Cilia- and flagella-associated protein 157

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AE45_LEIMA

TriTrypDb:

LmjF.29.1840 , LMJLV39_290026100 , LMJSD75_290026300

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AE45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AE45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.621
CLV_C14_Caspase3-7	220	224	PF00656	0.371
CLV_C14_Caspase3-7	3	7	PF00656	0.663
CLV_NRD_NRD_1	102	104	PF00675	0.499
CLV_NRD_NRD_1	320	322	PF00675	0.740
CLV_PCSK_FUR_1	111	115	PF00082	0.477
CLV_PCSK_KEX2_1	102	104	PF00082	0.511
CLV_PCSK_KEX2_1	113	115	PF00082	0.455
CLV_PCSK_KEX2_1	212	214	PF00082	0.554
CLV_PCSK_KEX2_1	319	321	PF00082	0.735
CLV_PCSK_KEX2_1	329	331	PF00082	0.746
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.475
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.557
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.766
CLV_PCSK_PC7_1	109	115	PF00082	0.501
CLV_PCSK_SKI1_1	237	241	PF00082	0.582
CLV_PCSK_SKI1_1	255	259	PF00082	0.372
CLV_PCSK_SKI1_1	295	299	PF00082	0.696
CLV_PCSK_SKI1_1	85	89	PF00082	0.454
DEG_APCC_DBOX_1	225	233	PF00400	0.614
DEG_APCC_DBOX_1	62	70	PF00400	0.583
DEG_SCF_FBW7_2	297	302	PF00400	0.743
DOC_MAPK_gen_1	212	218	PF00069	0.524
DOC_MAPK_gen_1	255	261	PF00069	0.507
DOC_USP7_MATH_1	19	23	PF00917	0.697
DOC_USP7_MATH_1	270	274	PF00917	0.623
DOC_USP7_MATH_1	40	44	PF00917	0.672
DOC_WW_Pin1_4	295	300	PF00397	0.697
LIG_Actin_WH2_2	225	242	PF00022	0.595
LIG_Clathr_ClatBox_1	189	193	PF01394	0.605
LIG_eIF4E_1	254	260	PF01652	0.549
LIG_FHA_1	117	123	PF00498	0.466
LIG_FHA_1	270	276	PF00498	0.519
LIG_FHA_1	40	46	PF00498	0.634
LIG_FHA_1	68	74	PF00498	0.523
LIG_FHA_1	82	88	PF00498	0.406
LIG_GBD_Chelix_1	141	149	PF00786	0.553
LIG_LIR_Gen_1	157	167	PF02991	0.484
LIG_LIR_Gen_1	305	315	PF02991	0.696
LIG_LIR_Nem_3	157	163	PF02991	0.486
LIG_LIR_Nem_3	251	257	PF02991	0.469
LIG_LIR_Nem_3	305	311	PF02991	0.686
LIG_NRP_CendR_1	329	332	PF00754	0.734
LIG_SH2_CRK	254	258	PF00017	0.471
LIG_SH2_CRK	308	312	PF00017	0.703
LIG_SH2_NCK_1	4	8	PF00017	0.639
LIG_SH2_SRC	4	7	PF00017	0.662
LIG_SH2_STAP1	4	8	PF00017	0.639
LIG_SH2_STAT3	32	35	PF00017	0.754
LIG_SH2_STAT5	32	35	PF00017	0.735
LIG_SH2_STAT5	8	11	PF00017	0.661
LIG_TRAF2_1	58	61	PF00917	0.627
LIG_TRAF2_1	92	95	PF00917	0.568
LIG_TYR_ITIM	252	257	PF00017	0.502
LIG_UBA3_1	258	266	PF00899	0.513
MOD_CK1_1	178	184	PF00069	0.601
MOD_CK2_1	270	276	PF00069	0.625
MOD_CK2_1	89	95	PF00069	0.567
MOD_Cter_Amidation	317	320	PF01082	0.722
MOD_GlcNHglycan	149	152	PF01048	0.521
MOD_GlcNHglycan	244	247	PF01048	0.560
MOD_GlcNHglycan	42	45	PF01048	0.694
MOD_GSK3_1	19	26	PF00069	0.754
MOD_GSK3_1	200	207	PF00069	0.518
MOD_GSK3_1	238	245	PF00069	0.532
MOD_GSK3_1	291	298	PF00069	0.648
MOD_GSK3_1	69	76	PF00069	0.614
MOD_N-GLC_1	81	86	PF02516	0.463
MOD_NEK2_1	239	244	PF00069	0.519
MOD_NEK2_1	69	74	PF00069	0.590
MOD_NEK2_1	81	86	PF00069	0.444
MOD_NEK2_1	89	94	PF00069	0.277
MOD_PIKK_1	197	203	PF00454	0.595
MOD_PIKK_1	87	93	PF00454	0.499
MOD_PKA_2	175	181	PF00069	0.601
MOD_Plk_1	81	87	PF00069	0.525
MOD_Plk_4	270	276	PF00069	0.583
MOD_ProDKin_1	295	301	PF00069	0.699
MOD_SUMO_rev_2	247	257	PF00179	0.472
MOD_SUMO_rev_2	302	307	PF00179	0.726
MOD_SUMO_rev_2	72	81	PF00179	0.476
MOD_SUMO_rev_2	90	99	PF00179	0.347
TRG_DiLeu_BaEn_1	48	53	PF01217	0.623
TRG_ENDOCYTIC_2	254	257	PF00928	0.474
TRG_ENDOCYTIC_2	308	311	PF00928	0.657
TRG_ER_diArg_1	101	103	PF00400	0.508
TRG_ER_diArg_1	108	111	PF00400	0.471
TRG_ER_diArg_1	14	17	PF00400	0.670
TRG_ER_diArg_1	329	332	PF00400	0.771
TRG_NLS_MonoExtC_3	318	324	PF00514	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC73	Leptomonas seymouri	71%	100%
A0A0S4J6B5	Bodo saltans	31%	70%
A0A1X0P000	Trypanosomatidae	31%	91%
A0A3S7X2L2	Leishmania donovani	97%	100%
A0A422NND5	Trypanosoma rangeli	28%	91%
A4HIY8	Leishmania braziliensis	86%	99%
A4I4P2	Leishmania infantum	97%	100%
E9ALP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%