Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE49_LEIMA

TriTrypDb:

LmjF.29.1880 , LMJLV39_290026500 , LMJSD75_290026700

Length:

979

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.569
CLV_C14_Caspase3-7	342	346	PF00656	0.466
CLV_C14_Caspase3-7	405	409	PF00656	0.617
CLV_C14_Caspase3-7	949	953	PF00656	0.570
CLV_NRD_NRD_1	117	119	PF00675	0.385
CLV_NRD_NRD_1	30	32	PF00675	0.425
CLV_NRD_NRD_1	355	357	PF00675	0.480
CLV_NRD_NRD_1	415	417	PF00675	0.607
CLV_NRD_NRD_1	545	547	PF00675	0.509
CLV_NRD_NRD_1	645	647	PF00675	0.401
CLV_NRD_NRD_1	695	697	PF00675	0.621
CLV_NRD_NRD_1	700	702	PF00675	0.566
CLV_NRD_NRD_1	749	751	PF00675	0.539
CLV_NRD_NRD_1	81	83	PF00675	0.678
CLV_NRD_NRD_1	858	860	PF00675	0.407
CLV_NRD_NRD_1	917	919	PF00675	0.610
CLV_NRD_NRD_1	936	938	PF00675	0.464
CLV_NRD_NRD_1	977	979	PF00675	0.584
CLV_PCSK_FUR_1	542	546	PF00082	0.508
CLV_PCSK_KEX2_1	116	118	PF00082	0.399
CLV_PCSK_KEX2_1	355	357	PF00082	0.480
CLV_PCSK_KEX2_1	415	417	PF00082	0.607
CLV_PCSK_KEX2_1	544	546	PF00082	0.513
CLV_PCSK_KEX2_1	645	647	PF00082	0.401
CLV_PCSK_KEX2_1	695	697	PF00082	0.621
CLV_PCSK_KEX2_1	700	702	PF00082	0.566
CLV_PCSK_KEX2_1	749	751	PF00082	0.539
CLV_PCSK_KEX2_1	81	83	PF00082	0.678
CLV_PCSK_KEX2_1	916	918	PF00082	0.554
CLV_PCSK_KEX2_1	936	938	PF00082	0.455
CLV_PCSK_KEX2_1	977	979	PF00082	0.530
CLV_PCSK_PC1ET2_1	916	918	PF00082	0.554
CLV_PCSK_PC7_1	696	702	PF00082	0.606
CLV_PCSK_PC7_1	913	919	PF00082	0.553
CLV_PCSK_SKI1_1	118	122	PF00082	0.395
CLV_PCSK_SKI1_1	297	301	PF00082	0.515
CLV_PCSK_SKI1_1	39	43	PF00082	0.492
CLV_PCSK_SKI1_1	700	704	PF00082	0.564
CLV_PCSK_SKI1_1	783	787	PF00082	0.406
CLV_PCSK_SKI1_1	913	917	PF00082	0.529
CLV_PCSK_SKI1_1	918	922	PF00082	0.556
CLV_PCSK_SKI1_1	95	99	PF00082	0.407
CLV_Separin_Metazoa	930	934	PF03568	0.570
DEG_APCC_DBOX_1	700	708	PF00400	0.566
DEG_APCC_DBOX_1	94	102	PF00400	0.411
DEG_ODPH_VHL_1	629	641	PF01847	0.464
DEG_SCF_FBW7_1	905	912	PF00400	0.631
DEG_SCF_TRCP1_1	882	887	PF00400	0.525
DEG_SPOP_SBC_1	420	424	PF00917	0.593
DOC_CDC14_PxL_1	435	443	PF14671	0.472
DOC_CKS1_1	897	902	PF01111	0.587
DOC_CYCLIN_RxL_1	33	45	PF00134	0.486
DOC_CYCLIN_RxL_1	780	791	PF00134	0.483
DOC_CYCLIN_RxL_1	913	923	PF00134	0.623
DOC_CYCLIN_yCln2_LP_2	436	442	PF00134	0.470
DOC_MAPK_gen_1	427	436	PF00069	0.532
DOC_MAPK_gen_1	542	552	PF00069	0.515
DOC_MAPK_gen_1	798	806	PF00069	0.353
DOC_MAPK_gen_1	936	944	PF00069	0.590
DOC_MAPK_MEF2A_6	429	438	PF00069	0.509
DOC_MAPK_MEF2A_6	544	552	PF00069	0.387
DOC_MAPK_MEF2A_6	761	770	PF00069	0.364
DOC_MAPK_MEF2A_6	798	806	PF00069	0.418
DOC_PP1_RVXF_1	533	540	PF00149	0.492
