Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AE69_LEIMA

TriTrypDb:

LmjF.29.2070 , LMJLV39_290028700 , LMJSD75_290028800

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	312	316	PF00656	0.660
CLV_MEL_PAP_1	256	262	PF00089	0.503
CLV_NRD_NRD_1	219	221	PF00675	0.716
CLV_NRD_NRD_1	233	235	PF00675	0.674
CLV_NRD_NRD_1	292	294	PF00675	0.734
CLV_NRD_NRD_1	30	32	PF00675	0.697
CLV_NRD_NRD_1	300	302	PF00675	0.626
CLV_NRD_NRD_1	376	378	PF00675	0.644
CLV_NRD_NRD_1	386	388	PF00675	0.587
CLV_NRD_NRD_1	389	391	PF00675	0.551
CLV_PCSK_FUR_1	217	221	PF00082	0.698
CLV_PCSK_FUR_1	290	294	PF00082	0.630
CLV_PCSK_FUR_1	296	300	PF00082	0.601
CLV_PCSK_KEX2_1	219	221	PF00082	0.720
CLV_PCSK_KEX2_1	233	235	PF00082	0.688
CLV_PCSK_KEX2_1	292	294	PF00082	0.781
CLV_PCSK_KEX2_1	296	298	PF00082	0.632
CLV_PCSK_KEX2_1	299	301	PF00082	0.586
CLV_PCSK_KEX2_1	386	388	PF00082	0.637
CLV_PCSK_PC7_1	292	298	PF00082	0.678
CLV_PCSK_SKI1_1	248	252	PF00082	0.585
CLV_PCSK_SKI1_1	285	289	PF00082	0.541
CLV_PCSK_SKI1_1	425	429	PF00082	0.676
DEG_SPOP_SBC_1	369	373	PF00917	0.657
DEG_SPOP_SBC_1	57	61	PF00917	0.685
DOC_CDC14_PxL_1	1	9	PF14671	0.573
DOC_CYCLIN_yCln2_LP_2	3	9	PF00134	0.514
DOC_MAPK_DCC_7	37	46	PF00069	0.738
DOC_MAPK_gen_1	243	253	PF00069	0.522
DOC_MAPK_MEF2A_6	190	199	PF00069	0.624
DOC_MAPK_MEF2A_6	37	46	PF00069	0.738
DOC_PP4_FxxP_1	435	438	PF00568	0.692
DOC_USP7_MATH_1	100	104	PF00917	0.664
DOC_USP7_MATH_1	227	231	PF00917	0.572
DOC_USP7_MATH_1	25	29	PF00917	0.689
DOC_USP7_MATH_1	323	327	PF00917	0.795
DOC_USP7_MATH_1	342	346	PF00917	0.784
DOC_USP7_MATH_1	35	39	PF00917	0.635
DOC_USP7_MATH_1	74	78	PF00917	0.660
DOC_USP7_UBL2_3	279	283	PF12436	0.652
DOC_USP7_UBL2_3	378	382	PF12436	0.720
DOC_WW_Pin1_4	189	194	PF00397	0.704
DOC_WW_Pin1_4	209	214	PF00397	0.758
DOC_WW_Pin1_4	321	326	PF00397	0.807
DOC_WW_Pin1_4	348	353	PF00397	0.745
DOC_WW_Pin1_4	415	420	PF00397	0.688
LIG_14-3-3_CanoR_1	159	163	PF00244	0.438
LIG_14-3-3_CanoR_1	222	232	PF00244	0.711
LIG_14-3-3_CanoR_1	233	242	PF00244	0.684
LIG_14-3-3_CanoR_1	308	317	PF00244	0.721
LIG_14-3-3_CanoR_1	37	41	PF00244	0.700
LIG_14-3-3_CanoR_1	390	398	PF00244	0.651
LIG_14-3-3_CanoR_1	425	430	PF00244	0.680
LIG_14-3-3_CanoR_1	43	52	PF00244	0.741
LIG_14-3-3_CanoR_1	96	100	PF00244	0.707
LIG_BIR_III_4	327	331	PF00653	0.697
LIG_FAT_LD_1	128	136	PF03623	0.549
LIG_FHA_1	159	165	PF00498	0.508
LIG_FHA_1	196	202	PF00498	0.610
LIG_FHA_1	253	259	PF00498	0.568
LIG_FHA_1	309	315	PF00498	0.741
LIG_FHA_1	390	396	PF00498	0.734
LIG_FHA_1	402	408	PF00498	0.558
LIG_FHA_2	112	118	PF00498	0.632
LIG_FHA_2	178	184	PF00498	0.729
LIG_FHA_2	200	206	PF00498	0.677
LIG_FHA_2	310	316	PF00498	0.727
LIG_Integrin_isoDGR_2	364	366	PF01839	0.602
LIG_IRF3_LxIS_1	197	204	PF10401	0.613
LIG_LIR_Apic_2	351	356	PF02991	0.796
LIG_LIR_Nem_3	210	214	PF02991	0.724
LIG_MAD2	16	24	PF02301	0.687
LIG_NRBOX	90	96	PF00104	0.636
LIG_SH2_STAP1	236	240	PF00017	0.637
LIG_SH3_3	18	24	PF00018	0.621
LIG_SH3_3	194	200	PF00018	0.590
LIG_SH3_3	319	325	PF00018	0.797
