DUF4139 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 37

Species:

Leishmania major

UniProt:

E9AE72_LEIMA

TriTrypDb:

LmjF.29.2100 , LMJLV39_290029000 , LMJSD75_290029100

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 12

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	2
GO:0016020	membrane	2	2
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AE72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.752
CLV_NRD_NRD_1	140	142	PF00675	0.484
CLV_NRD_NRD_1	335	337	PF00675	0.360
CLV_NRD_NRD_1	40	42	PF00675	0.427
CLV_NRD_NRD_1	597	599	PF00675	0.336
CLV_NRD_NRD_1	613	615	PF00675	0.463
CLV_PCSK_KEX2_1	140	142	PF00082	0.608
CLV_PCSK_KEX2_1	217	219	PF00082	0.492
CLV_PCSK_KEX2_1	335	337	PF00082	0.360
CLV_PCSK_KEX2_1	395	397	PF00082	0.288
CLV_PCSK_KEX2_1	40	42	PF00082	0.427
CLV_PCSK_KEX2_1	543	545	PF00082	0.367
CLV_PCSK_KEX2_1	597	599	PF00082	0.347
CLV_PCSK_KEX2_1	613	615	PF00082	0.482
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.472
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.288
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.336
CLV_PCSK_SKI1_1	218	222	PF00082	0.557
CLV_PCSK_SKI1_1	224	228	PF00082	0.490
CLV_PCSK_SKI1_1	509	513	PF00082	0.340
CLV_PCSK_SKI1_1	543	547	PF00082	0.477
CLV_PCSK_SKI1_1	86	90	PF00082	0.467
CLV_Separin_Metazoa	219	223	PF03568	0.446
DEG_APCC_DBOX_1	427	435	PF00400	0.379
DEG_Nend_UBRbox_3	1	3	PF02207	0.611
DOC_CKS1_1	356	361	PF01111	0.288
DOC_CKS1_1	47	52	PF01111	0.556
DOC_CYCLIN_yCln2_LP_2	434	440	PF00134	0.377
DOC_CYCLIN_yCln2_LP_2	573	579	PF00134	0.419
DOC_MAPK_gen_1	40	47	PF00069	0.459
DOC_MAPK_gen_1	554	563	PF00069	0.376
DOC_MAPK_gen_1	613	623	PF00069	0.459
DOC_MAPK_MEF2A_6	231	240	PF00069	0.421
DOC_MAPK_MEF2A_6	616	625	PF00069	0.360
DOC_MAPK_MEF2A_6	72	79	PF00069	0.463
DOC_PP2B_LxvP_1	434	437	PF13499	0.348
DOC_PP2B_LxvP_1	465	468	PF13499	0.419
DOC_PP4_FxxP_1	412	415	PF00568	0.325
DOC_PP4_FxxP_1	47	50	PF00568	0.591
DOC_USP7_MATH_1	119	123	PF00917	0.816
DOC_USP7_MATH_1	229	233	PF00917	0.388
DOC_USP7_MATH_1	446	450	PF00917	0.411
DOC_USP7_MATH_1	501	505	PF00917	0.290
DOC_USP7_MATH_1	545	549	PF00917	0.535
DOC_USP7_MATH_1	562	566	PF00917	0.249
DOC_USP7_MATH_1	6	10	PF00917	0.687
DOC_USP7_MATH_1	617	621	PF00917	0.367
DOC_WW_Pin1_4	21	26	PF00397	0.441
DOC_WW_Pin1_4	243	248	PF00397	0.667
DOC_WW_Pin1_4	352	357	PF00397	0.502
DOC_WW_Pin1_4	361	366	PF00397	0.247
DOC_WW_Pin1_4	46	51	PF00397	0.540
DOC_WW_Pin1_4	572	577	PF00397	0.414
LIG_14-3-3_CanoR_1	519	523	PF00244	0.339
LIG_APCC_ABBA_1	471	476	PF00400	0.419
LIG_APCC_ABBA_1	583	588	PF00400	0.409
LIG_BIR_III_4	125	129	PF00653	0.627
LIG_CtBP_PxDLS_1	341	345	PF00389	0.235
LIG_FHA_1	105	111	PF00498	0.584
LIG_FHA_1	169	175	PF00498	0.506
LIG_FHA_1	18	24	PF00498	0.596
