Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE52_LEIMA

TriTrypDb:

LmjF.29.1910 , LMJLV39_290026800 , LMJSD75_290027000

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AE52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE52

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	207	209	PF00675	0.572
CLV_NRD_NRD_1	322	324	PF00675	0.707
CLV_NRD_NRD_1	377	379	PF00675	0.448
CLV_NRD_NRD_1	436	438	PF00675	0.573
CLV_NRD_NRD_1	70	72	PF00675	0.563
CLV_PCSK_FUR_1	375	379	PF00082	0.513
CLV_PCSK_KEX2_1	207	209	PF00082	0.517
CLV_PCSK_KEX2_1	215	217	PF00082	0.519
CLV_PCSK_KEX2_1	324	326	PF00082	0.771
CLV_PCSK_KEX2_1	377	379	PF00082	0.446
CLV_PCSK_KEX2_1	70	72	PF00082	0.525
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.519
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.771
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.547
CLV_PCSK_PC7_1	66	72	PF00082	0.554
CLV_PCSK_SKI1_1	175	179	PF00082	0.427
CLV_PCSK_SKI1_1	216	220	PF00082	0.531
CLV_PCSK_SKI1_1	360	364	PF00082	0.524
CLV_PCSK_SKI1_1	371	375	PF00082	0.444
CLV_PCSK_SKI1_1	402	406	PF00082	0.537
CLV_PCSK_SKI1_1	70	74	PF00082	0.501
DOC_CYCLIN_RxL_1	10	24	PF00134	0.378
DOC_MAPK_gen_1	173	180	PF00069	0.476
DOC_MAPK_gen_1	95	101	PF00069	0.677
DOC_PP1_RVXF_1	14	21	PF00149	0.372
DOC_PP2B_LxvP_1	178	181	PF13499	0.481
DOC_PP4_FxxP_1	259	262	PF00568	0.536
DOC_PP4_FxxP_1	41	44	PF00568	0.519
DOC_USP7_MATH_1	135	139	PF00917	0.720
DOC_USP7_MATH_1	270	274	PF00917	0.664
DOC_USP7_MATH_1	340	344	PF00917	0.549
DOC_USP7_MATH_1	91	95	PF00917	0.699
DOC_USP7_UBL2_3	401	405	PF12436	0.591
DOC_WW_Pin1_4	101	106	PF00397	0.743
DOC_WW_Pin1_4	188	193	PF00397	0.525
LIG_14-3-3_CanoR_1	325	333	PF00244	0.802
LIG_14-3-3_CanoR_1	378	386	PF00244	0.503
LIG_Actin_WH2_2	159	177	PF00022	0.484
LIG_BIR_II_1	1	5	PF00653	0.544
LIG_BIR_III_4	339	343	PF00653	0.549
LIG_deltaCOP1_diTrp_1	283	289	PF00928	0.557
LIG_FHA_1	151	157	PF00498	0.417
LIG_FHA_1	180	186	PF00498	0.525
LIG_FHA_1	53	59	PF00498	0.427
LIG_FHA_2	324	330	PF00498	0.729
LIG_FHA_2	345	351	PF00498	0.549
LIG_FHA_2	385	391	PF00498	0.447
LIG_FHA_2	394	400	PF00498	0.418
LIG_FHA_2	410	416	PF00498	0.469
LIG_HCF-1_HBM_1	392	395	PF13415	0.537
LIG_LIR_Apic_2	256	262	PF02991	0.518
LIG_LIR_Apic_2	40	44	PF02991	0.521
LIG_LIR_Gen_1	240	251	PF02991	0.389
LIG_LIR_Gen_1	283	291	PF02991	0.494
LIG_LIR_Nem_3	240	246	PF02991	0.632
LIG_LIR_Nem_3	283	287	PF02991	0.488
LIG_Pex14_2	193	197	PF04695	0.390
LIG_PTAP_UEV_1	180	185	PF05743	0.374
LIG_PTB_Apo_2	226	233	PF02174	0.510
LIG_SH2_CRK	243	247	PF00017	0.389
LIG_SH2_NCK_1	395	399	PF00017	0.562
