Putative UDP-GlcNAc:PI a1-6 GlcNAc-transferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-acetylglucosamyl transferase component GPI1, putative

Species:

Leishmania major

UniProt:

E9AE65_LEIMA

TriTrypDb:

LmjF.29.2030 , LMJLV39_290028100 , LMJSD75_290028300

Length:

888

Annotations

LeishMANIAdb annotations

Related to other Eukaryotic GPI biosynthetic enzymes.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	8
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	8
GO:0000428	DNA-directed RNA polymerase complex	4	1
GO:0030880	RNA polymerase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9AE65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE65

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	8
GO:0006505	GPI anchor metabolic process	6	8
GO:0006506	GPI anchor biosynthetic process	6	8
GO:0006629	lipid metabolic process	3	8
GO:0006643	membrane lipid metabolic process	4	8
GO:0006644	phospholipid metabolic process	4	8
GO:0006650	glycerophospholipid metabolic process	5	8
GO:0006661	phosphatidylinositol biosynthetic process	6	8
GO:0006664	glycolipid metabolic process	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0008610	lipid biosynthetic process	4	8
GO:0008654	phospholipid biosynthetic process	5	8
GO:0009058	biosynthetic process	2	8
GO:0009247	glycolipid biosynthetic process	5	8
GO:0009987	cellular process	1	8
GO:0019538	protein metabolic process	3	8
GO:0019637	organophosphate metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0044255	cellular lipid metabolic process	3	8
GO:0045017	glycerolipid biosynthetic process	4	8
GO:0046467	membrane lipid biosynthetic process	4	8
GO:0046474	glycerophospholipid biosynthetic process	5	8
GO:0046486	glycerolipid metabolic process	4	8
GO:0046488	phosphatidylinositol metabolic process	6	8
GO:0071704	organic substance metabolic process	2	8
GO:0090407	organophosphate biosynthetic process	4	8
GO:1901135	carbohydrate derivative metabolic process	3	8
GO:1901137	carbohydrate derivative biosynthetic process	4	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901576	organic substance biosynthetic process	3	8
GO:1903509	liposaccharide metabolic process	4	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016740	transferase activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.625
CLV_C14_Caspase3-7	314	318	PF00656	0.524
CLV_C14_Caspase3-7	321	325	PF00656	0.579
CLV_NRD_NRD_1	111	113	PF00675	0.684
CLV_NRD_NRD_1	199	201	PF00675	0.728
CLV_NRD_NRD_1	215	217	PF00675	0.773
CLV_NRD_NRD_1	328	330	PF00675	0.742
CLV_NRD_NRD_1	390	392	PF00675	0.665
CLV_NRD_NRD_1	687	689	PF00675	0.326
CLV_NRD_NRD_1	779	781	PF00675	0.502
CLV_PCSK_KEX2_1	209	211	PF00082	0.794
