C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE51_LEIMA

TriTrypDb:

LmjF.29.1900 , LMJLV39_290026700 , LMJSD75_290026900

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	439	443	PF00656	0.492
CLV_NRD_NRD_1	216	218	PF00675	0.407
CLV_NRD_NRD_1	431	433	PF00675	0.597
CLV_NRD_NRD_1	6	8	PF00675	0.596
CLV_PCSK_KEX2_1	216	218	PF00082	0.407
CLV_PCSK_KEX2_1	431	433	PF00082	0.686
CLV_PCSK_SKI1_1	194	198	PF00082	0.416
CLV_PCSK_SKI1_1	333	337	PF00082	0.661
CLV_PCSK_SKI1_1	376	380	PF00082	0.711
DEG_APCC_DBOX_1	332	340	PF00400	0.638
DEG_Nend_UBRbox_2	1	3	PF02207	0.644
DEG_SPOP_SBC_1	100	104	PF00917	0.586
DEG_SPOP_SBC_1	245	249	PF00917	0.662
DOC_CKS1_1	23	28	PF01111	0.546
DOC_CKS1_1	322	327	PF01111	0.622
DOC_MAPK_gen_1	7	15	PF00069	0.578
DOC_MAPK_MEF2A_6	33	40	PF00069	0.509
DOC_MAPK_MEF2A_6	8	17	PF00069	0.504
DOC_PP2B_LxvP_1	433	436	PF13499	0.687
DOC_PP4_FxxP_1	378	381	PF00568	0.634
DOC_USP7_MATH_1	101	105	PF00917	0.503
DOC_USP7_MATH_1	110	114	PF00917	0.387
DOC_USP7_MATH_1	117	121	PF00917	0.571
DOC_USP7_MATH_1	180	184	PF00917	0.494
DOC_USP7_MATH_1	244	248	PF00917	0.663
DOC_USP7_MATH_1	252	256	PF00917	0.776
DOC_USP7_MATH_1	277	281	PF00917	0.613
DOC_USP7_MATH_1	29	33	PF00917	0.531
DOC_USP7_MATH_1	306	310	PF00917	0.681
DOC_USP7_MATH_1	314	318	PF00917	0.712
DOC_USP7_MATH_1	437	441	PF00917	0.670
DOC_USP7_MATH_1	84	88	PF00917	0.546
DOC_USP7_MATH_1	96	100	PF00917	0.495
DOC_USP7_UBL2_3	380	384	PF12436	0.656
DOC_WW_Pin1_4	22	27	PF00397	0.538
DOC_WW_Pin1_4	284	289	PF00397	0.657
DOC_WW_Pin1_4	321	326	PF00397	0.654
DOC_WW_Pin1_4	342	347	PF00397	0.678
LIG_14-3-3_CanoR_1	124	129	PF00244	0.485
LIG_14-3-3_CanoR_1	330	336	PF00244	0.597
LIG_BH_BH3_1	75	91	PF00452	0.319
LIG_BIR_III_4	243	247	PF00653	0.600
LIG_BRCT_BRCA1_1	13	17	PF00533	0.559
LIG_deltaCOP1_diTrp_1	202	210	PF00928	0.515
LIG_deltaCOP1_diTrp_1	9	18	PF00928	0.457
LIG_FHA_1	106	112	PF00498	0.691
LIG_FHA_1	287	293	PF00498	0.693
LIG_FHA_1	398	404	PF00498	0.630
LIG_FHA_1	408	414	PF00498	0.411
LIG_FHA_1	45	51	PF00498	0.492
LIG_LIR_Gen_1	136	146	PF02991	0.354
LIG_LIR_Gen_1	66	76	PF02991	0.415
LIG_LIR_Nem_3	136	141	PF02991	0.355
LIG_LIR_Nem_3	191	196	PF02991	0.453
LIG_LIR_Nem_3	66	72	PF02991	0.428
LIG_PDZ_Class_1	442	447	PF00595	0.626
LIG_PTB_Apo_2	334	341	PF02174	0.660
LIG_SH2_NCK_1	28	32	PF00017	0.600
LIG_SH2_PTP2	174	177	PF00017	0.462
LIG_SH2_SRC	174	177	PF00017	0.462
LIG_SH2_STAP1	374	378	PF00017	0.648
LIG_SH2_STAT5	138	141	PF00017	0.341
LIG_SH2_STAT5	174	177	PF00017	0.476
LIG_SH2_STAT5	221	224	PF00017	0.514
