LeishMANIAdb
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J domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
J domain-containing protein
Gene product:
DnaJ domain containing protein, putative
Species:
Leishmania major
UniProt:
E9AE50_LEIMA
TriTrypDb:
LmjF.29.1890 , LMJLV39_290026600 * , LMJSD75_290026800 *
Length:
395

Annotations

LeishMANIAdb annotations

Apparently a divergent chaperone with distant Eukaryotic affinities. Topology is very unclear. Likely non-TM

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

E9AE50
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE50

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 16 18 PF00675 0.382
CLV_NRD_NRD_1 199 201 PF00675 0.435
CLV_NRD_NRD_1 206 208 PF00675 0.407
CLV_NRD_NRD_1 256 258 PF00675 0.454
CLV_NRD_NRD_1 265 267 PF00675 0.434
CLV_NRD_NRD_1 331 333 PF00675 0.449
CLV_NRD_NRD_1 342 344 PF00675 0.347
CLV_PCSK_KEX2_1 16 18 PF00082 0.353
CLV_PCSK_KEX2_1 199 201 PF00082 0.443
CLV_PCSK_KEX2_1 206 208 PF00082 0.397
CLV_PCSK_KEX2_1 264 266 PF00082 0.415
CLV_PCSK_KEX2_1 330 332 PF00082 0.464
CLV_PCSK_KEX2_1 342 344 PF00082 0.376
CLV_PCSK_SKI1_1 153 157 PF00082 0.351
CLV_PCSK_SKI1_1 16 20 PF00082 0.284
CLV_PCSK_SKI1_1 33 37 PF00082 0.326
CLV_PCSK_SKI1_1 360 364 PF00082 0.685
CLV_PCSK_SKI1_1 39 43 PF00082 0.329
DEG_Nend_Nbox_1 1 3 PF02207 0.700
DEG_SPOP_SBC_1 334 338 PF00917 0.590
DOC_ANK_TNKS_1 140 147 PF00023 0.663
DOC_CKS1_1 361 366 PF01111 0.552
DOC_CKS1_1 375 380 PF01111 0.335
DOC_CYCLIN_RxL_1 11 23 PF00134 0.536
DOC_MAPK_gen_1 264 273 PF00069 0.716
DOC_PP2B_LxvP_1 278 281 PF13499 0.722
DOC_PP4_FxxP_1 177 180 PF00568 0.596
DOC_USP7_MATH_1 334 338 PF00917 0.689
DOC_USP7_MATH_1 78 82 PF00917 0.738
DOC_WW_Pin1_4 191 196 PF00397 0.618
DOC_WW_Pin1_4 25 30 PF00397 0.564
DOC_WW_Pin1_4 360 365 PF00397 0.544
DOC_WW_Pin1_4 374 379 PF00397 0.338
LIG_14-3-3_CanoR_1 332 341 PF00244 0.686
LIG_14-3-3_CanoR_1 353 358 PF00244 0.719
LIG_14-3-3_CanoR_1 371 375 PF00244 0.589
LIG_ActinCP_TwfCPI_2 177 186 PF01115 0.689
LIG_BIR_III_4 46 50 PF00653 0.472
LIG_BRCT_BRCA1_1 156 160 PF00533 0.653
LIG_EH_1 186 190 PF12763 0.592
LIG_FHA_2 140 146 PF00498 0.682
LIG_FHA_2 192 198 PF00498 0.589
LIG_FHA_2 26 32 PF00498 0.485
LIG_FHA_2 378 384 PF00498 0.507
LIG_LIR_Apic_2 174 180 PF02991 0.597
LIG_LIR_Apic_2 183 188 PF02991 0.696
LIG_LIR_Apic_2 244 250 PF02991 0.672
LIG_LIR_Apic_2 88 94 PF02991 0.720
LIG_LIR_Gen_1 111 120 PF02991 0.650
LIG_LIR_Gen_1 251 260 PF02991 0.642
LIG_LIR_Nem_3 173 178 PF02991 0.605
LIG_LIR_Nem_3 251 256 PF02991 0.643
LIG_LIR_Nem_3 52 57 PF02991 0.467
LIG_MAD2 353 361 PF02301 0.705
LIG_PDZ_Class_3 390 395 PF00595 0.469
LIG_Pex14_1 109 113 PF04695 0.680
LIG_Pex14_2 151 155 PF04695 0.731
LIG_Pex14_2 189 193 PF04695 0.552
LIG_SH2_CRK 185 189 PF00017 0.672
LIG_SH2_GRB2like 182 185 PF00017 0.628