LIG_SH3_3	405	411	PF00018	0.700
LIG_SH3_3	94	100	PF00018	0.669
LIG_SH3_4	378	385	PF00018	0.720
LIG_SUMO_SIM_anti_2	168	173	PF11976	0.628
LIG_SUMO_SIM_par_1	198	205	PF11976	0.737
LIG_SUMO_SIM_par_1	249	255	PF11976	0.481
LIG_TRAF2_1	109	112	PF00917	0.746
LIG_TRAF2_1	180	183	PF00917	0.730
MOD_CK1_1	165	171	PF00069	0.636
MOD_CK1_1	261	267	PF00069	0.643
MOD_CK1_1	344	350	PF00069	0.779
MOD_CK1_1	351	357	PF00069	0.693
MOD_CK1_1	368	374	PF00069	0.734
MOD_CK1_1	389	395	PF00069	0.733
MOD_CK1_1	45	51	PF00069	0.734
MOD_CK2_1	111	117	PF00069	0.708
MOD_CK2_1	177	183	PF00069	0.719
MOD_CK2_1	301	307	PF00069	0.750
MOD_CK2_1	323	329	PF00069	0.800
MOD_GlcNHglycan	186	189	PF01048	0.743
MOD_GlcNHglycan	225	228	PF01048	0.708
MOD_GlcNHglycan	229	232	PF01048	0.713
MOD_GlcNHglycan	260	263	PF01048	0.617
MOD_GlcNHglycan	293	296	PF01048	0.651
MOD_GlcNHglycan	344	347	PF01048	0.710
MOD_GlcNHglycan	367	370	PF01048	0.796
MOD_GlcNHglycan	76	79	PF01048	0.663
MOD_GlcNHglycan	80	83	PF01048	0.792
MOD_GSK3_1	158	165	PF00069	0.530
MOD_GSK3_1	195	202	PF00069	0.521
MOD_GSK3_1	223	230	PF00069	0.638
MOD_GSK3_1	344	351	PF00069	0.702
MOD_GSK3_1	365	372	PF00069	0.695
MOD_GSK3_1	397	404	PF00069	0.700
MOD_GSK3_1	44	51	PF00069	0.596
MOD_GSK3_1	64	71	PF00069	0.531
MOD_GSK3_1	74	81	PF00069	0.628
MOD_N-GLC_1	195	200	PF02516	0.514
MOD_NEK2_1	260	265	PF00069	0.608
MOD_NEK2_1	44	49	PF00069	0.621
MOD_NEK2_1	95	100	PF00069	0.728
MOD_NEK2_2	381	386	PF00069	0.646
MOD_PIKK_1	130	136	PF00454	0.594
MOD_PIKK_1	372	378	PF00454	0.799
MOD_PIKK_1	89	95	PF00454	0.618
MOD_PKA_1	386	392	PF00069	0.720
MOD_PKA_2	158	164	PF00069	0.426
MOD_PKA_2	221	227	PF00069	0.718
MOD_PKA_2	232	238	PF00069	0.670
MOD_PKA_2	258	264	PF00069	0.516
MOD_PKA_2	291	297	PF00069	0.726
MOD_PKA_2	307	313	PF00069	0.523
MOD_PKA_2	36	42	PF00069	0.790
MOD_PKA_2	365	371	PF00069	0.839
MOD_PKA_2	386	392	PF00069	0.751
MOD_PKA_2	95	101	PF00069	0.766
MOD_PKB_1	299	307	PF00069	0.624
MOD_Plk_1	111	117	PF00069	0.762
MOD_Plk_1	165	171	PF00069	0.636
MOD_Plk_1	195	201	PF00069	0.517
MOD_Plk_2-3	111	117	PF00069	0.762
MOD_Plk_4	36	42	PF00069	0.761
MOD_ProDKin_1	189	195	PF00069	0.695
MOD_ProDKin_1	209	215	PF00069	0.758
MOD_ProDKin_1	321	327	PF00069	0.809
MOD_ProDKin_1	348	354	PF00069	0.747
MOD_ProDKin_1	415	421	PF00069	0.686
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.656
TRG_ER_diArg_1	217	220	PF00400	0.726
TRG_ER_diArg_1	232	234	PF00400	0.485
TRG_ER_diArg_1	290	293	PF00400	0.720
TRG_ER_diArg_1	296	299	PF00400	0.802
TRG_ER_diArg_1	300	302	PF00400	0.668
TRG_ER_diArg_1	385	387	PF00400	0.686
TRG_NES_CRM1_1	134	147	PF08389	0.456
TRG_NLS_MonoCore_2	376	381	PF00514	0.718
TRG_NLS_MonoExtC_3	278	283	PF00514	0.692
TRG_NLS_MonoExtN_4	279	284	PF00514	0.690
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCW7	Leptomonas seymouri	29%	100%
A0A3Q8IRH8	Leishmania donovani	84%	99%
A4HHK6	Leishmania braziliensis	53%	100%
A4I4R7	Leishmania infantum	84%	99%
E9ALL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%