CLV_PCSK_KEX2_1	214	216	PF00082	0.759
CLV_PCSK_KEX2_1	249	251	PF00082	0.804
CLV_PCSK_KEX2_1	328	330	PF00082	0.742
CLV_PCSK_KEX2_1	390	392	PF00082	0.716
CLV_PCSK_KEX2_1	689	691	PF00082	0.318
CLV_PCSK_KEX2_1	779	781	PF00082	0.466
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.833
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.748
CLV_PCSK_PC1ET2_1	689	691	PF00082	0.342
CLV_PCSK_PC7_1	210	216	PF00082	0.762
CLV_PCSK_SKI1_1	206	210	PF00082	0.799
CLV_PCSK_SKI1_1	250	254	PF00082	0.685
CLV_PCSK_SKI1_1	556	560	PF00082	0.356
CLV_PCSK_SKI1_1	64	68	PF00082	0.738
CLV_PCSK_SKI1_1	669	673	PF00082	0.376
CLV_PCSK_SKI1_1	833	837	PF00082	0.371
DEG_APCC_DBOX_1	519	527	PF00400	0.556
DEG_APCC_DBOX_1	668	676	PF00400	0.376
DEG_Kelch_Keap1_1	236	241	PF01344	0.561
DEG_SCF_FBW7_2	868	874	PF00400	0.804
DEG_SIAH_1	356	364	PF03145	0.573
DEG_SPOP_SBC_1	2	6	PF00917	0.522
DEG_SPOP_SBC_1	600	604	PF00917	0.494
DOC_CKS1_1	344	349	PF01111	0.542
DOC_CKS1_1	868	873	PF01111	0.799
DOC_CYCLIN_RxL_1	427	437	PF00134	0.419
DOC_CYCLIN_RxL_1	666	673	PF00134	0.430
DOC_CYCLIN_yClb1_LxF_4	362	367	PF00134	0.581
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	122	128	PF00134	0.540
DOC_CYCLIN_yCln2_LP_2	747	753	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	807	813	PF00134	0.696
DOC_MAPK_FxFP_2	713	716	PF00069	0.430
DOC_MAPK_gen_1	109	119	PF00069	0.444
DOC_MAPK_gen_1	433	442	PF00069	0.399
DOC_MAPK_MEF2A_6	112	121	PF00069	0.441
DOC_MAPK_MEF2A_6	373	380	PF00069	0.518
DOC_MAPK_MEF2A_6	489	498	PF00069	0.317
DOC_PP1_RVXF_1	362	368	PF00149	0.542
DOC_PP1_RVXF_1	428	435	PF00149	0.426
DOC_PP2B_LxvP_1	747	750	PF13499	0.376
DOC_PP2B_LxvP_1	807	810	PF13499	0.648
DOC_PP4_FxxP_1	713	716	PF00568	0.430
DOC_USP7_MATH_1	2	6	PF00917	0.520
DOC_USP7_MATH_1	229	233	PF00917	0.560
DOC_USP7_MATH_1	25	29	PF00917	0.455
DOC_USP7_MATH_1	347	351	PF00917	0.584
DOC_USP7_MATH_1	374	378	PF00917	0.529
DOC_USP7_MATH_1	458	462	PF00917	0.379
DOC_USP7_MATH_1	582	586	PF00917	0.479
DOC_USP7_MATH_1	600	604	PF00917	0.461
DOC_USP7_MATH_1	641	645	PF00917	0.430
DOC_USP7_MATH_1	884	888	PF00917	0.811
DOC_USP7_UBL2_3	875	879	PF12436	0.803
DOC_WW_Pin1_4	343	348	PF00397	0.540
DOC_WW_Pin1_4	566	571	PF00397	0.536
DOC_WW_Pin1_4	605	610	PF00397	0.553
DOC_WW_Pin1_4	860	865	PF00397	0.662
DOC_WW_Pin1_4	867	872	PF00397	0.786
LIG_14-3-3_CanoR_1	215	221	PF00244	0.616
LIG_14-3-3_CanoR_1	250	256	PF00244	0.544
LIG_14-3-3_CanoR_1	280	285	PF00244	0.603
LIG_14-3-3_CanoR_1	433	443	PF00244	0.397
LIG_14-3-3_CanoR_1	444	452	PF00244	0.390
LIG_14-3-3_CanoR_1	865	869	PF00244	0.688
LIG_14-3-3_CanoR_1	89	94	PF00244	0.534
LIG_Actin_WH2_2	418	435	PF00022	0.422
LIG_Actin_WH2_2	551	569	PF00022	0.607
LIG_BRCT_BRCA1_1	603	607	PF00533	0.551
