PIH1_CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-RNA processing PIH1/Nop17, putative

Species:

Leishmania major

UniProt:

E9AE46_LEIMA

TriTrypDb:

LmjF.29.1850 , LMJLV39_290026200 , LMJSD75_290026400

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AE46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE46

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	13
GO:0016043	cellular component organization	3	13
GO:0022607	cellular component assembly	4	13
GO:0043933	protein-containing complex organization	4	13
GO:0065003	protein-containing complex assembly	5	13
GO:0070286	axonemal dynein complex assembly	6	13
GO:0071840	cellular component organization or biogenesis	2	13

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0005515	protein binding	2	13
GO:0045505	dynein intermediate chain binding	3	2
GO:0051087	protein-folding chaperone binding	3	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.657
CLV_C14_Caspase3-7	246	250	PF00656	0.562
CLV_NRD_NRD_1	125	127	PF00675	0.662
CLV_NRD_NRD_1	241	243	PF00675	0.354
CLV_NRD_NRD_1	95	97	PF00675	0.618
CLV_PCSK_FUR_1	123	127	PF00082	0.596
CLV_PCSK_KEX2_1	125	127	PF00082	0.602
CLV_PCSK_KEX2_1	241	243	PF00082	0.354
CLV_PCSK_SKI1_1	150	154	PF00082	0.727
CLV_PCSK_SKI1_1	256	260	PF00082	0.357
CLV_Separin_Metazoa	206	210	PF03568	0.577
DEG_APCC_DBOX_1	203	211	PF00400	0.562
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.685
DOC_MAPK_gen_1	256	263	PF00069	0.543
DOC_MAPK_MEF2A_6	256	263	PF00069	0.502
DOC_PP2B_LxvP_1	235	238	PF13499	0.577
DOC_PP2B_LxvP_1	83	86	PF13499	0.582
DOC_PP4_FxxP_1	154	157	PF00568	0.528
DOC_PP4_FxxP_1	165	168	PF00568	0.546
DOC_PP4_FxxP_1	21	24	PF00568	0.562
DOC_USP7_MATH_1	104	108	PF00917	0.710
DOC_USP7_MATH_1	157	161	PF00917	0.609
DOC_USP7_MATH_1	265	269	PF00917	0.568
DOC_USP7_MATH_1	46	50	PF00917	0.731
DOC_USP7_MATH_1	86	90	PF00917	0.587
DOC_WW_Pin1_4	155	160	PF00397	0.591
DOC_WW_Pin1_4	35	40	PF00397	0.631
LIG_14-3-3_CanoR_1	150	155	PF00244	0.716
LIG_14-3-3_CanoR_1	209	214	PF00244	0.551
LIG_14-3-3_CanoR_1	226	230	PF00244	0.393
LIG_14-3-3_CanoR_1	242	252	PF00244	0.553
LIG_14-3-3_CanoR_1	267	275	PF00244	0.662
LIG_Actin_WH2_2	213	228	PF00022	0.510
LIG_FHA_1	200	206	PF00498	0.542
LIG_FHA_1	258	264	PF00498	0.525
LIG_FHA_2	111	117	PF00498	0.524
LIG_FHA_2	162	168	PF00498	0.572
LIG_FHA_2	244	250	PF00498	0.562
LIG_FHA_2	75	81	PF00498	0.618
LIG_LIR_Apic_2	153	157	PF02991	0.653
LIG_LIR_Apic_2	164	168	PF02991	0.555
LIG_LIR_Nem_3	181	187	PF02991	0.523
LIG_PCNA_PIPBox_1	114	123	PF02747	0.644
LIG_PCNA_yPIPBox_3	114	126	PF02747	0.653
LIG_PDZ_Class_2	272	277	PF00595	0.707
LIG_SH2_STAP1	223	227	PF00017	0.504
LIG_SH2_STAT5	184	187	PF00017	0.471
LIG_SH2_STAT5	234	237	PF00017	0.475
LIG_SH3_3	100	106	PF00018	0.613
LIG_SH3_3	202	208	PF00018	0.495
LIG_TRAF2_1	164	167	PF00917	0.598
LIG_TRAF2_1	32	35	PF00917	0.598
MOD_CK1_1	141	147	PF00069	0.653
MOD_CK1_1	195	201	PF00069	0.520
MOD_CK1_1	268	274	PF00069	0.673
MOD_CK2_1	104	110	PF00069	0.601
MOD_CK2_1	161	167	PF00069	0.610
MOD_CK2_1	209	215	PF00069	0.577
MOD_CK2_1	29	35	PF00069	0.569
MOD_CK2_1	3	9	PF00069	0.577
MOD_GlcNHglycan	106	109	PF01048	0.686
MOD_GlcNHglycan	143	146	PF01048	0.645
MOD_GlcNHglycan	178	181	PF01048	0.546
MOD_GlcNHglycan	194	197	PF01048	0.203
MOD_GlcNHglycan	48	51	PF01048	0.738
MOD_GlcNHglycan	53	56	PF01048	0.761
MOD_GSK3_1	10	17	PF00069	0.596
MOD_GSK3_1	146	153	PF00069	0.738
MOD_GSK3_1	157	164	PF00069	0.473
MOD_GSK3_1	187	194	PF00069	0.504
MOD_GSK3_1	195	202	PF00069	0.489
MOD_N-GLC_1	176	181	PF02516	0.451
MOD_N-GLC_1	3	8	PF02516	0.583
MOD_NEK2_1	14	19	PF00069	0.691
MOD_NEK2_1	225	230	PF00069	0.491
MOD_PIKK_1	110	116	PF00454	0.625
MOD_PK_1	209	215	PF00069	0.577
MOD_PKA_2	104	110	PF00069	0.689
MOD_PKA_2	208	214	PF00069	0.539
MOD_PKA_2	225	231	PF00069	0.451
MOD_PKA_2	266	272	PF00069	0.633
MOD_Plk_2-3	161	167	PF00069	0.567
MOD_Plk_2-3	266	272	PF00069	0.651
MOD_Plk_4	10	16	PF00069	0.545
MOD_Plk_4	116	122	PF00069	0.565
MOD_Plk_4	150	156	PF00069	0.689
MOD_Plk_4	168	174	PF00069	0.299
MOD_ProDKin_1	155	161	PF00069	0.590
MOD_ProDKin_1	35	41	PF00069	0.630
MOD_SUMO_rev_2	266	276	PF00179	0.589
TRG_ENDOCYTIC_2	184	187	PF00928	0.502
TRG_ER_diArg_1	122	125	PF00400	0.612
TRG_ER_diArg_1	240	242	PF00400	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH00	Leptomonas seymouri	64%	99%
A0A0S4IJ87	Bodo saltans	38%	100%
A0A0S4JAL6	Bodo saltans	38%	100%
A0A1X0NZY8	Trypanosomatidae	32%	100%
A0A3Q8IIW1	Leishmania donovani	94%	99%
A0A422NNL4	Trypanosoma rangeli	38%	100%
A4HIY9	Leishmania braziliensis	81%	100%
A4I4P3	Leishmania infantum	94%	99%
C9ZLD4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ALN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
V5BBV3	Trypanosoma cruzi	37%	100%