LeishMANIAdb
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Putative serine/threonine protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative serine/threonine protein kinase
Gene product:
5'-AMP-activated protein kinase catalytic subunit alpha, putative
Species:
Leishmania major
UniProt:
E9AE64_LEIMA
TriTrypDb:
LmjF.29.2020 , LMJLV39_290028000 * , LMJSD75_290028200 *
Length:
814

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE64
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE64

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0007165 signal transduction 2 2
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0016310 phosphorylation 5 11
GO:0019538 protein metabolic process 3 11
GO:0035556 intracellular signal transduction 3 2
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0003824 catalytic activity 1 11
GO:0004672 protein kinase activity 3 11
GO:0004674 protein serine/threonine kinase activity 4 9
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0016301 kinase activity 4 11
GO:0016740 transferase activity 2 11
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 11
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 444 448 PF00656 0.772
CLV_NRD_NRD_1 329 331 PF00675 0.487
CLV_NRD_NRD_1 353 355 PF00675 0.428
CLV_NRD_NRD_1 504 506 PF00675 0.718
CLV_NRD_NRD_1 534 536 PF00675 0.700
CLV_NRD_NRD_1 615 617 PF00675 0.668
CLV_NRD_NRD_1 671 673 PF00675 0.738
CLV_NRD_NRD_1 678 680 PF00675 0.745
CLV_NRD_NRD_1 810 812 PF00675 0.478
CLV_PCSK_FUR_1 351 355 PF00082 0.503
CLV_PCSK_FUR_1 669 673 PF00082 0.712
CLV_PCSK_KEX2_1 320 322 PF00082 0.437
CLV_PCSK_KEX2_1 351 353 PF00082 0.437
CLV_PCSK_KEX2_1 504 506 PF00082 0.700
CLV_PCSK_KEX2_1 615 617 PF00082 0.668
CLV_PCSK_KEX2_1 671 673 PF00082 0.729
CLV_PCSK_KEX2_1 678 680 PF00082 0.745
CLV_PCSK_PC1ET2_1 320 322 PF00082 0.426
CLV_PCSK_SKI1_1 137 141 PF00082 0.297
CLV_PCSK_SKI1_1 158 162 PF00082 0.309
CLV_PCSK_SKI1_1 577 581 PF00082 0.497
DEG_MDM2_SWIB_1 579 586 PF02201 0.443
DEG_SPOP_SBC_1 480 484 PF00917 0.669
DEG_SPOP_SBC_1 751 755 PF00917 0.668
DOC_ANK_TNKS_1 634 641 PF00023 0.599
DOC_CKS1_1 103 108 PF01111 0.297
DOC_MAPK_gen_1 158 167 PF00069 0.315
DOC_MAPK_gen_1 306 315 PF00069 0.527
DOC_MAPK_gen_1 327 335 PF00069 0.394
DOC_MAPK_gen_1 780 789 PF00069 0.450
DOC_MAPK_gen_1 79 90 PF00069 0.286
DOC_MAPK_HePTP_8 205 217 PF00069 0.297
DOC_MAPK_MEF2A_6 208 217 PF00069 0.297
DOC_MAPK_MEF2A_6 306 315 PF00069 0.527
DOC_MAPK_MEF2A_6 391 399 PF00069 0.510
DOC_PP1_RVXF_1 172 179 PF00149 0.279
DOC_PP1_RVXF_1 206 212 PF00149 0.297
DOC_PP2B_LxvP_1 277 280 PF13499 0.297
DOC_PP4_FxxP_1 91 94 PF00568 0.279
DOC_USP7_MATH_1 252 256 PF00917 0.361
DOC_USP7_MATH_1 454 458 PF00917 0.782
DOC_USP7_MATH_1 459 463 PF00917 0.655
DOC_USP7_MATH_1 711 715 PF00917 0.703
