Protein geranylgeranyltransferase type II

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein farnesyltransferase alpha subunit, putative

Species:

Leishmania major

UniProt:

E9AE56_LEIMA

TriTrypDb:

LmjF.29.1950 , LMJLV39_290027200 , LMJSD75_290027400

Length:

760

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005953	CAAX-protein geranylgeranyltransferase complex	3	2
GO:0005965	protein farnesyltransferase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

E9AE56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE56

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0018342	protein prenylation	4	11
GO:0018343	protein farnesylation	5	2
GO:0018344	protein geranylgeranylation	5	2
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0097354	prenylation	3	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004659	prenyltransferase activity	4	11
GO:0008318	protein prenyltransferase activity	3	11
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0004660	protein farnesyltransferase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	662	666	PF00656	0.432
CLV_C14_Caspase3-7	701	705	PF00656	0.749
CLV_C14_Caspase3-7	710	714	PF00656	0.535
CLV_NRD_NRD_1	146	148	PF00675	0.377
CLV_NRD_NRD_1	246	248	PF00675	0.283
CLV_NRD_NRD_1	300	302	PF00675	0.580
CLV_NRD_NRD_1	349	351	PF00675	0.560
CLV_NRD_NRD_1	501	503	PF00675	0.345
CLV_NRD_NRD_1	670	672	PF00675	0.511
CLV_PCSK_KEX2_1	146	148	PF00082	0.377
CLV_PCSK_KEX2_1	300	302	PF00082	0.580
CLV_PCSK_KEX2_1	501	503	PF00082	0.345
CLV_PCSK_KEX2_1	669	671	PF00082	0.517
CLV_PCSK_SKI1_1	124	128	PF00082	0.378
CLV_PCSK_SKI1_1	147	151	PF00082	0.476
CLV_PCSK_SKI1_1	161	165	PF00082	0.475
CLV_PCSK_SKI1_1	248	252	PF00082	0.293
CLV_PCSK_SKI1_1	317	321	PF00082	0.518
CLV_PCSK_SKI1_1	350	354	PF00082	0.532
CLV_PCSK_SKI1_1	422	426	PF00082	0.389
CLV_PCSK_SKI1_1	427	431	PF00082	0.424
CLV_PCSK_SKI1_1	520	524	PF00082	0.467
CLV_PCSK_SKI1_1	731	735	PF00082	0.513
DEG_APCC_DBOX_1	160	168	PF00400	0.549
DEG_APCC_DBOX_1	223	231	PF00400	0.356
DEG_APCC_DBOX_1	312	320	PF00400	0.545
DEG_SCF_FBW7_2	55	60	PF00400	0.605
DEG_SPOP_SBC_1	442	446	PF00917	0.537
DEG_SPOP_SBC_1	698	702	PF00917	0.523
DOC_CDC14_PxL_1	522	530	PF14671	0.564
DOC_CKS1_1	344	349	PF01111	0.503
DOC_CKS1_1	549	554	PF01111	0.568
DOC_CYCLIN_RxL_1	245	252	PF00134	0.475
DOC_CYCLIN_RxL_1	597	608	PF00134	0.504
DOC_CYCLIN_yCln2_LP_2	150	156	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	167	173	PF00134	0.314
DOC_CYCLIN_yCln2_LP_2	527	530	PF00134	0.525
DOC_MAPK_DCC_7	161	169	PF00069	0.554
DOC_MAPK_gen_1	300	307	PF00069	0.556
DOC_MAPK_gen_1	742	751	PF00069	0.406
DOC_MAPK_MEF2A_6	124	131	PF00069	0.458
DOC_MAPK_MEF2A_6	161	169	PF00069	0.554
DOC_MAPK_NFAT4_5	124	132	PF00069	0.458
DOC_PP1_RVXF_1	219	226	PF00149	0.371
DOC_PP2B_LxvP_1	167	170	PF13499	0.505
DOC_PP2B_LxvP_1	345	348	PF13499	0.497
DOC_PP2B_LxvP_1	527	530	PF13499	0.446
DOC_USP7_MATH_1	24	28	PF00917	0.641
DOC_USP7_MATH_1	442	446	PF00917	0.668
DOC_USP7_MATH_1	450	454	PF00917	0.626
DOC_USP7_MATH_1	605	609	PF00917	0.618
DOC_USP7_MATH_1	698	702	PF00917	0.718
DOC_WW_Pin1_4	12	17	PF00397	0.706
DOC_WW_Pin1_4	149	154	PF00397	0.559
DOC_WW_Pin1_4	215	220	PF00397	0.469
DOC_WW_Pin1_4	255	260	PF00397	0.479
DOC_WW_Pin1_4	280	285	PF00397	0.657
DOC_WW_Pin1_4	343	348	PF00397	0.448
DOC_WW_Pin1_4	369	374	PF00397	0.624
DOC_WW_Pin1_4	393	398	PF00397	0.560
DOC_WW_Pin1_4	53	58	PF00397	0.586
DOC_WW_Pin1_4	545	550	PF00397	0.565
DOC_WW_Pin1_4	62	67	PF00397	0.649
DOC_WW_Pin1_4	93	98	PF00397	0.521
LIG_14-3-3_CanoR_1	119	127	PF00244	0.466
LIG_14-3-3_CanoR_1	134	143	PF00244	0.442
LIG_14-3-3_CanoR_1	198	206	PF00244	0.556
LIG_14-3-3_CanoR_1	414	423	PF00244	0.553
LIG_14-3-3_CanoR_1	581	587	PF00244	0.532
LIG_14-3-3_CanoR_1	611	618	PF00244	0.707
LIG_14-3-3_CanoR_1	632	638	PF00244	0.519
LIG_14-3-3_CanoR_1	9	19	PF00244	0.702
LIG_Actin_WH2_2	183	200	PF00022	0.602
LIG_Actin_WH2_2	303	319	PF00022	0.548
LIG_Actin_WH2_2	575	592	PF00022	0.485
LIG_APCC_ABBA_1	423	428	PF00400	0.588
LIG_APCC_ABBAyCdc20_2	422	428	PF00400	0.553
LIG_BIR_III_2	162	166	PF00653	0.602
LIG_BRCT_BRCA1_1	281	285	PF00533	0.572
LIG_deltaCOP1_diTrp_1	210	220	PF00928	0.551
LIG_deltaCOP1_diTrp_1	688	695	PF00928	0.581
LIG_FHA_1	250	256	PF00498	0.547
LIG_FHA_1	403	409	PF00498	0.486
LIG_FHA_1	442	448	PF00498	0.636
LIG_FHA_1	94	100	PF00498	0.621
LIG_FHA_2	175	181	PF00498	0.580
LIG_FHA_2	292	298	PF00498	0.536
LIG_FHA_2	377	383	PF00498	0.640
LIG_FHA_2	449	455	PF00498	0.619
LIG_FHA_2	54	60	PF00498	0.560
LIG_FHA_2	566	572	PF00498	0.418
LIG_FHA_2	590	596	PF00498	0.563
LIG_FHA_2	626	632	PF00498	0.482
LIG_FHA_2	732	738	PF00498	0.559
LIG_LIR_Apic_2	688	692	PF02991	0.628
LIG_LIR_Gen_1	306	314	PF02991	0.553
LIG_LIR_Gen_1	335	345	PF02991	0.367
LIG_LIR_Gen_1	471	479	PF02991	0.483
LIG_LIR_Gen_1	571	579	PF02991	0.371
LIG_LIR_Gen_1	639	649	PF02991	0.472
LIG_LIR_Nem_3	218	223	PF02991	0.368
LIG_LIR_Nem_3	282	288	PF02991	0.518
LIG_LIR_Nem_3	292	298	PF02991	0.344
LIG_LIR_Nem_3	306	310	PF02991	0.462
LIG_LIR_Nem_3	335	340	PF02991	0.311
LIG_LIR_Nem_3	46	51	PF02991	0.458
LIG_LIR_Nem_3	471	477	PF02991	0.448
LIG_LIR_Nem_3	571	576	PF02991	0.349
LIG_LIR_Nem_3	639	644	PF02991	0.438
LIG_LIR_Nem_3	657	663	PF02991	0.245
LIG_LIR_Nem_3	718	722	PF02991	0.448
LIG_LIR_Nem_3	80	86	PF02991	0.359
LIG_MYND_1	391	395	PF01753	0.541
LIG_MYND_1	526	530	PF01753	0.565
LIG_PALB2_WD40_1	121	129	PF16756	0.497
LIG_PCNA_yPIPBox_3	577	587	PF02747	0.486
LIG_Pex14_1	419	423	PF04695	0.482
LIG_PTB_Apo_2	747	754	PF02174	0.493
LIG_PTB_Phospho_1	747	753	PF10480	0.494
LIG_Rb_LxCxE_1	37	60	PF01857	0.545
LIG_SH2_CRK	86	90	PF00017	0.427
LIG_SH2_NCK_1	722	726	PF00017	0.469
LIG_SH2_PTP2	476	479	PF00017	0.502
LIG_SH2_SRC	337	340	PF00017	0.473
LIG_SH2_SRC	476	479	PF00017	0.502
LIG_SH2_SRC	569	572	PF00017	0.489
LIG_SH2_STAP1	470	474	PF00017	0.384
LIG_SH2_STAP1	722	726	PF00017	0.469
LIG_SH2_STAT3	253	256	PF00017	0.513
LIG_SH2_STAT3	470	473	PF00017	0.396
LIG_SH2_STAT5	140	143	PF00017	0.406
LIG_SH2_STAT5	298	301	PF00017	0.418
LIG_SH2_STAT5	337	340	PF00017	0.456
LIG_SH2_STAT5	476	479	PF00017	0.489
LIG_SH2_STAT5	485	488	PF00017	0.489
LIG_SH2_STAT5	521	524	PF00017	0.471
LIG_SH2_STAT5	569	572	PF00017	0.493
LIG_SH2_STAT5	649	652	PF00017	0.411
LIG_SH2_STAT5	95	98	PF00017	0.567
LIG_SH3_2	97	102	PF14604	0.469
LIG_SH3_3	162	168	PF00018	0.565
LIG_SH3_3	281	287	PF00018	0.628
LIG_SH3_3	388	394	PF00018	0.434
LIG_SH3_3	444	450	PF00018	0.688
LIG_SH3_3	523	529	PF00018	0.334
LIG_SH3_3	546	552	PF00018	0.619
LIG_SH3_3	63	69	PF00018	0.683
LIG_SH3_3	732	738	PF00018	0.504
LIG_SH3_3	94	100	PF00018	0.589
LIG_SUMO_SIM_anti_2	490	495	PF11976	0.446
LIG_TRFH_1	343	347	PF08558	0.487
LIG_WRC_WIRS_1	340	345	PF05994	0.279
LIG_WRC_WIRS_1	45	50	PF05994	0.500
LIG_WRC_WIRS_1	570	575	PF05994	0.392
LIG_WRC_WIRS_1	638	643	PF05994	0.536
MOD_CDC14_SPxK_1	218	221	PF00782	0.437
MOD_CDK_SPxK_1	215	221	PF00069	0.539
MOD_CDK_SPxxK_3	343	350	PF00069	0.493
MOD_CDK_SPxxK_3	548	555	PF00069	0.421
MOD_CK1_1	10	16	PF00069	0.669
MOD_CK1_1	138	144	PF00069	0.437
MOD_CK1_1	17	23	PF00069	0.611
MOD_CK1_1	27	33	PF00069	0.532
MOD_CK1_1	291	297	PF00069	0.485
MOD_CK1_1	396	402	PF00069	0.447
MOD_CK1_1	548	554	PF00069	0.538
MOD_CK2_1	174	180	PF00069	0.560
MOD_CK2_1	376	382	PF00069	0.588
MOD_CK2_1	448	454	PF00069	0.670
MOD_CK2_1	565	571	PF00069	0.428
MOD_CK2_1	589	595	PF00069	0.507
MOD_CK2_1	625	631	PF00069	0.480
MOD_GlcNHglycan	120	123	PF01048	0.435
MOD_GlcNHglycan	26	29	PF01048	0.634
MOD_GlcNHglycan	416	419	PF01048	0.266
MOD_GlcNHglycan	613	616	PF01048	0.681
MOD_GSK3_1	134	141	PF00069	0.461
MOD_GSK3_1	172	179	PF00069	0.612
MOD_GSK3_1	20	27	PF00069	0.521
MOD_GSK3_1	339	346	PF00069	0.476
MOD_GSK3_1	389	396	PF00069	0.545
MOD_GSK3_1	437	444	PF00069	0.575
MOD_GSK3_1	483	490	PF00069	0.455
MOD_GSK3_1	508	515	PF00069	0.515
MOD_GSK3_1	543	550	PF00069	0.619
MOD_GSK3_1	565	572	PF00069	0.492
MOD_GSK3_1	58	65	PF00069	0.602
MOD_GSK3_1	605	612	PF00069	0.639
MOD_GSK3_1	7	14	PF00069	0.683
MOD_N-GLC_1	138	143	PF02516	0.468
MOD_N-GLC_1	414	419	PF02516	0.282
MOD_N-GLC_1	468	473	PF02516	0.426
MOD_N-GLC_1	77	82	PF02516	0.526
MOD_NEK2_1	174	179	PF00069	0.606
MOD_NEK2_1	197	202	PF00069	0.555
MOD_NEK2_1	332	337	PF00069	0.387
MOD_NEK2_1	402	407	PF00069	0.492
MOD_NEK2_1	468	473	PF00069	0.477
MOD_NEK2_1	494	499	PF00069	0.381
MOD_NEK2_1	637	642	PF00069	0.463
MOD_NEK2_1	659	664	PF00069	0.498
MOD_NEK2_1	7	12	PF00069	0.772
MOD_NMyristoyl	1	7	PF02799	0.553
MOD_PIKK_1	198	204	PF00454	0.538
MOD_PIKK_1	27	33	PF00454	0.648
MOD_PIKK_1	631	637	PF00454	0.458
MOD_PKA_2	118	124	PF00069	0.454
MOD_PKA_2	197	203	PF00069	0.576
MOD_PKA_2	312	318	PF00069	0.516
MOD_PKA_2	389	395	PF00069	0.543
MOD_PKA_2	589	595	PF00069	0.493
MOD_PKA_2	610	616	PF00069	0.697
MOD_PKA_2	631	637	PF00069	0.498
MOD_PKA_2	675	681	PF00069	0.595
MOD_PKA_2	8	14	PF00069	0.750
MOD_Plk_1	138	144	PF00069	0.470
MOD_Plk_1	225	231	PF00069	0.463
MOD_Plk_1	291	297	PF00069	0.515
MOD_Plk_1	414	420	PF00069	0.490
MOD_Plk_1	468	474	PF00069	0.446
MOD_Plk_1	77	83	PF00069	0.545
MOD_Plk_2-3	625	631	PF00069	0.548
MOD_Plk_4	138	144	PF00069	0.435
MOD_Plk_4	332	338	PF00069	0.469
MOD_Plk_4	44	50	PF00069	0.431
MOD_Plk_4	494	500	PF00069	0.434
MOD_Plk_4	565	571	PF00069	0.439
MOD_Plk_4	582	588	PF00069	0.348
MOD_Plk_4	625	631	PF00069	0.509
MOD_Plk_4	659	665	PF00069	0.488
MOD_ProDKin_1	12	18	PF00069	0.705
MOD_ProDKin_1	149	155	PF00069	0.556
MOD_ProDKin_1	215	221	PF00069	0.465
MOD_ProDKin_1	255	261	PF00069	0.482
MOD_ProDKin_1	280	286	PF00069	0.644
MOD_ProDKin_1	343	349	PF00069	0.458
MOD_ProDKin_1	369	375	PF00069	0.627
MOD_ProDKin_1	393	399	PF00069	0.554
MOD_ProDKin_1	53	59	PF00069	0.595
MOD_ProDKin_1	545	551	PF00069	0.559
MOD_ProDKin_1	62	68	PF00069	0.645
MOD_ProDKin_1	93	99	PF00069	0.528
MOD_SUMO_for_1	618	621	PF00179	0.623
MOD_SUMO_rev_2	185	195	PF00179	0.577
MOD_SUMO_rev_2	267	275	PF00179	0.614
MOD_SUMO_rev_2	620	629	PF00179	0.591
MOD_SUMO_rev_2	696	701	PF00179	0.631
TRG_DiLeu_BaEn_1	571	576	PF01217	0.480
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.503
TRG_DiLeu_BaLyEn_6	523	528	PF01217	0.567
TRG_DiLeu_BaLyEn_6	552	557	PF01217	0.372
TRG_ENDOCYTIC_2	337	340	PF00928	0.430
TRG_ENDOCYTIC_2	86	89	PF00928	0.376
TRG_ER_diArg_1	299	301	PF00400	0.552
TRG_ER_diArg_1	557	560	PF00400	0.494
TRG_ER_diArg_1	587	590	PF00400	0.497
TRG_ER_diArg_1	669	671	PF00400	0.533
TRG_NES_CRM1_1	41	54	PF08389	0.523
TRG_NES_CRM1_1	467	478	PF08389	0.509
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	351	355	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	627	631	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKH9	Leptomonas seymouri	50%	98%
A0A1X0P015	Trypanosomatidae	32%	100%
A0A3S5H7L6	Leishmania donovani	91%	100%
A0A422NNG1	Trypanosoma rangeli	32%	100%
A4HHJ5	Leishmania braziliensis	78%	92%
A4I4Q3	Leishmania infantum	91%	100%
C9ZLE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ALM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	95%
V5DCL7	Trypanosoma cruzi	33%	100%