmania braziliensis	70%	99%
A4I4S2	Leishmania infantum	91%	100%
E9ALL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BBX4	Trypanosoma cruzi	32%	100%