Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE47_LEIMA

TriTrypDb:

LmjF.29.1860 , LMJLV39_290026300 , LMJSD75_290026500

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0020015	glycosome	7	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AE47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	432	436	PF00656	0.488
CLV_C14_Caspase3-7	540	544	PF00656	0.396
CLV_NRD_NRD_1	267	269	PF00675	0.747
CLV_NRD_NRD_1	447	449	PF00675	0.495
CLV_NRD_NRD_1	456	458	PF00675	0.289
CLV_NRD_NRD_1	483	485	PF00675	0.432
CLV_NRD_NRD_1	538	540	PF00675	0.417
CLV_PCSK_KEX2_1	447	449	PF00082	0.486
CLV_PCSK_KEX2_1	455	457	PF00082	0.300
CLV_PCSK_KEX2_1	538	540	PF00082	0.390
CLV_PCSK_SKI1_1	377	381	PF00082	0.532
CLV_PCSK_SKI1_1	468	472	PF00082	0.408
DEG_APCC_DBOX_1	136	144	PF00400	0.412
DEG_SPOP_SBC_1	274	278	PF00917	0.739
DOC_CKS1_1	37	42	PF01111	0.329
DOC_MAPK_gen_1	134	142	PF00069	0.411
DOC_MAPK_gen_1	265	275	PF00069	0.628
DOC_MAPK_gen_1	484	491	PF00069	0.482
DOC_MAPK_JIP1_4	15	21	PF00069	0.533
DOC_MAPK_MEF2A_6	468	475	PF00069	0.381
DOC_PP2B_LxvP_1	206	209	PF13499	0.388
DOC_PP4_FxxP_1	119	122	PF00568	0.382
DOC_PP4_FxxP_1	179	182	PF00568	0.339
DOC_PP4_FxxP_1	238	241	PF00568	0.632
DOC_USP7_MATH_1	274	278	PF00917	0.751
DOC_USP7_MATH_1	320	324	PF00917	0.679
DOC_USP7_MATH_1	331	335	PF00917	0.602
DOC_USP7_MATH_1	551	555	PF00917	0.652
DOC_USP7_UBL2_3	141	145	PF12436	0.321
DOC_WW_Pin1_4	178	183	PF00397	0.338
DOC_WW_Pin1_4	254	259	PF00397	0.670
DOC_WW_Pin1_4	309	314	PF00397	0.667
DOC_WW_Pin1_4	36	41	PF00397	0.334
DOC_WW_Pin1_4	547	552	PF00397	0.636
LIG_14-3-3_CanoR_1	103	111	PF00244	0.436
LIG_14-3-3_CanoR_1	448	454	PF00244	0.428
LIG_14-3-3_CanoR_1	474	480	PF00244	0.368
LIG_14-3-3_CanoR_1	505	511	PF00244	0.350
LIG_APCC_ABBA_1	115	120	PF00400	0.368
LIG_eIF4E_1	349	355	PF01652	0.557
LIG_FHA_1	103	109	PF00498	0.410
LIG_FHA_1	172	178	PF00498	0.340
LIG_FHA_1	225	231	PF00498	0.517
LIG_FHA_1	234	240	PF00498	0.614
LIG_FHA_1	381	387	PF00498	0.524
LIG_FHA_1	423	429	PF00498	0.491
LIG_FHA_1	460	466	PF00498	0.426
LIG_LIR_Apic_2	178	182	PF02991	0.337
LIG_LIR_Apic_2	236	241	PF02991	0.623
LIG_LIR_Apic_2	462	467	PF02991	0.299
LIG_LIR_Gen_1	67	73	PF02991	0.359
LIG_LIR_Nem_3	150	155	PF02991	0.385
LIG_LIR_Nem_3	440	445	PF02991	0.605
LIG_LIR_Nem_3	67	72	PF02991	0.364
LIG_LIR_Nem_3	83	88	PF02991	0.322
LIG_MYND_1	26	30	PF01753	0.439
LIG_PDZ_Class_1	551	556	PF00595	0.613
LIG_Pex14_1	151	155	PF04695	0.373
LIG_SH2_CRK	44	48	PF00017	0.311
LIG_SH2_SRC	464	467	PF00017	0.415
LIG_SH2_STAP1	44	48	PF00017	0.370
LIG_SH2_STAT3	118	121	PF00017	0.439
LIG_SH2_STAT5	118	121	PF00017	0.380
LIG_SH2_STAT5	155	158	PF00017	0.312
LIG_SH2_STAT5	205	208	PF00017	0.383
LIG_SH2_STAT5	221	224	PF00017	0.458
LIG_SH2_STAT5	349	352	PF00017	0.511
LIG_SH2_STAT5	353	356	PF00017	0.502
LIG_SH2_STAT5	368	371	PF00017	0.512
LIG_SH2_STAT5	442	445	PF00017	0.595
LIG_SH2_STAT5	451	454	PF00017	0.311
LIG_SH2_STAT5	464	467	PF00017	0.363
LIG_SH2_STAT5	506	509	PF00017	0.357
LIG_SH2_STAT5	510	513	PF00017	0.368
LIG_SH2_STAT5	52	55	PF00017	0.377
LIG_SH2_STAT5	520	523	PF00017	0.285
LIG_SH2_STAT5	85	88	PF00017	0.311
LIG_SH2_STAT5	90	93	PF00017	0.332
LIG_SH3_3	227	233	PF00018	0.506
LIG_SH3_3	238	244	PF00018	0.619
LIG_SH3_3	310	316	PF00018	0.656