LIG_BRCT_BRCA1_1	622	626	PF00533	0.551
LIG_deltaCOP1_diTrp_1	248	255	PF00928	0.545
LIG_deltaCOP1_diTrp_1	560	568	PF00928	0.556
LIG_deltaCOP1_diTrp_1	620	626	PF00928	0.542
LIG_DLG_GKlike_1	112	119	PF00625	0.481
LIG_EH1_1	695	703	PF00400	0.542
LIG_EH1_1	818	826	PF00400	0.580
LIG_eIF4E_1	116	122	PF01652	0.480
LIG_FHA_1	216	222	PF00498	0.618
LIG_FHA_1	4	10	PF00498	0.498
LIG_FHA_1	409	415	PF00498	0.439
LIG_FHA_1	421	427	PF00498	0.435
LIG_FHA_1	43	49	PF00498	0.521
LIG_FHA_1	435	441	PF00498	0.323
LIG_FHA_1	645	651	PF00498	0.306
LIG_FHA_1	715	721	PF00498	0.390
LIG_FHA_1	797	803	PF00498	0.662
LIG_FHA_1	810	816	PF00498	0.520
LIG_FHA_1	848	854	PF00498	0.676
LIG_FHA_1	857	863	PF00498	0.651
LIG_FHA_2	289	295	PF00498	0.615
LIG_FHA_2	312	318	PF00498	0.575
LIG_FHA_2	50	56	PF00498	0.532
LIG_FHA_2	735	741	PF00498	0.356
LIG_GBD_Chelix_1	821	829	PF00786	0.340
LIG_LIR_Apic_2	603	609	PF02991	0.544
LIG_LIR_Gen_1	115	126	PF02991	0.418
LIG_LIR_Gen_1	39	48	PF02991	0.459
LIG_LIR_Gen_1	445	455	PF02991	0.396
LIG_LIR_Gen_1	510	518	PF02991	0.334
LIG_LIR_Gen_1	560	570	PF02991	0.517
LIG_LIR_Gen_1	620	628	PF02991	0.556
LIG_LIR_Gen_1	705	716	PF02991	0.436
LIG_LIR_Gen_1	741	751	PF02991	0.417
LIG_LIR_Gen_1	76	85	PF02991	0.557
LIG_LIR_Gen_1	816	826	PF02991	0.572
LIG_LIR_Nem_3	115	121	PF02991	0.417
LIG_LIR_Nem_3	39	44	PF02991	0.473
LIG_LIR_Nem_3	445	451	PF02991	0.390
LIG_LIR_Nem_3	510	515	PF02991	0.334
LIG_LIR_Nem_3	532	537	PF02991	0.556
LIG_LIR_Nem_3	560	565	PF02991	0.517
LIG_LIR_Nem_3	673	679	PF02991	0.374
LIG_LIR_Nem_3	705	711	PF02991	0.436
LIG_LIR_Nem_3	741	747	PF02991	0.417
LIG_LIR_Nem_3	76	82	PF02991	0.505
LIG_LIR_Nem_3	816	822	PF02991	0.572
LIG_LYPXL_SIV_4	664	672	PF13949	0.430
LIG_PCNA_yPIPBox_3	187	201	PF02747	0.522
LIG_PCNA_yPIPBox_3	390	402	PF02747	0.559
LIG_PCNA_yPIPBox_3	615	629	PF02747	0.440
LIG_Pex14_1	251	255	PF04695	0.542
LIG_Pex14_1	533	537	PF04695	0.524
LIG_REV1ctd_RIR_1	551	560	PF16727	0.556
LIG_SH2_CRK	512	516	PF00017	0.268
LIG_SH2_CRK	684	688	PF00017	0.517
LIG_SH2_CRK	79	83	PF00017	0.499
LIG_SH2_GRB2like	79	82	PF00017	0.467
LIG_SH2_PTP2	41	44	PF00017	0.495
LIG_SH2_PTP2	480	483	PF00017	0.356
LIG_SH2_SRC	41	44	PF00017	0.495
LIG_SH2_STAP1	416	420	PF00017	0.478
LIG_SH2_STAP1	524	528	PF00017	0.556
LIG_SH2_STAT3	694	697	PF00017	0.607
LIG_SH2_STAT5	116	119	PF00017	0.485
LIG_SH2_STAT5	401	404	PF00017	0.589
LIG_SH2_STAT5	41	44	PF00017	0.475
LIG_SH2_STAT5	424	427	PF00017	0.406
LIG_SH2_STAT5	480	483	PF00017	0.356
LIG_SH2_STAT5	486	489	PF00017	0.356
LIG_SH2_STAT5	501	504	PF00017	0.430
LIG_SH2_STAT5	665	668	PF00017	0.424
LIG_SH2_STAT5	722	725	PF00017	0.376
LIG_SH2_STAT5	744	747	PF00017	0.430
LIG_SH2_STAT5	845	848	PF00017	0.654
LIG_SH3_3	178	184	PF00018	0.534
LIG_SH3_3	190	196	PF00018	0.524
