Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE67_LEIMA

TriTrypDb:

LmjF.29.2050 , LMJLV39_290028500 , LMJSD75_290028600

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE67

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	240	242	PF00675	0.626
CLV_NRD_NRD_1	374	376	PF00675	0.557
CLV_NRD_NRD_1	388	390	PF00675	0.523
CLV_NRD_NRD_1	487	489	PF00675	0.595
CLV_NRD_NRD_1	582	584	PF00675	0.655
CLV_NRD_NRD_1	659	661	PF00675	0.596
CLV_NRD_NRD_1	707	709	PF00675	0.783
CLV_NRD_NRD_1	717	719	PF00675	0.602
CLV_NRD_NRD_1	738	740	PF00675	0.458
CLV_PCSK_KEX2_1	486	488	PF00082	0.598
CLV_PCSK_KEX2_1	582	584	PF00082	0.646
CLV_PCSK_KEX2_1	659	661	PF00082	0.589
CLV_PCSK_KEX2_1	707	709	PF00082	0.610
CLV_PCSK_KEX2_1	723	725	PF00082	0.537
CLV_PCSK_PC1ET2_1	723	725	PF00082	0.669
CLV_PCSK_PC7_1	482	488	PF00082	0.622
CLV_PCSK_SKI1_1	482	486	PF00082	0.621
CLV_PCSK_SKI1_1	660	664	PF00082	0.661
CLV_PCSK_SKI1_1	723	727	PF00082	0.545
CLV_PCSK_SKI1_1	94	98	PF00082	0.692
DEG_SPOP_SBC_1	155	159	PF00917	0.527
DEG_SPOP_SBC_1	269	273	PF00917	0.590
DEG_SPOP_SBC_1	303	307	PF00917	0.477
DEG_SPOP_SBC_1	427	431	PF00917	0.639
DEG_SPOP_SBC_1	605	609	PF00917	0.689
DEG_SPOP_SBC_1	614	618	PF00917	0.659
DOC_ANK_TNKS_1	694	701	PF00023	0.637
DOC_CKS1_1	547	552	PF01111	0.608
DOC_CYCLIN_RxL_1	479	489	PF00134	0.641
DOC_CYCLIN_RxL_1	657	666	PF00134	0.625
DOC_CYCLIN_RxL_1	91	101	PF00134	0.635
DOC_CYCLIN_yCln2_LP_2	690	696	PF00134	0.578
DOC_MAPK_DCC_7	508	518	PF00069	0.602
DOC_PP1_RVXF_1	492	498	PF00149	0.624
DOC_PP2B_LxvP_1	162	165	PF13499	0.694
DOC_PP4_FxxP_1	92	95	PF00568	0.633
DOC_USP7_MATH_1	10	14	PF00917	0.664
DOC_USP7_MATH_1	155	159	PF00917	0.624
DOC_USP7_MATH_1	183	187	PF00917	0.611
DOC_USP7_MATH_1	19	23	PF00917	0.659
DOC_USP7_MATH_1	202	206	PF00917	0.521
DOC_USP7_MATH_1	225	229	PF00917	0.622
DOC_USP7_MATH_1	248	252	PF00917	0.664
DOC_USP7_MATH_1	26	30	PF00917	0.627
DOC_USP7_MATH_1	264	268	PF00917	0.521
DOC_USP7_MATH_1	269	273	PF00917	0.479
DOC_USP7_MATH_1	303	307	PF00917	0.473
DOC_USP7_MATH_1	364	368	PF00917	0.643
DOC_USP7_MATH_1	427	431	PF00917	0.705
DOC_USP7_MATH_1	471	475	PF00917	0.573
DOC_USP7_MATH_1	509	513	PF00917	0.597
DOC_USP7_MATH_1	573	577	PF00917	0.597
DOC_USP7_MATH_1	605	609	PF00917	0.643
DOC_USP7_MATH_1	614	618	PF00917	0.558
DOC_USP7_UBL2_3	250	254	PF12436	0.581
DOC_USP7_UBL2_3	719	723	PF12436	0.597
DOC_WW_Pin1_4	171	176	PF00397	0.640
DOC_WW_Pin1_4	216	221	PF00397	0.641
DOC_WW_Pin1_4	252	257	PF00397	0.638
DOC_WW_Pin1_4	40	45	PF00397	0.587
DOC_WW_Pin1_4	449	454	PF00397	0.716
DOC_WW_Pin1_4	511	516	PF00397	0.661
DOC_WW_Pin1_4	546	551	PF00397	0.595
DOC_WW_Pin1_4	568	573	PF00397	0.605
DOC_WW_Pin1_4	575	580	PF00397	0.603
LIG_14-3-3_CanoR_1	141	150	PF00244	0.562
LIG_14-3-3_CanoR_1	375	379	PF00244	0.522
LIG_14-3-3_CanoR_1	38	44	PF00244	0.644
LIG_14-3-3_CanoR_1	480	485	PF00244	0.623
LIG_14-3-3_CanoR_1	490	498	PF00244	0.646
LIG_14-3-3_CanoR_1	582	588	PF00244	0.671
LIG_14-3-3_CanoR_1	64	69	PF00244	0.560
LIG_14-3-3_CanoR_1	739	743	PF00244	0.605
LIG_14-3-3_CanoR_1	94	104	PF00244	0.585
LIG_14-3-3_CterR_2	739	743	PF00244	0.513
LIG_AP2alpha_2	692	694	PF02296	0.531
LIG_APCC_ABBAyCdc20_2	389	395	PF00400	0.557
LIG_BRCT_BRCA1_1	21	25	PF00533	0.604
LIG_BRCT_BRCA1_1	294	298	PF00533	0.476
LIG_BRCT_BRCA1_1	551	555	PF00533	0.533
LIG_BRCT_BRCA1_1	624	628	PF00533	0.591
LIG_EVH1_1	162	166	PF00568	0.693
LIG_FHA_1	157	163	PF00498	0.565
LIG_FHA_1	209	215	PF00498	0.580
LIG_FHA_1	346	352	PF00498	0.604
LIG_FHA_1	366	372	PF00498	0.545
LIG_FHA_1	474	480	PF00498	0.501
LIG_FHA_1	540	546	PF00498	0.633
LIG_FHA_1	563	569	PF00498	0.611
LIG_FHA_1	582	588	PF00498	0.636
LIG_FHA_1	636	642	PF00498	0.541
LIG_FHA_1	673	679	PF00498	0.685
LIG_FHA_2	221	227	PF00498	0.615
LIG_FHA_2	30	36	PF00498	0.700
LIG_FHA_2	303	309	PF00498	0.526
LIG_FHA_2	41	47	PF00498	0.570
LIG_FHA_2	541	547	PF00498	0.636
LIG_FHA_2	664	670	PF00498	0.639
LIG_LIR_Apic_2	233	237	PF02991	0.608
LIG_LIR_Gen_1	396	406	PF02991	0.461
LIG_LIR_Gen_1	552	563	PF02991	0.523
LIG_LIR_Nem_3	148	153	PF02991	0.671
LIG_LIR_Nem_3	396	402	PF02991	0.463
LIG_LIR_Nem_3	552	558	PF02991	0.520
LIG_MYND_1	661	665	PF01753	0.609
LIG_Pex14_2	732	736	PF04695	0.549
LIG_RPA_C_Fungi	483	495	PF08784	0.595
LIG_SH2_STAT5	234	237	PF00017	0.631
LIG_SH2_STAT5	417	420	PF00017	0.516
LIG_SH2_STAT5	478	481	PF00017	0.654
LIG_SH2_STAT5	517	520	PF00017	0.519
LIG_SH3_3	131	137	PF00018	0.563
LIG_SH3_3	160	166	PF00018	0.614
LIG_SH3_3	42	48	PF00018	0.625
LIG_SH3_3	544	550	PF00018	0.578
LIG_SH3_3	569	575	PF00018	0.663
LIG_SH3_3	655	661	PF00018	0.663
LIG_SH3_3	665	671	PF00018	0.692
LIG_SH3_3	690	696	PF00018	0.597
LIG_SUMO_SIM_anti_2	542	549	PF11976	0.613
LIG_SUMO_SIM_par_1	285	292	PF11976	0.567
LIG_SUMO_SIM_par_1	564	571	PF11976	0.634
LIG_TRAF2_1	383	386	PF00917	0.576
LIG_WW_2	572	575	PF00397	0.637