DOC_PP1_RVXF_1	644	651	PF00149	0.410
DOC_PP2B_LxvP_1	394	397	PF13499	0.521
DOC_PP2B_LxvP_1	436	439	PF13499	0.484
DOC_PP2B_LxvP_1	628	631	PF13499	0.489
DOC_USP7_MATH_1	172	176	PF00917	0.610
DOC_USP7_MATH_1	305	309	PF00917	0.629
DOC_USP7_MATH_1	320	324	PF00917	0.484
DOC_USP7_MATH_1	370	374	PF00917	0.387
DOC_USP7_MATH_1	480	484	PF00917	0.612
DOC_USP7_MATH_1	64	68	PF00917	0.549
DOC_USP7_MATH_1	644	648	PF00917	0.406
DOC_USP7_MATH_1	709	713	PF00917	0.651
DOC_USP7_MATH_1	753	757	PF00917	0.545
DOC_USP7_MATH_1	777	781	PF00917	0.455
DOC_USP7_MATH_1	842	846	PF00917	0.550
DOC_USP7_MATH_1	924	928	PF00917	0.652
DOC_WW_Pin1_4	163	168	PF00397	0.578
DOC_WW_Pin1_4	216	221	PF00397	0.598
DOC_WW_Pin1_4	225	230	PF00397	0.417
DOC_WW_Pin1_4	310	315	PF00397	0.621
DOC_WW_Pin1_4	52	57	PF00397	0.632
DOC_WW_Pin1_4	588	593	PF00397	0.495
DOC_WW_Pin1_4	629	634	PF00397	0.427
DOC_WW_Pin1_4	71	76	PF00397	0.652
DOC_WW_Pin1_4	713	718	PF00397	0.592
DOC_WW_Pin1_4	791	796	PF00397	0.495
DOC_WW_Pin1_4	8	13	PF00397	0.677
DOC_WW_Pin1_4	847	852	PF00397	0.509
DOC_WW_Pin1_4	888	893	PF00397	0.603
DOC_WW_Pin1_4	896	901	PF00397	0.484
DOC_WW_Pin1_4	905	910	PF00397	0.548
LIG_14-3-3_CanoR_1	100	108	PF00244	0.595
LIG_14-3-3_CanoR_1	174	181	PF00244	0.601
LIG_14-3-3_CanoR_1	297	306	PF00244	0.542
LIG_14-3-3_CanoR_1	355	360	PF00244	0.462
LIG_14-3-3_CanoR_1	415	421	PF00244	0.623
LIG_14-3-3_CanoR_1	429	433	PF00244	0.521
LIG_14-3-3_CanoR_1	645	649	PF00244	0.421
LIG_14-3-3_CanoR_1	700	705	PF00244	0.524
LIG_14-3-3_CanoR_1	737	745	PF00244	0.651
LIG_14-3-3_CanoR_1	749	758	PF00244	0.477
LIG_14-3-3_CanoR_1	859	865	PF00244	0.384
LIG_14-3-3_CanoR_1	936	944	PF00244	0.643
LIG_14-3-3_CanoR_1	947	955	PF00244	0.549
LIG_Actin_WH2_2	431	448	PF00022	0.488
LIG_BIR_III_4	197	201	PF00653	0.392
LIG_BRCT_BRCA1_1	754	758	PF00533	0.505
LIG_CaM_NSCaTE_8	250	257	PF13499	0.527
LIG_CtBP_PxDLS_1	47	51	PF00389	0.547
LIG_deltaCOP1_diTrp_1	325	331	PF00928	0.389
LIG_deltaCOP1_diTrp_1	852	861	PF00928	0.464
LIG_eIF4E_1	140	146	PF01652	0.391
LIG_eIF4E_1	781	787	PF01652	0.551
LIG_FHA_1	141	147	PF00498	0.407
LIG_FHA_1	180	186	PF00498	0.607
LIG_FHA_1	205	211	PF00498	0.430
LIG_FHA_1	445	451	PF00498	0.510
LIG_FHA_1	459	465	PF00498	0.342
LIG_FHA_1	547	553	PF00498	0.515
LIG_FHA_1	557	563	PF00498	0.363
LIG_FHA_1	589	595	PF00498	0.553
LIG_FHA_1	782	788	PF00498	0.340
LIG_FHA_1	906	912	PF00498	0.570
LIG_FHA_1	927	933	PF00498	0.612
LIG_FHA_2	255	261	PF00498	0.616
LIG_FHA_2	362	368	PF00498	0.518
LIG_FHA_2	421	427	PF00498	0.702
LIG_FHA_2	61	67	PF00498	0.742
LIG_FHA_2	630	636	PF00498	0.457
LIG_FHA_2	650	656	PF00498	0.297
LIG_FHA_2	722	728	PF00498	0.618
LIG_FHA_2	786	792	PF00498	0.471
LIG_LIR_Gen_1	24	34	PF02991	0.494
LIG_LIR_Gen_1	373	384	PF02991	0.527
LIG_LIR_Gen_1	458	466	PF02991	0.421
LIG_LIR_Gen_1	600	609	PF02991	0.348
LIG_LIR_Gen_1	635	644	PF02991	0.556
LIG_LIR_Gen_1	858	869	PF02991	0.368
LIG_LIR_Nem_3	24	30	PF02991	0.497
LIG_LIR_Nem_3	325	331	PF02991	0.395
LIG_LIR_Nem_3	358	362	PF02991	0.395
LIG_LIR_Nem_3	373	379	PF02991	0.490
LIG_LIR_Nem_3	458	462	PF02991	0.425
LIG_LIR_Nem_3	600	605	PF02991	0.352
LIG_LIR_Nem_3	635	641	PF02991	0.561
LIG_LIR_Nem_3	780	785	PF02991	0.410
LIG_LIR_Nem_3	852	857	PF02991	0.406
LIG_LIR_Nem_3	858	864	PF02991	0.386
LIG_LIR_Nem_3	967	972	PF02991	0.513
LIG_MAD2	39	47	PF02301	0.500
LIG_MYND_1	592	596	PF01753	0.483
LIG_NRBOX	440	446	PF00104	0.391
LIG_NRBOX	515	521	PF00104	0.396
LIG_Pex14_1	861	865	PF04695	0.375
LIG_SH2_CRK	27	31	PF00017	0.488
LIG_SH2_CRK	376	380	PF00017	0.429
LIG_SH2_CRK	764	768	PF00017	0.426
LIG_SH2_CRK	782	786	PF00017	0.285
LIG_SH2_NCK_1	376	380	PF00017	0.429
LIG_SH2_SRC	972	975	PF00017	0.447
LIG_SH2_STAP1	140	144	PF00017	0.444
LIG_SH2_STAP1	238	242	PF00017	0.347
LIG_SH2_STAP1	376	380	PF00017	0.364
LIG_SH2_STAT5	361	364	PF00017	0.407
LIG_SH2_STAT5	523	526	PF00017	0.378
LIG_SH2_STAT5	661	664	PF00017	0.466
LIG_SH2_STAT5	823	826	PF00017	0.397
LIG_SH2_STAT5	972	975	PF00017	0.472
LIG_SH3_1	545	551	PF00018	0.390
LIG_SH3_3	182	188	PF00018	0.596
LIG_SH3_3	281	287	PF00018	0.597
LIG_SH3_3	427	433	PF00018	0.578
LIG_SH3_3	498	504	PF00018	0.608
LIG_SH3_3	50	56	PF00018	0.542
LIG_SH3_3	545	551	PF00018	0.390
LIG_SH3_3	845	851	PF00018	0.531
LIG_SUMO_SIM_par_1	228	233	PF11976	0.453
LIG_SUMO_SIM_par_1	286	293	PF11976	0.523
LIG_SUMO_SIM_par_1	39	45	PF11976	0.518
LIG_SUMO_SIM_par_1	431	437	PF11976	0.527
LIG_SUMO_SIM_par_1	766	772	PF11976	0.362
LIG_SUMO_SIM_par_1	783	788	PF11976	0.449
LIG_TRAF2_1	385	388	PF00917	0.467
LIG_TRAF2_1	632	635	PF00917	0.419
LIG_TRAF2_1	729	732	PF00917	0.659
LIG_TRAF2_1	959	962	PF00917	0.488
LIG_TYR_ITIM	762	767	PF00017	0.359
LIG_WRC_WIRS_1	786	791	PF05994	0.436
MOD_CDC14_SPxK_1	891	894	PF00782	0.587
MOD_CDK_SPK_2	52	57	PF00069	0.523
MOD_CDK_SPxK_1	888	894	PF00069	0.584
MOD_CDK_SPxxK_3	791	798	PF00069	0.481
MOD_CK1_1	165	171	PF00069	0.661
MOD_CK1_1	228	234	PF00069	0.502
MOD_CK1_1	256	262	PF00069	0.640
MOD_CK1_1	273	279	PF00069	0.519
MOD_CK1_1	308	314	PF00069	0.644
MOD_CK1_1	419	425	PF00069	0.591
MOD_CK1_1	509	515	PF00069	0.542
MOD_CK1_1	67	73	PF00069	0.547
MOD_CK1_1	740	746	PF00069	0.650
MOD_CK1_1	756	762	PF00069	0.298
MOD_CK1_1	8	14	PF00069	0.555
MOD_CK1_1	815	821	PF00069	0.431
MOD_CK2_1	216	222	PF00069	0.639
MOD_CK2_1	420	426	PF00069	0.704
MOD_CK2_1	60	66	PF00069	0.768
MOD_CK2_1	629	635	PF00069	0.457
MOD_CK2_1	649	655	PF00069	0.294
MOD_CK2_1	726	732	PF00069	0.615
MOD_CK2_1	785	791	PF00069	0.492
MOD_CK2_1	924	930	PF00069	0.528
MOD_GlcNHglycan	12	15	PF01048	0.799
MOD_GlcNHglycan	222	226	PF01048	0.718
MOD_GlcNHglycan	321	325	PF01048	0.560
MOD_GlcNHglycan	430	433	PF01048	0.591
MOD_GlcNHglycan	44	47	PF01048	0.507
MOD_GlcNHglycan	508	511	PF01048	0.693
MOD_GlcNHglycan	554	557	PF01048	0.430
MOD_GlcNHglycan	731	735	PF01048	0.632
MOD_GlcNHglycan	814	817	PF01048	0.449
MOD_GlcNHglycan	882	885	PF01048	0.578
MOD_GlcNHglycan	901	904	PF01048	0.615
MOD_GlcNHglycan	922	925	PF01048	0.573
MOD_GlcNHglycan	926	929	PF01048	0.536
MOD_GlcNHglycan	938	941	PF01048	0.549
MOD_GlcNHglycan	949	952	PF01048	0.509
MOD_GSK3_1	221	228	PF00069	0.578
MOD_GSK3_1	289	296	PF00069	0.609
MOD_GSK3_1	308	315	PF00069	0.537
MOD_GSK3_1	416	423	PF00069	0.715
MOD_GSK3_1	42	49	PF00069	0.542
MOD_GSK3_1	440	447	PF00069	0.457
MOD_GSK3_1	552	559	PF00069	0.445
MOD_GSK3_1	588	595	PF00069	0.545
MOD_GSK3_1	60	67	PF00069	0.682
MOD_GSK3_1	696	703	PF00069	0.608
MOD_GSK3_1	709	716	PF00069	0.554
MOD_GSK3_1	717	724	PF00069	0.580
MOD_GSK3_1	726	733	PF00069	0.618
MOD_GSK3_1	740	747	PF00069	0.565
MOD_GSK3_1	749	756	PF00069	0.499
MOD_GSK3_1	777	784	PF00069	0.405
MOD_GSK3_1	787	794	PF00069	0.447
MOD_GSK3_1	8	15	PF00069	0.555
MOD_GSK3_1	836	843	PF00069	0.577
MOD_GSK3_1	855	862	PF00069	0.456
MOD_GSK3_1	880	887	PF00069	0.614
MOD_GSK3_1	905	912	PF00069	0.683
MOD_GSK3_1	920	927	PF00069	0.479
MOD_GSK3_1	932	939	PF00069	0.564
MOD_N-GLC_1	297	302	PF02516	0.543
MOD_NEK2_1	254	259	PF00069	0.572
MOD_NEK2_1	331	336	PF00069	0.574
MOD_NEK2_1	349	354	PF00069	0.283
MOD_NEK2_1	41	46	PF00069	0.493
MOD_NEK2_1	428	433	PF00069	0.644
MOD_NEK2_1	444	449	PF00069	0.345
MOD_NEK2_1	527	532	PF00069	0.413
MOD_NEK2_1	587	592	PF00069	0.527
MOD_NEK2_1	730	735	PF00069	0.719
MOD_NEK2_1	785	790	PF00069	0.416
MOD_NEK2_1	812	817	PF00069	0.434
MOD_NEK2_1	834	839	PF00069	0.538
MOD_NEK2_1	931	936	PF00069	0.555
MOD_NEK2_2	371	376	PF00069	0.362
MOD_NEK2_2	753	758	PF00069	0.523
MOD_PIKK_1	528	534	PF00454	0.436
MOD_PIKK_1	684	690	PF00454	0.631
MOD_PIKK_1	99	105	PF00454	0.511
MOD_PK_1	416	422	PF00069	0.602
MOD_PKA_1	355	361	PF00069	0.483
MOD_PKA_1	700	706	PF00069	0.557
MOD_PKA_1	749	755	PF00069	0.516
MOD_PKA_1	859	865	PF00069	0.426
MOD_PKA_1	936	942	PF00069	0.642
MOD_PKA_2	173	179	PF00069	0.626
MOD_PKA_2	355	361	PF00069	0.456
MOD_PKA_2	420	426	PF00069	0.662
MOD_PKA_2	428	434	PF00069	0.517