LIG_SH2_NCK_1 27 31 PF00017 0.496
LIG_SH2_SRC 91 94 PF00017 0.744
LIG_SH2_STAP1 381 385 PF00017 0.540
LIG_SH2_STAP1 61 65 PF00017 0.526
LIG_SH2_STAT3 252 255 PF00017 0.655
LIG_SH2_STAT5 113 116 PF00017 0.648
LIG_SH2_STAT5 176 179 PF00017 0.610
LIG_SH2_STAT5 228 231 PF00017 0.547
LIG_SH2_STAT5 27 30 PF00017 0.503
LIG_SH3_3 346 352 PF00018 0.489
LIG_SH3_3 358 364 PF00018 0.478
LIG_SH3_3 372 378 PF00018 0.346
LIG_TRAF2_1 194 197 PF00917 0.615
LIG_TRAF2_1 201 204 PF00917 0.602
LIG_WRPW_2 178 181 PF00400 0.597
MOD_CDK_SPK_2 374 379 PF00069 0.501
MOD_CK1_1 122 128 PF00069 0.786
MOD_CK1_1 81 87 PF00069 0.712
MOD_CK2_1 139 145 PF00069 0.688
MOD_CK2_1 191 197 PF00069 0.602
MOD_Cter_Amidation 70 73 PF01082 0.468
MOD_DYRK1A_RPxSP_1 360 364 PF00069 0.564
MOD_GlcNHglycan 13 16 PF01048 0.353
MOD_GlcNHglycan 220 223 PF01048 0.398
MOD_GlcNHglycan 294 297 PF01048 0.570
MOD_GlcNHglycan 309 312 PF01048 0.525
MOD_GlcNHglycan 345 348 PF01048 0.427
MOD_GlcNHglycan 87 90 PF01048 0.505
MOD_GSK3_1 314 321 PF00069 0.695
MOD_GSK3_1 370 377 PF00069 0.536
MOD_GSK3_1 81 88 PF00069 0.689
MOD_N-GLC_1 170 175 PF02516 0.418
MOD_N-GLC_1 307 312 PF02516 0.446
MOD_N-GLC_2 121 123 PF02516 0.485
MOD_NEK2_1 155 160 PF00069 0.694
MOD_NEK2_1 170 175 PF00069 0.517
MOD_NEK2_1 282 287 PF00069 0.585
MOD_NEK2_1 335 340 PF00069 0.714
MOD_NEK2_1 370 375 PF00069 0.528
MOD_PIKK_1 101 107 PF00454 0.655
MOD_PIKK_1 165 171 PF00454 0.691
MOD_PIKK_1 318 324 PF00454 0.658
MOD_PKA_1 264 270 PF00069 0.665
MOD_PKA_1 72 78 PF00069 0.687
MOD_PKA_2 165 171 PF00069 0.714
MOD_PKA_2 264 270 PF00069 0.626
MOD_PKA_2 370 376 PF00069 0.547
MOD_PKB_1 37 45 PF00069 0.539
MOD_Plk_1 170 176 PF00069 0.688
MOD_Plk_1 383 389 PF00069 0.512
MOD_Plk_1 66 72 PF00069 0.662
MOD_Plk_2-3 383 389 PF00069 0.523
MOD_Plk_4 171 177 PF00069 0.686
MOD_ProDKin_1 191 197 PF00069 0.617
MOD_ProDKin_1 25 31 PF00069 0.564
MOD_ProDKin_1 360 366 PF00069 0.543
MOD_ProDKin_1 374 380 PF00069 0.336
MOD_SUMO_rev_2 149 158 PF00179 0.635
MOD_SUMO_rev_2 26 35 PF00179 0.558
TRG_ENDOCYTIC_2 113 116 PF00928 0.648
TRG_ENDOCYTIC_2 61 64 PF00928 0.472
TRG_ER_diArg_1 16 18 PF00400 0.593
TRG_ER_diArg_1 198 200 PF00400 0.599
TRG_ER_diArg_1 264 266 PF00400 0.654
TRG_ER_diArg_1 330 332 PF00400 0.653
TRG_ER_diArg_1 341 343 PF00400 0.408
TRG_Pf-PMV_PEXEL_1 284 288 PF00026 0.571

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P346 Leptomonas seymouri 55% 100%
A0A0N1I1W6 Leptomonas seymouri 29% 100%
A0A1X0NJW8 Trypanosomatidae 32% 100%
A0A3Q8IEI2 Leishmania donovani 94% 100%
A0A422P027 Trypanosoma rangeli 32% 100%
A4HHI9 Leishmania braziliensis 74% 96%
A4I4P7 Leishmania infantum 94% 100%
E9ALN5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q6N7 Leishmania major 29% 100%
V5BN31 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS