Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AE53_LEIMA

TriTrypDb:

LmjF.29.1920 , LMJLV39_290026900 , LMJSD75_290027100

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.714
CLV_NRD_NRD_1	248	250	PF00675	0.651
CLV_PCSK_FUR_1	246	250	PF00082	0.767
CLV_PCSK_KEX2_1	246	248	PF00082	0.681
CLV_PCSK_KEX2_1	270	272	PF00082	0.583
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.583
CLV_PCSK_SKI1_1	175	179	PF00082	0.712
CLV_PCSK_SKI1_1	249	253	PF00082	0.750
DEG_SPOP_SBC_1	213	217	PF00917	0.651
DEG_SPOP_SBC_1	99	103	PF00917	0.735
DOC_CKS1_1	69	74	PF01111	0.644
DOC_CYCLIN_RxL_1	172	180	PF00134	0.698
DOC_CYCLIN_yCln2_LP_2	252	255	PF00134	0.762
DOC_MAPK_DCC_7	8	18	PF00069	0.602
DOC_MAPK_gen_1	129	138	PF00069	0.631
DOC_MAPK_gen_1	172	181	PF00069	0.733
DOC_MAPK_gen_1	246	253	PF00069	0.664
DOC_MAPK_MEF2A_6	172	181	PF00069	0.744
DOC_MAPK_MEF2A_6	260	269	PF00069	0.682
DOC_PP1_RVXF_1	173	179	PF00149	0.644
DOC_PP2B_LxvP_1	252	255	PF13499	0.762
DOC_PP4_FxxP_1	113	116	PF00568	0.645
DOC_USP7_MATH_1	120	124	PF00917	0.574
DOC_USP7_MATH_1	188	192	PF00917	0.689
DOC_USP7_MATH_1	211	215	PF00917	0.705
DOC_USP7_MATH_1	235	239	PF00917	0.692
DOC_USP7_MATH_1	99	103	PF00917	0.729
DOC_USP7_UBL2_3	224	228	PF12436	0.759
DOC_WW_Pin1_4	102	107	PF00397	0.574
DOC_WW_Pin1_4	182	187	PF00397	0.641
DOC_WW_Pin1_4	214	219	PF00397	0.711
DOC_WW_Pin1_4	68	73	PF00397	0.639
DOC_WW_Pin1_4	88	93	PF00397	0.484
LIG_14-3-3_CanoR_1	121	125	PF00244	0.697
LIG_14-3-3_CanoR_1	189	193	PF00244	0.684
LIG_14-3-3_CanoR_1	209	218	PF00244	0.460
LIG_Actin_WH2_2	177	195	PF00022	0.728
LIG_BIR_II_1	1	5	PF00653	0.728
LIG_FHA_1	172	178	PF00498	0.647
LIG_FHA_1	195	201	PF00498	0.623
LIG_FHA_1	259	265	PF00498	0.620
LIG_FHA_1	78	84	PF00498	0.684
LIG_LIR_Apic_2	110	116	PF02991	0.588
LIG_LIR_Apic_2	123	127	PF02991	0.685
LIG_LIR_Gen_1	261	269	PF02991	0.620
LIG_LIR_Nem_3	261	265	PF02991	0.616
LIG_SH2_CRK	124	128	PF00017	0.708
LIG_SH2_STAP1	118	122	PF00017	0.620
LIG_SH2_STAT5	207	210	PF00017	0.692
LIG_SH3_3	136	142	PF00018	0.671
LIG_SH3_3	25	31	PF00018	0.729
LIG_SH3_3	86	92	PF00018	0.770
LIG_SUMO_SIM_anti_2	50	56	PF11976	0.556
MOD_CDK_SPxxK_3	182	189	PF00069	0.644
MOD_CK1_1	107	113	PF00069	0.607
MOD_CK1_1	201	207	PF00069	0.727
MOD_CK1_1	212	218	PF00069	0.686
MOD_CK1_1	220	226	PF00069	0.593
MOD_CK1_1	98	104	PF00069	0.809
MOD_CK2_1	193	199	PF00069	0.674
MOD_GlcNHglycan	106	109	PF01048	0.591
MOD_GlcNHglycan	167	171	PF01048	0.742
MOD_GlcNHglycan	211	214	PF01048	0.683
MOD_GlcNHglycan	219	222	PF01048	0.681
MOD_GlcNHglycan	237	240	PF01048	0.691
MOD_GlcNHglycan	96	100	PF01048	0.784
MOD_GSK3_1	188	195	PF00069	0.720
MOD_GSK3_1	209	216	PF00069	0.693
MOD_GSK3_1	49	56	PF00069	0.674
MOD_GSK3_1	64	71	PF00069	0.728
MOD_GSK3_1	94	101	PF00069	0.775
MOD_NEK2_1	1	6	PF00069	0.805
MOD_NEK2_1	192	197	PF00069	0.725
MOD_NEK2_2	188	193	PF00069	0.722
MOD_PIKK_1	240	246	PF00454	0.803
MOD_PIKK_1	64	70	PF00454	0.563
MOD_PKA_2	120	126	PF00069	0.700
MOD_PKA_2	158	164	PF00069	0.805
MOD_PKA_2	188	194	PF00069	0.688
MOD_Plk_1	198	204	PF00069	0.635
MOD_Plk_1	47	53	PF00069	0.780
MOD_Plk_4	143	149	PF00069	0.565
MOD_ProDKin_1	102	108	PF00069	0.569
MOD_ProDKin_1	182	188	PF00069	0.644
MOD_ProDKin_1	214	220	PF00069	0.713
MOD_ProDKin_1	68	74	PF00069	0.640
MOD_ProDKin_1	88	94	PF00069	0.482
TRG_ER_diArg_1	246	249	PF00400	0.679
TRG_ER_diArg_1	59	62	PF00400	0.646
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.700

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ42	Leptomonas seymouri	38%	100%
A0A3Q8IBJ9	Leishmania donovani	90%	100%
A4HHJ2	Leishmania braziliensis	68%	100%
A4I4Q0	Leishmania infantum	91%	100%
E9ALN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%