DOC_USP7_MATH_1 750 754 PF00917 0.718
DOC_USP7_UBL2_3 383 387 PF12436 0.702
DOC_USP7_UBL2_3 580 584 PF12436 0.364
DOC_WW_Pin1_4 102 107 PF00397 0.297
DOC_WW_Pin1_4 193 198 PF00397 0.279
DOC_WW_Pin1_4 399 404 PF00397 0.519
DOC_WW_Pin1_4 584 589 PF00397 0.449
DOC_WW_Pin1_4 734 739 PF00397 0.741
DOC_WW_Pin1_4 742 747 PF00397 0.652
DOC_WW_Pin1_4 759 764 PF00397 0.648
LIG_14-3-3_CanoR_1 295 305 PF00244 0.364
LIG_14-3-3_CanoR_1 309 314 PF00244 0.396
LIG_14-3-3_CanoR_1 594 602 PF00244 0.516
LIG_14-3-3_CanoR_1 610 619 PF00244 0.687
LIG_Actin_RPEL_3 147 166 PF02755 0.410
LIG_Actin_WH2_2 59 75 PF00022 0.322
LIG_BIR_II_1 1 5 PF00653 0.687
LIG_BIR_III_3 1 5 PF00653 0.694
LIG_BRCT_BRCA1_1 770 774 PF00533 0.423
LIG_FHA_1 597 603 PF00498 0.528
LIG_FHA_1 619 625 PF00498 0.781
LIG_FHA_1 752 758 PF00498 0.726
LIG_FHA_2 103 109 PF00498 0.279
LIG_FHA_2 387 393 PF00498 0.527
LIG_FHA_2 431 437 PF00498 0.674
LIG_FHA_2 539 545 PF00498 0.468
LIG_FHA_2 654 660 PF00498 0.770
LIG_GBD_Chelix_1 797 805 PF00786 0.469
LIG_LIR_Apic_2 196 202 PF02991 0.279
LIG_LIR_Gen_1 107 116 PF02991 0.279
LIG_LIR_Gen_1 120 126 PF02991 0.279
LIG_LIR_Gen_1 570 581 PF02991 0.415
LIG_LIR_Gen_1 58 67 PF02991 0.410
LIG_LIR_Gen_1 598 604 PF02991 0.416
LIG_LIR_Nem_3 120 125 PF02991 0.279
LIG_LIR_Nem_3 46 50 PF02991 0.296
LIG_LIR_Nem_3 570 576 PF02991 0.377
LIG_LIR_Nem_3 58 64 PF02991 0.279
LIG_LIR_Nem_3 587 592 PF02991 0.318
LIG_LIR_Nem_3 598 603 PF02991 0.304
LIG_LIR_Nem_3 771 777 PF02991 0.552
LIG_LIR_Nem_3 788 792 PF02991 0.285
LIG_MAD2 154 162 PF02301 0.410
LIG_MLH1_MIPbox_1 770 774 PF16413 0.423
LIG_NRBOX 223 229 PF00104 0.297
LIG_NRBOX 800 806 PF00104 0.424
LIG_OCRL_FandH_1 773 785 PF00620 0.496
LIG_PCNA_yPIPBox_3 766 780 PF02747 0.527
LIG_Pex14_2 579 583 PF04695 0.388
LIG_REV1ctd_RIR_1 772 780 PF16727 0.485
LIG_SH2_CRK 122 126 PF00017 0.357
LIG_SH2_CRK 225 229 PF00017 0.291
LIG_SH2_CRK 251 255 PF00017 0.297
LIG_SH2_CRK 344 348 PF00017 0.301
LIG_SH2_CRK 573 577 PF00017 0.359
LIG_SH2_NCK_1 100 104 PF00017 0.279
LIG_SH2_NCK_1 199 203 PF00017 0.279
LIG_SH2_NCK_1 251 255 PF00017 0.410
LIG_SH2_PTP2 61 64 PF00017 0.410
LIG_SH2_SRC 115 118 PF00017 0.297
LIG_SH2_SRC 122 125 PF00017 0.297
LIG_SH2_SRC 251 254 PF00017 0.320
LIG_SH2_SRC 485 488 PF00017 0.590
LIG_SH2_STAP1 122 126 PF00017 0.326
LIG_SH2_STAP1 298 302 PF00017 0.527
LIG_SH2_STAT3 124 127 PF00017 0.410
LIG_SH2_STAT3 138 141 PF00017 0.279
LIG_SH2_STAT5 110 113 PF00017 0.315
LIG_SH2_STAT5 115 118 PF00017 0.336
LIG_SH2_STAT5 124 127 PF00017 0.361
LIG_SH2_STAT5 138 141 PF00017 0.298
LIG_SH2_STAT5 149 152 PF00017 0.350
LIG_SH2_STAT5 210 213 PF00017 0.279
LIG_SH2_STAT5 36 39 PF00017 0.286
LIG_SH2_STAT5 540 543 PF00017 0.460
LIG_SH2_STAT5 61 64 PF00017 0.410
LIG_SH2_STAT5 699 702 PF00017 0.712
LIG_SH2_STAT5 773 776 PF00017 0.453
LIG_SH2_STAT5 785 788 PF00017 0.367