LIG_SH3_1	39	45	PF00018	0.542
LIG_SH3_3	174	180	PF00018	0.544
LIG_SH3_3	319	325	PF00018	0.654
LIG_SH3_3	39	45	PF00018	0.503
LIG_SH3_4	380	387	PF00018	0.629
LIG_SUMO_SIM_anti_2	412	418	PF11976	0.667
LIG_SUMO_SIM_par_1	410	418	PF11976	0.666
LIG_WRC_WIRS_1	315	320	PF05994	0.753
LIG_WRC_WIRS_1	332	337	PF05994	0.407
LIG_WW_3	340	344	PF00397	0.665
MOD_CDK_SPxxK_3	342	349	PF00069	0.677
MOD_CK1_1	99	105	PF00069	0.626
MOD_CK2_1	60	66	PF00069	0.440
MOD_GlcNHglycan	119	122	PF01048	0.539
MOD_GlcNHglycan	256	259	PF01048	0.717
MOD_GlcNHglycan	274	277	PF01048	0.421
MOD_GlcNHglycan	279	282	PF01048	0.587
MOD_GlcNHglycan	294	297	PF01048	0.615
MOD_GlcNHglycan	308	311	PF01048	0.546
MOD_GlcNHglycan	391	394	PF01048	0.635
MOD_GlcNHglycan	66	69	PF01048	0.492
MOD_GlcNHglycan	98	101	PF01048	0.603
MOD_GSK3_1	105	112	PF00069	0.586
MOD_GSK3_1	18	25	PF00069	0.501
MOD_GSK3_1	205	212	PF00069	0.442
MOD_GSK3_1	283	290	PF00069	0.594
MOD_GSK3_1	324	331	PF00069	0.629
MOD_GSK3_1	60	67	PF00069	0.577
MOD_GSK3_1	96	103	PF00069	0.549
MOD_N-GLC_1	252	257	PF02516	0.619
MOD_NEK2_1	18	23	PF00069	0.511
MOD_NEK2_1	200	205	PF00069	0.410
MOD_NEK2_1	206	211	PF00069	0.459
MOD_NEK2_1	292	297	PF00069	0.705
MOD_NEK2_1	335	340	PF00069	0.674
MOD_PIKK_1	2	8	PF00454	0.609
MOD_PIKK_1	44	50	PF00454	0.495
MOD_PKA_2	117	123	PF00069	0.558
MOD_PKA_2	91	97	PF00069	0.492
MOD_PKB_1	22	30	PF00069	0.532
MOD_Plk_1	328	334	PF00069	0.671
MOD_Plk_2-3	60	66	PF00069	0.440
MOD_Plk_4	110	116	PF00069	0.593
MOD_Plk_4	180	186	PF00069	0.509
MOD_Plk_4	200	206	PF00069	0.496
MOD_Plk_4	335	341	PF00069	0.615
MOD_Plk_4	60	66	PF00069	0.492
MOD_ProDKin_1	22	28	PF00069	0.540
MOD_ProDKin_1	284	290	PF00069	0.659
MOD_ProDKin_1	321	327	PF00069	0.647
MOD_ProDKin_1	342	348	PF00069	0.675
MOD_SUMO_for_1	379	382	PF00179	0.635
MOD_SUMO_for_1	403	406	PF00179	0.703
MOD_SUMO_rev_2	231	240	PF00179	0.629
TRG_DiLeu_BaEn_1	166	171	PF01217	0.338
TRG_ENDOCYTIC_2	138	141	PF00928	0.342
TRG_ENDOCYTIC_2	174	177	PF00928	0.489
TRG_ENDOCYTIC_2	193	196	PF00928	0.474
TRG_ER_diArg_1	216	218	PF00400	0.408
TRG_ER_diArg_1	430	432	PF00400	0.665
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Q6	Leptomonas seymouri	64%	95%
A0A0S4KK06	Bodo saltans	26%	92%
A0A1X0NJ10	Trypanosomatidae	33%	100%
A0A3Q8IRG7	Leishmania donovani	95%	100%
A0A3R7NSU2	Trypanosoma rangeli	34%	100%
A4HHJ0	Leishmania braziliensis	88%	100%
A4I4P8	Leishmania infantum	95%	100%
C9ZN48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ALN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BIJ5	Trypanosoma cruzi	32%	100%