Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE60_LEIMA

TriTrypDb:

LmjF.29.1990 , LMJLV39_290027600 , LMJSD75_290027800

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	400	404	PF00656	0.564
CLV_C14_Caspase3-7	418	422	PF00656	0.612
CLV_NRD_NRD_1	370	372	PF00675	0.640
CLV_NRD_NRD_1	42	44	PF00675	0.688
CLV_NRD_NRD_1	97	99	PF00675	0.624
CLV_PCSK_FUR_1	40	44	PF00082	0.681
CLV_PCSK_KEX2_1	343	345	PF00082	0.725
CLV_PCSK_KEX2_1	370	372	PF00082	0.640
CLV_PCSK_KEX2_1	42	44	PF00082	0.688
CLV_PCSK_KEX2_1	473	475	PF00082	0.552
CLV_PCSK_KEX2_1	97	99	PF00082	0.624
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.725
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.548
DEG_SPOP_SBC_1	348	352	PF00917	0.726
DOC_ANK_TNKS_1	451	458	PF00023	0.679
DOC_CKS1_1	273	278	PF01111	0.437
DOC_CKS1_1	6	11	PF01111	0.662
DOC_CYCLIN_yCln2_LP_2	146	152	PF00134	0.770
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.576
DOC_PP2B_LxvP_1	189	192	PF13499	0.631
DOC_PP4_FxxP_1	150	153	PF00568	0.777
DOC_PP4_FxxP_1	6	9	PF00568	0.730
DOC_SPAK_OSR1_1	238	242	PF12202	0.688
DOC_USP7_MATH_1	161	165	PF00917	0.805
DOC_USP7_MATH_1	198	202	PF00917	0.695
DOC_USP7_MATH_1	348	352	PF00917	0.740
DOC_USP7_MATH_1	438	442	PF00917	0.703
DOC_USP7_MATH_1	66	70	PF00917	0.724
DOC_WW_Pin1_4	127	132	PF00397	0.719
DOC_WW_Pin1_4	165	170	PF00397	0.671
DOC_WW_Pin1_4	172	177	PF00397	0.639
DOC_WW_Pin1_4	272	277	PF00397	0.454
DOC_WW_Pin1_4	41	46	PF00397	0.715
DOC_WW_Pin1_4	434	439	PF00397	0.799
DOC_WW_Pin1_4	5	10	PF00397	0.756
LIG_14-3-3_CanoR_1	121	131	PF00244	0.618
LIG_14-3-3_CanoR_1	238	242	PF00244	0.533
LIG_14-3-3_CanoR_1	362	367	PF00244	0.669
LIG_14-3-3_CanoR_1	370	377	PF00244	0.649
LIG_14-3-3_CanoR_1	64	74	PF00244	0.703
LIG_APCC_ABBA_1	90	95	PF00400	0.723
LIG_BIR_II_1	1	5	PF00653	0.772
LIG_BIR_III_4	421	425	PF00653	0.695
LIG_BIR_III_4	429	433	PF00653	0.617
LIG_BIR_III_4	480	484	PF00653	0.702
LIG_deltaCOP1_diTrp_1	310	315	PF00928	0.644
LIG_deltaCOP1_diTrp_1	373	380	PF00928	0.536
LIG_eIF4E_1	12	18	PF01652	0.522
LIG_FHA_1	166	172	PF00498	0.712
LIG_FHA_1	355	361	PF00498	0.581
LIG_FHA_1	370	376	PF00498	0.673
LIG_FHA_1	386	392	PF00498	0.511
LIG_FHA_1	42	48	PF00498	0.691
LIG_FHA_1	448	454	PF00498	0.642
LIG_FHA_2	273	279	PF00498	0.436
LIG_FHA_2	328	334	PF00498	0.682
LIG_FHA_2	410	416	PF00498	0.769
LIG_LIR_Apic_2	3	9	PF02991	0.566
LIG_LIR_Gen_1	132	142	PF02991	0.643
LIG_LIR_Nem_3	13	18	PF02991	0.746
LIG_LIR_Nem_3	132	137	PF02991	0.723
LIG_LIR_Nem_3	140	145	PF02991	0.612
LIG_LIR_Nem_3	374	380	PF02991	0.543
LIG_LIR_Nem_3	91	96	PF02991	0.661
LIG_MYND_1	517	521	PF01753	0.617
LIG_PCNA_PIPBox_1	498	507	PF02747	0.663
LIG_SH2_CRK	134	138	PF00017	0.719
LIG_SH2_GRB2like	12	15	PF00017	0.571
LIG_SH2_PTP2	270	273	PF00017	0.458
LIG_SH2_STAP1	134	138	PF00017	0.719
LIG_SH2_STAP1	282	286	PF00017	0.483
LIG_SH2_STAT3	282	285	PF00017	0.586
LIG_SH2_STAT3	324	327	PF00017	0.551
LIG_SH2_STAT5	12	15	PF00017	0.688
LIG_SH2_STAT5	181	184	PF00017	0.521
LIG_SH2_STAT5	270	273	PF00017	0.483
LIG_SH2_STAT5	33	36	PF00017	0.709
LIG_SH3_3	146	152	PF00018	0.675
LIG_SH3_3	298	304	PF00018	0.603
