LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AE61_LEIMA
TriTrypDb:
LmjF.29.1995 , LMJLV39_290027700 , LMJSD75_290027900
Length:
371

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0005815 microtubule organizing center 2 2
GO:0036064 ciliary basal body 3 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9AE61
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE61

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 126 128 PF00675 0.576
CLV_NRD_NRD_1 130 132 PF00675 0.584
CLV_NRD_NRD_1 15 17 PF00675 0.799
CLV_PCSK_KEX2_1 126 128 PF00082 0.590
CLV_PCSK_KEX2_1 130 132 PF00082 0.636
CLV_PCSK_KEX2_1 15 17 PF00082 0.799
CLV_PCSK_KEX2_1 221 223 PF00082 0.621
CLV_PCSK_KEX2_1 86 88 PF00082 0.738
CLV_PCSK_PC1ET2_1 221 223 PF00082 0.621
CLV_PCSK_PC1ET2_1 86 88 PF00082 0.738
CLV_PCSK_PC7_1 126 132 PF00082 0.573
CLV_PCSK_SKI1_1 126 130 PF00082 0.568
CLV_PCSK_SKI1_1 231 235 PF00082 0.604
CLV_PCSK_SKI1_1 280 284 PF00082 0.638
DEG_APCC_DBOX_1 125 133 PF00400 0.367
DOC_CYCLIN_RxL_1 121 133 PF00134 0.363
DOC_MAPK_MEF2A_6 331 338 PF00069 0.327
DOC_PP1_SILK_1 231 236 PF00149 0.392
DOC_PP4_FxxP_1 107 110 PF00568 0.369
DOC_PP4_FxxP_1 310 313 PF00568 0.295
DOC_USP7_MATH_1 246 250 PF00917 0.328
DOC_USP7_MATH_1 25 29 PF00917 0.554
DOC_USP7_MATH_1 268 272 PF00917 0.449
DOC_USP7_MATH_1 274 278 PF00917 0.458
DOC_USP7_MATH_1 287 291 PF00917 0.332
DOC_USP7_MATH_1 59 63 PF00917 0.472
DOC_WW_Pin1_4 163 168 PF00397 0.486
DOC_WW_Pin1_4 175 180 PF00397 0.513
DOC_WW_Pin1_4 189 194 PF00397 0.400
DOC_WW_Pin1_4 21 26 PF00397 0.611
DOC_WW_Pin1_4 264 269 PF00397 0.470
DOC_WW_Pin1_4 280 285 PF00397 0.430
DOC_WW_Pin1_4 329 334 PF00397 0.338
DOC_WW_Pin1_4 339 344 PF00397 0.299
LIG_14-3-3_CanoR_1 130 136 PF00244 0.427
LIG_14-3-3_CanoR_1 170 175 PF00244 0.493
LIG_Actin_WH2_2 121 138 PF00022 0.361
LIG_Actin_WH2_2 216 233 PF00022 0.363
LIG_BIR_III_2 298 302 PF00653 0.433
LIG_BRCT_BRCA1_1 180 184 PF00533 0.370
LIG_FHA_1 171 177 PF00498 0.569
LIG_FHA_1 344 350 PF00498 0.308
LIG_FHA_2 59 65 PF00498 0.463
LIG_FHA_2 91 97 PF00498 0.460
LIG_Integrin_isoDGR_2 75 77 PF01839 0.653
LIG_LIR_Gen_1 270 276 PF02991 0.465
LIG_LIR_Nem_3 209 215 PF02991 0.326
LIG_LIR_Nem_3 270 275 PF02991 0.462
LIG_LIR_Nem_3 314 319 PF02991 0.296
LIG_NRBOX 124 130 PF00104 0.346
LIG_SH2_NCK_1 253 257 PF00017 0.330
LIG_SH2_SRC 253 256 PF00017 0.332
LIG_SH2_STAP1 253 257 PF00017 0.330
LIG_SH3_3 173 179 PF00018 0.460
LIG_SH3_3 187 193 PF00018 0.304
MOD_CDK_SPxK_1 329 335 PF00069 0.402
MOD_CDK_SPxxK_3 163 170 PF00069 0.611
MOD_CK1_1 166 172 PF00069 0.648
MOD_CK1_1 178 184 PF00069 0.402
MOD_CK1_1 21 27 PF00069 0.643
MOD_CK1_1 267 273 PF00069 0.550
MOD_CK1_1 28 34 PF00069 0.698
MOD_CK1_1 291 297 PF00069 0.511
MOD_CK2_1 58 64 PF00069 0.572
MOD_CK2_1 90 96 PF00069 0.574
MOD_GlcNHglycan 161 164 PF01048 0.619
MOD_GlcNHglycan 198 201 PF01048 0.601
MOD_GlcNHglycan 20 23 PF01048 0.603
MOD_GlcNHglycan 248 251 PF01048 0.405
MOD_GlcNHglycan 276 279 PF01048 0.611
MOD_GlcNHglycan 285 288 PF01048 0.474
MOD_GlcNHglycan 70 74 PF01048 0.610
MOD_GSK3_1 159 166 PF00069 0.666
MOD_GSK3_1 21 28 PF00069 0.663
MOD_GSK3_1 264 271 PF00069 0.504
MOD_GSK3_1 274 281 PF00069 0.543
MOD_GSK3_1 283 290 PF00069 0.448
MOD_GSK3_1 32 39 PF00069 0.579
MOD_GSK3_1 339 346 PF00069 0.308
MOD_N-GLC_1 28 33 PF02516 0.571
MOD_N-GLC_2 79 81 PF02516 0.613
MOD_NEK2_1 18 23 PF00069 0.594
MOD_NEK2_1 184 189 PF00069 0.449
MOD_NEK2_1 32 37 PF00069 0.591
MOD_NEK2_2 343 348 PF00069 0.362
MOD_PIKK_1 161 167 PF00454 0.607
MOD_PKA_1 130 136 PF00069 0.489
MOD_PKA_2 130 136 PF00069 0.527
MOD_PKA_2 169 175 PF00069 0.723
MOD_PKA_2 36 42 PF00069 0.660
MOD_PKA_2 68 74 PF00069 0.679
MOD_PKB_1 67 75 PF00069 0.548
MOD_Plk_1 28 34 PF00069 0.548
MOD_Plk_1 59 65 PF00069 0.548
MOD_Plk_4 48 54 PF00069 0.539
MOD_ProDKin_1 163 169 PF00069 0.612
MOD_ProDKin_1 175 181 PF00069 0.635
MOD_ProDKin_1 189 195 PF00069 0.504
MOD_ProDKin_1 21 27 PF00069 0.785
MOD_ProDKin_1 264 270 PF00069 0.600
MOD_ProDKin_1 280 286 PF00069 0.526
MOD_ProDKin_1 329 335 PF00069 0.402
MOD_ProDKin_1 339 345 PF00069 0.299
TRG_DiLeu_BaEn_4 329 335 PF01217 0.374
TRG_DiLeu_BaLyEn_6 124 129 PF01217 0.395
TRG_ENDOCYTIC_2 253 256 PF00928 0.330
TRG_ENDOCYTIC_2 272 275 PF00928 0.744
TRG_ER_diArg_1 125 127 PF00400 0.432
TRG_ER_diArg_1 129 131 PF00400 0.452
TRG_ER_diArg_1 15 17 PF00400 0.630
TRG_ER_diArg_1 324 327 PF00400 0.427

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBV2 Leptomonas seymouri 43% 92%
A0A3Q8IIX3 Leishmania donovani 89% 100%
E9AIT7 Leishmania braziliensis 67% 100%
E9ALM4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS