US8A

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

US8A

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE55_LEIMA

TriTrypDb:

LmjF.29.1940 , LMJLV39_290027100 , LMJSD75_290027300

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	92	96	PF00656	0.467
CLV_NRD_NRD_1	134	136	PF00675	0.713
CLV_PCSK_KEX2_1	134	136	PF00082	0.728
CLV_PCSK_SKI1_1	112	116	PF00082	0.514
CLV_PCSK_SKI1_1	177	181	PF00082	0.604
DEG_APCC_DBOX_1	67	75	PF00400	0.578
DOC_PP1_RVXF_1	175	182	PF00149	0.602
DOC_USP7_MATH_2	43	49	PF00917	0.620
DOC_USP7_UBL2_3	169	173	PF12436	0.599
DOC_WW_Pin1_4	10	15	PF00397	0.662
DOC_WW_Pin1_4	25	30	PF00397	0.540
DOC_WW_Pin1_4	75	80	PF00397	0.793
LIG_14-3-3_CanoR_1	7	12	PF00244	0.801
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_deltaCOP1_diTrp_1	136	144	PF00928	0.549
LIG_FHA_1	103	109	PF00498	0.611
LIG_FHA_2	55	61	PF00498	0.692
LIG_FHA_2	70	76	PF00498	0.532
LIG_LIR_Apic_2	10	14	PF02991	0.759
LIG_LIR_Gen_1	136	147	PF02991	0.597
LIG_LIR_Nem_3	13	19	PF02991	0.670
LIG_LIR_Nem_3	136	142	PF02991	0.605
LIG_LIR_Nem_3	95	100	PF02991	0.535
LIG_MYND_1	29	33	PF01753	0.673
LIG_PDZ_Class_2	179	184	PF00595	0.608
LIG_SH2_CRK	11	15	PF00017	0.814
LIG_SH2_GRB2like	19	22	PF00017	0.680
LIG_SH2_GRB2like	87	90	PF00017	0.624
LIG_SH2_NCK_1	11	15	PF00017	0.661
LIG_SH2_SRC	93	96	PF00017	0.568
LIG_SH2_STAP1	97	101	PF00017	0.572
LIG_SH2_STAT5	100	103	PF00017	0.666
LIG_SH2_STAT5	11	14	PF00017	0.637
LIG_SH2_STAT5	137	140	PF00017	0.556
LIG_SH2_STAT5	16	19	PF00017	0.656
LIG_SH2_STAT5	93	96	PF00017	0.667
LIG_SH3_3	23	29	PF00018	0.727
LIG_SH3_3	76	82	PF00018	0.666
LIG_WRC_WIRS_1	138	143	PF05994	0.546
MOD_CK1_1	10	16	PF00069	0.640
MOD_CK1_1	53	59	PF00069	0.638
MOD_GlcNHglycan	109	112	PF01048	0.658
MOD_GlcNHglycan	34	37	PF01048	0.603
MOD_GlcNHglycan	60	64	PF01048	0.818
MOD_GSK3_1	10	17	PF00069	0.665
MOD_GSK3_1	50	57	PF00069	0.667
MOD_NEK2_1	101	106	PF00069	0.568
MOD_NEK2_1	107	112	PF00069	0.520
MOD_NEK2_1	44	49	PF00069	0.547
MOD_NEK2_2	14	19	PF00069	0.577
MOD_PIKK_1	102	108	PF00454	0.573
MOD_PIKK_1	152	158	PF00454	0.579
MOD_PKA_2	161	167	PF00069	0.615
MOD_PKB_1	7	15	PF00069	0.630
MOD_Plk_1	102	108	PF00069	0.642
MOD_Plk_2-3	69	75	PF00069	0.683
MOD_Plk_4	14	20	PF00069	0.670
MOD_ProDKin_1	10	16	PF00069	0.666
MOD_ProDKin_1	25	31	PF00069	0.539
MOD_ProDKin_1	75	81	PF00069	0.795
TRG_ER_diArg_1	133	135	PF00400	0.718

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I4Q2	Leishmania infantum	91%	89%
E9ALN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	66%