MOD_PKA_2	472	478	PF00069	0.510
MOD_PKA_2	644	650	PF00069	0.406
MOD_PKA_2	691	697	PF00069	0.634
MOD_PKA_2	700	706	PF00069	0.502
MOD_PKA_2	743	749	PF00069	0.633
MOD_PKA_2	932	938	PF00069	0.628
MOD_PKA_2	946	952	PF00069	0.520
MOD_PKA_2	99	105	PF00069	0.413
MOD_PKB_1	116	124	PF00069	0.388
MOD_PKB_1	544	552	PF00069	0.518
MOD_Plk_1	203	209	PF00069	0.464
MOD_Plk_1	726	732	PF00069	0.643
MOD_Plk_1	940	946	PF00069	0.558
MOD_Plk_4	140	146	PF00069	0.391
MOD_Plk_4	331	337	PF00069	0.429
MOD_Plk_4	371	377	PF00069	0.371
MOD_Plk_4	390	396	PF00069	0.529
MOD_Plk_4	440	446	PF00069	0.565
MOD_Plk_4	753	759	PF00069	0.510
MOD_Plk_4	777	783	PF00069	0.387
MOD_Plk_4	860	866	PF00069	0.380
MOD_Plk_4	868	874	PF00069	0.421
MOD_ProDKin_1	163	169	PF00069	0.577
MOD_ProDKin_1	216	222	PF00069	0.601
MOD_ProDKin_1	225	231	PF00069	0.406
MOD_ProDKin_1	310	316	PF00069	0.620
MOD_ProDKin_1	52	58	PF00069	0.630
MOD_ProDKin_1	588	594	PF00069	0.497
MOD_ProDKin_1	629	635	PF00069	0.426
MOD_ProDKin_1	71	77	PF00069	0.655
MOD_ProDKin_1	713	719	PF00069	0.593
MOD_ProDKin_1	791	797	PF00069	0.487
MOD_ProDKin_1	8	14	PF00069	0.673
MOD_ProDKin_1	847	853	PF00069	0.500
MOD_ProDKin_1	888	894	PF00069	0.600
MOD_ProDKin_1	896	902	PF00069	0.493
MOD_ProDKin_1	905	911	PF00069	0.549
MOD_SUMO_for_1	964	967	PF00179	0.466
MOD_SUMO_rev_2	664	674	PF00179	0.571
MOD_SUMO_rev_2	675	683	PF00179	0.646
MOD_SUMO_rev_2	962	966	PF00179	0.472
TRG_AP2beta_CARGO_1	635	645	PF09066	0.379
TRG_DiLeu_BaEn_2	633	639	PF01217	0.390
TRG_DiLeu_BaEn_2	773	779	PF01217	0.388
TRG_DiLeu_BaEn_4	634	640	PF01217	0.366
TRG_DiLeu_BaEn_4	666	672	PF01217	0.536
TRG_DiLeu_BaLyEn_6	637	642	PF01217	0.376
TRG_ENDOCYTIC_2	27	30	PF00928	0.482
TRG_ENDOCYTIC_2	359	362	PF00928	0.394
TRG_ENDOCYTIC_2	376	379	PF00928	0.486
TRG_ENDOCYTIC_2	764	767	PF00928	0.363
TRG_ENDOCYTIC_2	782	785	PF00928	0.390
TRG_ER_diArg_1	116	118	PF00400	0.422
TRG_ER_diArg_1	354	356	PF00400	0.479
TRG_ER_diArg_1	542	545	PF00400	0.447
TRG_ER_diArg_1	695	697	PF00400	0.650
TRG_ER_diArg_1	700	702	PF00400	0.606
TRG_ER_diArg_1	798	801	PF00400	0.368
TRG_ER_diArg_1	936	938	PF00400	0.749
TRG_ER_diArg_1	976	978	PF00400	0.567
TRG_NLS_MonoExtN_4	913	920	PF00514	0.555
TRG_Pf-PMV_PEXEL_1	337	342	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	525	529	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	761	765	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS01	Leptomonas seymouri	40%	97%
A0A3Q8IHD3	Leishmania donovani	90%	92%
A4HHI8	Leishmania braziliensis	73%	93%
A4I4P6	Leishmania infantum	90%	92%
E9ALN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	92%