LIG_SH3_3	522	528	PF00018	0.420
LIG_SH3_3	60	66	PF00018	0.456
LIG_SUMO_SIM_anti_2	18	24	PF11976	0.545
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.458
LIG_SUMO_SIM_anti_2	469	474	PF11976	0.325
LIG_SUMO_SIM_par_1	15	20	PF11976	0.581
LIG_SUMO_SIM_par_1	172	178	PF11976	0.400
LIG_SUMO_SIM_par_1	221	227	PF11976	0.447
LIG_SUMO_SIM_par_1	487	493	PF11976	0.430
LIG_Vh1_VBS_1	289	307	PF01044	0.518
LIG_WRC_WIRS_1	341	346	PF05994	0.606
MOD_CDC14_SPxK_1	550	553	PF00782	0.651
MOD_CDK_SPK_2	254	259	PF00069	0.670
MOD_CDK_SPxK_1	547	553	PF00069	0.639
MOD_CDK_SPxxK_3	178	185	PF00069	0.324
MOD_CK1_1	195	201	PF00069	0.341
MOD_CK1_1	257	263	PF00069	0.641
MOD_CK1_1	276	282	PF00069	0.742
MOD_CK1_1	293	299	PF00069	0.718
MOD_CK1_1	323	329	PF00069	0.632
MOD_CK1_1	388	394	PF00069	0.483
MOD_DYRK1A_RPxSP_1	311	315	PF00069	0.614
MOD_GlcNHglycan	147	150	PF01048	0.436
MOD_GlcNHglycan	195	198	PF01048	0.362
MOD_GlcNHglycan	233	236	PF01048	0.592
MOD_GlcNHglycan	259	262	PF01048	0.682
MOD_GlcNHglycan	283	286	PF01048	0.599
MOD_GlcNHglycan	325	328	PF01048	0.629
MOD_GlcNHglycan	333	336	PF01048	0.595
MOD_GSK3_1	147	154	PF00069	0.470
MOD_GSK3_1	171	178	PF00069	0.345
MOD_GSK3_1	188	195	PF00069	0.424
MOD_GSK3_1	264	271	PF00069	0.636
MOD_GSK3_1	273	280	PF00069	0.699
MOD_GSK3_1	292	299	PF00069	0.727
MOD_GSK3_1	300	307	PF00069	0.736
MOD_GSK3_1	314	321	PF00069	0.655
MOD_GSK3_1	506	513	PF00069	0.381
MOD_GSK3_1	543	550	PF00069	0.487
MOD_GSK3_1	98	105	PF00069	0.399
MOD_N-GLC_1	323	328	PF02516	0.736
MOD_N-GLC_1	422	427	PF02516	0.484
MOD_NEK2_1	171	176	PF00069	0.496
MOD_NEK2_1	192	197	PF00069	0.460
MOD_NEK2_1	275	280	PF00069	0.610
MOD_NEK2_1	3	8	PF00069	0.601
MOD_NEK2_1	380	385	PF00069	0.529
MOD_NEK2_1	421	426	PF00069	0.478
MOD_NEK2_1	73	78	PF00069	0.402
MOD_NEK2_2	211	216	PF00069	0.392
MOD_NEK2_2	233	238	PF00069	0.603
MOD_NMyristoyl	1	7	PF02799	0.578
MOD_PIKK_1	224	230	PF00454	0.495
MOD_PIKK_1	380	386	PF00454	0.510
MOD_PKA_1	268	274	PF00069	0.599
MOD_PKA_2	102	108	PF00069	0.362
MOD_PKA_2	264	270	PF00069	0.823
MOD_PKA_2	92	98	PF00069	0.362
MOD_PKB_1	338	346	PF00069	0.598
MOD_Plk_1	188	194	PF00069	0.550
MOD_Plk_1	31	37	PF00069	0.424
MOD_Plk_4	147	153	PF00069	0.450
MOD_Plk_4	233	239	PF00069	0.607
MOD_Plk_4	31	37	PF00069	0.402
MOD_Plk_4	487	493	PF00069	0.436
MOD_Plk_4	506	512	PF00069	0.363
MOD_ProDKin_1	178	184	PF00069	0.339
MOD_ProDKin_1	254	260	PF00069	0.673
MOD_ProDKin_1	309	315	PF00069	0.662
MOD_ProDKin_1	36	42	PF00069	0.331
MOD_ProDKin_1	547	553	PF00069	0.639
MOD_SUMO_for_1	26	29	PF00179	0.381
MOD_SUMO_rev_2	490	497	PF00179	0.411
TRG_ENDOCYTIC_2	221	224	PF00928	0.420
TRG_ENDOCYTIC_2	44	47	PF00928	0.311
TRG_ENDOCYTIC_2	442	445	PF00928	0.397
TRG_ENDOCYTIC_2	85	88	PF00928	0.370
TRG_ER_diArg_1	446	448	PF00400	0.472
TRG_ER_diArg_1	454	457	PF00400	0.474
TRG_ER_diArg_1	537	539	PF00400	0.357
TRG_NES_CRM1_1	348	364	PF08389	0.563
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.499
TRG_PTS1	553	556	PF00515	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS69	Leptomonas seymouri	63%	94%
A0A0S4KE41	Bodo saltans	44%	100%
A0A3Q8IEE2	Leishmania donovani	95%	100%
A4HIZ0	Leishmania braziliensis	82%	98%
A4I4P4	Leishmania infantum	95%	100%
E9ALN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%