SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE62_LEIMA

TriTrypDb:

LmjF.29.2000 , LMJLV39_290027800 , LMJSD75_290028000

Length:

710

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AE62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE62

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009451	RNA modification	5	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0032259	methylation	2	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0043414	macromolecule methylation	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0008168	methyltransferase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10
GO:0003676	nucleic acid binding	3	5
GO:0003723	RNA binding	4	5
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.679
CLV_C14_Caspase3-7	505	509	PF00656	0.638
CLV_NRD_NRD_1	122	124	PF00675	0.531
CLV_NRD_NRD_1	198	200	PF00675	0.492
CLV_NRD_NRD_1	324	326	PF00675	0.533
CLV_NRD_NRD_1	455	457	PF00675	0.681
CLV_NRD_NRD_1	48	50	PF00675	0.604
CLV_NRD_NRD_1	584	586	PF00675	0.598
CLV_NRD_NRD_1	626	628	PF00675	0.611
CLV_PCSK_KEX2_1	122	124	PF00082	0.569
CLV_PCSK_KEX2_1	323	325	PF00082	0.579
CLV_PCSK_KEX2_1	340	342	PF00082	0.552
CLV_PCSK_KEX2_1	47	49	PF00082	0.626
CLV_PCSK_KEX2_1	584	586	PF00082	0.598
CLV_PCSK_KEX2_1	626	628	PF00082	0.611
CLV_PCSK_KEX2_1	690	692	PF00082	0.435
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.635
CLV_PCSK_PC1ET2_1	690	692	PF00082	0.435
CLV_PCSK_SKI1_1	39	43	PF00082	0.682
CLV_Separin_Metazoa	581	585	PF03568	0.559
DEG_APCC_DBOX_1	137	145	PF00400	0.537
DEG_SPOP_SBC_1	332	336	PF00917	0.617
DEG_SPOP_SBC_1	392	396	PF00917	0.739
DOC_CYCLIN_yCln2_LP_2	590	596	PF00134	0.484
DOC_MAPK_DCC_7	687	697	PF00069	0.473
DOC_MAPK_gen_1	199	207	PF00069	0.509
DOC_MAPK_gen_1	47	53	PF00069	0.596
DOC_MAPK_gen_1	584	591	PF00069	0.548
DOC_MAPK_gen_1	676	685	PF00069	0.589
DOC_MAPK_gen_1	687	697	PF00069	0.523
DOC_MAPK_MEF2A_6	133	141	PF00069	0.526
DOC_MAPK_MEF2A_6	466	474	PF00069	0.619
DOC_MAPK_MEF2A_6	690	699	PF00069	0.605
DOC_PP2B_LxvP_1	427	430	PF13499	0.648
DOC_PP4_FxxP_1	163	166	PF00568	0.488
DOC_USP7_MATH_1	117	121	PF00917	0.611
DOC_USP7_MATH_1	148	152	PF00917	0.516
DOC_USP7_MATH_1	237	241	PF00917	0.588
DOC_USP7_MATH_1	384	388	PF00917	0.682
DOC_USP7_MATH_1	414	418	PF00917	0.482
DOC_USP7_MATH_1	487	491	PF00917	0.806
DOC_USP7_MATH_1	493	497	PF00917	0.811
DOC_USP7_MATH_1	519	523	PF00917	0.556
DOC_USP7_MATH_1	541	545	PF00917	0.561
DOC_USP7_MATH_1	8	12	PF00917	0.702
DOC_WW_Pin1_4	235	240	PF00397	0.638
DOC_WW_Pin1_4	357	362	PF00397	0.681
DOC_WW_Pin1_4	393	398	PF00397	0.748
DOC_WW_Pin1_4	508	513	PF00397	0.675
DOC_WW_Pin1_4	85	90	PF00397	0.616
LIG_14-3-3_CanoR_1	260	264	PF00244	0.518
LIG_14-3-3_CanoR_1	480	487	PF00244	0.762
LIG_14-3-3_CanoR_1	666	670	PF00244	0.570
LIG_14-3-3_CanoR_1	676	685	PF00244	0.450
LIG_14-3-3_CanoR_1	80	89	PF00244	0.729
LIG_14-3-3_CanoR_1	93	99	PF00244	0.553
LIG_Actin_WH2_2	134	152	PF00022	0.510
LIG_Actin_WH2_2	517	535	PF00022	0.496
LIG_BIR_II_1	1	5	PF00653	0.676
LIG_Clathr_ClatBox_1	182	186	PF01394	0.463
LIG_CSL_BTD_1	156	159	PF09270	0.521
LIG_EVH1_2	31	35	PF00568	0.564
LIG_FHA_1	332	338	PF00498	0.768
LIG_FHA_1	585	591	PF00498	0.527
LIG_FHA_1	694	700	PF00498	0.599
LIG_FHA_1	81	87	PF00498	0.695
LIG_FHA_2	110	116	PF00498	0.610
LIG_FHA_2	317	323	PF00498	0.542
LIG_FHA_2	38	44	PF00498	0.509
LIG_FHA_2	576	582	PF00498	0.777
LIG_LIR_Gen_1	542	553	PF02991	0.575
LIG_LIR_Gen_1	648	656	PF02991	0.654
LIG_LIR_Gen_1	680	688	PF02991	0.401
LIG_LIR_LC3C_4	242	247	PF02991	0.467
LIG_LIR_Nem_3	526	532	PF02991	0.510
LIG_LIR_Nem_3	542	548	PF02991	0.516
LIG_LIR_Nem_3	639	643	PF02991	0.545
LIG_LIR_Nem_3	648	653	PF02991	0.617
LIG_LIR_Nem_3	671	677	PF02991	0.508
LIG_LIR_Nem_3	680	685	PF02991	0.404
LIG_MAD2	203	211	PF02301	0.490
LIG_Pex14_1	674	678	PF04695	0.476
LIG_Pex14_2	163	167	PF04695	0.532
LIG_Pex14_2	678	682	PF04695	0.455
LIG_PTB_Apo_2	171	178	PF02174	0.569
LIG_SH2_CRK	529	533	PF00017	0.476
LIG_SH2_CRK	545	549	PF00017	0.476
LIG_SH2_CRK	640	644	PF00017	0.566
LIG_SH2_PTP2	50	53	PF00017	0.453
LIG_SH2_SRC	367	370	PF00017	0.552
LIG_SH2_SRC	650	653	PF00017	0.651
LIG_SH2_STAP1	596	600	PF00017	0.549
LIG_SH2_STAT5	50	53	PF00017	0.440
LIG_SH2_STAT5	547	550	PF00017	0.527
LIG_SH2_STAT5	552	555	PF00017	0.525
LIG_SH2_STAT5	652	655	PF00017	0.724
LIG_SH2_STAT5	684	687	PF00017	0.488
LIG_SH3_3	233	239	PF00018	0.724
LIG_SH3_3	363	369	PF00018	0.597
LIG_SH3_3	394	400	PF00018	0.781
LIG_SH3_3	580	586	PF00018	0.687
LIG_SUMO_SIM_par_1	232	238	PF11976	0.506
LIG_SUMO_SIM_par_1	694	700	PF11976	0.599
LIG_TRAF2_1	88	91	PF00917	0.630
LIG_UBA3_1	517	523	PF00899	0.550
MOD_CK1_1	235	241	PF00069	0.649
MOD_CK1_1	297	303	PF00069	0.567
MOD_CK1_1	354	360	PF00069	0.710
MOD_CK1_1	447	453	PF00069	0.783
MOD_CK1_1	488	494	PF00069	0.792
MOD_CK1_1	513	519	PF00069	0.420
MOD_CK2_1	316	322	PF00069	0.545
MOD_CK2_1	478	484	PF00069	0.760
MOD_CK2_1	575	581	PF00069	0.774
MOD_CK2_1	659	665	PF00069	0.694
MOD_CK2_1	85	91	PF00069	0.643
MOD_GlcNHglycan	17	20	PF01048	0.675
MOD_GlcNHglycan	299	302	PF01048	0.540
MOD_GlcNHglycan	309	312	PF01048	0.592
MOD_GlcNHglycan	345	348	PF01048	0.760
MOD_GlcNHglycan	440	443	PF01048	0.729
MOD_GlcNHglycan	446	449	PF01048	0.725
MOD_GlcNHglycan	487	490	PF01048	0.787
MOD_GlcNHglycan	512	515	PF01048	0.714
MOD_GlcNHglycan	661	664	PF01048	0.670