LIG_FHA_1	188	194	PF00498	0.472
LIG_FHA_1	256	262	PF00498	0.546
LIG_FHA_1	263	269	PF00498	0.531
LIG_FHA_1	301	307	PF00498	0.374
LIG_FHA_1	356	362	PF00498	0.392
LIG_FHA_1	404	410	PF00498	0.428
LIG_FHA_1	424	430	PF00498	0.382
LIG_FHA_1	506	512	PF00498	0.343
LIG_FHA_1	525	531	PF00498	0.406
LIG_FHA_1	544	550	PF00498	0.407
LIG_FHA_2	255	261	PF00498	0.557
LIG_FHA_2	378	384	PF00498	0.235
LIG_FHA_2	491	497	PF00498	0.299
LIG_LIR_Apic_2	283	287	PF02991	0.319
LIG_LIR_Apic_2	46	50	PF02991	0.618
LIG_LIR_Gen_1	376	387	PF02991	0.235
LIG_LIR_Gen_1	441	450	PF02991	0.306
LIG_LIR_Gen_1	461	472	PF02991	0.371
LIG_LIR_Nem_3	376	382	PF02991	0.235
LIG_LIR_Nem_3	441	445	PF02991	0.306
LIG_LIR_Nem_3	461	467	PF02991	0.371
LIG_PDZ_Class_2	635	640	PF00595	0.477
LIG_Pex14_1	291	295	PF04695	0.335
LIG_Pex14_2	79	83	PF04695	0.448
LIG_SH2_CRK	284	288	PF00017	0.288
LIG_SH2_CRK	442	446	PF00017	0.320
LIG_SH2_GRB2like	309	312	PF00017	0.319
LIG_SH2_GRB2like	33	36	PF00017	0.441
LIG_SH2_NCK_1	442	446	PF00017	0.292
LIG_SH2_STAP1	170	174	PF00017	0.513
LIG_SH2_STAP1	295	299	PF00017	0.354
LIG_SH2_STAP1	533	537	PF00017	0.344
LIG_SH2_STAT5	170	173	PF00017	0.647
LIG_SH2_STAT5	281	284	PF00017	0.309
LIG_SH2_STAT5	442	445	PF00017	0.312
LIG_SH2_STAT5	479	482	PF00017	0.391
LIG_SH2_STAT5	498	501	PF00017	0.403
LIG_SH2_STAT5	522	525	PF00017	0.420
LIG_SH3_3	265	271	PF00018	0.583
LIG_SH3_3	348	354	PF00018	0.466
LIG_SH3_3	53	59	PF00018	0.556
LIG_SH3_3	573	579	PF00018	0.372
LIG_SH3_3	626	632	PF00018	0.356
LIG_SUMO_SIM_anti_2	171	177	PF11976	0.385
LIG_SUMO_SIM_anti_2	257	263	PF11976	0.550
LIG_SUMO_SIM_anti_2	619	625	PF11976	0.419
LIG_SUMO_SIM_par_1	104	111	PF11976	0.654
LIG_SUMO_SIM_par_1	169	177	PF11976	0.386
LIG_SUMO_SIM_par_1	260	265	PF11976	0.470
LIG_SUMO_SIM_par_1	606	612	PF11976	0.473
LIG_TRAF2_1	564	567	PF00917	0.346
LIG_TRFH_1	464	468	PF08558	0.419
LIG_TYR_ITIM	440	445	PF00017	0.303
MOD_CDC14_SPxK_1	575	578	PF00782	0.419
MOD_CDK_SPK_2	21	26	PF00069	0.411
MOD_CDK_SPK_2	243	248	PF00069	0.551
MOD_CDK_SPxK_1	572	578	PF00069	0.419
MOD_CK1_1	104	110	PF00069	0.558
MOD_CK1_1	355	361	PF00069	0.408
MOD_CK1_1	441	447	PF00069	0.377
MOD_CK1_1	46	52	PF00069	0.549
MOD_CK1_1	633	639	PF00069	0.550
MOD_CK2_1	174	180	PF00069	0.558
MOD_CK2_1	229	235	PF00069	0.537
MOD_CK2_1	377	383	PF00069	0.429
MOD_CK2_1	441	447	PF00069	0.398
MOD_CK2_1	561	567	PF00069	0.358
MOD_GlcNHglycan	119	122	PF01048	0.817
MOD_GlcNHglycan	135	138	PF01048	0.509
MOD_GlcNHglycan	176	179	PF01048	0.557
MOD_GlcNHglycan	287	290	PF01048	0.441
MOD_GlcNHglycan	330	333	PF01048	0.325
MOD_GlcNHglycan	490	493	PF01048	0.374
MOD_GSK3_1	117	124	PF00069	0.747
MOD_GSK3_1	17	24	PF00069	0.522
MOD_GSK3_1	323	330	PF00069	0.504
MOD_GSK3_1	501	508	PF00069	0.344
MOD_GSK3_1	525	532	PF00069	0.427