LIG_SH3_3	441	447	PF00018	0.749
LIG_SH3_3	514	520	PF00018	0.663
LIG_SUMO_SIM_anti_2	203	208	PF11976	0.465
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.627
LIG_UBA3_1	379	387	PF00899	0.607
LIG_WW_1	520	523	PF00397	0.539
LIG_WW_1	9	12	PF00397	0.533
MOD_CDK_SPK_2	41	46	PF00069	0.715
MOD_CK1_1	126	132	PF00069	0.798
MOD_CK1_1	334	340	PF00069	0.608
MOD_CK1_1	351	357	PF00069	0.536
MOD_CK1_1	365	371	PF00069	0.630
MOD_CK1_1	408	414	PF00069	0.756
MOD_CK1_1	53	59	PF00069	0.786
MOD_CK1_1	68	74	PF00069	0.564
MOD_CK2_1	272	278	PF00069	0.430
MOD_CK2_1	327	333	PF00069	0.600
MOD_CK2_1	334	340	PF00069	0.705
MOD_CK2_1	409	415	PF00069	0.772
MOD_GlcNHglycan	196	199	PF01048	0.545
MOD_GlcNHglycan	218	222	PF01048	0.527
MOD_GlcNHglycan	252	255	PF01048	0.587
MOD_GlcNHglycan	351	354	PF01048	0.784
MOD_GlcNHglycan	412	415	PF01048	0.805
MOD_GlcNHglycan	52	55	PF01048	0.765
MOD_GlcNHglycan	70	73	PF01048	0.531
MOD_GlcNHglycan	86	90	PF01048	0.489
MOD_GSK3_1	122	129	PF00069	0.826
MOD_GSK3_1	161	168	PF00069	0.651
MOD_GSK3_1	194	201	PF00069	0.654
MOD_GSK3_1	327	334	PF00069	0.648
MOD_GSK3_1	338	345	PF00069	0.711
MOD_GSK3_1	347	354	PF00069	0.619
MOD_GSK3_1	365	372	PF00069	0.751
MOD_GSK3_1	398	405	PF00069	0.628
MOD_GSK3_1	41	48	PF00069	0.748
MOD_GSK3_1	434	441	PF00069	0.721
MOD_GSK3_1	50	57	PF00069	0.679
MOD_N-GLC_1	295	300	PF02516	0.577
MOD_N-GLC_1	405	410	PF02516	0.737
MOD_N-GLC_1	66	71	PF02516	0.721
MOD_NEK2_1	113	118	PF00069	0.742
MOD_NEK2_1	137	142	PF00069	0.603
MOD_NEK2_1	171	176	PF00069	0.719
MOD_NEK2_1	217	222	PF00069	0.656
MOD_NEK2_1	326	331	PF00069	0.628
MOD_NEK2_1	380	385	PF00069	0.698
MOD_NEK2_1	397	402	PF00069	0.509
MOD_PIKK_1	114	120	PF00454	0.704
MOD_PIKK_1	405	411	PF00454	0.784
MOD_PK_1	280	286	PF00069	0.690
MOD_PKA_1	343	349	PF00069	0.724
MOD_PKA_2	113	119	PF00069	0.621
MOD_PKA_2	237	243	PF00069	0.604
MOD_PKA_2	343	349	PF00069	0.624
MOD_PKA_2	369	375	PF00069	0.695
MOD_PKA_2	45	51	PF00069	0.763
MOD_Plk_1	280	286	PF00069	0.690
MOD_Plk_1	334	340	PF00069	0.806
MOD_Plk_1	85	91	PF00069	0.706
MOD_Plk_2-3	295	301	PF00069	0.542
MOD_Plk_2-3	369	375	PF00069	0.625
MOD_Plk_4	380	386	PF00069	0.675
MOD_Plk_4	387	393	PF00069	0.562
MOD_Plk_4	440	446	PF00069	0.694
MOD_ProDKin_1	127	133	PF00069	0.716
MOD_ProDKin_1	165	171	PF00069	0.667
MOD_ProDKin_1	172	178	PF00069	0.628
MOD_ProDKin_1	272	278	PF00069	0.451
MOD_ProDKin_1	41	47	PF00069	0.718
MOD_ProDKin_1	434	440	PF00069	0.799
MOD_ProDKin_1	5	11	PF00069	0.754
MOD_SUMO_for_1	416	419	PF00179	0.588
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.704
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.558
TRG_ENDOCYTIC_2	134	137	PF00928	0.701
TRG_ENDOCYTIC_2	270	273	PF00928	0.481
TRG_ENDOCYTIC_2	523	526	PF00928	0.576
TRG_ENDOCYTIC_2	93	96	PF00928	0.598
TRG_ER_diArg_1	41	43	PF00400	0.683
TRG_ER_diArg_1	96	98	PF00400	0.616
TRG_NES_CRM1_1	456	469	PF08389	0.546
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXW3	Leptomonas seymouri	26%	92%
A0A3Q8IDU7	Leishmania donovani	88%	100%
A4HHJ8	Leishmania braziliensis	68%	100%
A4I4Q7	Leishmania infantum	88%	100%
E9ALM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%