MOD_GSK3_1	332	339	PF00069	0.681
MOD_GSK3_1	357	364	PF00069	0.651
MOD_GSK3_1	391	398	PF00069	0.758
MOD_GSK3_1	414	421	PF00069	0.476
MOD_GSK3_1	434	441	PF00069	0.708
MOD_GSK3_1	446	453	PF00069	0.707
MOD_GSK3_1	539	546	PF00069	0.479
MOD_GSK3_1	81	88	PF00069	0.673
MOD_GSK3_1	94	101	PF00069	0.570
MOD_N-GLC_1	251	256	PF02516	0.455
MOD_N-GLC_1	330	335	PF02516	0.656
MOD_NEK2_1	178	183	PF00069	0.404
MOD_NEK2_1	256	261	PF00069	0.550
MOD_NEK2_1	305	310	PF00069	0.651
MOD_NEK2_1	494	499	PF00069	0.771
MOD_NEK2_1	677	682	PF00069	0.464
MOD_NEK2_1	81	86	PF00069	0.733
MOD_NEK2_1	94	99	PF00069	0.434
MOD_NEK2_2	451	456	PF00069	0.683
MOD_PIKK_1	117	123	PF00454	0.668
MOD_PIKK_1	277	283	PF00454	0.644
MOD_PIKK_1	384	390	PF00454	0.634
MOD_PIKK_1	395	401	PF00454	0.565
MOD_PIKK_1	478	484	PF00454	0.768
MOD_PIKK_1	488	494	PF00454	0.803
MOD_PKA_1	584	590	PF00069	0.476
MOD_PKA_2	259	265	PF00069	0.561
MOD_PKA_2	575	581	PF00069	0.735
MOD_PKA_2	584	590	PF00069	0.539
MOD_PKA_2	665	671	PF00069	0.526
MOD_PKA_2	678	684	PF00069	0.445
MOD_PKB_1	341	349	PF00069	0.718
MOD_Plk_1	251	257	PF00069	0.517
MOD_Plk_1	693	699	PF00069	0.574
MOD_Plk_2-3	37	43	PF00069	0.511
MOD_Plk_4	178	184	PF00069	0.484
MOD_Plk_4	361	367	PF00069	0.573
MOD_Plk_4	513	519	PF00069	0.401
MOD_Plk_4	534	540	PF00069	0.476
MOD_Plk_4	543	549	PF00069	0.476
MOD_Plk_4	678	684	PF00069	0.548
MOD_Plk_4	82	88	PF00069	0.716
MOD_ProDKin_1	235	241	PF00069	0.630
MOD_ProDKin_1	357	363	PF00069	0.664
MOD_ProDKin_1	393	399	PF00069	0.748
MOD_ProDKin_1	508	514	PF00069	0.668
MOD_ProDKin_1	85	91	PF00069	0.607
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.665
TRG_DiLeu_BaLyEn_6	628	633	PF01217	0.664
TRG_ENDOCYTIC_2	50	53	PF00928	0.453
TRG_ENDOCYTIC_2	529	532	PF00928	0.473
TRG_ENDOCYTIC_2	545	548	PF00928	0.433
TRG_ENDOCYTIC_2	640	643	PF00928	0.531
TRG_ENDOCYTIC_2	650	653	PF00928	0.605
TRG_ER_diArg_1	122	125	PF00400	0.636
TRG_ER_diArg_1	323	325	PF00400	0.575
TRG_ER_diArg_1	341	344	PF00400	0.688
TRG_ER_diArg_1	47	49	PF00400	0.518
TRG_ER_diArg_1	573	576	PF00400	0.577
TRG_ER_diArg_1	583	585	PF00400	0.494
TRG_NLS_Bipartite_1	323	344	PF00514	0.681
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.676
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.710
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B6	Leptomonas seymouri	44%	100%
A0A1X0P1I1	Trypanosomatidae	30%	100%
A0A3S7X2L4	Leishmania donovani	90%	100%
A0A422NNK7	Trypanosoma rangeli	29%	100%
A4HHJ9	Leishmania braziliensis	68%	95%
C9ZLE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ALM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5DCM2	Trypanosoma cruzi	29%	100%