MOD_N-GLC_1	207	212	PF02516	0.439
MOD_N-GLC_1	34	39	PF02516	0.423
MOD_N-GLC_1	342	347	PF02516	0.344
MOD_N-GLC_1	410	415	PF02516	0.364
MOD_N-GLC_1	459	464	PF02516	0.342
MOD_N-GLC_1	633	638	PF02516	0.617
MOD_NEK2_1	174	179	PF00069	0.541
MOD_NEK2_1	187	192	PF00069	0.593
MOD_NEK2_1	327	332	PF00069	0.346
MOD_NEK2_1	410	415	PF00069	0.282
MOD_NEK2_1	45	50	PF00069	0.602
MOD_NEK2_2	535	540	PF00069	0.325
MOD_PIKK_1	142	148	PF00454	0.447
MOD_PIKK_1	480	486	PF00454	0.342
MOD_PIKK_1	525	531	PF00454	0.440
MOD_PKA_1	543	549	PF00069	0.319
MOD_PKA_1	597	603	PF00069	0.250
MOD_PKA_2	28	34	PF00069	0.481
MOD_PKA_2	518	524	PF00069	0.340
MOD_PKA_2	535	541	PF00069	0.418
MOD_PKA_2	543	549	PF00069	0.409
MOD_PKA_2	597	603	PF00069	0.520
MOD_PKA_2	71	77	PF00069	0.481
MOD_Plk_1	110	116	PF00069	0.562
MOD_Plk_1	168	174	PF00069	0.548
MOD_Plk_1	323	329	PF00069	0.288
MOD_Plk_1	34	40	PF00069	0.479
MOD_Plk_1	342	348	PF00069	0.225
MOD_Plk_1	410	416	PF00069	0.367
MOD_Plk_1	446	452	PF00069	0.307
MOD_Plk_1	505	511	PF00069	0.414
MOD_Plk_1	633	639	PF00069	0.581
MOD_Plk_4	28	34	PF00069	0.436
MOD_Plk_4	280	286	PF00069	0.338
MOD_Plk_4	342	348	PF00069	0.379
MOD_Plk_4	416	422	PF00069	0.442
MOD_Plk_4	518	524	PF00069	0.444
MOD_Plk_4	633	639	PF00069	0.602
MOD_ProDKin_1	21	27	PF00069	0.430
MOD_ProDKin_1	243	249	PF00069	0.673
MOD_ProDKin_1	352	358	PF00069	0.495
MOD_ProDKin_1	361	367	PF00069	0.247
MOD_ProDKin_1	46	52	PF00069	0.544
MOD_ProDKin_1	572	578	PF00069	0.414
MOD_SUMO_for_1	216	219	PF00179	0.536
MOD_SUMO_rev_2	230	238	PF00179	0.517
MOD_SUMO_rev_2	320	325	PF00179	0.314
MOD_SUMO_rev_2	78	88	PF00179	0.558
TRG_DiLeu_BaEn_1	619	624	PF01217	0.288
TRG_DiLeu_BaEn_2	469	475	PF01217	0.319
TRG_DiLeu_BaLyEn_6	598	603	PF01217	0.319
TRG_ENDOCYTIC_2	442	445	PF00928	0.303
TRG_ER_diArg_1	334	336	PF00400	0.394
TRG_ER_diArg_1	613	616	PF00400	0.463
TRG_NES_CRM1_1	146	158	PF08389	0.474
TRG_NLS_MonoExtN_4	540	546	PF00514	0.419
TRG_NLS_MonoExtN_4	597	602	PF00514	0.288
TRG_Pf-PMV_PEXEL_1	141	146	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	509	514	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	601	606	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3W3	Leptomonas seymouri	60%	100%
A0A0S4JNB4	Bodo saltans	22%	100%
A0A3Q8IFG9	Leishmania donovani	94%	100%
A0A3Q8IHT6	Leishmania donovani	26%	100%
A0A3R7LIT5	Trypanosoma rangeli	31%	100%
A4HHL0	Leishmania braziliensis	76%	100%
A4I4S0	Leishmania infantum	94%	100%
A4I5C4	Leishmania infantum	26%	100%
C9ZQQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZUB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	92%
E9ALL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B0M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q7L0	Leishmania major	26%	100%