MOD_CDK_SPxxK_3	575	582	PF00069	0.648
MOD_CK1_1	114	120	PF00069	0.728
MOD_CK1_1	132	138	PF00069	0.614
MOD_CK1_1	142	148	PF00069	0.588
MOD_CK1_1	151	157	PF00069	0.705
MOD_CK1_1	230	236	PF00069	0.603
MOD_CK1_1	244	250	PF00069	0.610
MOD_CK1_1	272	278	PF00069	0.579
MOD_CK1_1	29	35	PF00069	0.620
MOD_CK1_1	292	298	PF00069	0.600
MOD_CK1_1	337	343	PF00069	0.567
MOD_CK1_1	344	350	PF00069	0.585
MOD_CK1_1	367	373	PF00069	0.579
MOD_CK1_1	374	380	PF00069	0.563
MOD_CK1_1	430	436	PF00069	0.651
MOD_CK1_1	562	568	PF00069	0.662
MOD_CK1_1	607	613	PF00069	0.612
MOD_CK1_1	615	621	PF00069	0.571
MOD_CK1_1	622	628	PF00069	0.619
MOD_CK1_1	80	86	PF00069	0.640
MOD_CK1_1	98	104	PF00069	0.587
MOD_CK2_1	132	138	PF00069	0.657
MOD_CK2_1	155	161	PF00069	0.627
MOD_CK2_1	302	308	PF00069	0.532
MOD_CK2_1	378	384	PF00069	0.601
MOD_CK2_1	698	704	PF00069	0.677
MOD_CMANNOS	419	422	PF00535	0.553
MOD_Cter_Amidation	705	708	PF01082	0.692
MOD_GlcNHglycan	147	150	PF01048	0.681
MOD_GlcNHglycan	153	156	PF01048	0.627
MOD_GlcNHglycan	185	188	PF01048	0.623
MOD_GlcNHglycan	200	203	PF01048	0.550
MOD_GlcNHglycan	204	207	PF01048	0.505
MOD_GlcNHglycan	229	232	PF01048	0.743
MOD_GlcNHglycan	243	246	PF01048	0.558
MOD_GlcNHglycan	285	288	PF01048	0.616
MOD_GlcNHglycan	339	342	PF01048	0.744
MOD_GlcNHglycan	343	346	PF01048	0.600
MOD_GlcNHglycan	432	435	PF01048	0.636
MOD_GlcNHglycan	444	447	PF01048	0.521
MOD_GlcNHglycan	462	465	PF01048	0.668
MOD_GlcNHglycan	473	476	PF01048	0.525
MOD_GlcNHglycan	561	564	PF01048	0.760
MOD_GlcNHglycan	609	612	PF01048	0.634
MOD_GlcNHglycan	684	687	PF01048	0.600
MOD_GlcNHglycan	699	703	PF01048	0.650
MOD_GlcNHglycan	79	82	PF01048	0.664
MOD_GlcNHglycan	86	89	PF01048	0.674
MOD_GSK3_1	107	114	PF00069	0.628
MOD_GSK3_1	139	146	PF00069	0.793
MOD_GSK3_1	151	158	PF00069	0.606
MOD_GSK3_1	179	186	PF00069	0.626
MOD_GSK3_1	198	205	PF00069	0.534
MOD_GSK3_1	216	223	PF00069	0.585
MOD_GSK3_1	244	251	PF00069	0.661
MOD_GSK3_1	26	33	PF00069	0.825
MOD_GSK3_1	264	271	PF00069	0.576
MOD_GSK3_1	337	344	PF00069	0.749
MOD_GSK3_1	367	374	PF00069	0.717
MOD_GSK3_1	426	433	PF00069	0.780
MOD_GSK3_1	442	449	PF00069	0.748
MOD_GSK3_1	558	565	PF00069	0.698
MOD_GSK3_1	593	600	PF00069	0.597
MOD_GSK3_1	605	612	PF00069	0.619
MOD_GSK3_1	613	620	PF00069	0.698
MOD_GSK3_1	648	655	PF00069	0.767
MOD_GSK3_1	69	76	PF00069	0.642
MOD_GSK3_1	694	701	PF00069	0.720
MOD_GSK3_1	734	741	PF00069	0.640
MOD_GSK3_1	80	87	PF00069	0.570
MOD_GSK3_1	95	102	PF00069	0.722
MOD_N-GLC_1	143	148	PF02516	0.563
MOD_N-GLC_1	427	432	PF02516	0.642
MOD_N-GLC_2	465	467	PF02516	0.621
MOD_NEK2_1	139	144	PF00069	0.621
MOD_NEK2_1	208	213	PF00069	0.612
MOD_NEK2_1	268	273	PF00069	0.597
MOD_NEK2_1	353	358	PF00069	0.524
MOD_NEK2_1	371	376	PF00069	0.521
MOD_NEK2_1	39	44	PF00069	0.597
MOD_NEK2_1	599	604	PF00069	0.711
MOD_NEK2_1	606	611	PF00069	0.621
MOD_NEK2_1	96	101	PF00069	0.611
MOD_NMyristoyl	1	7	PF02799	0.677
MOD_PIKK_1	19	25	PF00454	0.602
MOD_PIKK_1	345	351	PF00454	0.666
MOD_PIKK_1	549	555	PF00454	0.654
MOD_PIKK_1	663	669	PF00454	0.698
MOD_PIKK_1	734	740	PF00454	0.477
MOD_PK_1	636	642	PF00069	0.609
MOD_PK_1	64	70	PF00069	0.648
MOD_PKA_1	241	247	PF00069	0.643
MOD_PKA_1	582	588	PF00069	0.648
MOD_PKA_2	337	343	PF00069	0.740
MOD_PKA_2	374	380	PF00069	0.729
MOD_PKA_2	489	495	PF00069	0.665
MOD_PKA_2	502	508	PF00069	0.650
MOD_PKA_2	581	587	PF00069	0.672
MOD_PKA_2	635	641	PF00069	0.678
MOD_PKA_2	694	700	PF00069	0.669
MOD_PKB_1	488	496	PF00069	0.661
MOD_Plk_1	139	145	PF00069	0.677
MOD_Plk_1	225	231	PF00069	0.616
MOD_Plk_1	289	295	PF00069	0.607
MOD_Plk_1	378	384	PF00069	0.580
MOD_Plk_1	393	399	PF00069	0.442
MOD_Plk_4	204	210	PF00069	0.597
MOD_Plk_4	415	421	PF00069	0.543
MOD_Plk_4	636	642	PF00069	0.609
MOD_ProDKin_1	171	177	PF00069	0.641
MOD_ProDKin_1	216	222	PF00069	0.642
MOD_ProDKin_1	252	258	PF00069	0.636
MOD_ProDKin_1	40	46	PF00069	0.591
MOD_ProDKin_1	449	455	PF00069	0.713
MOD_ProDKin_1	511	517	PF00069	0.664
MOD_ProDKin_1	546	552	PF00069	0.591
MOD_ProDKin_1	568	574	PF00069	0.606
MOD_ProDKin_1	575	581	PF00069	0.604
MOD_SUMO_rev_2	595	605	PF00179	0.633
TRG_DiLeu_BaEn_2	394	400	PF01217	0.508
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.646
TRG_DiLeu_BaLyEn_6	658	663	PF01217	0.655
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.588
TRG_ENDOCYTIC_2	417	420	PF00928	0.512
TRG_ER_diArg_1	479	482	PF00400	0.613
TRG_ER_diArg_1	485	488	PF00400	0.577
TRG_ER_diArg_1	658	660	PF00400	0.592
TRG_ER_diArg_1	707	709	PF00400	0.614
TRG_Pf-PMV_PEXEL_1	660	664	PF00026	0.681
TRG_Pf-PMV_PEXEL_1	724	728	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW90	Leptomonas seymouri	30%	88%
A0A3S7X2M1	Leishmania donovani	86%	100%
A4HHK4	Leishmania braziliensis	50%	100%
A4I4R6	Leishmania infantum	86%	100%
E9ALL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%