LIG_SH3_3 20 26 PF00018 0.682
LIG_SH3_3 267 273 PF00018 0.279
LIG_SH3_3 582 588 PF00018 0.440
LIG_SH3_3 735 741 PF00018 0.796
LIG_SH3_3 754 760 PF00018 0.486
LIG_SH3_3 761 767 PF00018 0.639
LIG_SUMO_SIM_anti_2 800 807 PF11976 0.424
LIG_SUMO_SIM_anti_2 84 89 PF11976 0.410
LIG_SUMO_SIM_par_1 267 272 PF11976 0.282
LIG_SUMO_SIM_par_1 404 413 PF11976 0.590
LIG_SUMO_SIM_par_1 766 771 PF11976 0.491
LIG_SUMO_SIM_par_1 800 807 PF11976 0.480
LIG_TRAF2_1 541 544 PF00917 0.495
LIG_TYR_ITIM 223 228 PF00017 0.279
LIG_TYR_ITIM 342 347 PF00017 0.298
LIG_UBA3_1 242 250 PF00899 0.279
LIG_WRC_WIRS_1 460 465 PF05994 0.686
LIG_WRC_WIRS_1 576 581 PF05994 0.422
MOD_CDC14_SPxK_1 587 590 PF00782 0.495
MOD_CDK_SPK_2 734 739 PF00069 0.609
MOD_CDK_SPxK_1 584 590 PF00069 0.487
MOD_CK1_1 104 110 PF00069 0.322
MOD_CK1_1 181 187 PF00069 0.357
MOD_CK1_1 193 199 PF00069 0.216
MOD_CK1_1 301 307 PF00069 0.564
MOD_CK1_1 430 436 PF00069 0.628
MOD_CK1_1 441 447 PF00069 0.600
MOD_CK1_1 479 485 PF00069 0.594
MOD_CK1_1 606 612 PF00069 0.598
MOD_CK1_1 620 626 PF00069 0.566
MOD_CK1_1 641 647 PF00069 0.763
MOD_CK1_1 665 671 PF00069 0.613
MOD_CK1_1 716 722 PF00069 0.701
MOD_CK1_1 732 738 PF00069 0.727
MOD_CK2_1 294 300 PF00069 0.419
MOD_CK2_1 301 307 PF00069 0.480
MOD_CK2_1 363 369 PF00069 0.597
MOD_CK2_1 386 392 PF00069 0.535
MOD_CK2_1 538 544 PF00069 0.510
MOD_CK2_1 592 598 PF00069 0.444
MOD_CK2_1 727 733 PF00069 0.740
MOD_DYRK1A_RPxSP_1 742 746 PF00069 0.538
MOD_GlcNHglycan 18 21 PF01048 0.736
MOD_GlcNHglycan 205 208 PF01048 0.297
MOD_GlcNHglycan 365 368 PF01048 0.615
MOD_GlcNHglycan 447 451 PF01048 0.774
MOD_GlcNHglycan 470 473 PF01048 0.719
MOD_GlcNHglycan 476 479 PF01048 0.507
MOD_GlcNHglycan 569 572 PF01048 0.509
MOD_GlcNHglycan 625 629 PF01048 0.715
MOD_GlcNHglycan 635 638 PF01048 0.604
MOD_GlcNHglycan 640 643 PF01048 0.735
MOD_GlcNHglycan 681 684 PF01048 0.715
MOD_GlcNHglycan 713 716 PF01048 0.678
MOD_GlcNHglycan 718 721 PF01048 0.701
MOD_GlcNHglycan 723 726 PF01048 0.696
MOD_GlcNHglycan 729 732 PF01048 0.717
MOD_GlcNHglycan 73 76 PF01048 0.431
MOD_GlcNHglycan 742 745 PF01048 0.691
MOD_GlcNHglycan 748 751 PF01048 0.679
MOD_GlcNHglycan 754 757 PF01048 0.728
MOD_GSK3_1 189 196 PF00069 0.279
MOD_GSK3_1 294 301 PF00069 0.437
MOD_GSK3_1 309 316 PF00069 0.409
MOD_GSK3_1 363 370 PF00069 0.615
MOD_GSK3_1 459 466 PF00069 0.590
MOD_GSK3_1 470 477 PF00069 0.601
MOD_GSK3_1 494 501 PF00069 0.747
MOD_GSK3_1 508 515 PF00069 0.630
MOD_GSK3_1 592 599 PF00069 0.395
MOD_GSK3_1 6 13 PF00069 0.675
MOD_GSK3_1 606 613 PF00069 0.580
MOD_GSK3_1 620 627 PF00069 0.654
MOD_GSK3_1 727 734 PF00069 0.710
MOD_GSK3_1 742 749 PF00069 0.646
MOD_N-GLC_1 181 186 PF02516 0.355
MOD_N-GLC_1 522 527 PF02516 0.601
MOD_N-GLC_1 610 615 PF02516 0.564
MOD_N-GLC_2 95 97 PF02516 0.279
MOD_NEK2_1 166 171 PF00069 0.410