LIG_SH2_STAP1	158	162	PF00017	0.525
LIG_SH2_STAT5	395	398	PF00017	0.463
LIG_SH3_3	146	152	PF00018	0.426
LIG_SH3_3	178	184	PF00018	0.558
LIG_SH3_3	254	260	PF00018	0.398
LIG_TRAF2_1	109	112	PF00917	0.680
LIG_WRC_WIRS_1	286	291	PF05994	0.563
MOD_CK1_1	316	322	PF00069	0.740
MOD_CK1_1	382	388	PF00069	0.593
MOD_CK1_1	414	420	PF00069	0.522
MOD_CK2_1	118	124	PF00069	0.762
MOD_CK2_1	316	322	PF00069	0.745
MOD_CK2_1	344	350	PF00069	0.685
MOD_CK2_1	384	390	PF00069	0.451
MOD_CK2_1	393	399	PF00069	0.404
MOD_CK2_1	409	415	PF00069	0.444
MOD_GlcNHglycan	137	140	PF01048	0.696
MOD_GlcNHglycan	267	271	PF01048	0.761
MOD_GlcNHglycan	273	276	PF01048	0.549
MOD_GlcNHglycan	333	336	PF01048	0.693
MOD_GSK3_1	130	137	PF00069	0.743
MOD_GSK3_1	139	146	PF00069	0.582
MOD_GSK3_1	266	273	PF00069	0.728
MOD_GSK3_1	308	315	PF00069	0.727
MOD_GSK3_1	340	347	PF00069	0.720
MOD_GSK3_1	52	59	PF00069	0.524
MOD_GSK3_1	91	98	PF00069	0.655
MOD_N-GLC_1	228	233	PF02516	0.590
MOD_N-GLC_1	270	275	PF02516	0.743
MOD_N-GLC_1	301	306	PF02516	0.776
MOD_N-GLC_1	308	313	PF02516	0.767
MOD_NEK2_1	21	26	PF00069	0.476
MOD_NEK2_1	228	233	PF00069	0.531
MOD_NEK2_1	99	104	PF00069	0.757
MOD_NEK2_2	444	449	PF00069	0.526
MOD_PIKK_1	316	322	PF00454	0.829
MOD_PKA_1	323	329	PF00069	0.794
MOD_PKA_1	95	101	PF00069	0.677
MOD_PKA_2	340	346	PF00069	0.542
MOD_PKA_2	433	439	PF00069	0.570
MOD_PKB_1	323	331	PF00069	0.799
MOD_Plk_1	129	135	PF00069	0.761
MOD_Plk_1	228	234	PF00069	0.603
MOD_Plk_1	382	388	PF00069	0.596
MOD_Plk_4	151	157	PF00069	0.346
MOD_Plk_4	223	229	PF00069	0.514
MOD_Plk_4	43	49	PF00069	0.504
MOD_Plk_4	95	101	PF00069	0.707
MOD_ProDKin_1	101	107	PF00069	0.741
MOD_ProDKin_1	188	194	PF00069	0.517
MOD_SUMO_rev_2	212	217	PF00179	0.548
MOD_SUMO_rev_2	316	326	PF00179	0.778
TRG_DiLeu_BaEn_1	399	404	PF01217	0.554
TRG_DiLeu_BaEn_1	78	83	PF01217	0.447
TRG_DiLeu_BaEn_2	414	420	PF01217	0.599
TRG_ENDOCYTIC_2	243	246	PF00928	0.410
TRG_ER_diArg_1	172	175	PF00400	0.438
TRG_ER_diArg_1	206	208	PF00400	0.509
TRG_ER_diArg_1	69	71	PF00400	0.549
TRG_NES_CRM1_1	279	294	PF08389	0.368
TRG_NLS_MonoExtC_3	323	329	PF00514	0.746
TRG_NLS_MonoExtN_4	323	328	PF00514	0.804
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB34	Leptomonas seymouri	48%	88%
A0A0S4JH57	Bodo saltans	27%	86%
A0A1X0P158	Trypanosomatidae	30%	100%
A0A3R7MJJ2	Trypanosoma rangeli	32%	100%
A0A3S7X2K3	Leishmania donovani	92%	100%
A4HHJ1	Leishmania braziliensis	73%	97%
A4I4P9	Leishmania infantum	92%	100%
C9ZLD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ALN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BGH3	Trypanosoma cruzi	29%	100%