LIG_SH3_3	463	469	PF00018	0.317
LIG_SH3_3	72	78	PF00018	0.566
LIG_SH3_3	747	753	PF00018	0.501
LIG_SUMO_SIM_par_1	557	563	PF11976	0.556
LIG_SUMO_SIM_par_1	797	803	PF11976	0.668
LIG_TRAF2_1	103	106	PF00917	0.541
LIG_TRAF2_1	291	294	PF00917	0.574
LIG_TYR_ITIM	499	504	PF00017	0.430
LIG_TYR_ITIM	682	687	PF00017	0.556
LIG_TYR_ITIM	742	747	PF00017	0.430
LIG_TYR_ITIM	77	82	PF00017	0.498
LIG_UBA3_1	428	436	PF00899	0.390
LIG_UBA3_1	825	833	PF00899	0.587
LIG_WRC_WIRS_1	576	581	PF05994	0.556
LIG_WRC_WIRS_1	724	729	PF05994	0.340
LIG_WW_3	361	365	PF00397	0.581
MOD_CDC14_SPxK_1	872	875	PF00782	0.741
MOD_CDK_SPK_2	860	865	PF00069	0.648
MOD_CDK_SPxK_1	869	875	PF00069	0.728
MOD_CK1_1	232	238	PF00069	0.579
MOD_CK1_1	273	279	PF00069	0.597
MOD_CK1_1	350	356	PF00069	0.537
MOD_CK1_1	4	10	PF00069	0.498
MOD_CK1_1	569	575	PF00069	0.556
MOD_CK1_1	602	608	PF00069	0.577
MOD_CK1_1	644	650	PF00069	0.356
MOD_CK1_1	860	866	PF00069	0.646
MOD_CK1_1	92	98	PF00069	0.508
MOD_CK2_1	185	191	PF00069	0.489
MOD_CK2_1	2	8	PF00069	0.515
MOD_CK2_1	288	294	PF00069	0.594
MOD_CK2_1	313	319	PF00069	0.575
MOD_CK2_1	49	55	PF00069	0.535
MOD_CK2_1	734	740	PF00069	0.356
MOD_CK2_1	98	104	PF00069	0.516
MOD_GlcNHglycan	16	19	PF01048	0.743
MOD_GlcNHglycan	160	163	PF01048	0.685
MOD_GlcNHglycan	168	171	PF01048	0.687
MOD_GlcNHglycan	175	178	PF01048	0.720
MOD_GlcNHglycan	302	306	PF01048	0.810
MOD_GlcNHglycan	333	336	PF01048	0.756
MOD_GlcNHglycan	352	355	PF01048	0.789
MOD_GlcNHglycan	504	507	PF01048	0.430
MOD_GlcNHglycan	764	767	PF01048	0.293
MOD_GlcNHglycan	91	94	PF01048	0.709
MOD_GSK3_1	147	154	PF00069	0.471
MOD_GSK3_1	232	239	PF00069	0.522
MOD_GSK3_1	259	266	PF00069	0.507
MOD_GSK3_1	288	295	PF00069	0.546
MOD_GSK3_1	311	318	PF00069	0.571
MOD_GSK3_1	343	350	PF00069	0.558
MOD_GSK3_1	595	602	PF00069	0.602
MOD_GSK3_1	644	651	PF00069	0.356
MOD_GSK3_1	734	741	PF00069	0.356
MOD_GSK3_1	796	803	PF00069	0.691
MOD_GSK3_1	809	816	PF00069	0.587
MOD_GSK3_1	856	863	PF00069	0.646
MOD_N-GLC_1	221	226	PF02516	0.744
MOD_N-GLC_1	25	30	PF02516	0.674
MOD_N-GLC_1	257	262	PF02516	0.731
MOD_N-GLC_1	280	285	PF02516	0.757
MOD_N-GLC_1	458	463	PF02516	0.607
MOD_N-GLC_1	49	54	PF02516	0.683
MOD_N-GLC_2	589	591	PF02516	0.324
MOD_N-GLC_2	98	100	PF02516	0.724
MOD_NEK2_1	160	165	PF00069	0.490
MOD_NEK2_1	259	264	PF00069	0.615
MOD_NEK2_1	331	336	PF00069	0.573
MOD_NEK2_1	342	347	PF00069	0.543
MOD_NEK2_1	379	384	PF00069	0.488
MOD_NEK2_1	420	425	PF00069	0.417
MOD_NEK2_1	432	437	PF00069	0.309
MOD_NEK2_1	502	507	PF00069	0.430
MOD_NEK2_1	634	639	PF00069	0.395
MOD_NEK2_1	702	707	PF00069	0.359
MOD_NEK2_1	723	728	PF00069	0.296
MOD_NEK2_1	857	862	PF00069	0.698
MOD_NEK2_2	229	234	PF00069	0.548
MOD_NEK2_2	374	379	PF00069	0.506
MOD_NEK2_2	648	653	PF00069	0.356
MOD_NEK2_2	743	748	PF00069	0.452
MOD_PIKK_1	288	294	PF00454	0.545
MOD_PIKK_1	347	353	PF00454	0.583
MOD_PK_1	151	157	PF00069	0.502
MOD_PK_1	216	222	PF00069	0.479
MOD_PKA_1	112	118	PF00069	0.484
MOD_PKA_1	215	221	PF00069	0.480
MOD_PKA_2	155	161	PF00069	0.474
MOD_PKA_2	215	221	PF00069	0.536
MOD_PKA_2	236	242	PF00069	0.526
MOD_PKA_2	279	285	PF00069	0.586
MOD_PKA_2	432	438	PF00069	0.390
MOD_PKA_2	443	449	PF00069	0.321
MOD_PKA_2	762	768	PF00069	0.547
MOD_PKA_2	864	870	PF00069	0.683
MOD_PKB_1	214	222	PF00069	0.536
MOD_Plk_1	151	157	PF00069	0.387
MOD_Plk_1	221	227	PF00069	0.556
MOD_Plk_1	229	235	PF00069	0.556
MOD_Plk_1	240	246	PF00069	0.540
MOD_Plk_1	25	31	PF00069	0.470
MOD_Plk_1	257	263	PF00069	0.452
MOD_Plk_1	270	276	PF00069	0.574
MOD_Plk_1	280	286	PF00069	0.556
MOD_Plk_1	292	298	PF00069	0.549
MOD_Plk_1	36	42	PF00069	0.504
MOD_Plk_1	374	380	PF00069	0.490
MOD_Plk_1	403	409	PF00069	0.517
MOD_Plk_1	49	55	PF00069	0.505
MOD_Plk_1	800	806	PF00069	0.656
MOD_Plk_2-3	294	300	PF00069	0.584
MOD_Plk_4	112	118	PF00069	0.482
MOD_Plk_4	155	161	PF00069	0.454
MOD_Plk_4	216	222	PF00069	0.579
MOD_Plk_4	241	247	PF00069	0.590
MOD_Plk_4	374	380	PF00069	0.529
MOD_Plk_4	42	48	PF00069	0.526
MOD_Plk_4	420	426	PF00069	0.419
MOD_Plk_4	507	513	PF00069	0.380
MOD_Plk_4	526	532	PF00069	0.474
MOD_Plk_4	572	578	PF00069	0.571
MOD_Plk_4	602	608	PF00069	0.549
MOD_Plk_4	702	708	PF00069	0.376
MOD_Plk_4	714	720	PF00069	0.376
MOD_Plk_4	728	734	PF00069	0.301
MOD_ProDKin_1	343	349	PF00069	0.541
MOD_ProDKin_1	566	572	PF00069	0.536
MOD_ProDKin_1	605	611	PF00069	0.553
MOD_ProDKin_1	860	866	PF00069	0.662
MOD_ProDKin_1	867	873	PF00069	0.791
MOD_SUMO_for_1	56	59	PF00179	0.522
TRG_DiLeu_BaEn_1	8	13	PF01217	0.476
TRG_DiLeu_BaEn_2	374	380	PF01217	0.506
TRG_DiLeu_BaEn_2	446	452	PF01217	0.389
TRG_DiLeu_BaEn_4	293	299	PF01217	0.581
TRG_ENDOCYTIC_2	116	119	PF00928	0.485
TRG_ENDOCYTIC_2	41	44	PF00928	0.493
TRG_ENDOCYTIC_2	480	483	PF00928	0.356
TRG_ENDOCYTIC_2	501	504	PF00928	0.430
TRG_ENDOCYTIC_2	512	515	PF00928	0.430
TRG_ENDOCYTIC_2	619	622	PF00928	0.525
TRG_ENDOCYTIC_2	684	687	PF00928	0.517
TRG_ENDOCYTIC_2	722	725	PF00928	0.376
TRG_ENDOCYTIC_2	744	747	PF00928	0.376
TRG_ENDOCYTIC_2	79	82	PF00928	0.499
TRG_ER_diArg_1	214	216	PF00400	0.527
TRG_ER_diArg_1	389	391	PF00400	0.515
TRG_ER_diArg_1	687	690	PF00400	0.531
TRG_ER_diArg_1	778	780	PF00400	0.608
TRG_ER_diArg_1	839	842	PF00400	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C0	Leptomonas seymouri	67%	99%
A0A0S4IQS6	Bodo saltans	24%	100%
A0A3Q8IEF3	Leishmania donovani	95%	100%
A4HHK2	Leishmania braziliensis	77%	100%
E9AHJ3	Leishmania infantum	94%	100%
E9ALM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%