MOD_NEK2_1 178 183 PF00069 0.328
MOD_NEK2_1 189 194 PF00069 0.257
MOD_NEK2_1 241 246 PF00069 0.344
MOD_NEK2_1 294 299 PF00069 0.513
MOD_NEK2_1 32 37 PF00069 0.429
MOD_NEK2_1 397 402 PF00069 0.499
MOD_NEK2_1 463 468 PF00069 0.574
MOD_NEK2_1 474 479 PF00069 0.581
MOD_NEK2_1 508 513 PF00069 0.621
MOD_NEK2_1 592 597 PF00069 0.392
MOD_NEK2_1 688 693 PF00069 0.635
MOD_NEK2_2 298 303 PF00069 0.488
MOD_NEK2_2 459 464 PF00069 0.660
MOD_PIKK_1 397 403 PF00454 0.501
MOD_PIKK_1 515 521 PF00454 0.689
MOD_PIKK_1 604 610 PF00454 0.648
MOD_PIKK_1 653 659 PF00454 0.552
MOD_PIKK_1 689 695 PF00454 0.649
MOD_PK_1 309 315 PF00069 0.498
MOD_PK_1 529 535 PF00069 0.612
MOD_PKA_1 615 621 PF00069 0.595
MOD_PKA_2 131 137 PF00069 0.424
MOD_PKA_2 275 281 PF00069 0.279
MOD_PKA_2 294 300 PF00069 0.401
MOD_PKA_2 38 44 PF00069 0.410
MOD_PKA_2 463 469 PF00069 0.677
MOD_PKA_2 593 599 PF00069 0.448
MOD_PKA_2 615 621 PF00069 0.658
MOD_Plk_1 235 241 PF00069 0.297
MOD_Plk_1 441 447 PF00069 0.684
MOD_Plk_4 298 304 PF00069 0.504
MOD_Plk_4 309 315 PF00069 0.365
MOD_Plk_4 32 38 PF00069 0.435
MOD_Plk_4 470 476 PF00069 0.760
MOD_Plk_4 768 774 PF00069 0.446
MOD_ProDKin_1 102 108 PF00069 0.297
MOD_ProDKin_1 193 199 PF00069 0.279
MOD_ProDKin_1 399 405 PF00069 0.517
MOD_ProDKin_1 584 590 PF00069 0.447
MOD_ProDKin_1 734 740 PF00069 0.742
MOD_ProDKin_1 742 748 PF00069 0.651
MOD_ProDKin_1 759 765 PF00069 0.644
MOD_SUMO_for_1 160 163 PF00179 0.279
MOD_SUMO_rev_2 74 81 PF00179 0.331
MOD_SUMO_rev_2 782 792 PF00179 0.517
TRG_DiLeu_BaEn_2 542 548 PF01217 0.469
TRG_DiLeu_BaEn_3 543 549 PF01217 0.468
TRG_DiLeu_BaLyEn_6 237 242 PF01217 0.410
TRG_DiLeu_BaLyEn_6 587 592 PF01217 0.416
TRG_ENDOCYTIC_2 100 103 PF00928 0.317
TRG_ENDOCYTIC_2 110 113 PF00928 0.279
TRG_ENDOCYTIC_2 122 125 PF00928 0.297
TRG_ENDOCYTIC_2 225 228 PF00928 0.291
TRG_ENDOCYTIC_2 344 347 PF00928 0.300
TRG_ENDOCYTIC_2 573 576 PF00928 0.332
TRG_ENDOCYTIC_2 61 64 PF00928 0.410
TRG_ER_diArg_1 351 354 PF00400 0.497
TRG_ER_diArg_1 503 505 PF00400 0.690
TRG_ER_diArg_1 669 672 PF00400 0.732
TRG_ER_diArg_1 678 680 PF00400 0.748
TRG_NES_CRM1_1 355 369 PF08389 0.570
TRG_NLS_MonoExtN_4 245 251 PF00514 0.357
TRG_NLS_MonoExtN_4 49 55 PF00514 0.357
TRG_Pf-PMV_PEXEL_1 137 141 PF00026 0.308
TRG_Pf-PMV_PEXEL_1 158 163 PF00026 0.279
TRG_Pf-PMV_PEXEL_1 262 266 PF00026 0.279

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I379 Leptomonas seymouri 70% 99%
A0A1X0P022 Trypanosomatidae 61% 100%
A0A3R7MPF2 Trypanosoma rangeli 60% 100%
A0A3S7X2Q3 Leishmania donovani 97% 100%
A4HHK1 Leishmania braziliensis 87% 100%
A4I4Q9 Leishmania infantum 97% 100%
C9ZLF2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9ALM1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5BL06 Trypanosoma cruzi 58% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS